金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响
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摘要
目的:探讨金天格胶囊对骨质疏松骨折患者炎性反应递质表达的影响。方法:选取2016年1月至2016年12月昆明市延安医院收治的骨质疏松性骨折140例作为研究对象,按照入组先后顺序分为观察组与对照组,每组70例,对照组给予口服钙尔奇D3元素片,观察组给予金天格胶囊口服,疗程6个月。结果:治疗3个月后肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)-1、IL-6、IL-10、IL-17及单核细胞趋化蛋白-1(MCP-1)水平观察组显著低于对照组,差异有统计学意义(P <0. 05);观察组治疗6个月后TNF-α、IL-1、IL-10、IL-17及MCP-1水平显著低于对照组,差异有统计学意义(P <0. 05);观察组治疗6个月后的L1-4骨密度高于对照组,差异有统计学意义(P <0. 05);骨质疏松后骨折患者L1-4骨密度平与TNF-α、IL-1、IL-10、IL-17及MCP-1呈负相关(P <0. 05)。结论:金天格胶囊可有效提升骨质疏松骨折患者L1-4骨密度,抑制骨细胞炎性反应递质表达可能是骨密度提升的机制之一。
Objective: To explore the effects of Jintiange Capsules on the expression of inflammatory factors in patients with osteoporotic fracture. Methods: A total of 140 cases of patients with osteoporotic fracture admitted to Yan'an Hospital of Kunming City from January 2016 to December 2016 were included and were divided into study group and control group according to the joining order,with 70 cases in each group. The control group was given oral calcium element tablets of Caltrate,while the study group was given Jintiange Capsules orally for 6 months. Results: The levels of TNF-α,IL-1,IL-6,IL-10,IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 3 months of treatment. The levels of TNF-Α,IL-1,IL-10,IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 6 months of treatment( P < 0. 05). The levels of L1-4 BMD of the study group was significantly higher than that of the control group at the same period( P < 0. 05). The level of L1-4 BMD in patients with osteoporosis showed a significant negative correlation with TNF-α,IL-1,IL-10,IL-17 and MCP-1( P< 0. 05). Conclusion: Jintiange Capsules can effectively improve the bone mineral density of L1-4 bone in patients with osteoporotic fracture,and one of the mechanisms may be its effects in suppressing the expression of inflammatory factors of bone cells.
Objective: To explore the effects of Jintiange Capsules on the expression of inflammatory factors in patients with osteoporotic fracture. Methods: A total of 140 cases of patients with osteoporotic fracture admitted to Yan'an Hospital of Kunming City from January 2016 to December 2016 were included and were divided into study group and control group according to the joining order,with 70 cases in each group. The control group was given oral calcium element tablets of Caltrate,while the study group was given Jintiange Capsules orally for 6 months. Results: The levels of TNF-α,IL-1,IL-6,IL-10,IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 3 months of treatment. The levels of TNF-Α,IL-1,IL-10,IL-17 and MCP-1 of the study group were significantly lower than those of the control group after 6 months of treatment( P < 0. 05). The levels of L1-4 BMD of the study group was significantly higher than that of the control group at the same period( P < 0. 05). The level of L1-4 BMD in patients with osteoporosis showed a significant negative correlation with TNF-α,IL-1,IL-10,IL-17 and MCP-1( P< 0. 05). Conclusion: Jintiange Capsules can effectively improve the bone mineral density of L1-4 bone in patients with osteoporotic fracture,and one of the mechanisms may be its effects in suppressing the expression of inflammatory factors of bone cells.
引文
[1]彭杰威,黄子奇,黄伟彦,等.金天格胶囊对膝骨关节炎患者关节软骨及膝关节功能的作用及机制[J].中国老年学杂志,2018,38(2):393-395.
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[10]赵玉玺,张彬,湛梅圣,等.金天格胶囊对骨质疏松性骨折大鼠血清IL-2、IL-4和TNF-α表达的影响[J].中国骨质疏松杂志,2015,21(7):796-800.
[11]欧阳嵘,崔世维,朱轶晴,等.2型糖尿病炎症因子水平与骨质疏松症的关系[J].中华全科医学,2013,11(5):690-691.
[12]Johnell O,Kanis JA.An estimate of the worldwide prevalence and disability associated with osteoporotic fractures[J].Osteoporos Int,2006,17(12):1726-1733.
[13]刘晓宁,孔德明,肖继龙,等.辛伐他汀对桡骨远端骨折老年女性骨密度及骨折愈合的影响[J].中国骨质疏松杂志,2017,23(1):74-77,121.
[14]徐少文,顾耕华,赵光锋,等.实验性骨质疏松性骨折愈合中的骨密度及组织学观察[J].中华急诊医学杂志,2002,11(5):324-326.
[15]张弛,叶斌,张海林,等.抗骨质疏松治疗对老年性膝关节骨关节炎疗效的影响[J].实用老年医学,2011,25(4):346-347.
[16]马猛,张志国,马晓辉.单味及复方中药防治骨质疏松症的研究进展[J].中国医药导刊,2018,20(8):477-481.
[17]王均华,肖蔚林,杨依然,等.金天格胶囊对股骨粗隆间骨折患者术后骨密度影响的临床研究[J].中国中医骨伤科杂志,2018,26(8):26-29.
[18]周大勇.辛伐他汀治疗骨质疏松症的相关研究[J].中国现代药物应用,2011,5(21):117-119.
[19]李卫勤,邢永军,杨智泉,等.金天格在老年骨质疏松性椎体骨折术后的应用及临床分析[J].现代生物医学进展,2018,18(6):1116-1119.
[20]郭建利.金天格胶囊对老年绝经后膝骨关节炎患者血清OPN、MMP-3、IL-1β及TGF-β1水平的影响[J].中国老年学杂志,2018,38(3):635-637.
[2]周悦彬,郭洪刚,张园,等.金天格胶囊联合非甾体镇痛剂治疗膝关节退行性关节炎的临床研究[J].中国骨质疏松杂志,2017,23(1):62-65.
[3]高爱荣,王雅萍,路丽,等.金天格胶囊治疗骨质疏松症疗效观察[J].中国骨质疏松杂志,2016,22(1):99-101,106.
[4]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南(2011年)[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17.
[5]白彦逵,王建年.微创手术联合术后胎盘多肽注射液治疗对老年股骨粗隆间骨折患者骨折愈合、血液流变学的影响[J].海南医学院学报,2016,22(22):2745-2748.
[6]王燕,刘瑾,侯彦雪,等.金天格胶囊联合辛伐他汀对骨质疏松性Ⅰ度胸腰椎压缩性骨折疗效的临床观察[J].中国骨质疏松杂志,2018,24(2):239-243.
[7]Song HY,Jeon ES,Kim JI,et al.Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells[J].J Cell Biochem,2007,101(5):1238-1251.
[8]Tabung FK,Steck SE,Zhang J,et al.Construct validation of the dietary inflammatory index among postmenopausal women[J].Ann Epidemiol,2015,25(6):398-405.
[9]Xing D,Feng W,Miller AP,et al.Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation[J].Am J Physiol Heart Circ Physiol,2007,292(6):H2607-2612.
[10]赵玉玺,张彬,湛梅圣,等.金天格胶囊对骨质疏松性骨折大鼠血清IL-2、IL-4和TNF-α表达的影响[J].中国骨质疏松杂志,2015,21(7):796-800.
[11]欧阳嵘,崔世维,朱轶晴,等.2型糖尿病炎症因子水平与骨质疏松症的关系[J].中华全科医学,2013,11(5):690-691.
[12]Johnell O,Kanis JA.An estimate of the worldwide prevalence and disability associated with osteoporotic fractures[J].Osteoporos Int,2006,17(12):1726-1733.
[13]刘晓宁,孔德明,肖继龙,等.辛伐他汀对桡骨远端骨折老年女性骨密度及骨折愈合的影响[J].中国骨质疏松杂志,2017,23(1):74-77,121.
[14]徐少文,顾耕华,赵光锋,等.实验性骨质疏松性骨折愈合中的骨密度及组织学观察[J].中华急诊医学杂志,2002,11(5):324-326.
[15]张弛,叶斌,张海林,等.抗骨质疏松治疗对老年性膝关节骨关节炎疗效的影响[J].实用老年医学,2011,25(4):346-347.
[16]马猛,张志国,马晓辉.单味及复方中药防治骨质疏松症的研究进展[J].中国医药导刊,2018,20(8):477-481.
[17]王均华,肖蔚林,杨依然,等.金天格胶囊对股骨粗隆间骨折患者术后骨密度影响的临床研究[J].中国中医骨伤科杂志,2018,26(8):26-29.
[18]周大勇.辛伐他汀治疗骨质疏松症的相关研究[J].中国现代药物应用,2011,5(21):117-119.
[19]李卫勤,邢永军,杨智泉,等.金天格在老年骨质疏松性椎体骨折术后的应用及临床分析[J].现代生物医学进展,2018,18(6):1116-1119.
[20]郭建利.金天格胶囊对老年绝经后膝骨关节炎患者血清OPN、MMP-3、IL-1β及TGF-β1水平的影响[J].中国老年学杂志,2018,38(3):635-637.