Strain-dependent mercury influences on hematopoietic stem and progenitor cells in mice during sub-acute exposure
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- 英文论文题名：Strain-dependent mercury influences on hematopoietic stem and progenitor cells in mice during sub-acute exposure
- 论文作者：Xinchun Yu ; Qian Li ; Yandong Zhang ; Zhengli Yang ; Qiang Li ; Yifan Zhao ; Xiuli Chang ; Zhijun Zhou ; Yubin Zhang
- 英文论文作者：Xinchun Yu ; Qian Li ; Yandong Zhang ; Zhengli Yang ; Qiang Li ; Yifan Zhao ; Xiuli Chang ; Zhijun Zhou ; Yubin Zhang ; School of Public Health and Key Laboratory of Public Health ; MOE ; Fudan University ; Putuo District Center for Disease Control and Prevention
- 年：2016
- 作者机构：School of Public Health and Key Laboratory of Public Health,MOE,Fudan University;Putuo District Center for Disease Control and Prevention,Shanghai;
- 会议召开时间：2016-11-16
- 会议录名称：第六届中国毒理学会免疫毒理专业委员会换届及学术会议资料汇编
- 语种：英文
- 分类号：R114
- 学会代码：ZGDV
- 会议名称：第六届中国毒理学会免疫毒理专业委员会换届及学术会议
- 会议地点：中国河南开封
- 主办单位：中国毒理学会免疫毒理专业委员会
- 学会名称：中国毒理学会
- 页数：2
- 文件大小：123k
- 原文格式：O
- 会议级别：全国
摘要
Although immunotoxic effects of mercury(Hg) on mature immune cells have been widely studied,the influences of Hg on hematopoiesis remain to be defined.The aim of this study was to investigate the effects of Hg on hematopoietic stem and progenitor cells(HSPCs) in the bone marrow(BM) during sub-acute exposure.Herein,we show that methyl Hg(MeHg,1.25 uM via drinking water) increased the number of granulocyte-macrophage progenitors(GMPs) and decreased the number of common lymphoid progenitors(CLPs),while Hg chloride(HgCh,50μM via drinking water) increased the number of GMPs and decreased the numbers of multipotent progenitors(MPPs) and CLPs in B10.S mice.Neither MeHg nor HgCl_2 affected the numbers of long-term hematopoietic stem cells(LT-HSCs),short-term HSC(ST-HSCs),or common myeloid progenitors(CMPs) in B10.S mice.In accordance with the modulation of Hg on hematopoietic progenitors,MeHg and HgCl_2 increased the numbers of mature myeloid cells and decreased the number of B cells in the BM of B10.S mice.Additionally,MeHg did not affect the cell cycling of LT-HSCs,but HgCl_2 promoted the cell cycling of LT-HSCs dependent on IFNγ signaling in B10.S mice.In DBA/2 mice,MeHg did not affect HSPCs,but HgCl_2 decreased the number of LT-HSCs associated with their suppressed proliferation,and increased the numbers of GMPs and monocytes in the BM.These data indicate Hg modulations on hematopoiesis are strain-dependent.Our study reveals a previously unrecognized hematopoietic toxicity of Hg.
Although immunotoxic effects of mercury(Hg) on mature immune cells have been widely studied,the influences of Hg on hematopoiesis remain to be defined.The aim of this study was to investigate the effects of Hg on hematopoietic stem and progenitor cells(HSPCs) in the bone marrow(BM) during sub-acute exposure.Herein,we show that methyl Hg(MeHg,1.25 uM via drinking water) increased the number of granulocyte-macrophage progenitors(GMPs) and decreased the number of common lymphoid progenitors(CLPs),while Hg chloride(HgCh,50μM via drinking water) increased the number of GMPs and decreased the numbers of multipotent progenitors(MPPs) and CLPs in B10.S mice.Neither MeHg nor HgCl_2 affected the numbers of long-term hematopoietic stem cells(LT-HSCs),short-term HSC(ST-HSCs),or common myeloid progenitors(CMPs) in B10.S mice.In accordance with the modulation of Hg on hematopoietic progenitors,MeHg and HgCl_2 increased the numbers of mature myeloid cells and decreased the number of B cells in the BM of B10.S mice.Additionally,MeHg did not affect the cell cycling of LT-HSCs,but HgCl_2 promoted the cell cycling of LT-HSCs dependent on IFNγ signaling in B10.S mice.In DBA/2 mice,MeHg did not affect HSPCs,but HgCl_2 decreased the number of LT-HSCs associated with their suppressed proliferation,and increased the numbers of GMPs and monocytes in the BM.These data indicate Hg modulations on hematopoiesis are strain-dependent.Our study reveals a previously unrecognized hematopoietic toxicity of Hg.
Although immunotoxic effects of mercury(Hg) on mature immune cells have been widely studied,the influences of Hg on hematopoiesis remain to be defined.The aim of this study was to investigate the effects of Hg on hematopoietic stem and progenitor cells(HSPCs) in the bone marrow(BM) during sub-acute exposure.Herein,we show that methyl Hg(MeHg,1.25 uM via drinking water) increased the number of granulocyte-macrophage progenitors(GMPs) and decreased the number of common lymphoid progenitors(CLPs),while Hg chloride(HgCh,50μM via drinking water) increased the number of GMPs and decreased the numbers of multipotent progenitors(MPPs) and CLPs in B10.S mice.Neither MeHg nor HgCl_2 affected the numbers of long-term hematopoietic stem cells(LT-HSCs),short-term HSC(ST-HSCs),or common myeloid progenitors(CMPs) in B10.S mice.In accordance with the modulation of Hg on hematopoietic progenitors,MeHg and HgCl_2 increased the numbers of mature myeloid cells and decreased the number of B cells in the BM of B10.S mice.Additionally,MeHg did not affect the cell cycling of LT-HSCs,but HgCl_2 promoted the cell cycling of LT-HSCs dependent on IFNγ signaling in B10.S mice.In DBA/2 mice,MeHg did not affect HSPCs,but HgCl_2 decreased the number of LT-HSCs associated with their suppressed proliferation,and increased the numbers of GMPs and monocytes in the BM.These data indicate Hg modulations on hematopoiesis are strain-dependent.Our study reveals a previously unrecognized hematopoietic toxicity of Hg.
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