膝骨关节炎非手术治疗的动物实验研究进展
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摘要
膝骨关节炎(KOA)是骨科常见疾病,以关节软骨退行性改变及继发性骨质增生为特征。KOA的治疗方式多样,主要分为手术治疗和非手术治疗,适用于不同的临床分期。非手术治疗的临床研究及实验研究一直在深入开展,由于医学伦理、精准医疗以及风险控制等因素的要求,进行动物实验极为必要,甚至是开展临床试验和治疗前的必需进程。分析KOA非手术治疗的动物实验研究,总结经验与成果,为开展相应实验研究提供思路和借鉴,可为KOA的临床研究和治疗提供参考和指导。
Knee osteoarthritis( KOA) is a common disease in orthopedics,which is characterized by the degeneration of articular cartilage and the secondary bone hyperplasia. The treatment of KOA is varied,and mainly includes surgical treatment and non-surgical treatment,adapted to different clinical stages. The clinical study and experimental study of non-surgical treatment has been carried out in depth,as the result of medical ethics,precision medical treatment,and the risk management,making animal experiments very necessary,or even the must process of conducting clinical trials and treatment. Analysis on the animal experimental researches of nonoperative treatment for KOA,will provide ideas and reference for carrying out corresponding experimental research,and reference and guidance for the clinical research and treatment.
Knee osteoarthritis( KOA) is a common disease in orthopedics,which is characterized by the degeneration of articular cartilage and the secondary bone hyperplasia. The treatment of KOA is varied,and mainly includes surgical treatment and non-surgical treatment,adapted to different clinical stages. The clinical study and experimental study of non-surgical treatment has been carried out in depth,as the result of medical ethics,precision medical treatment,and the risk management,making animal experiments very necessary,or even the must process of conducting clinical trials and treatment. Analysis on the animal experimental researches of nonoperative treatment for KOA,will provide ideas and reference for carrying out corresponding experimental research,and reference and guidance for the clinical research and treatment.
引文
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[17]程园园,刘健,冯云霞,等.超氧化物歧化酶在膝骨关节炎患者血清中的变化及相关因素分析[J].中国临床保健杂志,2012,15(5):475-478.
[18]金晓飞,郭长青,蒋昭霞,等.膝骨关节炎模型内侧副韧带的生物力学特性[J].中国组织工程研究与临床康复,2011,15(43):8046-8049.
[19]郭长青,张丽萍.针刀干预对膝骨关节炎兔髌韧带拉伸、蠕变及应力松弛等生物力学特性的影响[J].中国科学(生命科学),2016,46(8):976-982.
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