膜性肾病发病机制的研究进展
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摘要
膜性肾病是一种以血清抗免疫球蛋白IgG沿基底膜上皮下沉积为特征的慢性肾小球疾病,其发病率呈逐年上升趋势。目前膜性肾病发病机制尚未完全明确, M-型磷脂酶A2受体、1型血小板反应蛋白7A域等靶抗原、遗传、环境等因素可能参与其发生、发展过程。故本文就相关最新报道做一综述。
引文
[1] Beck LH, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy[J]. N Engl J Med,2009, 361(1): 11-21.
[2] Zhu Q. Anti-Phospholipase A2 Receptor Autoantibody: A New Biomarker for Primary Membranous Nephropathy[J]. Immunol Endocr Metab Agents Med Chem,2016, 16(1): 4-17.
[3] Kumar V, Ramachandran R, Kumar A, et al. Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy[J]. Nephrology (Carlton), 2015, 20(8): 572-575.
[4] Kao L, Lam V, Waldman M, et al. Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy[J]. J Am Soc Nephrol, 2015,26(2): 291-301.
[5] Tomas NM, Beck LH, Meyer-Schwesinger C, et al. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy[J]. N Engl J Med, 2014, 371(24): 2277-2287.
[6] Iwakura T, Ohashi N, Kato A, et al. Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy[J]. PLoS One, 2015, 10(9): e0138841.
[7] Iwakura T, Fujigaki Y, Katahashi N, et al. Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman[J]. Intern Med, 2016, 55(18): 2663-2668.
[8] Beck LH. PLA2R and THSD7A: Disparate Paths to the Same Disease[J]. J Am Soc Nephrol, 2017, 28(9): 2579-2589.
[9] Tomas NM, Hoxha E, Reinicke AT, et al. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy[J]. J Clin Invest, 2016, 126(7): 2519-2532.
[10] Larsen CP, Cossey LN, Beck LH. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity[J]. Mod Pathol, 2016, 29(4): 421-426.
[11] Ronco P, Debiec H. A podocyte view of membranous nephropathy: from Heymann nephritis to the childhood human disease[J]. Pflugers Arch, 2017, 469(7/8): 997-1005.
[12] Ronco P, Debiec H. Advances in membranous nephropathy: success stories of a long journey[J]. Clin Exp Pharmacol Physiol, 2011, 38(7): 460-466.
[13] Vivarelli M, Emma F, Pellé T, et al. Genetic homogeneity but IgG subclass-dependent clinical variability of alloimmune membranous nephropathy with anti-neutral endopeptidase antibodies[J]. Kidney Int, 2015, 87(3): 602-609.
[14] Debiec H, Lefeu F, Kemper MJ, et al. Early-childhood membranous nephropathy due to cationic bovine serum albumin[J]. N Engl J Med, 2011, 364(22): 2101-2110.
[15] Herrmann SM, Sethi S, Fervenza FC. Membranous nephropathy: the start of a paradigm shift[J]. Curr Opin Nephrol Hypertens, 2012,21(2): 203-210.
[16] Ireland R.Glomerular disease: Bovine serum albumin: involved in childhood membranous nephropathy[J]. Nat Rev Nephrol, 2011, 7(8): 423.
[17] Prunotto M, Carnevali ML, Candiano G, et al. Autoimmunity in membranous nephropathy targets aldose reductase and SOD2[J]. J Am Soc Nephrol, 2010, 21(3): 507-519.
[18] Murtas C, Bruschi M, Candiano G, et al. Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy[J]. Clin J Am Soc Nephrol, 2012, 7(9): 1394-1400.
[19] Beck LH, Salant DJ. Membranous nephropathy: from models to man[J]. J Clin Invest, 2014, 124(6): 2307-2314.
[20] Takahashi S, Hiromura K, Tsukida M, et al. Nephrotic syndrome caused by immune-mediated acquired LCAT deficiency[J]. J Am Soc Nephrol, 2013, 24(8): 1305-1312.
[21] Debiec H, Ronco P. Immunopathogenesis of membranous nephropathy: an update[J]. Semin Immunopathol, 2014, 36(4): 381-397.
[22] 周广宇,刘锋,张文龙,等.M型磷脂酶A2受体基因单核苷酸多态性与膜性肾病的相关性[J].中华医学遗传学杂志,2013,30(6):706-710.
[23] Thiri M, Honda K, Kashiwase K, et al. High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese[J]. Sci Rep, 2016, 6: 38189.
[24] Saeed M, Beggs ML, Walker PD, et al. PLA2R-associated membranous glomerulopathy is modulated by common variants in PLA2R1 and HLA-DQA1 genes[J]. Genes Immun, 2014, 15(8): 556-561.
[25] Lv J, Hou W, Zhou X, et al. Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy[J]. J Am Soc Nephrol, 2013, 24(8): 1323-1329.
[26] Stanescu HC, Arcos-Burgos M, Medlar A, et al. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy[J]. N Engl J Med, 2011, 364(7): 616-626.
[27] Ramachandran R, Kumar V, Kumar A, et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians[J]. Nephrol Dial Transplant,2016, 31(9): 1486-1489.
[28] Le WB, Shi JS, Zhang T, et al. HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy[J]. J Am Soc Nephrol, 2017, 28(5): 1642-1650.
[29] Tabibzadeh S, Kong QF, Kapur S, et al. TNF-α induces dyscohesion of epithelial cells. Association with disassembly of actin filaments[J]. Endocrine, 1995,3(8): 549-556.
[30] Bantis C, Heering PJ, Aker S, et al. Tumor necrosis factor-alpha gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis[J]. Am J Nephrol, 2006,26(1): 12-15.
[31] Thibaudin D, Thibaudin L, Berthoux P, et al. TNFA2 and d2 alleles of the tumor necrosis factor alpha gene polymorphism are associated with onset/occurrence of idiopathic membranous nephropathy[J]. Kidney Int, 2007, 71(5): 431-437.
[32] 程桂雪, 刘建华, 秦晓松. 特发性膜性肾病相关基因单核苷酸多态性研究进展[J]. 中国免疫学杂志,2016, 32(9): 1405-1409.
[33] Chen SY, Chen CH, Huang YC, et al. Association of STAT4 polymorphisms with susceptibility to primary membranous glomerulonephritis and renal failure[J]. Clin Chim Acta, 2011, 412(21/22): 1899-1904.
[34] Xu X, Wang G, Chen N, et al. Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China[J]. J Am Soc Nephrol, 2016, 27(12): 3739-3746.
[2] Zhu Q. Anti-Phospholipase A2 Receptor Autoantibody: A New Biomarker for Primary Membranous Nephropathy[J]. Immunol Endocr Metab Agents Med Chem,2016, 16(1): 4-17.
[3] Kumar V, Ramachandran R, Kumar A, et al. Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy[J]. Nephrology (Carlton), 2015, 20(8): 572-575.
[4] Kao L, Lam V, Waldman M, et al. Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy[J]. J Am Soc Nephrol, 2015,26(2): 291-301.
[5] Tomas NM, Beck LH, Meyer-Schwesinger C, et al. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy[J]. N Engl J Med, 2014, 371(24): 2277-2287.
[6] Iwakura T, Ohashi N, Kato A, et al. Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy[J]. PLoS One, 2015, 10(9): e0138841.
[7] Iwakura T, Fujigaki Y, Katahashi N, et al. Membranous Nephropathy with an Enhanced Granular Expression of Thrombospondin Type-1 Domain-containing 7A in a Pregnant Woman[J]. Intern Med, 2016, 55(18): 2663-2668.
[8] Beck LH. PLA2R and THSD7A: Disparate Paths to the Same Disease[J]. J Am Soc Nephrol, 2017, 28(9): 2579-2589.
[9] Tomas NM, Hoxha E, Reinicke AT, et al. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy[J]. J Clin Invest, 2016, 126(7): 2519-2532.
[10] Larsen CP, Cossey LN, Beck LH. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity[J]. Mod Pathol, 2016, 29(4): 421-426.
[11] Ronco P, Debiec H. A podocyte view of membranous nephropathy: from Heymann nephritis to the childhood human disease[J]. Pflugers Arch, 2017, 469(7/8): 997-1005.
[12] Ronco P, Debiec H. Advances in membranous nephropathy: success stories of a long journey[J]. Clin Exp Pharmacol Physiol, 2011, 38(7): 460-466.
[13] Vivarelli M, Emma F, Pellé T, et al. Genetic homogeneity but IgG subclass-dependent clinical variability of alloimmune membranous nephropathy with anti-neutral endopeptidase antibodies[J]. Kidney Int, 2015, 87(3): 602-609.
[14] Debiec H, Lefeu F, Kemper MJ, et al. Early-childhood membranous nephropathy due to cationic bovine serum albumin[J]. N Engl J Med, 2011, 364(22): 2101-2110.
[15] Herrmann SM, Sethi S, Fervenza FC. Membranous nephropathy: the start of a paradigm shift[J]. Curr Opin Nephrol Hypertens, 2012,21(2): 203-210.
[16] Ireland R.Glomerular disease: Bovine serum albumin: involved in childhood membranous nephropathy[J]. Nat Rev Nephrol, 2011, 7(8): 423.
[17] Prunotto M, Carnevali ML, Candiano G, et al. Autoimmunity in membranous nephropathy targets aldose reductase and SOD2[J]. J Am Soc Nephrol, 2010, 21(3): 507-519.
[18] Murtas C, Bruschi M, Candiano G, et al. Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy[J]. Clin J Am Soc Nephrol, 2012, 7(9): 1394-1400.
[19] Beck LH, Salant DJ. Membranous nephropathy: from models to man[J]. J Clin Invest, 2014, 124(6): 2307-2314.
[20] Takahashi S, Hiromura K, Tsukida M, et al. Nephrotic syndrome caused by immune-mediated acquired LCAT deficiency[J]. J Am Soc Nephrol, 2013, 24(8): 1305-1312.
[21] Debiec H, Ronco P. Immunopathogenesis of membranous nephropathy: an update[J]. Semin Immunopathol, 2014, 36(4): 381-397.
[22] 周广宇,刘锋,张文龙,等.M型磷脂酶A2受体基因单核苷酸多态性与膜性肾病的相关性[J].中华医学遗传学杂志,2013,30(6):706-710.
[23] Thiri M, Honda K, Kashiwase K, et al. High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese[J]. Sci Rep, 2016, 6: 38189.
[24] Saeed M, Beggs ML, Walker PD, et al. PLA2R-associated membranous glomerulopathy is modulated by common variants in PLA2R1 and HLA-DQA1 genes[J]. Genes Immun, 2014, 15(8): 556-561.
[25] Lv J, Hou W, Zhou X, et al. Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy[J]. J Am Soc Nephrol, 2013, 24(8): 1323-1329.
[26] Stanescu HC, Arcos-Burgos M, Medlar A, et al. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy[J]. N Engl J Med, 2011, 364(7): 616-626.
[27] Ramachandran R, Kumar V, Kumar A, et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians[J]. Nephrol Dial Transplant,2016, 31(9): 1486-1489.
[28] Le WB, Shi JS, Zhang T, et al. HLA-DRB1*15:01 and HLA-DRB3*02:02 in PLA2R-Related Membranous Nephropathy[J]. J Am Soc Nephrol, 2017, 28(5): 1642-1650.
[29] Tabibzadeh S, Kong QF, Kapur S, et al. TNF-α induces dyscohesion of epithelial cells. Association with disassembly of actin filaments[J]. Endocrine, 1995,3(8): 549-556.
[30] Bantis C, Heering PJ, Aker S, et al. Tumor necrosis factor-alpha gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis[J]. Am J Nephrol, 2006,26(1): 12-15.
[31] Thibaudin D, Thibaudin L, Berthoux P, et al. TNFA2 and d2 alleles of the tumor necrosis factor alpha gene polymorphism are associated with onset/occurrence of idiopathic membranous nephropathy[J]. Kidney Int, 2007, 71(5): 431-437.
[32] 程桂雪, 刘建华, 秦晓松. 特发性膜性肾病相关基因单核苷酸多态性研究进展[J]. 中国免疫学杂志,2016, 32(9): 1405-1409.
[33] Chen SY, Chen CH, Huang YC, et al. Association of STAT4 polymorphisms with susceptibility to primary membranous glomerulonephritis and renal failure[J]. Clin Chim Acta, 2011, 412(21/22): 1899-1904.
[34] Xu X, Wang G, Chen N, et al. Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China[J]. J Am Soc Nephrol, 2016, 27(12): 3739-3746.