MicroRNA在肿瘤中的研究进展
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摘要
肿瘤是危害世界最严重的疾病之一,它的发生、发展是多因素、多步骤的复杂过程。虽然在研究癌基因、抑癌基因及相关信号传导通路等方面取得一定进展,但至今肿瘤形成的机制仍未完全阐明。从分子生物学角度,肿瘤是多基因异常而导致的一类疾病,由于一种或几种抑癌基因的缺失或突变及癌基因的过度表达,从而引起肿瘤细胞的过度增殖。近年来研究发现一类新的、非编码的miRNAs(microRNA)在肿瘤组织中的表达水平有不同程度的异常表达,提示miRNA表达与肿瘤的发生存在相关性,深入揭示miRNA在肿瘤中的作用,对其早期诊断及建立有效的miRNA靶向治疗具有重要意义。
Tumor is one of the most serious diseases in the world,its occurrence and development is a multi-factor,multi-step complex process.Although some progress has been made in the study of cancer genes,tumor suppressor genes and related signaling pathways,the mechanism of tumorigeness has not been fully elucidated.From the point of view of molecular biology,tumor is a kind of disease caused by multiple gene abnormalities,which causes the excessive proliferation of tumor cells due to the absence or mutation of one or several anticancer genes and the excessive expression of oncogenes.In recent years,it has been found that an new,non-encoded miRNAs(MicroRNA) in tumor tissues has different degrees of abnormal expressions,which suggests that miRNA expression has a correlation with the occurrence of tumor,and deeply reveals the role of miRNA in tumorigeness, it is of great significance for its early diagnosis and the establishment of effective miRNA targeted therapy.
Tumor is one of the most serious diseases in the world,its occurrence and development is a multi-factor,multi-step complex process.Although some progress has been made in the study of cancer genes,tumor suppressor genes and related signaling pathways,the mechanism of tumorigeness has not been fully elucidated.From the point of view of molecular biology,tumor is a kind of disease caused by multiple gene abnormalities,which causes the excessive proliferation of tumor cells due to the absence or mutation of one or several anticancer genes and the excessive expression of oncogenes.In recent years,it has been found that an new,non-encoded miRNAs(MicroRNA) in tumor tissues has different degrees of abnormal expressions,which suggests that miRNA expression has a correlation with the occurrence of tumor,and deeply reveals the role of miRNA in tumorigeness, it is of great significance for its early diagnosis and the establishment of effective miRNA targeted therapy.
引文
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21 Zhang R,Li M,Zang W,et al.MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2.Tumour Biol,2014,35:837-844.
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23 Saini S,Majid S,Yamamura S,et al.Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis.Clin Cancer Res,2011,17:5287-5298.
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27 Shi ZM,Wang J,Yan Z,et al.MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1.PLoS One,2012,7:e32709.
28 Pan YZ,Morris ME,Yu AM.MicroRNA-328 negatively regulates the expression of breast cancer resistance protein(BCRP/ABCG2)in human cancer cells.Mol Pharmacol,2009,75:1374-1379.
29 Zhou X,Zhang J,Jia Q,et al.Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3.Oncol Rep,2010,24:195-201.
30 Hatley ME,Patrick DM,Garcia MR,et al.Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.Cancer Cell,2010,18:282-293.
31 D'Urso PI,D'Urso OF,Storelli C,et al.miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors.Int J Oncol,2012,41:228-234.
32 Yao GD,Zhang YF,Chen P,et al.MicroRNA-544 promotes colorectal cancer progression by targeting foxhead box O1.Oncology Letters.2018,15:991-997.
33 Yang F,Wang W,Zhou C,et al.MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2.Tumour Biol,2015,36:3763-3773.
34 Madamanchi A,Santoro SA,Zutter MM.alpha2beta1 Integrin.Adv Exp Med Biol,2014,819:41-60.
35 Mori H,Lo AT,Inman JL,et al.Transmembrane/cytoplasmic,rather than catalytic,domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1.Development,2013,140:343-352.
36 Ouyang YB,Lu Y,Yue S,et al.miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.Mitochondrion,2012,12:213-219.
2 Almeida MI,RM Reis,GA Calin.MicroRNA history:discovery,recent applications,and next frontiers.Mutat Res,2011,717:1-8.
3 Friedman RC,Farh KK,Burge CB,et al.Most mammalian mRNAs are conserved targets of microRNAs.Genome Res,2009,19:92-105.
4 Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function.Cell,2004,116:281-297.
5 Sotillo E,Thomas-Tikhonenko A.Shielding the messenger(RNA):microRNA-based anticancer therapies.Pharmacol Ther,2011,131:18-32.
6 Wiemer EA.The role of microRNAs in cancer:no small matter.Eur J Cancer,2007,43:1529-1544.
7 Giovannetti EA,Erozenci J,Smit M,et al.Molecular mechanisms underlying the role of microRNAs(miRNAs)in anticancer drug resistance and implications for clinical practice.Crit Rev Oncol Hematol,2012,81:103-122.
8 Deng W,Lin H.Miwi,a murine homolog of piwi,encodes a cytoplasmic protein essential for spermatogenesis.Dev Cell,2002,2:819-830.
9 Piao X,Zhang X,Wu L,et al.CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.Mol Cell Biol,2010,30:1486-1494.
10 Hanahan D,Weinberg RA.The hallmarks of cancer.Cell,2000,100:57-70.
11 Rukov JL,Shomron N.MicroRNA pharmacogenomics:post-transcripti- onal regulation of drug response.Trends Mol Med,2011,17:412-423.
12 Montano M.MicroRNAs:miRRORS of health and disease.Transl Res,2011,157:157-162.
13 Takamizawa J,Konishi H,Yanagisawa K,et al.Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.Cancer Res,2004,64:3753-3756.
14 Shi L,Cheng Z,Zhang J,et al.hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells.Brain Res,2008,1236:185-193.
15 Li Z,Cao Y,Jie Z,et al.miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3.Cancer Lett,2012,323:41-47.
16 He,XX,Y Chang,FY Meng,et al.MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo.Oncogene,2012,31:3357-3369.
17 Feber A,Xi L,Luketich JD,et al.MicroRNA expression profiles of esophageal cancer.J Thorac Cardiovasc Surg,2008,135:255-260.
18 Zhang T,Liu M,Wang C,et al.Down-regulation of MiR-206 promotes proliferation and invasion of laryngeal cancer by regulating VEGF expression.Anticancer Res,2011,31:3859-3863.
19 Wu J,Wu G,Lv L,et al.MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1.Carcinogenesis,2012,33:519-528.
20 Navarro F,Lieberman J.miR-34 and p53:New Insights into a Complex Functional Relationship.PLoS One,2015,10:e0132767.
21 Zhang R,Li M,Zang W,et al.MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2.Tumour Biol,2014,35:837-844.
22 Li X,Gong X,Chen J,et al.miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6,cyclin-D1 and cyclin-D2.Biochem Biophys Res Commun,2015,460:670-677.
23 Saini S,Majid S,Yamamura S,et al.Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis.Clin Cancer Res,2011,17:5287-5298.
24 Aleksandrova A,Rongish BJ,Little CD,et al.Active cell and ECM movements during development.Methods Mol Biol,2015,1189:123-132.
25 Liu C,Yu J,Yu S,et al.MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma.J Hepatol,2010,53:98-107.
26 Feng S,Cong S,Zhang X,et al.MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells.Nucleic Acids Res,2011,39:6669-6678.
27 Shi ZM,Wang J,Yan Z,et al.MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1.PLoS One,2012,7:e32709.
28 Pan YZ,Morris ME,Yu AM.MicroRNA-328 negatively regulates the expression of breast cancer resistance protein(BCRP/ABCG2)in human cancer cells.Mol Pharmacol,2009,75:1374-1379.
29 Zhou X,Zhang J,Jia Q,et al.Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3.Oncol Rep,2010,24:195-201.
30 Hatley ME,Patrick DM,Garcia MR,et al.Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.Cancer Cell,2010,18:282-293.
31 D'Urso PI,D'Urso OF,Storelli C,et al.miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors.Int J Oncol,2012,41:228-234.
32 Yao GD,Zhang YF,Chen P,et al.MicroRNA-544 promotes colorectal cancer progression by targeting foxhead box O1.Oncology Letters.2018,15:991-997.
33 Yang F,Wang W,Zhou C,et al.MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2.Tumour Biol,2015,36:3763-3773.
34 Madamanchi A,Santoro SA,Zutter MM.alpha2beta1 Integrin.Adv Exp Med Biol,2014,819:41-60.
35 Mori H,Lo AT,Inman JL,et al.Transmembrane/cytoplasmic,rather than catalytic,domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1.Development,2013,140:343-352.
36 Ouyang YB,Lu Y,Yue S,et al.miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.Mitochondrion,2012,12:213-219.