羟氯喹联合甲硝唑或阿奇霉素治疗酒渣鼻的疗效观察
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摘要
目的观察甲硝唑或阿奇霉素联合羟氯喹治疗酒渣鼻的疗效和安全性。方法将我院门诊就诊的酒渣鼻患者240例随机分为A、B、C和D组各60例,A组口服甲硝唑(一日2次,每次0.2 g)配合外用硫软膏(一日2次);B组口服甲硝唑(一日1次,每次0.25 g,每周3次)联合羟氯喹(一日2次,每次0.1 g)配合外用硫软膏(一日2次);C组口服阿奇霉素(一日1次,每次0.25 g,每周3次)配合外用硫软膏(一日2次);D组口服阿奇霉素(一日1次,每次0.25 g,每周3次)联合硫酸羟氯喹(一日2次,每次0.1 g)配合外用硫软膏(一日2次),疗程均为12周。观察4组治疗前后炎症损害、丘疹脓疱数目及红斑血管扩张情况。结果治疗12周后,A与C组的显效率明显低于B与D组,差异有统计学意义(P<0.01);且A与C组的痊愈率及总有效率亦低于B与D组,差异有统计学意义(P<0.05)。红斑血管扩张评分与丘疹脓疱数目,两两比较差异有统计学意义(P<0.01)。结论阿奇霉素或甲硝唑联合羟氯喹治疗酒渣鼻比单用阿奇霉素或甲硝唑疗效更为显著,且不良反应短暂而轻微。
Objective To observe the efficacy and safety of drug combination therapy and monotherapy in the treatment of rosacea. Methods 240 cases of rosacea patients who were treated in our hospital were randomly divided into four groups(group A, B, C and D) with 60 cases each group. The patients in group A were given compound metronidazole orally(0.2 g, bid) coordinated with topical sulfur ointment(b.i.d). The group B patients were given compound metronidazole(0.25 g, qd, three times a week) combined with oral hydroxychloroquine sulfate(0.1g, bid), and coordinated with topical sulfur ointment(bid) for 2 weeks; The patients in group C were given oral azithromycin(0.25 g, qd, three times a week) combined with topical sulfur ointment(bid), and the group D patients were given oral azithromycin(0.25 g, qd, three times a week) plus hydroxychloroquine sulfate(0.1 g, bid), and combined with topical sulfur ointment(b.i.d). The inflammatory damage, numbers of pustules and papules, and score of erythema and vasodilation in all patients were observed and compared. Results The patients in group A and C had lower effective rate than group B and D after 2 weeks treatment, and there were significant differences in all groups(P<0.01). The cure rate and the general effective rate of patients in group A and C were lower than those in other two groups(P<0.05). There were obvious differences in the numbers of pustules and papules, and pairwise comparison the scores of erythema and vasodilation of all patients(P<0.01). Conclusion Azithromycin or metronidazole combined with hydroxychloroquine sulfate is more effective and tolerable than monotherapy in rosacea treatment.
Objective To observe the efficacy and safety of drug combination therapy and monotherapy in the treatment of rosacea. Methods 240 cases of rosacea patients who were treated in our hospital were randomly divided into four groups(group A, B, C and D) with 60 cases each group. The patients in group A were given compound metronidazole orally(0.2 g, bid) coordinated with topical sulfur ointment(b.i.d). The group B patients were given compound metronidazole(0.25 g, qd, three times a week) combined with oral hydroxychloroquine sulfate(0.1g, bid), and coordinated with topical sulfur ointment(bid) for 2 weeks; The patients in group C were given oral azithromycin(0.25 g, qd, three times a week) combined with topical sulfur ointment(bid), and the group D patients were given oral azithromycin(0.25 g, qd, three times a week) plus hydroxychloroquine sulfate(0.1 g, bid), and combined with topical sulfur ointment(b.i.d). The inflammatory damage, numbers of pustules and papules, and score of erythema and vasodilation in all patients were observed and compared. Results The patients in group A and C had lower effective rate than group B and D after 2 weeks treatment, and there were significant differences in all groups(P<0.01). The cure rate and the general effective rate of patients in group A and C were lower than those in other two groups(P<0.05). There were obvious differences in the numbers of pustules and papules, and pairwise comparison the scores of erythema and vasodilation of all patients(P<0.01). Conclusion Azithromycin or metronidazole combined with hydroxychloroquine sulfate is more effective and tolerable than monotherapy in rosacea treatment.
引文
[1]韩飞,宋为民.酒渣鼻的激光与强脉冲光治疗进展[J].中国中西医结合皮肤性病学杂志,2012,11(2):134-136.
[2]林笛,蒋娟.酒渣鼻病因及发病机制的研究进展[J].国际皮肤性病学杂志,2013,39(4):27-30.
[3]高辉.酒渣鼻的治疗[J].上海医药,2009,30(3):135-136.
[4]张云玲,闵彬彬,任丽.浅谈中医对酒渣鼻的治疗[J].中医眼耳鼻喉杂志,2012,2(2):90-92.
[5]赵廷元,肖世锋.多西环素联合羟基氯喹治疗酒渣鼻[J].实用医药杂志,2011,28(1):27-28.
[6]庄慈妹,孙澍彬,欧健梅.阿奇霉素联合羟氯喹治疗酒渣鼻的疗效观察[J].国际医药卫生导报,2013,19(18):2849-2851.
[7]杨志锦.呋喃西林滴鼻液合用盐酸多西环素治疗酒渣鼻的疗效观察[J].微创医学,2013,8(4):507-508.
[8]郑晓玲,胡晋华.口服阿奇霉素治疗酒渣鼻疗效观察[J].山西医药杂志,2004,33(10):892-892.
[9]杨桂兰,郑家润.酒渣鼻的病因,发病机制与治疗学进展[J].国外医学:皮肤性病学分册,2001,27(3):135-138.
[10]Gallo R,Drago F,Paolino S,et al.Rosacea treatments:What's new and what's on the horizon?[J].Am J Clin Dermatol,2010,11(5):299-303.
[11]高启发,陈向东.酒渣鼻治疗进展[J].中国美容医学,2010,19(5):783-785.
[12]白云静,姜德训,申洪波,等.硫酸羟氯喹的不良反应临床调查分析[J].北京医学,2011,33(7):575-577.
[13]黄伟,羟氯喹.羟氯喹研究进展及在皮肤科的应用[J].右江民族医学院学报,2010,32(4):612-612.
[2]林笛,蒋娟.酒渣鼻病因及发病机制的研究进展[J].国际皮肤性病学杂志,2013,39(4):27-30.
[3]高辉.酒渣鼻的治疗[J].上海医药,2009,30(3):135-136.
[4]张云玲,闵彬彬,任丽.浅谈中医对酒渣鼻的治疗[J].中医眼耳鼻喉杂志,2012,2(2):90-92.
[5]赵廷元,肖世锋.多西环素联合羟基氯喹治疗酒渣鼻[J].实用医药杂志,2011,28(1):27-28.
[6]庄慈妹,孙澍彬,欧健梅.阿奇霉素联合羟氯喹治疗酒渣鼻的疗效观察[J].国际医药卫生导报,2013,19(18):2849-2851.
[7]杨志锦.呋喃西林滴鼻液合用盐酸多西环素治疗酒渣鼻的疗效观察[J].微创医学,2013,8(4):507-508.
[8]郑晓玲,胡晋华.口服阿奇霉素治疗酒渣鼻疗效观察[J].山西医药杂志,2004,33(10):892-892.
[9]杨桂兰,郑家润.酒渣鼻的病因,发病机制与治疗学进展[J].国外医学:皮肤性病学分册,2001,27(3):135-138.
[10]Gallo R,Drago F,Paolino S,et al.Rosacea treatments:What's new and what's on the horizon?[J].Am J Clin Dermatol,2010,11(5):299-303.
[11]高启发,陈向东.酒渣鼻治疗进展[J].中国美容医学,2010,19(5):783-785.
[12]白云静,姜德训,申洪波,等.硫酸羟氯喹的不良反应临床调查分析[J].北京医学,2011,33(7):575-577.
[13]黄伟,羟氯喹.羟氯喹研究进展及在皮肤科的应用[J].右江民族医学院学报,2010,32(4):612-612.