摘要
C-MET是由C-MET原癌基因编码的蛋白质,它参与了多种肿瘤的形成、转移和侵袭。C-MET抑制剂是一种非常具有挑战性的新型抗肿瘤药物,它是针对C-MET信号通路治疗肿瘤的研发产物,且基于此靶点的上市药品并不多见,。我们通过集C-MET抑制剂近年在国内的研究进展,综述其在国内的设计开发理念及活性筛选成果,探讨其在国内的未来前景。
C- MET is a kind of protein that participates in a variety of tumor formation,metastasis and invasion,it is coded by C- MET proto- oncogene. C- MET inhibitor is a very challenging anticancer drugs,which is cure the cancer by cut the C- MET signaling pathway,and there is only one listed drug of C- MET inhibitor in the world. We collect all the research progress of C- MET inhibitor in recent years,review its design and development concepts and activity screening achievement,discuss its future prospects in China.
引文
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