C反应蛋白、血清降钙素原、D-二聚体联合检测在重症院内获得性肺炎患者诊治中的应用价值
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- 论文作者：王仕榕 ; 曹晋峰
- 年：2016
- 作者机构：凉山彝族自治州第二人民医院;凉山彝族自治州第二人民医院核医学科;
- 论文关键词：C反应蛋白 ; 降钙素原 ; D-二聚体 ; 重症院内获得性肺炎
- 英文论文关键词：C reactive protein ; detection ; D-dimer ; Severe hospital acquired pneumonia
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R563.1
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：2077k
- 原文格式：D
- 会议级别：全国
摘要
目的:研究C反应蛋白(CRP)、血清降钙素原(PCT)、D-二聚体(D-D)联合检测在重症院内获得性肺炎(SHAP)患者诊治中的应用价值;方法:选择2014年6月~2015年5月我院SHAP患者108例,按照院内获得性肺炎严重程度分为轻症组(62例)与重症组(46例),两组一般资料比较无统计学意义(p>0.05)。选择同期在我院接受健康体检的正常人50例纳入健康组,三组一般资料比较无统计学意义(p>0.05)。观察三组CRP、PCT、D-D水平及肺炎严重指数得分(PSI得分);观察死亡患者与生存患者CRP、PCT、D-D水平及PSI得分;分析SHAP患者CRP、PCT、D-D水平与PSI得分的相关性;结果:重症组CRP、PCT、D-D均高于轻症组、健康组(均p<0.05),轻症组CRP、PCT、D-D均高于健康组(均p<0.05),三组CRP、PCT、D-D存在统计学意义(均p<0.05)。重症组PSI得分显著高于轻症组(p<0.05)。死亡患者CRP、PCT、D-D与PSI得分均高于生存患者(均p<0.05)。SHAP患者CRP、PCT、D-D与PSI得分之间均呈显著的相关性;结论:CRP、PCT、D-D可准确评估SHAP患者病情及预后。
Objective: investigation of C-reactive protein(CRP), Procalcitonin(PCT), D-dimer(D-D) joint detection in Severe hospital acquired pneumonia(SHAP) in diagnosis and treatmentof patients with application value; methods: 2014 June~2015 May in our hospital shap of 108 patients, according to the hospital care for pneumonia severity as mild group(62 cases) and severe group(46 cases), two groups of average data no statistical significance(P>0.05). 50 healthy subjects were included in the healthy group, and there was no statistical significance between the three groups(P>0.05). Observe three groups of CRP, PCT, D-D level and pneumonia severity index score(PSI) score, observed the patients with survival in patients with CRP, PCT and D-D levels and PSI score ofdeath; correlation analysis of shap in patients with CRP, PCT, DD levels and PSI score; results: severe group, CRP, PCT and D-D were higher than those of the mild group and healthy group(P<0.05), mild group, CRP, PCT and D-D were higher than healthy group(P< 0.05), three groups of CRP, PCT and D-D are statistically significant(P<0.05). The PSI score in severe group was significantly higherthan that in the mild group(P<0.05). PSI, PCT, D-D and CRP were higher than those of the patients(P< 0.05). There were significant correlations between, PCT, D-D, CRP and PSI in SHAP patients. Conclusion: CRP, PCT, D-D can accurately evaluate the patient's condition and prognosis of SHAP patients.
Objective: investigation of C-reactive protein(CRP), Procalcitonin(PCT), D-dimer(D-D) joint detection in Severe hospital acquired pneumonia(SHAP) in diagnosis and treatmentof patients with application value; methods: 2014 June~2015 May in our hospital shap of 108 patients, according to the hospital care for pneumonia severity as mild group(62 cases) and severe group(46 cases), two groups of average data no statistical significance(P>0.05). 50 healthy subjects were included in the healthy group, and there was no statistical significance between the three groups(P>0.05). Observe three groups of CRP, PCT, D-D level and pneumonia severity index score(PSI) score, observed the patients with survival in patients with CRP, PCT and D-D levels and PSI score ofdeath; correlation analysis of shap in patients with CRP, PCT, DD levels and PSI score; results: severe group, CRP, PCT and D-D were higher than those of the mild group and healthy group(P<0.05), mild group, CRP, PCT and D-D were higher than healthy group(P< 0.05), three groups of CRP, PCT and D-D are statistically significant(P<0.05). The PSI score in severe group was significantly higherthan that in the mild group(P<0.05). PSI, PCT, D-D and CRP were higher than those of the patients(P< 0.05). There were significant correlations between, PCT, D-D, CRP and PSI in SHAP patients. Conclusion: CRP, PCT, D-D can accurately evaluate the patient's condition and prognosis of SHAP patients.
引文
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[2]赵大海,赵卉.多中心初治失败社区获得性肺炎的病原学及临床因素分析[J].安徽医科大学学报,2015,50(3):361-364.
[3]Johansson N,Kalin M,Backman-Johansson C,et al.Procalcitonin levels in communityacquired pneumonia correlation with aetiology and severity[J].Scand J Infect Dis,2014,46(11):787-791.
[4]龙威,黄高忠,李利娟,等.D-二聚体对社区获得性肺炎病情及长期预后的判断[J].中华急诊医学杂志,2015,24(1):77-80.
[5]王希敏,郑东旭.老年获得性肺炎支原体感染的检测与分析[J].中国人兽共患病学报,2015,31(2):189-190.
[6]Pfister R,Kochanek M,Leygeber T,et al.Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic:a prospective cohort study,systematic review and individual patient data mcta-analysis[J].Crit Care,2014,18(2):R44.
[7]赵瑾,周童,施敏骅.血清降钙素原对社区获得性肺炎严重程度的预测价值[J].江苏医药,2015,41(1):36-38.