高分子囊泡在药物释放体系的应用
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摘要
高分子囊泡作为一种新型的纳米药物载体,具有生物可降解性、稳定性、生物相容性及可修饰的多功能化等特点。改变聚合物种类和亲水-疏水嵌段的比例,可以制备具有不同形态和膜特性的高分子囊泡。经过修饰后的高分子囊泡,可赋予其更多的功能,从而实现药物的控释和药物靶向的能力。对高分子囊泡的结构、组成和制备方法以及在药物释放体系的应用等方面进行了较为详细的综述,目的是了解高分子囊泡最新研究进展以及未来科学家们亟须解决的重要问题。
As a novel kind of nano-drug carrier, the polymersomes have the characteristics of biodegradability,stability,biocompatibility and modifiable multi-functionalization and so on. Polymersomes can be prepared by changing polymer type and the ratio of hydrophilic-hydrophobic block,which possess different morphological and membrane properties. After modifiing polymersomes,more functions can be given to realize the ability of controlling drug release and targeting drugs. The structure,composition,preparation methods and the application of drug delivery system about polymersomes have been reviewed in detail. The purpose is to know the latest research progress of polymersomes and some important problems in this field need to be solved by scientists in the future.
As a novel kind of nano-drug carrier, the polymersomes have the characteristics of biodegradability,stability,biocompatibility and modifiable multi-functionalization and so on. Polymersomes can be prepared by changing polymer type and the ratio of hydrophilic-hydrophobic block,which possess different morphological and membrane properties. After modifiing polymersomes,more functions can be given to realize the ability of controlling drug release and targeting drugs. The structure,composition,preparation methods and the application of drug delivery system about polymersomes have been reviewed in detail. The purpose is to know the latest research progress of polymersomes and some important problems in this field need to be solved by scientists in the future.
引文
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[12]Kim Y J,Kim B,Hyun D C.Photocrosslinkable poly(ε-caprolactone)-b-hyperbranched polyglycerol(PCL b-hbPG)with improved biocompatibility and stability for drug delivery.Macromolecular Chemistry and Physics,2015,216(11):1161-1170.
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[16]Qin J,Liu Q,Zhang J,et al.Rationally separating the corona and membrane functions of polymer vesicles for enhanced T(2)MRI and drug delivery.ACS Applied Materials Interfaces,2015,7(25):14043-14052.
[17]Wuytens P,Parakhonskiy B,Yashchenok A,et al.Pharmacological aspects of release from microcapsules from polymeric multilayers to lipid membranes.Current Opinion in Pharmacology,2014,18:129-140.
[18]Craciun I,Belluati A,Cornelia G,et al.Expanding the potential of MRI contrast agents through multifunctional polymeric nanocarriers.Nanomedicine,2017,12(7):811-817.
[19]Yewle J,Wattamwar P,Tao Z,et al.Progressive saturation improves the encapsulation of functional proteins in nanoscale polymer vesicles.Pharmaceutical Research,2016,33(3):573-589.
[20]Iyisan B,Kluge J,Formanek P,et al.Multifunctional and dualresponsive polymersomes as robust nanocontainers:design,formation by sequential post-conjugations,and pH-controlled drug release.Chemistry of Materials,2016,28(5):1513-1525.
[21]Nahire R,Haldar M K,Paul S,et al.Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells.Biomaterials,2014,35(24):6482-6497.
[22]Chiang W H,Huang W C,Chang C W,et al.Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging.Journal of Control Release,2013,168(3):280-288.
[23]Du J,O’Reilly R K.Advances and challenges in smart and functional polymer vesicles.Soft Matter,2009,5(19):3544-3561.
[24]Messager L,Gaitzsch J,Chierico L,et al.Novel aspects of encapsulation and delivery using polymersomes.Current Opinion in Pharmacology,2014,18:104-111.
[25]Zhang L F,Eisenberg A.Multiple morphologiesof“crew-cut”aggregates of polystyrene-b-poly(acrylicacid)block copolymers.Science,1995,268(5218):1728-1731.
[26]Kui Y,Eisenberg A.Multiple morphologies in aqueous solutions of aggregates of polystyrene-block poly(ethylene oxide)diblock copolymers.Macromolecules,1996,29(19):6359-6361.
[27]Zhang L F,Eisenberg L.Multiple morphologies and characteristics of“crew-cut”micelle-like aggregates of polystyrene-b-poly(acrylic acid)diblock copolymers in aqueous solutions.Journal of the American Chemical Society,1996,118(13):3168-3181.
[28]Zhang L F,Bartels C,Yu Y S,et al.Mesosized crystal-like structure of hexagonally packed hollow hoops by solution selfassembly of diblock copolymers.Physical Review Letters,1997,79(25):5034-5037.
[29]Yu Y S,Zhang L F,Eisenberg L.Morphogenic effect of solvent on crew-cut aggregates of apmphiphilic diblock copolymers.Macromolecules,1998,31(4):1144-1154.
[30]Shen H W,Eisenberg A.Block length dependence of morphological phase diagrams of the ternary system of PS-b-PAA/dioxane/H2O.Macromolecules,2000,33(7):2561-2572.
[31]Discher D E,Eisenberg A.Polymer vesicles.Science,2002,297(5583):967-73.
[32]Li S L,Byme B,Welsh J E,Palmer A F.Self-assembled poly(butadiene)-b-poly(ethylene oxide)polymersomes as paclitaxel carriers.Biotechnology Progress,2007,23(1):278-285.
[33]Mai Y,Eisenberg A.Self-assembly of block copolymers.Chemical Society Reviews,2012,41(18):5969-5985.
[34]Zhu D,Wu S,Hu C,et al.Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma.Acta Biomaterialia,2017,58:399-412.
[35]Laskar P,Dey J.Ghosh S K,Spontaneously formed redox-and p H-sensitive polymersomes by m PEG based cytocompatible random copolymers.Journal of Colloid Interface Science,2017,501:122-133.
[36]Laskar P,Dey J,Banik P,et al.In vitro drug and gene delivery using random cationic copolymers forming stable and pH-sensitive polymersomes.Macromolecular Bioscience,2017,17(4):1-14.
[37]Sanchez-Purra M,Ramos V,Petrenko V A,et al.Doubletargeted polymersomes and liposomes for multiple barrier crossing.International Journal of Pharmaceutics,2016,511(2):946-956.
[38]Li X,Yang W,Zou Y,et al.Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes.Journal of Control Release,2015,220:704-714.
[39]Meng F H,Zhong Y N,Cheng R,et al.pH-sensitive polymeric nanoparticles for tumor-targeting Doxoubicin delivery:concept and recent advances.Nanomedicine,2014,9(3):487-499.
[40]Danafar H,Rostamizadeh K,Davaran S,et al.PLA-PEG-PLAcopolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs:preparation and evaluation with atorvastatin and lisinopril.Drug Development and Industrial Pharmacy,2014,40(10):1411-1420.
[41]Chen C Y,Wang H L.Dual thermo-and pH-responsive zwitterionic sulfobataine copolymers for oral delivery system.Macromolecular Rapid Communications,2014,35(17):1534-1540.
[42]Li G,Guo L,Wen Q,et al.Thermo-and pH-sensitive ioniccrosslinked hollow spheres from chitosan-based graft copolymer for5-fluorouracil release.International Journal of Biological Macromolecules,2013,55:69-74.
[43]He C,Zhuang X,Tang Z,et al.Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery.Advanced Healthcare Materials,2012,1(1):48-78.
[44]Wang Y,Gao S,Ye W H,et al.Co-delivery of drugs and DNAfrom cationic core-shell nanoparticles self assembled from a biodegradable copolymer.Nature Materials,2006,5(10):791-796.
[45]Xiong X Y,Li Q H,Li Y P,et al.Pluronic P85/poly(lactic acid)vesicles as novel carrier for oral insulin delivery.Colloids and Surfaces B:Biointerfaces,2013,111:282-288.
[46]Chu B,Zhang L,Qu Y,et al.Synthesis,characterization and drug loading property of monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(D,L-lactide)(MPEG-PCLA)copolymers.Scientific Reports,2016,6:34069.
[47]Kang S W,Li Y,Park J H,et al.pH-triggered unimer/vesicletransformable and biodegradable polymersomes based on PEG-bPCL-grafted poly(β-amino ester)for anti-cancer drug delivery.Polymer,2013,54(1):102-110.
[48]Oliveira H,Perez-Andres E,Thevenot J,et al.Magnetic field triggered drug release from polymersomes for cancer therapeutics.Journal of Control Release,2013,169(3):165-170.
[49]Car A,Baumann P,Duskey J T,et al.pH-responsive PDMS-bPDMAEMA micelles for intracellular anticancer drug delivery.Biomacromolecules,2014,15(9):3235-3245.
[50]Photos P J,Bacakova L,Discher B,et al.Polymer vesicles in vivo:correlations with PEG molecular weight.Journal of Controlled Release,2003,90(3):323-334.
[51]Lin T,Fang Q,Peng D,et al.PEGylated non-ionic surfactant vesicles as drug delivery systems for gambogenic acid.Drug Delivery,2013,20(7):277-284.
[52]Yassin M A,Appelhans D,Wiedemuth R,et al.Overcoming concealment effects of targeting moieties in the PEG corona:controlled permeable polymersomes decorated with folate-antennae for selective targeting of tumor cells.Small,2015,11(13):1580-1591.
[53]Liu F T,Eisenberg A.Preparation and pH triggered inversion of vesicles from poly(acrylic acid)-block polystyrene-block-poly(4-vinyl pyridine).Journal of the American Chemical Society,2003,125(49):15059-15064.
[54]Bollhorst T,Rezwan K,Maas M.Colloidal capsules:nano-and microcapsules with colloidal particle shells.Chemical Society Reviews,2017,46(8):2091-2126.
[55]Thambi T,Park J H,Lee D S.Stimuli-responsive polymersomes for cancer therapy.Biomaterial Science,2016,4(1):55-69.
[56]Brinkhuis R P,Rutjes F P J T,van Hest J C M.Polymeric vesicles in biomedical applications.Polymer Chemistry,2011,2(7):1449-1462.
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