关于宫颈癌及癌前病变筛查与诊断方法的研究进展
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摘要
宫颈癌在世界女性恶性肿瘤发病率中排名第三,并有逐年上升趋势,严重威胁着广大女性的生命健康,由此导致的生活质量降低以及死亡,应引起广泛关注.因此,宫颈癌的防治工作迫在眉睫.近些年,随着医疗技术的飞速发展,发现了许多宫颈癌筛查的新方法,宫颈癌疫苗也在世界范围内广泛接种,在宫颈癌防治方面取得了较大进步.现就宫颈癌及癌前病变筛查与诊断方法予以综述.
引文
[1]蔡晓婷,符浮,林飞雅.初诊宫颈癌妇女对宫颈癌认知和筛查现况分析[J].中国计划生育学杂志,2018(7):563-565,569.
[2]LIU Y,ZHANG L,ZHAO G,et al.The clinical research of Thinprep Cytology Test(TCT)combined with HPV-DNA detection in screening cervical cancer[J].Cellular and molecular biology(Noisy-le-Grand,France),2017,63(2):92-95.
[3]XIE Y,TAN X,SHAO H,et al.VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region:a health economic evaluation[J].BMC public health,2017,17(1):118.
[4]于露露,陈汶.子宫颈癌筛查技术新进展[J].中华妇产科杂志,2015(4):312-315.
[5]Luttmer R,Dijkstra MG,Snijders PJ,et al.p16/Ki-67dual-stained cytology for detecting cervical(pre)cancer in a HPV-positive gynecologic outpatient population[J].Modern pathology:an official journal of the United States and Canadian Academy of Pathology,Inc,2016,29(8):870-878.
[6]Dong L,Wang MZ,Zhao XL,et al.Human papillomavirus viral load as a useful triage tool for non-16/18high-risk human papillomavirus positive women:A prospective screening cohort study[J].Gynecologic oncology,2018,148(1):103-110.
[7]Lie AK,TropéA,Skare GB,et al.HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia[J].Gynecologic oncology,2018,148(1):111-117.
[8]Granados R,Tellez-Safina H,Solis I,et al.Cervical cancer screening cotesting with cytology and MRNA HPV E6/E7yields high rates of CIN2+lesions in young women[J].Diagnostic cytopathology,2017,45(12):1065-1072.
[9]Cuschieri K,Ronco G,Lorincz A,et al.Eurogin roadmap 2017:Triage strategies for the management of HPV-positive women in cervical screening programs[J].International journal of cancer,2018,143(4):735-745.
[10]Nghiem VT,Davies KR,Beck JR,et al.Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening[J].British journal of cancer,2015,112(12):1951-1957.
[11]Clinical application of DNA ploidy to cervical cancer screening:A review[J].World journal of clinical oncology,2014,5(5):931-965.
[12]甘密密,张锡流.DNA定量分析及TCT技术诊断宫颈病变的临床研究[J].实用妇产科杂志,2014(9):674-677.
[13]Lando M,Fjeldbo CS,Wilting SM,et al.Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14in cervical cancer[J].Epigenetics,2015,10(10):970-980.
[14]Mills AM,Dirks DC,Poulter MD,et al.HR-HPV E6/E7mRNA In Situ Hybridization:Validation Against PCR,DNA In Situ Hybridization,and p16Immunohistochemistry in 102Samples of Cervical,Vulvar,Anal,and Head and Neck Neoplasia[J].Am J Surg Pathol 2017,41:607-615.
[15]Coppock JD,Willis BC,Stoler MH.HPV RNA in situ hybridization can inform cervical cytology-histology correlation[J].Cancer cytopathology,2018,126(8):533-540.
[16]Ren C,Zhu Y,Yang L,et al.Diagnostic performance of HPV E6/E7mRNA assay for detection of cervical high-grade intraepithelial neoplasia and cancer among women with ASCUS Papanicolaou smears[J].Archives of gynecology and obstetrics,2018,297(2):425-432.
[17]YANG L,ZHU Y,BAI Y,et al.The clinical application of HPV E6/E7mRNA testing in triaging women with atypical squamous cells of undetermined significance or low-grade squamous intra-epithelial lesion Pap smear:A meta-analysis[J].J Cancer Res Ther 2017,13:613-620.
[18]Arbyn M,Roelens J,Cuschieri K.The APTIMA HPV assay versus the Hybrid Capture 2test in triage of women with ASC-USor LSIL cervical cytology:a meta-analysis of the diagnostic accuracy[J].Int J Cancer,2013,132(1):101-108.
[19]Snoek BC,Verlaat W,Babion I,et al.Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer[J].International journal of cancer,2018.
[20]Hasanzadeh M,Movahedi M,Rejali M,et al.The potential prognostic and therapeutic application of tissue and circulating microRNAs in cervical cancer[J].Journal of cellular physiology,2018.
[21]Au Yeung CL,Tsang TY,Yau PL.Human papillomavirus type 16E6induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway[J].Oncogene,2011,30(21):2401-2410.
[22]Babion I,Snoek BC,Novianti PW,et al.Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes;a feasibility study[J].Clinical epigenetics,2018,10:76.
[23]Greco D,Kivi N,Qian K,et a1.Human papillomavirus 16E5mod-ulates Ihe expression of host microRNAs[J].Plos0ne,20ll,6(7):e21646.
[24]Jung HM,Phillips BL,Chan EK.miR-375activates p21and suppresses telomerase activity by coordinately regulating HPV E6/E7,E6AP,CIP2A,and 14-3-3ζ[J].Mol Cancer,2014,13:8.
[25]Zhang L,Zhan X,Yan D,et a1.Circulating MicroRNA 21Is In-volved in Lymph Node Metastasis in Cervical Cancer by Targeting RASAI[J].Int J Gynecol Cancer,2016,26(5):810.
[26]WANG S,ZHANG Y,YUAN S.MicroRNA485targets MACC1and inhibits cervical cancer cell proliferation and invasion[J].Molecular medicine reports,2018,18(2):2407-2416.
[27]陈玉容,谢辉,唐慧,等.宫颈癌组织中微小RNA-155水平及其对细胞增殖和侵袭的影响[J].临床肿瘤学杂志,2018,23(08):690-695.
[28]ZHANG R,GE X,YOU K,et al.p16/Ki67dual staining improves the detection specificity of high-grade cervical lesions[J].The journal of obstetrics and gynaecology research,2018.
[29]Qian QP,Zhang X,Ding B,et al.Performance of P16/Ki67dual staining in triaging hr-HPV-positive population during cervical Cancer screening in the younger women[J].Clinica chimica acta;international journal of clinical chemistry,2018,483:281-285.
[30]Areán-CunsC,Mercado-Gutiérrez M,Paniello-Alastruey I,et al.Dual staining for p16/Ki67is a more specific test than cytology for triage of HPV-positive women[J].Virchows Archiv:an international journal of pathology,2018.
[31]Stanczuk GA,Baxter GJ,Currie H,et al.Defining Optimal Triage Strategies for hrHPV Screen-Positive Women-An Evaluation of HPV 16/18Genotyping,Cytology,and p16/Ki-67Cytoimmunochemistry[J].Cancer Epidemiol Biomarkers Prev,2017,26:1629-1635.
[32]李雨聪,雷海科,易琳,等.p16/Ki-67双染在宫颈癌及癌前病变初筛中的应用价值研究[J].实用妇产科杂志,2017(10):760-763.
[33]殷爱军.DNA甲基化检测在宫颈癌筛查中的应用[D].山东大学,2016.
[34]Chaiwongkot A,Vinokurova S.Pientong C,et a1.Differenti-al methylation of E2binding sites in episomal and integrated HPV 16genomes in preinvasive and invasinve cervical lesions[J].Int J Cancer,2013,132:2087-2094.
[35]Kalantari M,Callega‘Macias IE,Tewari D.et a1.Conserved methylation patterns of HPVl 6DNA in asymptomatic infec-tion and cervical meoplasia[J].Journal of virology,2004,78:12762-12772.
[36]Chang Sun,Laura L,Reimers et a1.Methylation of HPV 16genome CpG sites is associated with cervix precancer and cancer[J].Gynecol Oncol,2011,121(1):59-63.
[37]Mirabello L,Schiffman M,Ghosh A,et a1.Elevated methy-lation of HPVl6DNA is associated with the development of high grade cervical intraepithelial neoplasia[J].Int J Cancer,2013,132(6):1412-1422.
[38]Mina K,Kathryn O,hzel EC,et a1.Methlation of HPV 16.18,3I,and 45L2and L1genes and the cellular DAPKgene:Considerations for use as biomarkers of the progression of cervical neoplasia[J].Virology,2014,448:314-321.
[39]Turan T,Kalantari M,Cuschieri K,et a1.High-throughput detection of human papillomavirs.18L1gene methylation,acandidate biomarker for the progession of cervical meoplasia[J].Virology,2007,361(46):185-193.
[40]姚霁航,杨紫伟,郭科军.CDH11甲基化在宫颈癌中的表达及临床意义[J].现代肿瘤医学,2018,(10):1581-1584.
[41]SUN Y,LI S,SHEN K,et a1.DAPKl.MGMT and RARB pro-moter methylation as biomarkers for high-grade cervical le-sions[J].Int J C/in Exp Pathol,2015,8(11):14939-14945.
[42]Cohen Y,Singer G.Lavie O,et a1.The RASSFlA tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix[J].Clin Cancer Res,2003,9(8):2981-2984.
[43]Kang S,Kim JW,Kang GH,et a1.Comparison of DNA hy-permethylation patterns in different types of uterine cancer:cervical squamous cell carcinoma,cervical adenocarcinoma and endometrial adenocarcinoma[J].Int J Cancer,2006,118(9):2168-21 71.
[44]Bruhn LV,Andersen SJ,Hariri J.HPV-testing versus HPV-cytology co-testing to predict the outcome after conization[J].Acta Obstet Gynecol Scand,2018,97(6):758-765.
[45]Biasiolo A,Tono N,Zaninotto M,et al.Specificity of squamous cell carcinoma antigen(SCCA)-IgM detection in patients with HCV infection and rheumatoid factor seropositivity[J].Med Virol,2013,85:1005-100818.
[46]Chansaenroj J,Theamboonlers A,Junyangdikul P,et al.Polymorphisms in TP53(rs1042522),p16(rs11515and rs3088440)and NQO1(rs1800566)genes in Thai cervical cancer patients with HPV 16infection[J].Asian Pac JCancer Prev,2013,14:341-346.
[47]Shimura K,Mabuchi S,Yokoi T,et al.Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice[J].Gynecol Oncol,2013,24:321-329.
[48]梁指荣,杨洁飞,苏锡康.多种肿瘤标记物检测在宫颈癌诊治中的意义[J].国际检验医学杂志,2016,37(01):21-23.
[49]王飞霞,杨瑞利,韩双.细胞DNA定量分析联合HR-HPV、SCCA、CYFRA21-1检测在早期宫颈癌筛查中的价值[J].肿瘤学杂志,2018(3):281-284.
[50]李佩媛,王金声,康媛.TruScreen系统在宫颈癌筛查中的应用效果[J].癌症进展,2016,14(06):557-558+562.
[51]Wang SM,Zhang SK,Pan XF,et al.Human papillomavirus vaccine awareness,acceptability,and decision-making factors among Chinese college students[J].Asian Pacific journal of cancer prevention:APJCP,2014,15(7):3239-3245.
[2]LIU Y,ZHANG L,ZHAO G,et al.The clinical research of Thinprep Cytology Test(TCT)combined with HPV-DNA detection in screening cervical cancer[J].Cellular and molecular biology(Noisy-le-Grand,France),2017,63(2):92-95.
[3]XIE Y,TAN X,SHAO H,et al.VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region:a health economic evaluation[J].BMC public health,2017,17(1):118.
[4]于露露,陈汶.子宫颈癌筛查技术新进展[J].中华妇产科杂志,2015(4):312-315.
[5]Luttmer R,Dijkstra MG,Snijders PJ,et al.p16/Ki-67dual-stained cytology for detecting cervical(pre)cancer in a HPV-positive gynecologic outpatient population[J].Modern pathology:an official journal of the United States and Canadian Academy of Pathology,Inc,2016,29(8):870-878.
[6]Dong L,Wang MZ,Zhao XL,et al.Human papillomavirus viral load as a useful triage tool for non-16/18high-risk human papillomavirus positive women:A prospective screening cohort study[J].Gynecologic oncology,2018,148(1):103-110.
[7]Lie AK,TropéA,Skare GB,et al.HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia[J].Gynecologic oncology,2018,148(1):111-117.
[8]Granados R,Tellez-Safina H,Solis I,et al.Cervical cancer screening cotesting with cytology and MRNA HPV E6/E7yields high rates of CIN2+lesions in young women[J].Diagnostic cytopathology,2017,45(12):1065-1072.
[9]Cuschieri K,Ronco G,Lorincz A,et al.Eurogin roadmap 2017:Triage strategies for the management of HPV-positive women in cervical screening programs[J].International journal of cancer,2018,143(4):735-745.
[10]Nghiem VT,Davies KR,Beck JR,et al.Economic evaluation of DNA ploidy analysis vs liquid-based cytology for cervical screening[J].British journal of cancer,2015,112(12):1951-1957.
[11]Clinical application of DNA ploidy to cervical cancer screening:A review[J].World journal of clinical oncology,2014,5(5):931-965.
[12]甘密密,张锡流.DNA定量分析及TCT技术诊断宫颈病变的临床研究[J].实用妇产科杂志,2014(9):674-677.
[13]Lando M,Fjeldbo CS,Wilting SM,et al.Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14in cervical cancer[J].Epigenetics,2015,10(10):970-980.
[14]Mills AM,Dirks DC,Poulter MD,et al.HR-HPV E6/E7mRNA In Situ Hybridization:Validation Against PCR,DNA In Situ Hybridization,and p16Immunohistochemistry in 102Samples of Cervical,Vulvar,Anal,and Head and Neck Neoplasia[J].Am J Surg Pathol 2017,41:607-615.
[15]Coppock JD,Willis BC,Stoler MH.HPV RNA in situ hybridization can inform cervical cytology-histology correlation[J].Cancer cytopathology,2018,126(8):533-540.
[16]Ren C,Zhu Y,Yang L,et al.Diagnostic performance of HPV E6/E7mRNA assay for detection of cervical high-grade intraepithelial neoplasia and cancer among women with ASCUS Papanicolaou smears[J].Archives of gynecology and obstetrics,2018,297(2):425-432.
[17]YANG L,ZHU Y,BAI Y,et al.The clinical application of HPV E6/E7mRNA testing in triaging women with atypical squamous cells of undetermined significance or low-grade squamous intra-epithelial lesion Pap smear:A meta-analysis[J].J Cancer Res Ther 2017,13:613-620.
[18]Arbyn M,Roelens J,Cuschieri K.The APTIMA HPV assay versus the Hybrid Capture 2test in triage of women with ASC-USor LSIL cervical cytology:a meta-analysis of the diagnostic accuracy[J].Int J Cancer,2013,132(1):101-108.
[19]Snoek BC,Verlaat W,Babion I,et al.Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer[J].International journal of cancer,2018.
[20]Hasanzadeh M,Movahedi M,Rejali M,et al.The potential prognostic and therapeutic application of tissue and circulating microRNAs in cervical cancer[J].Journal of cellular physiology,2018.
[21]Au Yeung CL,Tsang TY,Yau PL.Human papillomavirus type 16E6induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway[J].Oncogene,2011,30(21):2401-2410.
[22]Babion I,Snoek BC,Novianti PW,et al.Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes;a feasibility study[J].Clinical epigenetics,2018,10:76.
[23]Greco D,Kivi N,Qian K,et a1.Human papillomavirus 16E5mod-ulates Ihe expression of host microRNAs[J].Plos0ne,20ll,6(7):e21646.
[24]Jung HM,Phillips BL,Chan EK.miR-375activates p21and suppresses telomerase activity by coordinately regulating HPV E6/E7,E6AP,CIP2A,and 14-3-3ζ[J].Mol Cancer,2014,13:8.
[25]Zhang L,Zhan X,Yan D,et a1.Circulating MicroRNA 21Is In-volved in Lymph Node Metastasis in Cervical Cancer by Targeting RASAI[J].Int J Gynecol Cancer,2016,26(5):810.
[26]WANG S,ZHANG Y,YUAN S.MicroRNA485targets MACC1and inhibits cervical cancer cell proliferation and invasion[J].Molecular medicine reports,2018,18(2):2407-2416.
[27]陈玉容,谢辉,唐慧,等.宫颈癌组织中微小RNA-155水平及其对细胞增殖和侵袭的影响[J].临床肿瘤学杂志,2018,23(08):690-695.
[28]ZHANG R,GE X,YOU K,et al.p16/Ki67dual staining improves the detection specificity of high-grade cervical lesions[J].The journal of obstetrics and gynaecology research,2018.
[29]Qian QP,Zhang X,Ding B,et al.Performance of P16/Ki67dual staining in triaging hr-HPV-positive population during cervical Cancer screening in the younger women[J].Clinica chimica acta;international journal of clinical chemistry,2018,483:281-285.
[30]Areán-CunsC,Mercado-Gutiérrez M,Paniello-Alastruey I,et al.Dual staining for p16/Ki67is a more specific test than cytology for triage of HPV-positive women[J].Virchows Archiv:an international journal of pathology,2018.
[31]Stanczuk GA,Baxter GJ,Currie H,et al.Defining Optimal Triage Strategies for hrHPV Screen-Positive Women-An Evaluation of HPV 16/18Genotyping,Cytology,and p16/Ki-67Cytoimmunochemistry[J].Cancer Epidemiol Biomarkers Prev,2017,26:1629-1635.
[32]李雨聪,雷海科,易琳,等.p16/Ki-67双染在宫颈癌及癌前病变初筛中的应用价值研究[J].实用妇产科杂志,2017(10):760-763.
[33]殷爱军.DNA甲基化检测在宫颈癌筛查中的应用[D].山东大学,2016.
[34]Chaiwongkot A,Vinokurova S.Pientong C,et a1.Differenti-al methylation of E2binding sites in episomal and integrated HPV 16genomes in preinvasive and invasinve cervical lesions[J].Int J Cancer,2013,132:2087-2094.
[35]Kalantari M,Callega‘Macias IE,Tewari D.et a1.Conserved methylation patterns of HPVl 6DNA in asymptomatic infec-tion and cervical meoplasia[J].Journal of virology,2004,78:12762-12772.
[36]Chang Sun,Laura L,Reimers et a1.Methylation of HPV 16genome CpG sites is associated with cervix precancer and cancer[J].Gynecol Oncol,2011,121(1):59-63.
[37]Mirabello L,Schiffman M,Ghosh A,et a1.Elevated methy-lation of HPVl6DNA is associated with the development of high grade cervical intraepithelial neoplasia[J].Int J Cancer,2013,132(6):1412-1422.
[38]Mina K,Kathryn O,hzel EC,et a1.Methlation of HPV 16.18,3I,and 45L2and L1genes and the cellular DAPKgene:Considerations for use as biomarkers of the progression of cervical neoplasia[J].Virology,2014,448:314-321.
[39]Turan T,Kalantari M,Cuschieri K,et a1.High-throughput detection of human papillomavirs.18L1gene methylation,acandidate biomarker for the progession of cervical meoplasia[J].Virology,2007,361(46):185-193.
[40]姚霁航,杨紫伟,郭科军.CDH11甲基化在宫颈癌中的表达及临床意义[J].现代肿瘤医学,2018,(10):1581-1584.
[41]SUN Y,LI S,SHEN K,et a1.DAPKl.MGMT and RARB pro-moter methylation as biomarkers for high-grade cervical le-sions[J].Int J C/in Exp Pathol,2015,8(11):14939-14945.
[42]Cohen Y,Singer G.Lavie O,et a1.The RASSFlA tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix[J].Clin Cancer Res,2003,9(8):2981-2984.
[43]Kang S,Kim JW,Kang GH,et a1.Comparison of DNA hy-permethylation patterns in different types of uterine cancer:cervical squamous cell carcinoma,cervical adenocarcinoma and endometrial adenocarcinoma[J].Int J Cancer,2006,118(9):2168-21 71.
[44]Bruhn LV,Andersen SJ,Hariri J.HPV-testing versus HPV-cytology co-testing to predict the outcome after conization[J].Acta Obstet Gynecol Scand,2018,97(6):758-765.
[45]Biasiolo A,Tono N,Zaninotto M,et al.Specificity of squamous cell carcinoma antigen(SCCA)-IgM detection in patients with HCV infection and rheumatoid factor seropositivity[J].Med Virol,2013,85:1005-100818.
[46]Chansaenroj J,Theamboonlers A,Junyangdikul P,et al.Polymorphisms in TP53(rs1042522),p16(rs11515and rs3088440)and NQO1(rs1800566)genes in Thai cervical cancer patients with HPV 16infection[J].Asian Pac JCancer Prev,2013,14:341-346.
[47]Shimura K,Mabuchi S,Yokoi T,et al.Utility of serum squamous cell carcinoma antigen levels at the time of recurrent cervical cancer diagnosis in determining the optimal treatment choice[J].Gynecol Oncol,2013,24:321-329.
[48]梁指荣,杨洁飞,苏锡康.多种肿瘤标记物检测在宫颈癌诊治中的意义[J].国际检验医学杂志,2016,37(01):21-23.
[49]王飞霞,杨瑞利,韩双.细胞DNA定量分析联合HR-HPV、SCCA、CYFRA21-1检测在早期宫颈癌筛查中的价值[J].肿瘤学杂志,2018(3):281-284.
[50]李佩媛,王金声,康媛.TruScreen系统在宫颈癌筛查中的应用效果[J].癌症进展,2016,14(06):557-558+562.
[51]Wang SM,Zhang SK,Pan XF,et al.Human papillomavirus vaccine awareness,acceptability,and decision-making factors among Chinese college students[J].Asian Pacific journal of cancer prevention:APJCP,2014,15(7):3239-3245.