摘要
目的观察补肾益髓胶囊治疗神经脊髓炎(NMO)患者的临床疗效及其对外周血B细胞活化因子(BAFF)、趋化因子配体(CXCL) 13及白细胞介素(IL) 6表达的影响。方法缓解期NMO患者26例,使用补肾益髓胶囊治疗3个月。同时招募健康志愿者22例作为对照。比较患者服药前后扩展残疾状态量表(EDSS)评分、中医症状评分以及B细胞相关细胞因子表达水平的变化。结果经补肾益髓胶囊治疗后,缓解期NMO患者的EDSS评分、中医症状评分较治疗前明显降低(P <0. 05,P <0. 01),外周血IL-6表达水平显著降低(P <0. 01),BAFF和CXCL13表达水平变化差异无统计学意义(P> 0. 05)。缓解期NMO患者血清CXCL13的表达水平较健康组明显升高(P=0. 000),BAFF表达水平与健康组比较差异无统计学意义(P=0. 197),缓解期NMO患者血清IL-6表达水平较健康组明显升高(P=0. 009)。结论补肾益髓胶囊可以显著改善缓解期NMO患者的神经功能缺损症状,可能与其能够有效降低缓解期NMO患者血清IL-6表达水平有关。
Objective To observe clinical efficacy of Bushenyisui Capsules in treatment of the remission period of patients with optic neuromyelitis( NMO) and its effect on levels of BAFF,CXCL13 and IL-6. Methods 26 patients with NMO during remission were treated with Bushen Yisui Capsule for 3 months. At the same time,22 healthy volunteers were recruited as controls. The changes of the Extended Disability Status Scale( EDSS) score,TCM symptom score,and B cell-associated cytokine expression levels before and after treatment were compared. Results After treatment with Bushen Yisui Capsule,the EDSS score and TCM symptom score of NMO patients during the remission period were significantly lower than those before treatment( P < 0. 05,P < 0. 01),and the expression of IL-6 in peripheral blood was significantly decreased( P < 0. 01). There was no significant difference in the expression level of BAFF and CXCL13 before and after treatment( P > 0. 05). The expression level of CXCL13 in NMO patients was significantly higher than that in healthy group( P = 0. 000). There was no significant difference in the expression level of BAFF expression between NMO patients and healthy person( P = 0. 197). The expression of serum IL-6 in NMO patients during remission period was higher than that in healthy group( P = 0. 009). Conclusion Bushen Yisui Capsule can significantly improve the symptoms of neurological deficits in patients with NMO during remission,which may be related to its ability to effectively reduce the level of serum IL-6.
引文
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