摘要
肿瘤细胞的多药耐药性(MDR,multidrug resistance)是癌症治疗过程中的主要挑战[1]。荧光硅纳米颗粒凭借其良好的生物安全性、强且稳定的荧光性质,已经被运用于肿瘤细胞实时成像以及治疗[2-3]。我们将荧光硅纳米颗粒作为纳米药物载体负载盐酸阿霉素(DOX,doxorubicin,一种广泛的癌症治疗药物)用于耐药细胞的治疗。该载体可以近一步用来输送MDR1(P-糖蛋白的编码基因)小干扰RNA(small interfering RNA,SiRNA),其对克服肿瘤细胞的耐药性具有协同作用,能够明显抑制P-糖蛋白的表达,增强药物在胞内的富集量,进而高效地克服细胞的耐药性。
The acquisition of multidrug resistance(MDR) is a major hurdle for the successful chemotherapy of tumors.Taking advantage of various salient merits such as favorable biocompatibility,strong fluorescence and photostability,fluorescent silicon nanoparticles have been applied to cell bioimaging and cancer therapy.Herein,doxorubicin(DOX,one of the most potential anti-cancer drugs for treating various solid tumors) loaded fluorescent silicon nanoparticles are reported for reversing DOX resistance in drug resistant cancer cells.These smart nanocarriers are further employed for co-delivering MDR1(encoding gene of P-glycoprotein) siRNA to synergistically overcome the MDR of drug resistant cancer cells resulting from decreased P-glycoprotein expression and enhanced drug accumulation in cancer cells.
引文
[1]Peng F.,Su Y.Y.,Wei X.P.,et al.Angew.Chem.Int.Ed.2013,52(5):1457.
[2]Zhong Y.,Sun X.,Wang S.,et al.ACS Nano.2015,9(6):5958.
[3]Ji X.Y.,Peng F.,Zhong Y.L.,et al.Adv.Mater.2015,27(5):1029.