保神汤治疗抑郁性神经症及抑郁性神经症与IL-1β、IL-2的关系
摘要
为了解白细胞介素-1β(IL-1β)、白介素-2(IL-2)与抑郁性神经症的关系，并初步探讨IL-1β、IL-2可否作为抑郁性神经症的诊断指标，采用双抗体夹心步骤的酶联免疫吸附测定(ABC-ELISA)来检测抑郁性神经症30例、正常健康者24例的血清IL-1β、IL-2的含量，同时予保神汤治疗6周，前后通过汉密尔顿抑郁量表(HAMD)测定其分值，观察并评定其疗效。结果显示，抑郁性神经症组IL-1β含量较正常对照组有显著升高(P＜0.05)，而IL-2无明显差异(P＞0.05)，IL-1β、IL-2分别与病程呈正相关，且病例组经治疗后总有效率达93.33％。结论：抑郁性神经症患者IL-1β升高比IL-2快，IL-2反应滞后，两者均与病程呈正相关。IL-1β是可供判断抑郁性神经症的一个参考标准，保神汤具有明显的抗抑郁作用。
To understand the relationship between the depressive neuroses and interleukin-1β (IL-1β ),interleukin-2(IL-2),and to investigate whether IL-1 β , IL-2 can be regarded as diagnosis index to depressive neuroses. In this study, emzyme-linked immunosorbent assay(ABC-ELISA) were used to detect the content of IL-1β and IL-2 in the blood, serum of 30 depressive neuroses patients and 10 healthy person. At the same time, the depressive neuroses group was treated with Baoshen Decoction for six weeks, HAMD were used to measure their scores before and after the treatment to observe and evaluate its curative effect. The result showed that the content of IL-1 β in depressive neuroses group is significantly higher than the control group (P<0.05),but there is no significant difference between the two group as for IL-2,(P>0.05).Positive correlations exist between IL-1β, IL-2 and course respectively. And the total effective rate is about 93.33%.In conclusion,IL-1β is more sensitive than IL-2 and both of them have positive correlation to course.IL-1β can be used as a reference standard for diagnosis of depressive neuroses. Baoshen Decoction has obvious anti-depression effect.
To understand the relationship between the depressive neuroses and interleukin-1β (IL-1β ),interleukin-2(IL-2),and to investigate whether IL-1 β , IL-2 can be regarded as diagnosis index to depressive neuroses. In this study, emzyme-linked immunosorbent assay(ABC-ELISA) were used to detect the content of IL-1β and IL-2 in the blood, serum of 30 depressive neuroses patients and 10 healthy person. At the same time, the depressive neuroses group was treated with Baoshen Decoction for six weeks, HAMD were used to measure their scores before and after the treatment to observe and evaluate its curative effect. The result showed that the content of IL-1 β in depressive neuroses group is significantly higher than the control group (P<0.05),but there is no significant difference between the two group as for IL-2,(P>0.05).Positive correlations exist between IL-1β, IL-2 and course respectively. And the total effective rate is about 93.33%.In conclusion,IL-1β is more sensitive than IL-2 and both of them have positive correlation to course.IL-1β can be used as a reference standard for diagnosis of depressive neuroses. Baoshen Decoction has obvious anti-depression effect.
引文
[1] 杨德森．行为医学．湖南科学技术出版社．1999：400。
[2] 张中启，等．巴戟天寡糖对鼠强迫游泳和获得性无助抑郁模型的影响．中国药理学与毒理学杂志．2001；15(4)：262。
[3] 中华医学会精神科学会．中国精神疾病分类方案和诊断标准(CCMD-2-R)．东南大学出版社．1994：56-72。
[4] 张明圆．精神科评定量表手册．湖南科学技术出版社．1998：121-126。
[5] 王雪琦，等．大鼠抑郁症模型脑磁共振成像和波谱研究．中国神经科学杂志．1999；15(2)：139。
[6] 王雪琦，等．大鼠抑郁型的脑磁共振成像研究．中华神经科学杂志．1999；32(1)：12。
[7] Boutillier AL,et al.Cortieoropin releasing hormone stimulates proopiomelanocortin transcription by c-fos-dependent and-independent path-ways. characterization of an API site in exonl[J].Mol Endocrinol,1995;9(6):745.
[8] Brady LS, et al.The antidepressants Fluoxetine [J].Idazoxan and phenelzine alter cortieotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain:therapeutic implications [J].Brain Res,1992:572(1-2):117.
[9] Mc Ewen BS.Prevention of Stress-induced morphological and congnitive consequences.Eur Neuropsycho-pharmacal.1997:(suppl 3):323.
[10] Robert M Sapolshy.Why stress is bad for your brain, Science.1996:9(273):749.
[11] SchleiferST, et al.Immunity in young adults with major depressive disorder[J]. Am J Psychiatry,1996:153(4):477.
[12] Maes M, et al. Absolute number and percentage of circulating natural killer, non-MHC-restricted Cytotoxic,and phagocytic cells in unipolar depression [J]. Neuropsychobiology,1994: 29(4): 157.
[13] 陈品，等．抑郁症患者外周血T淋巴细胞亚群变化．河南医科大学学报，2000：35(6)：
548。
[14] 林文娟．抑郁症神经内分泌免疫学的研究进展及心理治疗的作用．中国临床心理学杂志．2003：11(1)：77。
[15] 徐成敏．白细胞介素与精神分裂症的相关性研究进展．中国行为医学科学．2001；10(6)：631。
[16] 李明亚，陈红梅．石菖蒲对行为绝望动物抑郁模型的抗抑郁作用．中药材．2001；24(1)：40。
[17] 杨进，谢忠礼．菖欢1号对大鼠抑郁症模型脑内单胺类神经递质的影响：南京中医药大学学报自然科学版．2001：17(5)：294。
[2] 张中启，等．巴戟天寡糖对鼠强迫游泳和获得性无助抑郁模型的影响．中国药理学与毒理学杂志．2001；15(4)：262。
[3] 中华医学会精神科学会．中国精神疾病分类方案和诊断标准(CCMD-2-R)．东南大学出版社．1994：56-72。
[4] 张明圆．精神科评定量表手册．湖南科学技术出版社．1998：121-126。
[5] 王雪琦，等．大鼠抑郁症模型脑磁共振成像和波谱研究．中国神经科学杂志．1999；15(2)：139。
[6] 王雪琦，等．大鼠抑郁型的脑磁共振成像研究．中华神经科学杂志．1999；32(1)：12。
[7] Boutillier AL,et al.Cortieoropin releasing hormone stimulates proopiomelanocortin transcription by c-fos-dependent and-independent path-ways. characterization of an API site in exonl[J].Mol Endocrinol,1995;9(6):745.
[8] Brady LS, et al.The antidepressants Fluoxetine [J].Idazoxan and phenelzine alter cortieotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain:therapeutic implications [J].Brain Res,1992:572(1-2):117.
[9] Mc Ewen BS.Prevention of Stress-induced morphological and congnitive consequences.Eur Neuropsycho-pharmacal.1997:(suppl 3):323.
[10] Robert M Sapolshy.Why stress is bad for your brain, Science.1996:9(273):749.
[11] SchleiferST, et al.Immunity in young adults with major depressive disorder[J]. Am J Psychiatry,1996:153(4):477.
[12] Maes M, et al. Absolute number and percentage of circulating natural killer, non-MHC-restricted Cytotoxic,and phagocytic cells in unipolar depression [J]. Neuropsychobiology,1994: 29(4): 157.
[13] 陈品，等．抑郁症患者外周血T淋巴细胞亚群变化．河南医科大学学报，2000：35(6)：
548。
[14] 林文娟．抑郁症神经内分泌免疫学的研究进展及心理治疗的作用．中国临床心理学杂志．2003：11(1)：77。
[15] 徐成敏．白细胞介素与精神分裂症的相关性研究进展．中国行为医学科学．2001；10(6)：631。
[16] 李明亚，陈红梅．石菖蒲对行为绝望动物抑郁模型的抗抑郁作用．中药材．2001；24(1)：40。
[17] 杨进，谢忠礼．菖欢1号对大鼠抑郁症模型脑内单胺类神经递质的影响：南京中医药大学学报自然科学版．2001：17(5)：294。