Macular retinal thickness and flow density change by optical coherence tomography angiography after posterior scleral reinforcement
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摘要
Optical coherence tomography angiography(Angio-OCT) has introduced a new non-invasive, quantitative method to assess superficial and deep capillary networks of the retina. In this study, we investigated macular retinal thickness and flow density change following posterior scleral reinforcement(PSR) surgery, using an RTVue XR Avanti Angio-OCT, in patients with pathological myopia. A total of 13 patients with pathological myopia were recruited and all patients completed the 6 months follow-up visit. Data from 22 eyes were used in this study. The mean age was 36.23±15.29 years, and 43%(n=6) were men.Spherical equivalent refractive error(SE) ranged from –8.0 to –24.0 D. Postoperative axial length, best-corrected visual acuity and SE did not change significantly at each follow-up, compared with pre-operative measures(P>0.05). Postoperative flow density of superficial and deep retinal layers at each sector did not change significantly at each follow-up, compared with preoperative measures(P>0.05). However, we found significant decrease in retinal thickness of parafovea-inferior sector after PSR surgery(P<0.01), indicating potential relaxation of vitreofoveal traction after PSR surgery.
Optical coherence tomography angiography(Angio-OCT) has introduced a new non-invasive, quantitative method to assess superficial and deep capillary networks of the retina. In this study, we investigated macular retinal thickness and flow density change following posterior scleral reinforcement(PSR) surgery, using an RTVue XR Avanti Angio-OCT, in patients with pathological myopia. A total of 13 patients with pathological myopia were recruited and all patients completed the 6 months follow-up visit. Data from 22 eyes were used in this study. The mean age was 36.23±15.29 years, and 43%(n=6) were men.Spherical equivalent refractive error(SE) ranged from –8.0 to –24.0 D. Postoperative axial length, best-corrected visual acuity and SE did not change significantly at each follow-up, compared with pre-operative measures(P>0.05). Postoperative flow density of superficial and deep retinal layers at each sector did not change significantly at each follow-up, compared with preoperative measures(P>0.05). However, we found significant decrease in retinal thickness of parafovea-inferior sector after PSR surgery(P<0.01), indicating potential relaxation of vitreofoveal traction after PSR surgery.
Optical coherence tomography angiography(Angio-OCT) has introduced a new non-invasive, quantitative method to assess superficial and deep capillary networks of the retina. In this study, we investigated macular retinal thickness and flow density change following posterior scleral reinforcement(PSR) surgery, using an RTVue XR Avanti Angio-OCT, in patients with pathological myopia. A total of 13 patients with pathological myopia were recruited and all patients completed the 6 months follow-up visit. Data from 22 eyes were used in this study. The mean age was 36.23±15.29 years, and 43%(n=6) were men.Spherical equivalent refractive error(SE) ranged from –8.0 to –24.0 D. Postoperative axial length, best-corrected visual acuity and SE did not change significantly at each follow-up, compared with pre-operative measures(P>0.05). Postoperative flow density of superficial and deep retinal layers at each sector did not change significantly at each follow-up, compared with preoperative measures(P>0.05). However, we found significant decrease in retinal thickness of parafovea-inferior sector after PSR surgery(P<0.01), indicating potential relaxation of vitreofoveal traction after PSR surgery.
引文
Benhamou,N.,Massin,P.,Haouchine,B.,Erginay,A.,and Gaudric,A.(2002).Macular retinoschisis in highly myopic eyes.Am J Ophthalmol133,794-800.
Chen,M.,Dai,J.,Chu,R.,and Qian,Y.(2013).The efficacy and safety of modified Snyder-Thompson posterior scleral reinforcement in extensive high myopia of Chinese children.Graefes Arch Clin Exp Ophthalmol251,2633-2638.
Curtin,B.J.,and Whitmore,W.G.(1987).Long-term results of scleral reinforcement surgery.Am J Ophthalmol 103,544-548.
Guo,X.,Xiao,O.,Chen,Y.,Wu,H.,Chen,L.,Morgan,I.G.,and He,M.(2017).Three-dimensional eye shape,myopic maculopathy,and visual acuity:The Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study.Ophthalmology 124,679-687.
Hayashi,K.,Ohno-Matsui,K.,Shimada,N.,Moriyama,M.,Kojima,A.,Hayashi,W.,Yasuzumi,K.,Nagaoka,N.,Saka,N.,Yoshida,T.,et al.(2010).Long-term pattern of progression of myopic maculopathy.Ophthalmology 117,1595-1611.e4.
Ikuno,Y.,Gomi,F.,and Tano,Y.(2005).Potent retinal arteriolar traction as a possible cause of myopic foveoschisis.Am J Ophthalmol 139,462-467.
Ji,X.,Wang,J.,Zhang,J.,Sun,H.,Jia,X.,and Zhang,W.(2011).The effect of posterior scleral reinforcement for high myopia macular splitting.J Int Med Res 39,662-666.
Jia,Y.,Tan,O.,Tokayer,J.,Potsaid,B.,Wang,Y.,Liu,J.J.,Kraus,M.F.,Subhash,H.,Fujimoto,J.G.,Hornegger,J.,et al.(2012).Split-spectrum amplitude-decorrelation angiography with optical coherence tomography.Opt Express 20,4710-4725.
Li,M.,Wang,H.,Liu,Y.,Zhang,X.,and Wang,N.(2016).Comparison of time-domain,spectral-domain and swept-source OCT in evaluating aqueous cells in vitro.Sci China Life Sci 59,1319-1323.
Mateo,C.,Burés-Jelstrup,A.,Navarro,R.,and Corcóstegui,B.(2012).Macular buckling for eyes with myopic foveoschisis secondary to posterior staphyloma.Retina 32,1121-1128.
McAlinden,C.,Khadka,J.,and Pesudovs,K.(2011).Statistical methods for conducting agreement(comparison of clinical tests)and precision(repeatability or reproducibility)studies in optometry and ophthalmology.Ophthal Physiol Opt 31,330-338.
Mo,J.,Duan,A.L.,Chan,S.Y.,Wang,X.F.,and Wei,W.B.(2016).Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia.Int J Ophthalmol 9,1761-1765.
Morgan,I.G.,French,A.N.,Ashby,R.S.,Guo,X.,Ding,X.,He,M.,and Rose,K.A.(2017).The epidemics of myopia:Aetiology and prevention.Prog Retinal Eye Res 62,134-149.
Savastano,M.C.,Lumbroso,B.,and Rispoli,M.(2015).In vivo characterization of retinal vascularization morphology using optical coherence tomography angiography.Retina 35,2196-2203.
Shen,Z.M.,Zhang,Z.Y.,Zhang,L.Y.,Li,Z.G.,and Chu,R.Y.(2015).Posterior scleral reinforcement combined with patching therapy for preschool children with unilateral high myopia.Graefes Arch Clin Exp Ophthalmol 253,1391-1395.
Su,J.,Iomdina,E.,Tarutta,E.,Ward,B.,Song,J.,and Wildsoet,C.F.(2009).Effects of poly(2-hydroxyethyl methacrylate)and poly(vinylpyrrolidone)hydrogel implants on myopic and normal chick sclera.Exp Eye Res 88,445-457.
Thompson,F.B.(1978).A simplified scleral reinforcement technique.Am JOphthalmol 86,782-790.
Thompson,F.B.(1985).Scleral reinforcement for high myopia.Ophthalmic Surg 16,90-94.
Ward,B.(2013).Degenerative myopia.Retina 33,224-231.
Ward,B.,Tarutta,E.P.,and Mayer,M.J.(2009).The efficacy and safety of posterior pole buckles in the control of progressive high myopia.Eye23,2169-2174.
Xin,C.,Tian,N.,Li,M.,Wang,H.,and Wang,N.(2018).Mechanism of the reconstruction of aqueous outflow drainage.Sci China Life Sci 61,534-540.
Xue,A.,Bao,F.,Zheng,L.,Wang,Q.,Cheng,L.,and Qu,J.(2014).Posterior scleral reinforcement on progressive high myopic young patients.Optom Vis Sci 91,412-418.
Yan,Z.,Wang,C.,Chen,W.,and Song,X.(2010).Biomechanical considerations:evaluating scleral reinforcement materials for pathological myopia.Can J Ophthalmol 45,252-255.
Yuan,Y.,Zong,Y.,Zheng,Q.,Qian,G.,Qian,X.,Li,Y.,Shao,W.,and Gao,Q.(2016).The efficacy and safety of a novel posterior scleral reinforcement device in rabbits.Mater Sci Eng C Mater Biol Appl 62,233-241.
Zhang,X.F.,Qiao,L.Y.,Li,X.X.,Ma,N.,Li,M.,Guan,Z.,Wang,H.Z.,and Wang,N.L.(2017).A preliminary study on macular retinal and choroidal thickness and blood flow change after posterior scleral reinforcement by optical coherence tomography angiography(in Chinese).Zhonghua Yan Ke Za Zhi 53,39-45.
Zhu,S.Q.,Wang,Q.M.,Xue,A.Q.,Zheng,L.Y.,Su,Y.F.,and Yu,A.Y.(2014).Posterior sclera reinforcement and phakic intraocular lens implantation for highly myopic amblyopia in children:a 3-year followup.Eye 28,1310-1314.
Zhu,Z.,Ji,X.,Zhang,J.,and Ke,G.(2009).Posterior scleral reinforcement in the treatment of macular retinoschisis in highly myopic patients.Clin Exp Ophthalmol 37,660-663.
Chen,M.,Dai,J.,Chu,R.,and Qian,Y.(2013).The efficacy and safety of modified Snyder-Thompson posterior scleral reinforcement in extensive high myopia of Chinese children.Graefes Arch Clin Exp Ophthalmol251,2633-2638.
Curtin,B.J.,and Whitmore,W.G.(1987).Long-term results of scleral reinforcement surgery.Am J Ophthalmol 103,544-548.
Guo,X.,Xiao,O.,Chen,Y.,Wu,H.,Chen,L.,Morgan,I.G.,and He,M.(2017).Three-dimensional eye shape,myopic maculopathy,and visual acuity:The Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study.Ophthalmology 124,679-687.
Hayashi,K.,Ohno-Matsui,K.,Shimada,N.,Moriyama,M.,Kojima,A.,Hayashi,W.,Yasuzumi,K.,Nagaoka,N.,Saka,N.,Yoshida,T.,et al.(2010).Long-term pattern of progression of myopic maculopathy.Ophthalmology 117,1595-1611.e4.
Ikuno,Y.,Gomi,F.,and Tano,Y.(2005).Potent retinal arteriolar traction as a possible cause of myopic foveoschisis.Am J Ophthalmol 139,462-467.
Ji,X.,Wang,J.,Zhang,J.,Sun,H.,Jia,X.,and Zhang,W.(2011).The effect of posterior scleral reinforcement for high myopia macular splitting.J Int Med Res 39,662-666.
Jia,Y.,Tan,O.,Tokayer,J.,Potsaid,B.,Wang,Y.,Liu,J.J.,Kraus,M.F.,Subhash,H.,Fujimoto,J.G.,Hornegger,J.,et al.(2012).Split-spectrum amplitude-decorrelation angiography with optical coherence tomography.Opt Express 20,4710-4725.
Li,M.,Wang,H.,Liu,Y.,Zhang,X.,and Wang,N.(2016).Comparison of time-domain,spectral-domain and swept-source OCT in evaluating aqueous cells in vitro.Sci China Life Sci 59,1319-1323.
Mateo,C.,Burés-Jelstrup,A.,Navarro,R.,and Corcóstegui,B.(2012).Macular buckling for eyes with myopic foveoschisis secondary to posterior staphyloma.Retina 32,1121-1128.
McAlinden,C.,Khadka,J.,and Pesudovs,K.(2011).Statistical methods for conducting agreement(comparison of clinical tests)and precision(repeatability or reproducibility)studies in optometry and ophthalmology.Ophthal Physiol Opt 31,330-338.
Mo,J.,Duan,A.L.,Chan,S.Y.,Wang,X.F.,and Wei,W.B.(2016).Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia.Int J Ophthalmol 9,1761-1765.
Morgan,I.G.,French,A.N.,Ashby,R.S.,Guo,X.,Ding,X.,He,M.,and Rose,K.A.(2017).The epidemics of myopia:Aetiology and prevention.Prog Retinal Eye Res 62,134-149.
Savastano,M.C.,Lumbroso,B.,and Rispoli,M.(2015).In vivo characterization of retinal vascularization morphology using optical coherence tomography angiography.Retina 35,2196-2203.
Shen,Z.M.,Zhang,Z.Y.,Zhang,L.Y.,Li,Z.G.,and Chu,R.Y.(2015).Posterior scleral reinforcement combined with patching therapy for preschool children with unilateral high myopia.Graefes Arch Clin Exp Ophthalmol 253,1391-1395.
Su,J.,Iomdina,E.,Tarutta,E.,Ward,B.,Song,J.,and Wildsoet,C.F.(2009).Effects of poly(2-hydroxyethyl methacrylate)and poly(vinylpyrrolidone)hydrogel implants on myopic and normal chick sclera.Exp Eye Res 88,445-457.
Thompson,F.B.(1978).A simplified scleral reinforcement technique.Am JOphthalmol 86,782-790.
Thompson,F.B.(1985).Scleral reinforcement for high myopia.Ophthalmic Surg 16,90-94.
Ward,B.(2013).Degenerative myopia.Retina 33,224-231.
Ward,B.,Tarutta,E.P.,and Mayer,M.J.(2009).The efficacy and safety of posterior pole buckles in the control of progressive high myopia.Eye23,2169-2174.
Xin,C.,Tian,N.,Li,M.,Wang,H.,and Wang,N.(2018).Mechanism of the reconstruction of aqueous outflow drainage.Sci China Life Sci 61,534-540.
Xue,A.,Bao,F.,Zheng,L.,Wang,Q.,Cheng,L.,and Qu,J.(2014).Posterior scleral reinforcement on progressive high myopic young patients.Optom Vis Sci 91,412-418.
Yan,Z.,Wang,C.,Chen,W.,and Song,X.(2010).Biomechanical considerations:evaluating scleral reinforcement materials for pathological myopia.Can J Ophthalmol 45,252-255.
Yuan,Y.,Zong,Y.,Zheng,Q.,Qian,G.,Qian,X.,Li,Y.,Shao,W.,and Gao,Q.(2016).The efficacy and safety of a novel posterior scleral reinforcement device in rabbits.Mater Sci Eng C Mater Biol Appl 62,233-241.
Zhang,X.F.,Qiao,L.Y.,Li,X.X.,Ma,N.,Li,M.,Guan,Z.,Wang,H.Z.,and Wang,N.L.(2017).A preliminary study on macular retinal and choroidal thickness and blood flow change after posterior scleral reinforcement by optical coherence tomography angiography(in Chinese).Zhonghua Yan Ke Za Zhi 53,39-45.
Zhu,S.Q.,Wang,Q.M.,Xue,A.Q.,Zheng,L.Y.,Su,Y.F.,and Yu,A.Y.(2014).Posterior sclera reinforcement and phakic intraocular lens implantation for highly myopic amblyopia in children:a 3-year followup.Eye 28,1310-1314.
Zhu,Z.,Ji,X.,Zhang,J.,and Ke,G.(2009).Posterior scleral reinforcement in the treatment of macular retinoschisis in highly myopic patients.Clin Exp Ophthalmol 37,660-663.