多囊卵巢综合征患者血清结合珠蛋白、半乳糖凝集素-3水平变化观察
摘要
目的观察多囊卵巢综合征(PCOS)患者血清结合珠蛋白(Hp)、半乳糖凝集素-3(Galectin-3)的水平变化,并分析其与胰岛素抵抗、血清性激素水平的相关性。方法初诊PCOS患者107例为PCOS组,因输卵管因素或男方因素致使不孕的女性患者90例为对照组。两组均抽取月经周期的第2～6天空腹肘静脉血,EUSA法检测血清Hp、Galectin-3。空腹抽取肘静脉血,测算稳定模型胰岛素抵抗指数(HOMA-IR)。抽取月经周期的第2～6天空腹肘静脉血,免疫化学发光法检测血清性激素指标[卵泡雌激素(FSH)、雌二醇(E2)、促黄体生成素(LH)、睾酮(T)、催乳素(PRO)]。结果与对照组比较,PCOS组血清Hp、Galectin-3均升高(P均<0. 05)。与对照组比较,PCOS组HOMA-IR升高(P均<0. 05); PCOS患者分为非胰岛素抵抗者46例、胰岛素抵抗者61例,与非胰岛素抵抗者比较,胰岛素抵抗者PCOS患者血清Hp、Galectin-3水平及HOMA-IR均升高(P均<0. 05)。与对照组比较,PCOS组血清LH、T均升高(P均<0. 05);与非胰岛素抵抗者比较,胰岛素抵抗者PCOS患者血清LH、T均升高(P均<0. 05)。血清Hp、Galectin-3水平与PCOS患者血清HOMA-IR、LH、T水平均呈正相关(r分别为0. 489,0. 628,0. 426,P均<0. 05; r分别为0. 473,0. 603,0. 403,P均<0. 05)。结论 PCOS患者血清Hp、Galectin-3水平升高。血清Hp、Galectin-3改变与患者胰岛素抵抗指标、性激素指标水平呈正相关。
引文
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[13]吴锐,丁瑶,周晴,等.多囊卵巢综合征患者血浆半乳糖凝集素-3与慢性炎症和胰岛素抵抗的相关性研究[J].中华内分泌代谢杂志,2018,34(7):578-582.
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[15]任洁.半乳凝素-3在肥胖和2型糖尿病中的作用及机制[J].国际儿科学杂志,2018,45(2):108-111.
[2]赵越,阮祥燕,李扬璐,等.来曲唑联合高纯度尿促性素治疗克罗米芬耐药的多囊卵巢综合征不孕患者的临床研究[J].首都医科大学学报,2016,37(4):431-436.
[3]郑思远,张莹,龙涛,等.不同胰岛素抵抗及肥胖水平对多囊卵巢综合征患者高雄激素血症特征的影响[J].广东医学,2017,38(3):406-409.
[4]Erriah M,Pabreja K,Fricker M,et al. Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma[J]. Respir Res,2019,20(1):1.
[5]Abah SE,BurtéF,Marquet S,et al. Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis[J]. Sci Rep,2018,8(1):17527.
[6]中华医学会妇产科学分会内分泌学组.多囊卵巢综合征的诊断和治疗专家共识[J].中华妇产科杂志,2008,43(7):553-555.
[7] Speelman DL. Nonpharmacologic management of symptoms in females with polycystic ovary syndrome:a narrative review[J]. J Am Osteopath Assoc,2019,119(1):25-39.
[8]牛志宏,吴丹丹,谷瑞环,等.多囊卵巢综合征患者体重指数与卵泡液氧化应激指标的相关研究[J].中华内分泌代谢杂志,2012,28(8):627-630.
[9]韩志明,谷欣.血清结合珠蛋白对2型糖尿病患者肾功能预测价值分析[J].检验医学与临床,2015,12(17):2605-2607.
[10]Belcher JD,Chen C,Nguyen J,et al. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease:Role of heme oxygenase-1 induction[J]. PLo S One,2018,13(4):e0196455.
[11]Carvalho LML,Ferreira CN,de Oliveira DKD,et al. Haptoglobin levels,but not Hp1-Hp2 polymorphism,are associated with polycystic ovary syndrome[J]. J Assist Reprod Genet,2017,34(12):1691-1698.
[12]张丽静,丘彦.多囊卵巢综合征胰岛素抵抗差异蛋白的分析[J].重庆医科大学学报,2011,36(2):145-147.
[13]吴锐,丁瑶,周晴,等.多囊卵巢综合征患者血浆半乳糖凝集素-3与慢性炎症和胰岛素抵抗的相关性研究[J].中华内分泌代谢杂志,2018,34(7):578-582.
[14]刘仲尼,杨力明.半乳糖凝集素-3与巨噬细胞炎性反应的关系[J].上海大学学报(自然科学版),2017,23(3):395-401.
[15]任洁.半乳凝素-3在肥胖和2型糖尿病中的作用及机制[J].国际儿科学杂志,2018,45(2):108-111.