葛根在保健食品中的应用规律分析
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摘要
以葛根为主要原料的保健食品共计486种,主要包括保肝保健食品、调节血脂保健食品、调节血压保健食品、调节血糖保健食品、调节免疫保健食品。在构建含葛根的保健食品配方数据库的基础上,运用关联规则中Apriori算法对葛根保健食品配方规律进行探究。结果表明174种保肝保健食品中,原料应用最多的是枳椇子、五味子,常见的3种原料搭配组合为葛根-栀子-白芍、葛根-绞股蓝-决明子等; 91种调节血脂作用的保健食品中,原料应用最多的是决明子、绞股蓝,常见的3种原料搭配组合为葛根-决明子-菊花、葛根-泽泻-桑叶等; 41种调节血压作用的保健食品中,原料应用最多的是杜仲、丹参,常见的3种原料搭配组合为葛根-决明子-牡蛎、葛根-丹参-槐花等; 105种调节血糖的保健食品中,原料应用最多的是山药、黄芪,常见的3种原料搭配组合为葛根-三七-地骨皮、葛根-山药-茯苓、葛根-山药-地骨皮等; 75种调节免疫的保健食品中,原料应用最多的是黄芪、枸杞,常见的3种原料搭配组合为葛根-天麻-杜仲、葛根-桑椹-金银花、葛根-西洋参-山楂等。
There are 486 kinds of health food with Puerariae Lobatae Radix as the main raw material,mainly including health food for protecting liver,health food for regulating blood lipid,health food for adjusting blood pressure,health food for regulating blood sugar,and health food for regulating immunity.Based on the establishment of a health food recipe database with Puerariae Lobatae Radix as the main raw material,the Apriori algorithm in association rules was used to explore the formula rule of health food of Puerariae Lobatae Radix.The results showed that among the 174 kinds of hepatoprotective health food,the most used raw materials were Noveniae Fructus and Schisandrae Chinensis Fructus;the common combinations of three raw materials were Puerariae Lobatae Radix-Gardeniae Fructus-Paeoniae Radix Alba,Puerariae Lobatae Radix-Gynostemmatis Pentaphylli Herba-Cassiae Semen,etc.Among the 91 kinds of health food for regulating blood lipid,the most widely used raw materials were Cassiae Semen and Gynostemmatis Pentaphylli Herba;the common combinations of three raw materials were Puerariae Lobatae Radix-Cassiae Semen-Chrysanthemi Flos,Puerariae Lobatae RadixAlismatis Rhizoma-Mori Folium,etc.Among the 41 kinds of health food for regulating blood pressure,the most widely used raw materials were Eucommiae Cortex and Salviae Miltiorrhizae Radix et Rhizoma;the common combinations of the three raw materials were Puerariae Lobatae Radix-Cassiae Semen-Ostreae Concha,Puerariae Lobatae Radix-Salviae Miltiorrhizae Radix et Rhizoma-Sophorae Flos,etc.Among the 105 kinds of health food for regulating blood sugar,the most widely used raw materials were Dioscoreae Rhizoma and Astragali Radix;the common combinations of three raw materials were Puerariae Lobatae Radix-Notoginseng Radix et Rhizoma-Lycii Cortex,Puerariae Lobatae Radix-Dioscoreae Rhizoma-Poria,Puerariae Lobatae Radix-Dioscoreae Rhizoma-Lycii Cortex,etc.Among the 75 kinds of health food for regulating immunity,the most widely used raw materials were Astragali Radix and Lycii Fructus;the common combinations of three raw materials were Puerariae Lobatae RadixGastrodiae Rhizoma-Eucommiae Cortex,Puerariae Lobatae Radix-Mori Fructus-Lonicerae Japonicae Flos,Puerariae Lobatae Radix-Panacis Quinquefolii Radix-Crataegi Fructus,etc.
There are 486 kinds of health food with Puerariae Lobatae Radix as the main raw material,mainly including health food for protecting liver,health food for regulating blood lipid,health food for adjusting blood pressure,health food for regulating blood sugar,and health food for regulating immunity.Based on the establishment of a health food recipe database with Puerariae Lobatae Radix as the main raw material,the Apriori algorithm in association rules was used to explore the formula rule of health food of Puerariae Lobatae Radix.The results showed that among the 174 kinds of hepatoprotective health food,the most used raw materials were Noveniae Fructus and Schisandrae Chinensis Fructus;the common combinations of three raw materials were Puerariae Lobatae Radix-Gardeniae Fructus-Paeoniae Radix Alba,Puerariae Lobatae Radix-Gynostemmatis Pentaphylli Herba-Cassiae Semen,etc.Among the 91 kinds of health food for regulating blood lipid,the most widely used raw materials were Cassiae Semen and Gynostemmatis Pentaphylli Herba;the common combinations of three raw materials were Puerariae Lobatae Radix-Cassiae Semen-Chrysanthemi Flos,Puerariae Lobatae RadixAlismatis Rhizoma-Mori Folium,etc.Among the 41 kinds of health food for regulating blood pressure,the most widely used raw materials were Eucommiae Cortex and Salviae Miltiorrhizae Radix et Rhizoma;the common combinations of the three raw materials were Puerariae Lobatae Radix-Cassiae Semen-Ostreae Concha,Puerariae Lobatae Radix-Salviae Miltiorrhizae Radix et Rhizoma-Sophorae Flos,etc.Among the 105 kinds of health food for regulating blood sugar,the most widely used raw materials were Dioscoreae Rhizoma and Astragali Radix;the common combinations of three raw materials were Puerariae Lobatae Radix-Notoginseng Radix et Rhizoma-Lycii Cortex,Puerariae Lobatae Radix-Dioscoreae Rhizoma-Poria,Puerariae Lobatae Radix-Dioscoreae Rhizoma-Lycii Cortex,etc.Among the 75 kinds of health food for regulating immunity,the most widely used raw materials were Astragali Radix and Lycii Fructus;the common combinations of three raw materials were Puerariae Lobatae RadixGastrodiae Rhizoma-Eucommiae Cortex,Puerariae Lobatae Radix-Mori Fructus-Lonicerae Japonicae Flos,Puerariae Lobatae Radix-Panacis Quinquefolii Radix-Crataegi Fructus,etc.
引文
[1]国家中医药管理局《中华本草》编委会.中华本草[M].上海:上海科学技术出版社,1998:896.
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[3]巩红岩,秦元旭,王更富,等.葛根素对大鼠体外循环后心肌缺血再灌注损伤的保护作用及抗氧化应激机制的探讨[J].中国实验方剂学杂志,2012,18(1):165-168.
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[5]朱敏杰,郝海英,陈洁,等.葛根素对肾缺血再灌注大鼠肾脏组织细胞凋亡的影响及其机制探讨[J].中国实验方剂学杂志,2016,22(23):127-132.
[6]方新华,卢晓,吴国清.葛根素对妊娠期糖尿病大鼠调节血脂和抗氧化作用的实验研究[J].中华中医药学刊,2016,34(6):1504-1507.
[7]朱振元,罗游,薛婧,等.葛根功能饮料的急性毒性及解酒护肝功效评价[J].食品研究与开发,2016,37(21):160-163.
[8]周步高,邹勇,王馨,等.葛根素对损伤后肝细胞再生障碍大鼠的肝保护作用评价[J].中华中医药杂志,2017,32(5):2046-2049.
[9]万强,周凤华,崔小冰,等.葛根素降低Apo E-/-小鼠visfatin表达抑制动脉粥样硬化形成的研究[J].时珍国医国药,2015,26(6):1305-1308.
[10]刘娇梅.葛根素对妊娠期糖尿病大鼠氧化应激损伤保护作用的研究[J].中药药理与临床,2015,31(5):54-57.
[11]ZUO Z,GE B,ZHANG Z,et al.CYP 450 inhibition and cardiovascular biomarkers alteration by Radix Puerariae lobatae(Gegen):inside story from an herb-drug interaction study[J].Acta Pharmacol Sin,2017,38(7):1074.
[12]ZHANG Y,WANG P,XU Y,et al.Metabolomic analysis of biochemical changes in the plasma of high-fat diet and streptozotocin-induced diabetic rats after treatment with isoflavones extract of Radix Puerariae[J].Evid Based Complement Alternat Med,2016,doi:10.1155/2016/4701890.
[13]LI H,LUO K J,HOU J.Inhibitory effect of Puerariae radix flavones on platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells via PI3K and ERK pathways[J].Exp Ther Med,2015,9(1):257-261.
[14]钟赣生.中药学[M].9版.北京:中国中医药出版杜,2012.
[15]南京中医药大学.中药大辞典[M].2版.上海:上海科学技术出版社,2014.
[16]管咏梅,陶玲,肖芳,等.雷公藤在临床治疗类风湿性关节炎中的用药规律探析[J].中国医院药学杂志,2018,38(1):64-68.
[17]Pravallika P,Narendra K.Analysis on medical data sets using Apriori algorithm based on association rules[J].IJSRET,2018,1(4):717-722.
[18]朱蕾蕾,孙继佳,金采映,等.基于数据库及数据挖掘的中医医案方法学研究---蒋健教授治疗胃痛的临床经验总结[J].中华中医药杂志,2013,28(10):2888-2893.
[19]曹玉洁,陈艳琰,唐于平,等.基于Apriori算法与网络关联的大黄-甘草药对数据挖掘分析[J].中国实验方剂学杂志,2018,24(14):182-187.
[2]李昕,潘俊娴,陈士国,等.葛根化学成分及药理作用研究进展[J].中国食品学报,2017,17(9):189-195.
[3]巩红岩,秦元旭,王更富,等.葛根素对大鼠体外循环后心肌缺血再灌注损伤的保护作用及抗氧化应激机制的探讨[J].中国实验方剂学杂志,2012,18(1):165-168.
[4]侯永春,严孜.葛根素对慢性脑缺血大鼠海马CA1区NGF表达的影响[J].中国实验方剂学杂志,2012,18(3):184-186.
[5]朱敏杰,郝海英,陈洁,等.葛根素对肾缺血再灌注大鼠肾脏组织细胞凋亡的影响及其机制探讨[J].中国实验方剂学杂志,2016,22(23):127-132.
[6]方新华,卢晓,吴国清.葛根素对妊娠期糖尿病大鼠调节血脂和抗氧化作用的实验研究[J].中华中医药学刊,2016,34(6):1504-1507.
[7]朱振元,罗游,薛婧,等.葛根功能饮料的急性毒性及解酒护肝功效评价[J].食品研究与开发,2016,37(21):160-163.
[8]周步高,邹勇,王馨,等.葛根素对损伤后肝细胞再生障碍大鼠的肝保护作用评价[J].中华中医药杂志,2017,32(5):2046-2049.
[9]万强,周凤华,崔小冰,等.葛根素降低Apo E-/-小鼠visfatin表达抑制动脉粥样硬化形成的研究[J].时珍国医国药,2015,26(6):1305-1308.
[10]刘娇梅.葛根素对妊娠期糖尿病大鼠氧化应激损伤保护作用的研究[J].中药药理与临床,2015,31(5):54-57.
[11]ZUO Z,GE B,ZHANG Z,et al.CYP 450 inhibition and cardiovascular biomarkers alteration by Radix Puerariae lobatae(Gegen):inside story from an herb-drug interaction study[J].Acta Pharmacol Sin,2017,38(7):1074.
[12]ZHANG Y,WANG P,XU Y,et al.Metabolomic analysis of biochemical changes in the plasma of high-fat diet and streptozotocin-induced diabetic rats after treatment with isoflavones extract of Radix Puerariae[J].Evid Based Complement Alternat Med,2016,doi:10.1155/2016/4701890.
[13]LI H,LUO K J,HOU J.Inhibitory effect of Puerariae radix flavones on platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells via PI3K and ERK pathways[J].Exp Ther Med,2015,9(1):257-261.
[14]钟赣生.中药学[M].9版.北京:中国中医药出版杜,2012.
[15]南京中医药大学.中药大辞典[M].2版.上海:上海科学技术出版社,2014.
[16]管咏梅,陶玲,肖芳,等.雷公藤在临床治疗类风湿性关节炎中的用药规律探析[J].中国医院药学杂志,2018,38(1):64-68.
[17]Pravallika P,Narendra K.Analysis on medical data sets using Apriori algorithm based on association rules[J].IJSRET,2018,1(4):717-722.
[18]朱蕾蕾,孙继佳,金采映,等.基于数据库及数据挖掘的中医医案方法学研究---蒋健教授治疗胃痛的临床经验总结[J].中华中医药杂志,2013,28(10):2888-2893.
[19]曹玉洁,陈艳琰,唐于平,等.基于Apriori算法与网络关联的大黄-甘草药对数据挖掘分析[J].中国实验方剂学杂志,2018,24(14):182-187.