摘要
目的:建立金属药物卡铂注射液和注射用卡铂中钠和铂元素的含量测定方法。方法:采用电感耦合等离子体发射光谱仪,发射功率1150W,载气流速0.60L/min同时测定钠和铂的含量。结果:采用电感耦合等离子体发射光谱法(ICP-AES)可以同时准确地测定出卡铂注射液中钠和铂的量以及注射用卡铂中铂的量,进而折算出依地酸二钠,控制铂总量以及预测卡铂的含量。结论:本实验建立的方法快捷、高效,方法准确稳定,可以作为卡铂注射剂中依地酸二钠和铂总量的测定方法,预测卡铂含量。
To simultaneously determine the contents of Na and Pt in Carboplatin Injection and Carboplatin for Injection.Method:A rapid method was established with Inductively Coupled Plasma Atomic Emission Spectrometry(ICP-AES),transmitting power:1150w,flow rate of carrier gas:0.60L/min.Results:ICP-AES could simultaneously determine the contents of Na and Pt in Carboplatin Injection and Carboplatin for Injection.The results could calculate the contents of EDTA-2Na and total Pt.Conclusion:The proposed method was accurate and rapid,and could be applied in the determination of the contents of EDTA-2Na and total Pt,and then calculate the contents of Carboplatin.
引文
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