摘要
目的研究原发性高血压患者脂蛋白a和胱抑素C血清水平与高血压分级的相关性,探讨脂蛋白a及胱抑素C在高血压患者病情严重程度评估的临床应用价值。方法将342例原发性高血压患者根据高血压分级标准分为低危组56例,中危组78例,高危组101例,极高危组107例,比较各组原发性高血压患者脂蛋白a和胱抑素C血清水平的差异,并研究脂蛋白a和胱抑素C血清水平与高血压分级的相关性。结果脂蛋白a与胱抑素C血清水平在低危组、中危组、高危组及极高危组依次升高,任意组间比较,差异均有统计学意义(P<0.05),脂蛋白a和胱抑素C血清水平与高血压分级均呈正相关,差异均有统计学意义(r=0.617、0.669,P<0.05)。结论脂蛋白a、胱抑素C血清水平的监测有助于了解原发性高血压患者病情的危重程度,对高血压的防治具有重要的临床意义。
Objective To study the relationship between hypertension and lipoprotein a serum cystatin C level and the grade of hypertension,investigate lipoprotein A and cystatin C in patients with hypertension disease severity assessment of the clinical value.Methods 342 cases of primary hypertension patients according to the grading criteria of hypertension were divided into low-risk group 56 cases,78 cases of risk group,high risk group of 101 cases,107 cases of high risk group,the differences were compared in patients with essential hypertension and lipoprotein a serum levels of cystatin C,and lipoprotein associated a and cystatin C in blood clear the level and the grade of hypertension.Results the serum lipoprotein A and serum cystatin C levels were significantly higher in the low risk group,medium risk group,high risk group and high risk group,any differences between groups were statistically significant(P<0.05),apolipoprotein A(r=0.617)and cystatin C(r=0.669)serum levels and hypertension grade were statistically significant(P<0.05).Conclusion the monitoring of lipoprotein A and cystatin c serum concentration is helpful for clinical understanding of the critical condition of patients with essential hypertension,and has important clinical significance for the prevention and treatment of hypertension.
引文
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