吡啶腙类金属配合物的合成及表征
摘要
为了研究和讨论N-氧化吡啶甲醛类Schiff碱及其配合物的结构与性质关系,本文从N-氧化吡啶-2-甲醛出发,得到了三个配合物,并解析了它们的晶体结构。另外从吡啶-3-甲醛和吡啶-2-甲醛出发,得到了六个配合物,并测定了它们的晶体结构。
第一章:以N-氧化吡啶-2-甲醛缩水杨酰腙和高氯酸钴为原料,用溶液法得到配合物C29H28ClCoN7O11(1)。晶体属三斜晶系,空间群为P-1。晶胞参数:a = 8.1716(17)A,b = 14.136(3) A,c = 14.644(3) A,α= 111.881(3)°,β= 90.534(3)°,γ= 92.854(4)°,V = 1567.1(6) A3,Z = 2,Dc = 1.579 Mg/m3。中心金属离子Co(II)为六配位畸变的八面体结构,Co(II)离子与2个配体中N(C=N),O(N→O),O(C=O)的原子配位。配合物通过氢键形成三维网状结构。
第二章:以N-氧化吡啶-2-甲醛缩氨基硫脲与硝酸镍为原料,用溶液法得到配合物C14H18N10NiO9S2(2)。晶体属正交晶系,空间群为Pca2(1)。晶胞参数:a = 20.728(2)A,b = 20.728(2) A,c = 11.7113(12) A,V = 2307.6(4) A3,Z = 4,Dc = 1.707 Mg/m3。中心金属离子Ni(II)为六配位的拉长的八面体结构,Ni(II)与2个配体中N(C=N),O(N→O),S(C=S)的原子配位。分子间通过配阳离子、结晶水和抗阴离子(NO3-)之间形成氢键,使配合物分子组装成三维网状结构。生物活性表明:配体对金黄色葡萄球菌和大肠杆菌无效果,配合物2对金黄色葡萄球菌、大肠杆菌、肺炎链球菌、乙型溶血性链球菌和炭疽杆菌均无效果。N-氧化吡啶-2-甲醛缩氨基硫脲与高氯酸钴在水热条件下,得到配合物C14H16ClCoN8O7S2(3)。晶体属三斜晶系,空间群为P-1。晶胞参数:a = 6.893(5)A,b = 11.671(8) A,c = 14.254(10) A,α= 93.457(10)o,β= 103.624(10)°,γ= 94.567(10)°,V = 1107.2(14) A3,Z = 2,Dc = 1.700 Mg/m3。中心金属离子Co(III)为六配位的压缩的八面体结构,Co(III)与2个配体中N(C=N),O(N→O),S(C=S)的原子配位,分子间通过配阳离子、结晶水和抗阴离子(ClO4-)之间形成氢键,使配合物分子组装成三维网状结构。生物活性表明配合物3对大肠杆菌无效果,对金黄色葡萄球菌有很好的抑制效果,对乙型溶血性链球菌、白色葡萄球菌有较好的抑制效果,而对肺炎链球菌有良好的抑制效果,其MIC值分别为0.30μg·mL-1、501.67μg·mL-1、501.67μg·mL-1、250.83μg·mL-1。
第三章:以氯化镍、醋酸镉、醋酸锰和吡啶-2-甲醛缩水杨酰腙为原料,用溶液法获得了Ni(II)、Cd(II)、Mn(II)的配合物单晶。C26H19N6NiO4(4)晶体属于单斜晶系,空间群为P2(1)/n,晶胞参数:a = 12.549(3) A,b = 17.788(5) A,c = 13.292(4) A,β= 115.310(5)°,V = 2682.1(12) A3,Z = 4,Dc = 1.333 Mg/m3。中心金属离子Ni(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构,配合物通过分子间氢键和分子内氢键形成二聚体。
C26H20CdN6O4(5)晶体属于单斜晶系,空间群为P2(1)/n,晶胞参数:a = 11.6648(10) A,b = 30.270(3) A,c = 21.764(2) A,β= 101.616(2)°,V = 7527.5(12) A3,Z = 12,Dc = 1.569 Mg/m3。中心金属离子Cd(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构。生物活性表明:配合物5对金黄色葡萄球菌有抑制效果,其MIC值为525.83μg·mL-1,而对大肠杆菌无效果。配合物在波长λem = 560 nm (λex = 449.8 nm)处有最大发射,Cd(II)具有d10电子构型,因而没有因为d-d跃迁而产生对光的吸收,配合物5的发光可以认为属于LLCT发射。
C26H21MnN6O4。50(6)晶体属于单斜晶系,空间群为P-1,晶胞参数:a = 18.56(2) A,b = 25.03(3) A,c = 11.515(18) A,β= 103.49(4)°,V = 5202(12) A3,Z = 8,Dc = 1.390 Mg/m3。中心金属离子Mn(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构。
C30H20Cd3N10O4S4(7)晶体属于单斜晶系,空间群为C2/c,晶胞参数:a = 20.088(6) A,b = 11.327(3) A,c = 17.659(4) A,β= 119.216(3)°,V = 3507.0(15) A3,Z = 4,Dc = 1.989 Mg/m3。中心金属离子Cd(II)(1)为五配位的四方锥,Cd(II)(2)为六配位拉长的八面体。在配合物7中配体L3脱酚羟基上的氢以负一价阴离子的形式参与配位,通过μ1,3-SCN-和配体桥连成二维配位聚合物。第四章:以吡啶-3-甲醛缩氨基脲与醋酸镉为原料,用溶液法得到配合C11H17CdN4O7(8),晶体属单斜晶系,空间群为P2(1)/c,晶胞参数:a = 8.2505(12) A,b = 19.858(3) A,c = 10.4917(15) A,β= 106.639(2)°,V = 1647.0(4) A3,Z = 4,Dc = 1.366 Mg/m3。Cd(II)离子配位数为七,其周围分别被一个配体分子中的吡啶氮原子和另一个配体中的酰肼氧原子,两个醋酸根和一个H2O分子所包围,醋酸根与Cd(II)离子双齿螯合配位,这种结构单元的无限延伸使整个分子呈现出一维链状结构。生物活性表明配合物8对金黄色葡萄球菌有很好的抑制效果,而对大肠杆菌均有良好的抑制效果,其MIC值分别为0.55μg·mL-1和281.9μg·mL-1。
第五章:以高氯酸钴、硫氰酸铵和吡啶-3-甲醛缩水杨酰腙为原料,用溶液法得到配合物C28H30CoN8O8S2(9)。晶体属单斜晶系,空间群为P2(1)/n,晶胞参数:a = 13.1482(19) A,b = 30.757(4) A,c = 8.1333(12) A,β= 94.378(3)°,V = 3279.5(8) A3,Z = 4,Dc = 1.478 Mg/m3。中心金属离子Co(II)为六配位的畸变八面体几何构型,与配体中吡啶环上的N原子和硫氰根上的N原子以及H2O配位,配合物通过氢键形成二维网状结构。生物活性表明配合物9对金黄色葡萄球菌和大肠杆菌有较好的抑制效果,而对乙型溶血性链球菌、肺炎链球菌和白色葡萄球菌都有很好的抑制效果,其MIC值分别为387.5、775、0.84、0.84、0.84μg·mL-1。
In order to investigate the relationship between the structure and property of the pyridinehydrazone and its complexs,nine complexs had been synthesized and their crystal structures had been characterized.
Chapter One: The complex C29H28ClCoN7O11(1) is obtained by the reaction of L1 (2-pyridinecarboxaldehyde N-oxide reacts with salicylhydrazide) and Co(ClO4)·6H2O, It belongs to triclinic crystal system,space group p-1,with cell parameters: a = 8.1716(17)?,b = 14.136(3) ?,c = 14.644(3) ?,α= 111.881(3)°,β= 90.534(3)°,γ= 92.854(4)°,V = 1567.1(6) ?3,Z = 2,Dc = 1.579 Mg/m3. In complex 1,the centeral metal ion Co(II) adopts six-coordinated distorted octahedron geometry.L1 is coordinated to Co(II) via the oxygen(N→O),nitrogen(C=N) and oxygen(C=O) atoms,the complex forms two-dimensional network by intermolecule hydrogen bonds.
Chapter Two: The complex C14H18N10NiO9S2(2) is obtained by the reaction of L2 (2-pyridinecarboxaldehyde N-oxide reacts with thiosemicarbazide) and Ni(NO3)·6H2O, It belongs to orthorhombic crystal system,space group Pca2(1),with cell parameters:a = 20.728(2)?,b = 20.728(2) ?,c = 11.7113(12) ?,V = 2307.6(4) ?3,Z = 4,Dc = 1.707 Mg/m3. In complex 2,the centeral metal ion Ni(II) adopts six-coordinated distorted octahedron geometry.L2 is coordinated to Ni(II)via the oxygen(N→O),nitrogen(C=N) and sulfur(C=S) atoms,there are a large number of hydrogen bond involving the cations,water molecules and nitrate counter-ions,which result in formation three-dimensional network structure.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae,β-hemolytic streptococcus and Anthrax bacillus). The test results indicate that the complex shows no activity. The complex C14H16ClCoN8O7S2(3) is obtained by the reaction of L2 and Ni(NO3)·6H2O, It belongs to triclinic crystal system,space group P-1,with cell parameters:a = 6.893(5) ?,b = 11.671(8) ?,c = 14.254(10) ?,α= 93.457(10)o,β= 103.624(10)°,γ= 94.567(10)°,V = 1107.2(14) ?3,Z = 2,Dc = 1.700 Mg/m3. In complex 3,the centeral metal ion Co(III) adopts six-coordinated distorted octahedron geometry . L2 is coordinated to Co(III) via the oxygen(N→O),nitrogen(C=N) and sulfur(C=S) atoms,there are a large number of hydrogen bond involving the cations,water molecules and perchlorate counter-ions,which result in formation two-dimensional network structure.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,β-hemolytic streptococcus and Staphylococcus whiteus, The test results indicate that the complex shows strong activity.
Chapter Three:The complex C26H19N6NiO4 (4) is obtained by the reaction of NiCl2·6H2O and L3 (2-pyridinecarboxaldehyde reacts with salicylhydrazide),It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 12.549(3) ?,b = 17.788(5) ?,c = 13.292(4) ?,β= 115.310(5)°,V = 2682.1(12) ?3,Z = 4,Dc = 1.333 Mg/m3.The centeral metal ion Ni(II) is six coordinated by two ligand anions,formed a distorted octahedron geometry. The complex forms dimer by intermolecule hydrogen bond. The complex C26H20CdN6O4(5) is obtained by the reaction of Cd(CH3COO)2·2H2O and L3,It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 11.6648(10) ?,b = 30.270(3) ?,c = 21.764(2) ?,β= 101.616(2)°,V = 7527.5(12) ?3,Z = 12,Dc = 1.569 Mg/m3.Cd(II) ion is six coordinated by two ligand anions,formed a distorted octahedron geometry. The antimicrobial activities of the extracts were evaluated by MIC against two bacteria (Escherichia coli,Staphylococcus aureus),The test results indicate that the complex shows weak activity.
The complex C26H21MnN6O4.50(6) is obtained by the reaction of Mn(CH3COO)2·2H2O and L3,It belongs to monclinic crystal system,space group P-1,with cell parameters:a = 18.56(2) ?,b = 25.03(3) ?,c = 11.515(18) ?,β= 103.49(4)°,V = 5202(12) ?3,Z = 8,Dc = 1.390 Mg/m3.Mn(II) ion is six coordinated by two ligand anions,formed a distorted octahedron geometry.
The complex C30H20Cd3N10O4S4(7) is obtained by the reaction of Cd(CH3COO)2·2H2O,NH4SCN and L3,It belongs to monoclinic crystal system,space group C2/c,with cell parameters:a = 20.088(6) ?,b = 11.327(3) ?,c = 17.659(4) ?,β= 119.216(3)°,V = 3507.0(15) ?3,Z = 4,Dc = 1.989 Mg/m3. Cd(1) ion is five coordinated by one ligand anions and SCN-,formed a distorted tetragonal pyramid geometry,Cd(2) ion is six coordinated by oxygen of the ligand and SCN- formed a distorted octahedron.geometry.The two-dimensional coordination polymers are formed through the SCN- bridging ligand.
Chapter Four : The complex C11H17CdN4O7(8) is obtained by the reaction of Cd(CH3COO)2·2H2O and L4 (3-pyridinecarboxaldehyde reacts with semicarbazide),It belongs to monoclinic crystal system,space group P2(1)/c,with cell parameters:a = 8.2505(12) ?,b = 19.858(3) ?,c = 10.4917(15) ?,β= 106.639(2)°,V = 1647.0(4) ?3,Z = 4,Dc = 1.366 Mg/m3. In the complex 8,Cd(II) ion is seven coordinated with NO6 enviroment,two oxygen atoms from C=O of the ligand and water molecule respectively,four oxygen atoms from two acetate groups and one nitrogen atom from pyridyl ring of the ligand.The complex forms a one dimensional polymer of infinite length connecting.The antimicrobial activities of the extracts were evaluated by MIC against two bacteria (Escherichia coli,Staphylococcus aureus),The test results indicate that the complex shows strong activity.
Chapter Five : The complex C28H30CoN8O8S2(9) is obtained by the reaction of Co(ClO4)2·6H2O,NH4CNS and L5 (3-pyridinecarboxaldehyde reacts with salicylhydrazide),It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 13.1482(19) ?,b = 30.757(4) ?,c = 8.1333(12) ?,β= 94.378(3)°,V = 3279.5(8) ?3,Z = 4,Dc = 1.478 Mg/m3. The crystal structure adopts distorted octahedron geometry with six coordination number,the Co(II) center surrounded by two nitrogen atoms from pyridyl ring of the ligand, two nitrogen atoms from thiocyanate and two oxygen from two water molecules . Two-dimensional network is formed via abundant intermolecular hydrogen bonds.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli , Staphylococcus aureus , Streptococcus pneumoniae ,β-hemolytic streptococcus and Staphylococcus white). The test results indicate that the complex shows strong activity.
第一章:以N-氧化吡啶-2-甲醛缩水杨酰腙和高氯酸钴为原料,用溶液法得到配合物C29H28ClCoN7O11(1)。晶体属三斜晶系,空间群为P-1。晶胞参数:a = 8.1716(17)A,b = 14.136(3) A,c = 14.644(3) A,α= 111.881(3)°,β= 90.534(3)°,γ= 92.854(4)°,V = 1567.1(6) A3,Z = 2,Dc = 1.579 Mg/m3。中心金属离子Co(II)为六配位畸变的八面体结构,Co(II)离子与2个配体中N(C=N),O(N→O),O(C=O)的原子配位。配合物通过氢键形成三维网状结构。
第二章:以N-氧化吡啶-2-甲醛缩氨基硫脲与硝酸镍为原料,用溶液法得到配合物C14H18N10NiO9S2(2)。晶体属正交晶系,空间群为Pca2(1)。晶胞参数:a = 20.728(2)A,b = 20.728(2) A,c = 11.7113(12) A,V = 2307.6(4) A3,Z = 4,Dc = 1.707 Mg/m3。中心金属离子Ni(II)为六配位的拉长的八面体结构,Ni(II)与2个配体中N(C=N),O(N→O),S(C=S)的原子配位。分子间通过配阳离子、结晶水和抗阴离子(NO3-)之间形成氢键,使配合物分子组装成三维网状结构。生物活性表明:配体对金黄色葡萄球菌和大肠杆菌无效果,配合物2对金黄色葡萄球菌、大肠杆菌、肺炎链球菌、乙型溶血性链球菌和炭疽杆菌均无效果。N-氧化吡啶-2-甲醛缩氨基硫脲与高氯酸钴在水热条件下,得到配合物C14H16ClCoN8O7S2(3)。晶体属三斜晶系,空间群为P-1。晶胞参数:a = 6.893(5)A,b = 11.671(8) A,c = 14.254(10) A,α= 93.457(10)o,β= 103.624(10)°,γ= 94.567(10)°,V = 1107.2(14) A3,Z = 2,Dc = 1.700 Mg/m3。中心金属离子Co(III)为六配位的压缩的八面体结构,Co(III)与2个配体中N(C=N),O(N→O),S(C=S)的原子配位,分子间通过配阳离子、结晶水和抗阴离子(ClO4-)之间形成氢键,使配合物分子组装成三维网状结构。生物活性表明配合物3对大肠杆菌无效果,对金黄色葡萄球菌有很好的抑制效果,对乙型溶血性链球菌、白色葡萄球菌有较好的抑制效果,而对肺炎链球菌有良好的抑制效果,其MIC值分别为0.30μg·mL-1、501.67μg·mL-1、501.67μg·mL-1、250.83μg·mL-1。
第三章:以氯化镍、醋酸镉、醋酸锰和吡啶-2-甲醛缩水杨酰腙为原料,用溶液法获得了Ni(II)、Cd(II)、Mn(II)的配合物单晶。C26H19N6NiO4(4)晶体属于单斜晶系,空间群为P2(1)/n,晶胞参数:a = 12.549(3) A,b = 17.788(5) A,c = 13.292(4) A,β= 115.310(5)°,V = 2682.1(12) A3,Z = 4,Dc = 1.333 Mg/m3。中心金属离子Ni(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构,配合物通过分子间氢键和分子内氢键形成二聚体。
C26H20CdN6O4(5)晶体属于单斜晶系,空间群为P2(1)/n,晶胞参数:a = 11.6648(10) A,b = 30.270(3) A,c = 21.764(2) A,β= 101.616(2)°,V = 7527.5(12) A3,Z = 12,Dc = 1.569 Mg/m3。中心金属离子Cd(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构。生物活性表明:配合物5对金黄色葡萄球菌有抑制效果,其MIC值为525.83μg·mL-1,而对大肠杆菌无效果。配合物在波长λem = 560 nm (λex = 449.8 nm)处有最大发射,Cd(II)具有d10电子构型,因而没有因为d-d跃迁而产生对光的吸收,配合物5的发光可以认为属于LLCT发射。
C26H21MnN6O4。50(6)晶体属于单斜晶系,空间群为P-1,晶胞参数:a = 18.56(2) A,b = 25.03(3) A,c = 11.515(18) A,β= 103.49(4)°,V = 5202(12) A3,Z = 8,Dc = 1.390 Mg/m3。中心金属离子Mn(II)与两个吡啶环上的N原子、亚胺基上的N原子和羰基上的O原子配位,形成六配位的拉长的八面体结构。
C30H20Cd3N10O4S4(7)晶体属于单斜晶系,空间群为C2/c,晶胞参数:a = 20.088(6) A,b = 11.327(3) A,c = 17.659(4) A,β= 119.216(3)°,V = 3507.0(15) A3,Z = 4,Dc = 1.989 Mg/m3。中心金属离子Cd(II)(1)为五配位的四方锥,Cd(II)(2)为六配位拉长的八面体。在配合物7中配体L3脱酚羟基上的氢以负一价阴离子的形式参与配位,通过μ1,3-SCN-和配体桥连成二维配位聚合物。第四章:以吡啶-3-甲醛缩氨基脲与醋酸镉为原料,用溶液法得到配合C11H17CdN4O7(8),晶体属单斜晶系,空间群为P2(1)/c,晶胞参数:a = 8.2505(12) A,b = 19.858(3) A,c = 10.4917(15) A,β= 106.639(2)°,V = 1647.0(4) A3,Z = 4,Dc = 1.366 Mg/m3。Cd(II)离子配位数为七,其周围分别被一个配体分子中的吡啶氮原子和另一个配体中的酰肼氧原子,两个醋酸根和一个H2O分子所包围,醋酸根与Cd(II)离子双齿螯合配位,这种结构单元的无限延伸使整个分子呈现出一维链状结构。生物活性表明配合物8对金黄色葡萄球菌有很好的抑制效果,而对大肠杆菌均有良好的抑制效果,其MIC值分别为0.55μg·mL-1和281.9μg·mL-1。
第五章:以高氯酸钴、硫氰酸铵和吡啶-3-甲醛缩水杨酰腙为原料,用溶液法得到配合物C28H30CoN8O8S2(9)。晶体属单斜晶系,空间群为P2(1)/n,晶胞参数:a = 13.1482(19) A,b = 30.757(4) A,c = 8.1333(12) A,β= 94.378(3)°,V = 3279.5(8) A3,Z = 4,Dc = 1.478 Mg/m3。中心金属离子Co(II)为六配位的畸变八面体几何构型,与配体中吡啶环上的N原子和硫氰根上的N原子以及H2O配位,配合物通过氢键形成二维网状结构。生物活性表明配合物9对金黄色葡萄球菌和大肠杆菌有较好的抑制效果,而对乙型溶血性链球菌、肺炎链球菌和白色葡萄球菌都有很好的抑制效果,其MIC值分别为387.5、775、0.84、0.84、0.84μg·mL-1。
In order to investigate the relationship between the structure and property of the pyridinehydrazone and its complexs,nine complexs had been synthesized and their crystal structures had been characterized.
Chapter One: The complex C29H28ClCoN7O11(1) is obtained by the reaction of L1 (2-pyridinecarboxaldehyde N-oxide reacts with salicylhydrazide) and Co(ClO4)·6H2O, It belongs to triclinic crystal system,space group p-1,with cell parameters: a = 8.1716(17)?,b = 14.136(3) ?,c = 14.644(3) ?,α= 111.881(3)°,β= 90.534(3)°,γ= 92.854(4)°,V = 1567.1(6) ?3,Z = 2,Dc = 1.579 Mg/m3. In complex 1,the centeral metal ion Co(II) adopts six-coordinated distorted octahedron geometry.L1 is coordinated to Co(II) via the oxygen(N→O),nitrogen(C=N) and oxygen(C=O) atoms,the complex forms two-dimensional network by intermolecule hydrogen bonds.
Chapter Two: The complex C14H18N10NiO9S2(2) is obtained by the reaction of L2 (2-pyridinecarboxaldehyde N-oxide reacts with thiosemicarbazide) and Ni(NO3)·6H2O, It belongs to orthorhombic crystal system,space group Pca2(1),with cell parameters:a = 20.728(2)?,b = 20.728(2) ?,c = 11.7113(12) ?,V = 2307.6(4) ?3,Z = 4,Dc = 1.707 Mg/m3. In complex 2,the centeral metal ion Ni(II) adopts six-coordinated distorted octahedron geometry.L2 is coordinated to Ni(II)via the oxygen(N→O),nitrogen(C=N) and sulfur(C=S) atoms,there are a large number of hydrogen bond involving the cations,water molecules and nitrate counter-ions,which result in formation three-dimensional network structure.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae,β-hemolytic streptococcus and Anthrax bacillus). The test results indicate that the complex shows no activity. The complex C14H16ClCoN8O7S2(3) is obtained by the reaction of L2 and Ni(NO3)·6H2O, It belongs to triclinic crystal system,space group P-1,with cell parameters:a = 6.893(5) ?,b = 11.671(8) ?,c = 14.254(10) ?,α= 93.457(10)o,β= 103.624(10)°,γ= 94.567(10)°,V = 1107.2(14) ?3,Z = 2,Dc = 1.700 Mg/m3. In complex 3,the centeral metal ion Co(III) adopts six-coordinated distorted octahedron geometry . L2 is coordinated to Co(III) via the oxygen(N→O),nitrogen(C=N) and sulfur(C=S) atoms,there are a large number of hydrogen bond involving the cations,water molecules and perchlorate counter-ions,which result in formation two-dimensional network structure.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,β-hemolytic streptococcus and Staphylococcus whiteus, The test results indicate that the complex shows strong activity.
Chapter Three:The complex C26H19N6NiO4 (4) is obtained by the reaction of NiCl2·6H2O and L3 (2-pyridinecarboxaldehyde reacts with salicylhydrazide),It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 12.549(3) ?,b = 17.788(5) ?,c = 13.292(4) ?,β= 115.310(5)°,V = 2682.1(12) ?3,Z = 4,Dc = 1.333 Mg/m3.The centeral metal ion Ni(II) is six coordinated by two ligand anions,formed a distorted octahedron geometry. The complex forms dimer by intermolecule hydrogen bond. The complex C26H20CdN6O4(5) is obtained by the reaction of Cd(CH3COO)2·2H2O and L3,It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 11.6648(10) ?,b = 30.270(3) ?,c = 21.764(2) ?,β= 101.616(2)°,V = 7527.5(12) ?3,Z = 12,Dc = 1.569 Mg/m3.Cd(II) ion is six coordinated by two ligand anions,formed a distorted octahedron geometry. The antimicrobial activities of the extracts were evaluated by MIC against two bacteria (Escherichia coli,Staphylococcus aureus),The test results indicate that the complex shows weak activity.
The complex C26H21MnN6O4.50(6) is obtained by the reaction of Mn(CH3COO)2·2H2O and L3,It belongs to monclinic crystal system,space group P-1,with cell parameters:a = 18.56(2) ?,b = 25.03(3) ?,c = 11.515(18) ?,β= 103.49(4)°,V = 5202(12) ?3,Z = 8,Dc = 1.390 Mg/m3.Mn(II) ion is six coordinated by two ligand anions,formed a distorted octahedron geometry.
The complex C30H20Cd3N10O4S4(7) is obtained by the reaction of Cd(CH3COO)2·2H2O,NH4SCN and L3,It belongs to monoclinic crystal system,space group C2/c,with cell parameters:a = 20.088(6) ?,b = 11.327(3) ?,c = 17.659(4) ?,β= 119.216(3)°,V = 3507.0(15) ?3,Z = 4,Dc = 1.989 Mg/m3. Cd(1) ion is five coordinated by one ligand anions and SCN-,formed a distorted tetragonal pyramid geometry,Cd(2) ion is six coordinated by oxygen of the ligand and SCN- formed a distorted octahedron.geometry.The two-dimensional coordination polymers are formed through the SCN- bridging ligand.
Chapter Four : The complex C11H17CdN4O7(8) is obtained by the reaction of Cd(CH3COO)2·2H2O and L4 (3-pyridinecarboxaldehyde reacts with semicarbazide),It belongs to monoclinic crystal system,space group P2(1)/c,with cell parameters:a = 8.2505(12) ?,b = 19.858(3) ?,c = 10.4917(15) ?,β= 106.639(2)°,V = 1647.0(4) ?3,Z = 4,Dc = 1.366 Mg/m3. In the complex 8,Cd(II) ion is seven coordinated with NO6 enviroment,two oxygen atoms from C=O of the ligand and water molecule respectively,four oxygen atoms from two acetate groups and one nitrogen atom from pyridyl ring of the ligand.The complex forms a one dimensional polymer of infinite length connecting.The antimicrobial activities of the extracts were evaluated by MIC against two bacteria (Escherichia coli,Staphylococcus aureus),The test results indicate that the complex shows strong activity.
Chapter Five : The complex C28H30CoN8O8S2(9) is obtained by the reaction of Co(ClO4)2·6H2O,NH4CNS and L5 (3-pyridinecarboxaldehyde reacts with salicylhydrazide),It belongs to monoclinic crystal system,space group P2(1)/n,with cell parameters:a = 13.1482(19) ?,b = 30.757(4) ?,c = 8.1333(12) ?,β= 94.378(3)°,V = 3279.5(8) ?3,Z = 4,Dc = 1.478 Mg/m3. The crystal structure adopts distorted octahedron geometry with six coordination number,the Co(II) center surrounded by two nitrogen atoms from pyridyl ring of the ligand, two nitrogen atoms from thiocyanate and two oxygen from two water molecules . Two-dimensional network is formed via abundant intermolecular hydrogen bonds.The antimicrobial activities of the extracts were evaluated by MIC against five bacteria (Escherichia coli , Staphylococcus aureus , Streptococcus pneumoniae ,β-hemolytic streptococcus and Staphylococcus white). The test results indicate that the complex shows strong activity.
引文
[1] Wiliams D.R.，Chem. Rev．，1972，3: 203-213．
[2] 何水样，陈军利，杨锐，等.水杨醛水杨酰腙及其稀土配合物的合成、波谱研究及生物活性[J].有机化学，2003，23(12): 1387-1392.
[3] Magdi F. ， Iskander ， Laila El-Sayed ， etc. ， Synthesis ， charaterization andmagnetlchemical studies of some copper(II) complexes derived from n-salicylidene-nalkanoylhydrazins:X-ray crystal and molecular structure of bis[monochloro-(μ-nsalicylidenemyristoylhydrazine)ono(-1)]dicopper(II)．Polyhedron，2004，23：23-31．
[4] 尹华，林韵，黄清明．糠醛水杨酰腙镍配合物的合成、表征与晶体结构[J]．福州大学学报，2004，32(3)：358-361．
[5] 范乃英，高山，霍丽华，等．2-羟基-1-萘甲醛缩对甲氧基苯甲酰腙[J]．黑龙江大学自然科学学报，2004，21(2)：128-134．
[6] 麻宝成，马兴铭，闫兰，等．2-羧甲氧基苯甲醛苯甲酰腙及其稀土配合物的合成、表征和抑菌活性[J].应用化学，2004，21(8): 841-843.
[7] Li X.Z．，Liao D.Z．，et al．，Synthesis and Crystal structure of a binuclear Zinc(II)complex of 2,6-diformylpyridine N-oxide bis(benzoylhydrazone).Polyhedron，1995，14：511-514．
[8] Ji B.M．，Du Q.Y．，Ding K.L．，Synthesis and characterization of acetylferrocene andits dinuclear yttrium and lanthanide(III) picrate complexes．Polyhedron，1996，15：403-408．
[9] Carcelli M.,Mazza P.,Pelizzi C.,et al.,Antimicrobial and Genotoxic Activityof2,6-diacetylpyridine Bis(Acylhydrazones) and Their complexes with SomeFirstTransition Series Metal Ions.X-Ray Crystal Structure of a Dinuclear Copper(II)Complex.Journal of Inorganic Biochemistry，1995，57：43-62．
[10] Complex.Carcelli M．，Mazza P．，Pelizzi C．，etc．，Antimicrobial and Genotoxic Activityof 2，6-diacetylpyridine Bis(Acylhydrazones) and Their complex with Some FirstTransition Series Metal Ions， X-Ray Crystal Structure of a Dinclear of a DinuclearCopper(II)．J. Inorg. Biochem．，1995，57：43-62．
[11] Bacchi A．，Bonardi A．，Carcelli M．，etc．，Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones) Synthesis，structure，antimicrobial activity andgenotoxicity．J. Inorg. Biochem．，1998，69：101-112．
[12] Saraswat R．，Singh S．，Rana V.B．，Divalent metal chelates of macrocycle derived fromdihydrazone and aromatic diketone．J.1ndian Chem. Soc．，1996，73：78-480．
[13] 尹华，刘世雄.一个不常见的Ni(II)的戊三酮二水杨酰腙配合物的合成和晶体结构[J].无机化学学报，2002，18(3)：269-274．
[14] 肖文，卢忠林，邓良容，等.一种新型含二茂铁基三角架配体的合成与表征[J].中山大学学报(自然科学版)，1999，38(5)：127-128．
[15] Xiao W．，Lu Z.L．，Deng L.Y．，et al.，Pol．J．Chem.，2000，74：1211-1220．
[16] Ainscough E.W．， Brodie A.M．，Dobbs A.J ．， et al. ， Antitumour copper(II)salicylaldehyde benzoylhydrazone (H2sb) complexes: physicochemical properties and thesingle-crystal X-ray structures of [{Cu(H2sb)(CCl3CO2)2}2] and [{Cu(Hsb)(ClO4)(C2H5OH)}2] and the related salicylaldehyde acetylhydrazone (H2sa)complex．Inorg.Chim.Acta．，1998，267：27-38．
[17] Hundekar A.M．，Sen D.N．，Indian J.Chem．，1984，23A：477．
[18] Carcelli M．，Lanelli S．，Pelaatti P．，et al．，Structural characterization of a new ligandmode of 2，6-diacetylpyridine bis(semicarbazone)，H2daps．Inorg. Chim. Acta.，1999，292：121-126．
[19] Sangeetha N.R．，Pal C.K．，Ghosh P．，J. Chem. Soc. Dalton Trans.，1996，3293．
[20] Ji B.M．，Du Q.Y．，Ding K.L．，Synthesis and characterization of acetylferrocene andits dinuclear yttrium and lanthanide(III) picrate complexes．Polyhedron，1996，15：403-408．
[21] Agarwa1 R.K．，Sharma S．，Pol. J.Chem，1993，67：581．
[22] Dodoff N．，Gracharov K．，Journal of Inorganic Biochemistry，1995，60：257．
[23] Atovmyan Y.G．，Nikonova L.A．，et al．，Infrared spectra and structure of hydrogenbonds in N’-substituted isonicotinic hydrazides formed by crystallization from solutionand via solid phase transformations．J. Mol. Strut．，1999，474：167-175．
[24] 吴文士，刘世雄.丙酰皮考林酰肼(C9H11N3O2)的合成和晶体结构[J].结构化学，2001，20(3)：226-228．
[25] 邹霞娟，来鲁华，金桂玉，黄贵琴.新型含哒嗪酮基双酰肼类化合物的3D-QSAR 研究[J].物理化学学报，2002，18(6)：513-516．
[26] 邹霞娟，金桂玉，杨昭．1-取代苯基-1，4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲的合成及其抗烟草花叶病毒活性[J]．高等学校化学学报，2002，23(3)：403-406．
[27] Ferrari M.B．，Fava G.G．，et al．，Synthetic，spectroscopic and X-ray crystallographicstudies on copper(II) complexes with pyruvic acid and pyridoxal thiosemicarbazones.Inorg. Chem. Acta．，1998，269：297-301．
[28] Thuery P．，Nierlich M．，Charbonnel M.C．，et al．，Complexation of lanthanum(III)nitrate by N，N’，N，N’-tetraethylmalonamide Crystal structure of three polymorphicforms．Polyhedron，1999，37：3599-3608．
[29] 梁芳珍，徐克花，殷伦祥.水杨醛双酰腙Cu(II)配合物的合成、表征与抑菌活性[J].化学通报，1999，8：37-39．
[30] 杨正银，杨汝栋.邻羧基苯甲醛苯甲酰腙稀土配合物的合成和抗氧化活件[J]．中国稀土学报，2002，20(4)：366-369．
[31] Lal R.A．，Adhidari S．，Pal A．，etc．，Synthesis and characterization of the homobimetallic [bis(2-hydroxy-1-naphthaldehyde) oxaloydihydrazonato] bisdioxomolybdenm(VI)tetrahydrate complex and its reactivity towards proton and electron donor reagents．J.Chem. Res.(S)，1997：122-123．
[32] Pelagtti P．，Bacchi A．，Carcell M．，etc．，Palladium complexes containing a P，Nchelating ligand Part 11I．J. Organomet Chem．，1999，583：94-145．
[33] 高峰，朱英贵，章丽，等．荧光试剂二(1-H 一苯并三唑)乙二酮缩氨基硫脲的合成及其在蛋白质测定中的应用[J]．化学试剂，2004，26(3)：168-170．
[34] 杨昌晖，杨志斌．新希夫碱3，5-二溴水杨醛缩氨基硫脲的合成及其在荧光滴定中的应用[J]．分析实验室，1994，13(4)：9-11．
[35] Ochiai E．，J. Org. Chem.，1953，18：534．
[36] Meiserheimer J．，Stotz E．，Ber.Deut.Chem.Ges．，1952，58：1334．
[37] Bohmer H．，Ber. Deut. chem. Ges．，1937，70：379．
[38] Orchin M.，Schimidt P.T．，Coord. Chem．Rev．，1968，3：345．
[39] Anthdine W.E．，Some Properties of Copper and Zinc Complexes of 2-FormylpyridineThiosemicarbazone. Inorg. Chem．，1977，16：569-574．
[40] Landers A.E．，Phillips D.I．，Inorg. Chim. Acta，1982，59：41．
[41] Autolovich M．，et al．，Inorg. Chim. Acta，1989，159：189．
[42] 阎世平，等．含烷氧基桥的双核Ni(II)配合物的合成、表征和磁性[J]．化学研究与应用，1997，9(2)：126-129．
[43] 阎世平，等．烷氧基桥的双核Co(II)配合物的合成和性质研究[J]．南开大学学报(自然科学)，1996，29(3)：101-103．
[44] Gembicky M．，et al．，Inorg. Chim. Acta，2005，305(1)：75．
[45] Liang H．，Yu Q．，Hu R.X．，zhou Z.Y．，zhou X.G．，Synthesis，crystal structure andspectroscpicpropereies of a copper(II) complex of the Schiff-base derived frompicolinade N-oxide and 4-aminoantipyrine[J]．Transition Metal Chemistry，2002，27(4)：454-457．
[46] 梁宏，陈雄斌，胡瑞祥，陈振锋，郁开北．Schiff 碱N-氧化吡啶-2-甲醛缩氨基脲及其铜配合物的合成晶体结构及谱学性质的研究[J]．化学学报，2002，60(5)：939-946．
[47] 于青，胡瑞祥，梁宏．希夫碱钼(VI)配合物的合成表征与生物活性研究[J]．广西师范大学学报（自然科学版），2001，19(1)：63-66．
[48] 于青，胡瑞祥.N-氧化吡啶-2-甲醛缩对苯二胺合成及表征[J]．广西师范大学学报（自然科学版），1999，17(4)：68-70．
[49] 胡瑞祥，于青，梁宏，等．Schiff 碱6-甲基-N-氧化吡啶-2-甲醛缩硫代氨基脲的合成及晶体结构[J]．结构化学，2001，20(4)：286-289．
[50] 从彦丽，罗济文，王修建，卢泽勤，梁宏．双(N-氧化吡啶-2-甲醛)缩1，3-二氨基-2-丙醇钼(VI)配合物的合成与活性[J]．广西科学，1996，3(4)：6-8．
[51] 宋会花，王修建，从彦丽，梁宏．钼-氮氧化吡啶系列Schiff 碱配合物的研究．I．N-氧化吡啶-2-甲醛氨基酸类Schiff 碱钼(VI)配合物的合成与表征[J]．合成化学，1998，6(2)：188-195．
[52] 宋会花，王修建，从彦丽，梁宏．N-氧化吡啶-2-甲醛缩邻苯二胺钼(VI)的合成与表征[J]．广西师范大学学报（自然科学版），1997，15(2)：56-60．
[53] 李冬青，从彦丽，王修建，梁宏．N-氧化吡啶-2-甲醛缩氨基硫脲钼(VI)的合成与表征[J]．广西师范大学学报（自然科学版），1996，14(3)：47-51．
[54] 陈雄斌，陈振锋，胡瑞祥，梁宏，周忠远．N-氧化吡啶-2-甲醛缩苯肼的晶体结构[J]．广西师范大学学报（自然科学版），2002，20(2)：43-46．
[55] 刘斌，胡瑞祥，梁宏，郁开北．Schiff 碱N-氧化吡啶-2-甲醛缩氨基硫脲的晶体结构[J]．结构化学，1999，18(6)：414-417．
[56] 陈雄斌，胡瑞祥，陈振锋，梁宏，郁开北．2-(2-氮氧化吡啶基)苯并噻唑的合成与晶体结构[J]．广西师范大学学报（自然科学版），2004，22(4)：45-48．
[57] 陈振锋，王修建，梁宏．双(N-氧化吡啶-2-甲醛)缩对苯二胺的合成与表征[J]．广西师范大学学报（自然科学版），1998，16(1)：79
[58] Lu Q．，et al．，XXV ICCC，Book of Abstract，1987，C2-492．
[59] 周健．广西师范大学硕士学位论文，2004．
[60] 龚钰秋，陈成刚，黄晓峰．金与铂和N-氧化吡啶-2-甲醛半卡巴腙配盐的合成及其晶体结构[J]．杭州大学学报（自然科学版），1993，20(4)：438-442．
[61] Gong Y.Q．，Chen C.G．，Huan X.F．，et al．，Synth. React. Inorg. Met.-Org. Chem.，1994，24(6)：877．
[62] 陆勤，王国雄，臧焰，尹湛峰，曾成，周忠远．N-氧化吡啶-2-甲醛衍生物的配合物研究．III．N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J]．化学学报，1989，47：1065-1070．
[63] 陆勤，王国雄，尹湛峰，曾成．N-氧化吡啶-2-甲醛缩氨基硫脲钴配合物的研究[J]．无机化学学报，1991，7(1)：65-68．
[64] 阎世平，等．N-氧化吡啶-2-甲醛单缩1，2-丙二胺Schiff 碱镍配合物的晶体结构[J]．高等学校化学学报，1992，13(11)：1355-1357．
[65] 王伯康，张世华，孙东，刘永江，曾成．N-氧化吡啶-2-甲醛缩二胍合铜配合物的合成、表征及磁性[J]．无机化学学报，1993，9(3)：244-248．
[66] Vrbova M．，et al．，Preparation and structure of 2-(2-benzimidazol-2-yl)pyridine N-oxideand its complexes．Polyhedron，2000，19：2195-2201．
[67] Boca M．，et al．，CuII complexes with the new Schiff base ligands as a mono- andbis-condensation products of 2-pyridinecarboxaldehyde-N-oxide with diethyllenetriamine．Inorg. Chim. Acta，2003，349：111-121．
[68] Gou S.H．，et al．，Transition metal complexes of the Schiff bases derived fromS-alkyldirhiocarbazate with 2-pyridinecarboxaldehyde N-oxide-I. Synthesis，propertiesand structure of four-coordinate copper(II) complexes．Polyhedron，1990，9(24)：2981-2985．
[69] Gou S.H．，et al．，Transition metal complexes of the Schiff bases derived fromS-alkyldithiocarbazate with 2-pyridinecarboxaldehyde-N-oxide-H.Synthesis，propertiesand X-ray crystal structure of five-coordinate copper(II) complexes．Polyhedron，1991，10(12)：1363-1366．
[70] Eariati，et al．，X-ray Structures of Cu(poph)Cl2，[Cu(pxo)Cl2]2 and [Cu(pxo)(pxo-H)Cl](poph=2-pyridinecarboxaldehyde 1-oxide-2′-pyridiny lhydrazone；pxo = 2-acetylpyridine–1-oxide oxime) one monomeric structure and two N-oxide-bridged dimeric structures，involving multidentepyridine N-oxide ligands．Inorg. Chim. Acta，1998，268：135-140．
[71] Chiumia G.C．，et al．，Terminal S-coordinaed thiocyanate in a nickel(II) complex.X-raystructures of Ni(poph)(H2O)(SCN)(NCS) and Ni(poqh)(H2O)(NCS)2．Inorg. Chim. Acta，1999，285：297-300．
[72] Baran P．，et al．，The spectroscopic and structural properties of copper(II) complexes ofthe novel tridentate(ONO) pyridine N-oxide ligand Hpoxap．Polyhedron，2002，21：1561-1571．
[73] Gou S.H．，et al．，Synthesis and characterization of a series of tripodal transition metalcomplexes with the schiff base of 2 ， 2′ ， 2″-triaminoethylamine and 2-pyridinecarboxaldehyde N-oxide crystal structure of heptacoordinate complexes of a sevencoordinateligand．Inorg. Chem.，1993，32：1883-1890．
[74] 尹湛峰，等．第一届全国配位化学会议论文摘要集，1989，A1，44．
[75] 龚钰秋，孙鑫泉，黄肖峰．N-氧化吡啶-2-甲醛肟与钯(II)、铂(IV)配合物的研究[J]．杭州大学学报（自然科学版），1994，21(4)：418-421．
[76] 于青．兰州大学博士学位论文，2003．
[77] 尹湛峰，臧焰，王国雄，曾成．N-氧化吡啶-2-甲醛双希夫碱配合物的研究[J]．无机化学学报，1990，6(2)：181-186．
[78] 王国雄，尹湛峰，臧焰，陆勤，曾成．N-氧化吡啶-2-甲醛衍生物的配合物研究(II)与二胺生成的双希夫碱铜配合物的电子结构[J]．物理化学学报，1989，5(3)：305-309．
[79] 臧焰，陆勤，尹湛峰，曾成，戴安邦，周忠远．N-氧化吡啶-2-甲醛衍生物的配合物研究(I)—与二胺生成的双Schiff 碱铜配合物的合成和晶体结构[J]．高等学校化学学报，1989，10(1)：1-5．
[80] Boca R ．， et al ．，Tetrahydropoxen: 2 ， 2′-(1 ， 2-ethanediylbis(iminomethylene))bis(pyridine N-oxide) and its complexes．X-ray structure of [Cu(H4-poxen)H2O](ClO4)2.H2O and [Co(poxen)H2O](ClO4)2. Polyhedron，2000，19：835-839．
[81] 崔爱莉，王凤山，于英.双N-氧化吡啶-2-甲醛丙二胺合锌配合物的合成、晶体结构和分子结构[J]．吉林大学自然科学学报，1994，2：81-86．
[82] Castineiras A., et al., Inorg. Chim. Acta，1994，216，229.
[83] 阎世平，等.结构化学，1992，11(2)：160.
[84] Cheng P．，et al．，Z. Anorg. Allg. Chem．，2003，629：1996．
[85] Boca M．，et al．，Selective Incidazolidine Ring Opening during Complex Formation ofIron(III) ， Copper(II) ， and Zinc(II) with a Multidentate Ligand obtained from2-pyridinecarboxaldehyde N-oxide and Triethylenetetramine.Inorg. Chem．，2000，39：3205-3212．
[86] Gou S.H．，et al．，Acta Crystallogr，Sect. C，1991，47：708．
[87] Yu Q．，Chen K．，Tan M Y．，Polish Journal of Chemistry，2003，77(7)：917．
[88] 尹湛峰，王国雄，叶玲，王凤山，樊玉国.双希夫碱镍(II)配合物的合成及晶体结构[J]．南京大学学报，1990，26(2)：256-262．.
[89] YU Qing，ZHU Li-Gang， BIAN He-Dong，et al.，Synthesis and Crystal Structure of aZinc(II) Complex Salt with the Schiff Base of Picolinaldehyde N-oxide andSemicarbazone．J. Struct. Chem．，2005，24：1271-1275．
[90] 朱立刚．广西师范大学硕士学位论文，2005．
[91] Karunaker G.V．，Sangeetha N.R．，Susila V．，Pal S．，J. Coord. Chem．，2000，50：51．
[92] Ali M.A．，et al．，Synthetic，spectroscopic and X-ray crystallographic structural studyof the monomeric [Cu(pysme)(sac)(MeOH)] and dimeric [Cu(6mptsc)(sac)]2complexes．Polyhedron，2004，23：2031-2036．
[93] Cheng Yong S.，et al．，J. Chem. Cryst.，1998，28：871．
[94] Domiano P．，et al．，Transition Met. Chem．，1980，5：172．
[95] Domiano P ．， et al ．， Crystal and moleaular structure of (N-picolinylidene-N’salicyloylhydrazinato)(N-picolinylidene-N’-salicyloylhydrazine) copper(II) perxhlorate-ethanlol.J. Chem. Soc，Dalton Trans：1979，8：1266-1269．
[96] Domiano P.，et al.，J. Chem. Soc，Dalton Trans.1974，3：531．
[97] Tojal G.J.，et al.，Spectroscopic ang magnetic properties of the pyridine-2-carbaldehydethiosemicarbazonateiron(III) complexes：[Fe(C7H7N4S)2]X.nH2O (X = Cl，ClO4，NO3，PF6). J. Inorg. Biochem．2001，84：271-278．
[98] Demertzi K.D．，Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehydethiosemicarbazone with potential biological activity.Synthesis，structure and spectralproperties. Extended network via hydrogen bond kinkages of [Pd(PyTsc)Cl]．Polyhedron，1999，18：1005-1013．
[99] Tojal G.J．，Spectroscopic and magnetic properties of the pyridine-2-carbaldehydethiosemicarbazonateiron(III) complexes：[Fe(C7H7N4S)2]X?nH2O(X = Cl，ClO4，NO3，PF6)．Inorg. Chim. Acta，1998，278：150-158．
[100] Casas J.S．，et a．，Synthesis，structure，spectroscopic properties and biological activityof mixed diorganotin(IV) complexes containing pyridine-2-carbaldehyde thiosemicarbazonato and diphenyldithiophosphinato ligands．J. Inorg. Biochem．1999，76：277-284．
[101] Labib L．，et al．，Organotin(IV) complexes with tridentate ligands-III. Synthesis andcharacterization of some organotin(IV) complexes with N-(2-pyridinyl methylene)hydrazinecarbothioamide ： The X-ray crystal structute of dimethylmonochloro[(N-(2-pyridinylmethylene) hydrazinecarbothioamidato) NS(-1)] tin(IV) hemihydrate．Polyhedron，1996，15：349-357．
[102] Barbieri R.S．，The reaction of 2-formylpyridine thiosemicarbazone (HFPT) with tintetrahalides.Crystal and molecular structure of [SnCl3(FPT)]．Inorg. Chim. Acta，1993，206：169-172．
[103] Lobana T.S ．， et al ．， Diphenylthallium(III) thiosemicarbazonates:flexibility ofcoordination in the solid state and polymorphism in chloroform solution．Inorg. Chim.Acta，2003，347：23-32．
[104] Casas J.S., Dimethylthallium(III) and methylmercury(II) derivatives ofpyridine-2-carbaldehyde thiosemicarbazone:synthesis and structure．J. Chem. Soc.，Dalton，Trans.，1993，8：1253-1259．
[105] Bingham A.G.，et al.，Synthertic，spectroscopic and X-ray crystrallographic studies onbinuclear copper(II) complexes with a tridentate NNS-bonding 2-formylpyridinethiosemicarbazone ligand.The characterization of both neutral and deprotonatedcoordinated ligand structures.J. Chem. Soc.，Dalton，Trans.，1987，3: 493-499.
[106] Tojal G.J.，et al.，Spectroscopic and magnetic properties of copper(II) complexesderived from pyridine-2-carbaldehyde thiosemicarbazone.Structures of [Cu(NO3)(C7H8N4S)(H2O)](NO3) and [{Cu(NCS)(C7H7N4S)}2].Polyhedron，1999，18：703-3711．
[107] Tojal G.J.，et al.，Synthesis，structures，spectroscopic and magnetic properties of twocopper(II) dimmers cononining pyridine-2-carbaldehyde thiosemicarbazonate (L)．J.Chem. Soc.，Dalton，Trans.，1994，15：2233-2238．
[108] Ainscough E.W.，et al.，Reaction of nitrogen and sulphur donor ligands with theantitumour complex [{CuL(MeCO2)}2] (HL = 2-formyl pyridine thiosemicarbazone) andthe single-crystal X-ray structure of [CuL(bipy)]ClO4 (bipy = 2，2′-bipyridyl). J. Chem.Soc.，Dalton，Trans.，1991，7：1737-1742．
[109] Tojal G.J. ， et al. ， Synthesis and spectroscopic properties of two pyridine-2-carbaldehyde thiosemicarbazone copper(II) compounds：[CuX2(C7H8N4S)]. H2O(X =Br，Cl).Inorg. Chim. Acta，1996，249：25-32．
[110] Smith H.W．，Acta Crystallogr，Sect B.，1975，31：2701．
[111] Mesa J.L.，et al．，Crystal structure and properties of the [Cu(C11H10N4)] compoundstereochemistry of [Cu(planar tridentate ligand)(unidentate ligand)2] complexes．Polyhedron，1988，7(15)：1383-1388．
[112] Baraniak E．，Structure and Properties of a Dimeriz nydroto-Bridged Ytterbium(III)Complex ， Di-H-hydroxo-bistriaquo(pyridine-2-carboxaldehyde 2’-pyridylhydrazone)ytterbiuni(III)] Tetrachloride Tetrahydrate．Inorg. Chem．，1976，15：2226-2230．
[113] Christidis C.P．，et al．，Acta. Crystallogr，Sect C，1999，55：707．
[114] Khalil T.E．，et al．，Organotin(IV) complex with tridentate ligands- II.synthesis andcharacterization of mono- and dimethyltin(IV)complexes with N-(2-pyridinylmethylene)benzoylhydrazine the crystal and molecular structure of monomethyldichloro[N-(2-pyridinylmethylene) benzoylhydrazinate NNO(-1)] Tin(IV)．Polyhedron，1994，13(17)：2569-2578．
[115] Pelagatti P．，et al．，Eur. J. Inorg. Chem．，2000：463．
[116] Paschaliclis G.D．，et al．，Synthesis，characterization and spectra of lanthanide(III)hydrazone complexes The X-ray molecular structures of the erbium(III) complex and theligand．Polyhedron，2000，19：2629-2637．
[117] Sangeetha N.R．，Pal S．，Dimeric and polymeric square-pyramidal copper(II) complexescontaining equatorial-apical chloride or acetatebridges ． Polyhedron ， 2000 ， 19 ：1593-1600．
[118] Pal S．，J. Chem. Soc.，Dalton，Trans.，2002：2102．
[119] Sulivan D.A.，Palenik G.J.，Magnetic and Spin LIFETIME studies in Solution of a △S = 1 spin-Equilibriumprocess for some Six-Coordinate Bis(N-R-2，6-pyridinedicarboxaldimine) Cobalt(II) Complexes. Inorg.Chem.，1997，16：1127．
[120] Mandal S.K．，Chakravarty A.R．，Synthesis，X-ray structure and properities of(?5-cyclopentadienyl) ruthenium(II) complexes of pyridyl-2-hydrazone ligands．Polyhedron，1991，10：2483-2486．
[121] Mondal B．，Puranik G.V．，Lahirl G.K．，examplex of highly stereoregulated rutheniumamidine copmplex formation: synthesis，crystal structures and spectral and redoxproperties of the complexes．Inorg. Chem．，2002，41：5831-5836．
[122] Sangeetha N.R．，et al．，A one-dimensional assembly of copper(II) polyhedra via dualuse of hydrogen-bonding and л-л interaxtion．Inorg. Chem. Comm．，2000，3：415-419．
[123] Ali M.A．，et al．，Trans. Met. Chem．，2002，27：262．
[124] Saiz G.P．，et al．，Evidence of Desulfurization in the Oxidative Cyclization ofThiosemicarbazones．Conversion to 1，3，4-Oxadiazole Derivatives．Inorg. Chem．，2002，41：1345-1347．
[125] Tarafder T.M．，Synthesis and charaterization of Zn(II) and Cd(II) complexes ofS-benzyl-β-N-(2-pyridyl) methylenedithiocarbazate (HNNS)：bioactivity of the HNNSSchiff base and its Zn(II)，Cu(II) and Cd(II) complexes and the X-ray structure of the[Zn(NNS)2] complex．Polyhedron，2001，20：2363-2370．
[126] Armstrong M.C．，Bernhardt P.V．，Pichardson D.R．，Eur. J. Inorg. Chem．，2003：1145．
[127] 蔡铁军，彭振山，邓谦，龙云飞，邓彤彤，郁开北．Schiff 碱铜(I)配合物的合成、结构及其与DNA 相互作用的研究[J]．无机化学学报，2004，20：731-733．
[128] Karuriaker V.G．，et al．，J. Coord. Chem．，2000，50：51．
[129] Zhou J．，et al，，Acta Crystallogr，Sect E．，2004，60：m586．
[130] Saiz G.P．，et al．，Eur. J. Inorg. Chem 2003：2639．
[131] Liang H．，Wang X.W．，Chen Z.F．，Acta，crys．2004，294：60．
[1] Labouta I.M., Hasscm A.M., Abouiwafa M.,et al.,Monatshefte Fur. Chin.,1989,120:571-573.
[2] Molina P.,Alnendros O.,Fresneda P.M.,Crystal and molecular structure of (N-picolinylidene-N′-salicyloylhydrazinato)(N-picolihylidene-N′-salicyloylhydrazine) copper(II) perchlorate-ethanol. Tetrahedron,1994,50(7):2241-2254.
[3] Sato H.,Tsuda M.,Watanabe K.,et al.,rhopaladins A-D,new indole alkaloids from marine tunicate rhopalaea sp. Tetrahedron,1998,54:8687-8690.
[4] Yang JG..,Pan FY.,Acta Cryst,2004,E60:o2009-o2010.
[5] 仉文升,李安良.药物化学,1999:458-464.
[6] King R.B.,Encyclopedia of Inorganic Chemistry,John Wiley&sons Ltd:New York[M].1994:p829.
[7] Singh B.,Sahai P.,Lanthanide complexes of 2-aminobenzophenone 2-thenoylhy drazone:synthesis and structural characterization. Synth React. Inorg. Met. Org. Chem.,1996,26(1):157-167.
[8] 杨正银,杨汝栋,郁开北.2-羰基丙酸(4-吡啶甲酰基)腙与碱土金属配合物的晶体结构及热稳定性[J].化学学报,1999,57(3):236-243.
[9] Duggal H.K.,Agarwala B.V.,Synthesis and characterization of nickel(II) and palladium(II) complexes of novel tetrauza annulene tetracarbonitrile. Synth. React. Inorg. Met. Org. Chem.,1992,22(8):871-882.
[10] Yang Z.Y.,Yang R.D.,Li F.S.,Yu K.B.,Crystal structure and antitumor activity of some rare earth metal complexes with schiff base.Polyhedron,2000,19:2599-2604.
[11] 何水样,曹文凯,陈军利,等.铜(II)与 2-羧基丙酸水杨酰腙配合物的合成、晶体结构和抑菌活性[J].高等学校化学学报,2002,6:991-993.
[12] 樊能廷著,有机合成事典,北京理工大学出版社[M].北京,1972:214.
[13] Ckalheide C.V.,J.Am.Chem.Soc.,1954,76:1286.
[14] 袁环.N-氧化吡啶工艺路线的改进[J].化学世界,1995,36(11):580-581.
[15] Peplinski Z.,Brown D.B.,et al.,Electrical properties of Na3Cu4S4,a mixed-valence one-dimensional metal.Inorg. Chem.,1982,21:1752.
[16] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,Crystal and molecular structure of (N-picolinylidene-N′-salicyloylhydrazinato) (N-picolinylidene-N′-salicyloyl hydrazine) copper(II) perchlorate-ethanol.JCS Dalton,1979:1266-1269.
[17] 于青,兰州大学博士学位论文,2003:48-53.
[1] Domagk G.,Naturwissenschanften,1964,33:315.
[2] Wilson H.R.,et al.,J. med. Chem.,1974,17:760.
[3] Winkelmann E.,Arzneim-Forsch,1977,27:950.
[4] Klayman D.L.,et al.,J. Med. Chem. Ther.,1981,16:317.
[5] 张来新,杨琼.新取代冠醚及其缩氨硫脲和缩氨脲化合物的合成[J].新疆大学学报,2001,18(1):69-71.
[6] 臧焰,王国雄,等.科学通报,1989,34(17):1316.
[7] 李冬青,从彦丽,王修建,梁宏.N-氧化吡啶-2-甲醛缩氨基硫脲钼(VI)的合成与表征[J].广西师范大学学报(自然科学版),1996,14(3):47-51.
[8] 陆勤,王国雄,臧焰,尹湛峰,曾成,周忠远.N-氧化吡啶-2-甲醛衍生物的配合物研究.III.N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J].化学学报,1989,47:1065-1070.
[9] Lu Q.,et al.,XXV ICCC,Book of Abstract,1987:C2-492.
[10] 刘斌,胡瑞祥,梁宏,郁开北.Schiff碱N-氧化吡啶-2-甲醛缩氨基硫脲的晶体结构[J].结构化学,1999,18(6):414-417.
[11] 陆勤,王国雄,尹湛峰,曾成.N-氧化吡啶-2-甲醛缩氨基硫脲钴配合物的研究[J].无机化学学报,1991,7(1):65-68.
[12] Janiak C.,A critical account on π-π stacking in metal complexes with aromatic nitrogen-coutaining ligands.J. Chem. Soc.,Dalton Trans.2000:3885-3896.
[13] 梁宏,陈雄斌,胡瑞祥,陈振锋,郁开北.Schiff碱N-氧化吡啶-2-甲醛缩氨基脲及其铜配合物的合成晶体结构及谱学性质的研究[J].化学学报,2002,60(5):939-946.
[14] Bindu P.,Kurup M.R.P.,Satyakeerty T.R.,EPR,cyclic voltammetric and biological activities of copper(II) complexes of salicylaldehyde N(4)-substituted thiosemicarbazone and heterocyclic bases. Polyhedron,1998,18:321-331.
[15] Jouad E.M.,Riou A.,Allain M.,Khan M.A.,Bouet G.M.,Synthesis,structural and spectral studies of 5-methyl 2-furaldehyde thiosemicarbazone and its Co,Ni,Cu and Cd complexes.Polyhedron,2001,20:67-74.
[16] Jouad E.M.,Larcher G.,Allain M.,et al.,Synthesis,structure and biological activity of nickel(II) complexes of 5-methyl 2-furfural thiosemicarbazone.J. Inorg. Biochem. 2001,86:565.
[17] Yu Q.,Tang Y.,Tan MY.,J. Rare Earths,2002,20:385.
[1] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,Crystal and molecular structure of catena-μ-isothiocyanato (N’-pyridyl-methylene-N″ salicyloylhydrazinato-NN’ O) copper(II).JCS Dalton,1975:2357-2360.
[2] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,JCS Dalton,1979:1266.
[3] Domiano P.,Musatti A.,Pelizzi C.,Predieri G..,Rhodium(I) complexes with pyidazine 4,6-dimethyl-pyrimidine,4,6-bis(3,5-dimethylpyrazol-1-yl) pyrimidine,3,6-bis(3,5-di methylpyrazol-1-yl) pyrimidine and 3-(3,5-dimethylpyrazol-1-yl)-6-chloropyridazine. Polyhedron,1984,3(2):213-221.
[4] Sheldrick G.M.,SHELXS-97 and SHELXL-97[CP/CD].Gottingen,Gremany:University of Gottingen,1997.
[5] 陈敏堂,廖代正,张若桦,等.烯醇式异桥双铜配合物的合成及磁换作用的研究[J].高等学校化学学报,1993,14(12):1638-1641.
[6] Sujittra Y.,Narongsak C.,Chaveng P.,Saksit B.,The coordination chemistry of mono and bis(di-2-pyridylamine)copper(II) complexes:preparation,characterization and crystal structures of [Cu(L)(NO3)2],[Cu(L)(H2O)2(SO4)],[Cu(L)2(NCS)](SCN)·0.5DMSO and [Cu(L)2(SCN)2].Polyhedron,2002,21:1279-1288.
[7] 王伟,张逢星,李珺,李恒欣,霍涌前,村桂香.Zn(II)-双呋喃甲醛缩二胺配合物的合成、结构和性质[J].化学学报,2004,64(16):1529-1532.
[8] 牛淑云,迟玉贤,金晶,杨我第,叶玲,两个二维Cd(II)配位聚合物的合成、晶体结构和荧光性质[J].高等学校化学学报,2004,25(10):1804-1806.
[1] Dey,K.,J. Scient. Ind. Res.,1974,33:39.
[2] Durga,N.D.,J. Scient. Ind. Res.,1982,41:501.
[3] 王耕霖,李盛荣,姜宗慧,王士贤.一价铜的缩氨基硫脲配合物及其抗癌活性的研究[J].化学通报,1988,11:37-38.
[4] Lumd,P.,Hannu,E.,Inorg Chim. Acta,1984,92:24.
[5] Dashora,R.,Singh,R.V.,Tandon,J.P.,Synth. React. Inorg. Met-Org. Chem.,1983,13:209.
[6] Chandra,S.,Snyth. React. Inorg. Met-Org. Chem.,1982,12(6):642.
[7] 吴自慎.华中师大学报(自然科学版),1983,1:61.
[8] Zhen-Feng Cheng,Jian Zhou,Hong Liang.,et al.,Acta Cryst.E. 60.
[9] France,H.C.,J. Chem. Eng. Data.,1980,25:404.
[10] 陆勤,王国雄,藏焰,尹湛峰,曾成,周忠远.N-氧化吡啶-2-甲醛衍生物的配合物研究.III.N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J].化学学报,1989,47:1065-1070.
[11] 周健,广西师范大学硕士论文,2004.
[12] 中本一雄著,黄德如,汪仁庆译,无机和配位化合物的红外和拉曼光谱,化学工业出版社,北京,1986.
[1] Buu- Hoi N.P.,Huong N.D.,Ham N.H.,et al.,J. Chem. Soc.,1953:1358.
[2] Sayed L.E.,Iskander M.F.,J. Inorg. Nucl. Chem.,1971,35:435.
[3] 杨正银,杨汝栋.邻羧基苯甲醛苯甲酰腙稀土配合物的合成和抗氧化活性[J].中国稀土学报,2002,20( 4):366-369.
[4] Yang Z.Y.,Yang R.D.,Li F.S.,Synth React Inorg Met-org Chem.,1999,29(2):205.
[5] Yang Z.Y.,Synth React Inorg Met-Org Chem.,2000,30(7):1265.
[6] Yang Z.Y.,Yang R.D.,J. Chem. Intemet.2001,3(4):034 018 pc.
[7] Yang Z.Y.,Yang R.D.,Li F.S.,Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base.Polyhedron,2000,19:2599-2604.
[8] 何水样,曹文凯,陈利军,等.铜(II)与 2-羰基丙酸水杨酰腙配合物的合成、晶体结构和抑菌活性[J].高等学校化学学报,2002,23( 6):991.
[9] 范能廷.有机合成事典[M].北京:科学技术出版社,1992:214.
[10] Marzilli L.G.,Summers M.F.,Brescian P.N.,Charland J.P.,Randaccio L.,J. Am. Chem. Soc.,1985,107:6680.
[11] 郑昊,沈应中,等.N-(2-吡啶基)-伯胺二甲基合镓(III)的制备及表征[J].无机化学学报,1999,3:336.
[12] Trofimenko S.,Calabrese J.C.,Kochi J.K.,Wolowic S.,Hulsgen F B.,Reedijk J.,spectroscopic analysis, coordination geometry, and X-ray structures of Nickel(II) compounds with sterically demanding tris(pyrazoly)borate ligands and azide or (this)cyanate anions. Inorg. Chem.1992,31(17):3943-3950.
[13] Rojo T.,Cortes R.,Lezama L.,Arrortua M.I.,Urtiaga K.,Villeneuve G. Spectroscopic and magnetic properties of two ferromagnetically coupled nickel(II) dimmers [{Ni(terpy)(NCX)2}2](terpy = 2,2′:6′2″-terpyridine, X = S or Se).J.Chem. Soc.,Dalton Trans.1991:1779-1783.
[14] Garcia-Tojal J.,Garcia-Orad A.,Diaz A.A.,Biological activity of complexes derived from pyridine-2-carbaldehyde thiosemicarbazone:Structure of [Co(C7H7N4S)2][NCS].J. Inorg. Biochem.,2001,84:271-278.
[2] 何水样，陈军利，杨锐，等.水杨醛水杨酰腙及其稀土配合物的合成、波谱研究及生物活性[J].有机化学，2003，23(12): 1387-1392.
[3] Magdi F. ， Iskander ， Laila El-Sayed ， etc. ， Synthesis ， charaterization andmagnetlchemical studies of some copper(II) complexes derived from n-salicylidene-nalkanoylhydrazins:X-ray crystal and molecular structure of bis[monochloro-(μ-nsalicylidenemyristoylhydrazine)ono(-1)]dicopper(II)．Polyhedron，2004，23：23-31．
[4] 尹华，林韵，黄清明．糠醛水杨酰腙镍配合物的合成、表征与晶体结构[J]．福州大学学报，2004，32(3)：358-361．
[5] 范乃英，高山，霍丽华，等．2-羟基-1-萘甲醛缩对甲氧基苯甲酰腙[J]．黑龙江大学自然科学学报，2004，21(2)：128-134．
[6] 麻宝成，马兴铭，闫兰，等．2-羧甲氧基苯甲醛苯甲酰腙及其稀土配合物的合成、表征和抑菌活性[J].应用化学，2004，21(8): 841-843.
[7] Li X.Z．，Liao D.Z．，et al．，Synthesis and Crystal structure of a binuclear Zinc(II)complex of 2,6-diformylpyridine N-oxide bis(benzoylhydrazone).Polyhedron，1995，14：511-514．
[8] Ji B.M．，Du Q.Y．，Ding K.L．，Synthesis and characterization of acetylferrocene andits dinuclear yttrium and lanthanide(III) picrate complexes．Polyhedron，1996，15：403-408．
[9] Carcelli M.,Mazza P.,Pelizzi C.,et al.,Antimicrobial and Genotoxic Activityof2,6-diacetylpyridine Bis(Acylhydrazones) and Their complexes with SomeFirstTransition Series Metal Ions.X-Ray Crystal Structure of a Dinuclear Copper(II)Complex.Journal of Inorganic Biochemistry，1995，57：43-62．
[10] Complex.Carcelli M．，Mazza P．，Pelizzi C．，etc．，Antimicrobial and Genotoxic Activityof 2，6-diacetylpyridine Bis(Acylhydrazones) and Their complex with Some FirstTransition Series Metal Ions， X-Ray Crystal Structure of a Dinclear of a DinuclearCopper(II)．J. Inorg. Biochem．，1995，57：43-62．
[11] Bacchi A．，Bonardi A．，Carcelli M．，etc．，Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones) Synthesis，structure，antimicrobial activity andgenotoxicity．J. Inorg. Biochem．，1998，69：101-112．
[12] Saraswat R．，Singh S．，Rana V.B．，Divalent metal chelates of macrocycle derived fromdihydrazone and aromatic diketone．J.1ndian Chem. Soc．，1996，73：78-480．
[13] 尹华，刘世雄.一个不常见的Ni(II)的戊三酮二水杨酰腙配合物的合成和晶体结构[J].无机化学学报，2002，18(3)：269-274．
[14] 肖文，卢忠林，邓良容，等.一种新型含二茂铁基三角架配体的合成与表征[J].中山大学学报(自然科学版)，1999，38(5)：127-128．
[15] Xiao W．，Lu Z.L．，Deng L.Y．，et al.，Pol．J．Chem.，2000，74：1211-1220．
[16] Ainscough E.W．， Brodie A.M．，Dobbs A.J ．， et al. ， Antitumour copper(II)salicylaldehyde benzoylhydrazone (H2sb) complexes: physicochemical properties and thesingle-crystal X-ray structures of [{Cu(H2sb)(CCl3CO2)2}2] and [{Cu(Hsb)(ClO4)(C2H5OH)}2] and the related salicylaldehyde acetylhydrazone (H2sa)complex．Inorg.Chim.Acta．，1998，267：27-38．
[17] Hundekar A.M．，Sen D.N．，Indian J.Chem．，1984，23A：477．
[18] Carcelli M．，Lanelli S．，Pelaatti P．，et al．，Structural characterization of a new ligandmode of 2，6-diacetylpyridine bis(semicarbazone)，H2daps．Inorg. Chim. Acta.，1999，292：121-126．
[19] Sangeetha N.R．，Pal C.K．，Ghosh P．，J. Chem. Soc. Dalton Trans.，1996，3293．
[20] Ji B.M．，Du Q.Y．，Ding K.L．，Synthesis and characterization of acetylferrocene andits dinuclear yttrium and lanthanide(III) picrate complexes．Polyhedron，1996，15：403-408．
[21] Agarwa1 R.K．，Sharma S．，Pol. J.Chem，1993，67：581．
[22] Dodoff N．，Gracharov K．，Journal of Inorganic Biochemistry，1995，60：257．
[23] Atovmyan Y.G．，Nikonova L.A．，et al．，Infrared spectra and structure of hydrogenbonds in N’-substituted isonicotinic hydrazides formed by crystallization from solutionand via solid phase transformations．J. Mol. Strut．，1999，474：167-175．
[24] 吴文士，刘世雄.丙酰皮考林酰肼(C9H11N3O2)的合成和晶体结构[J].结构化学，2001，20(3)：226-228．
[25] 邹霞娟，来鲁华，金桂玉，黄贵琴.新型含哒嗪酮基双酰肼类化合物的3D-QSAR 研究[J].物理化学学报，2002，18(6)：513-516．
[26] 邹霞娟，金桂玉，杨昭．1-取代苯基-1，4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲的合成及其抗烟草花叶病毒活性[J]．高等学校化学学报，2002，23(3)：403-406．
[27] Ferrari M.B．，Fava G.G．，et al．，Synthetic，spectroscopic and X-ray crystallographicstudies on copper(II) complexes with pyruvic acid and pyridoxal thiosemicarbazones.Inorg. Chem. Acta．，1998，269：297-301．
[28] Thuery P．，Nierlich M．，Charbonnel M.C．，et al．，Complexation of lanthanum(III)nitrate by N，N’，N，N’-tetraethylmalonamide Crystal structure of three polymorphicforms．Polyhedron，1999，37：3599-3608．
[29] 梁芳珍，徐克花，殷伦祥.水杨醛双酰腙Cu(II)配合物的合成、表征与抑菌活性[J].化学通报，1999，8：37-39．
[30] 杨正银，杨汝栋.邻羧基苯甲醛苯甲酰腙稀土配合物的合成和抗氧化活件[J]．中国稀土学报，2002，20(4)：366-369．
[31] Lal R.A．，Adhidari S．，Pal A．，etc．，Synthesis and characterization of the homobimetallic [bis(2-hydroxy-1-naphthaldehyde) oxaloydihydrazonato] bisdioxomolybdenm(VI)tetrahydrate complex and its reactivity towards proton and electron donor reagents．J.Chem. Res.(S)，1997：122-123．
[32] Pelagtti P．，Bacchi A．，Carcell M．，etc．，Palladium complexes containing a P，Nchelating ligand Part 11I．J. Organomet Chem．，1999，583：94-145．
[33] 高峰，朱英贵，章丽，等．荧光试剂二(1-H 一苯并三唑)乙二酮缩氨基硫脲的合成及其在蛋白质测定中的应用[J]．化学试剂，2004，26(3)：168-170．
[34] 杨昌晖，杨志斌．新希夫碱3，5-二溴水杨醛缩氨基硫脲的合成及其在荧光滴定中的应用[J]．分析实验室，1994，13(4)：9-11．
[35] Ochiai E．，J. Org. Chem.，1953，18：534．
[36] Meiserheimer J．，Stotz E．，Ber.Deut.Chem.Ges．，1952，58：1334．
[37] Bohmer H．，Ber. Deut. chem. Ges．，1937，70：379．
[38] Orchin M.，Schimidt P.T．，Coord. Chem．Rev．，1968，3：345．
[39] Anthdine W.E．，Some Properties of Copper and Zinc Complexes of 2-FormylpyridineThiosemicarbazone. Inorg. Chem．，1977，16：569-574．
[40] Landers A.E．，Phillips D.I．，Inorg. Chim. Acta，1982，59：41．
[41] Autolovich M．，et al．，Inorg. Chim. Acta，1989，159：189．
[42] 阎世平，等．含烷氧基桥的双核Ni(II)配合物的合成、表征和磁性[J]．化学研究与应用，1997，9(2)：126-129．
[43] 阎世平，等．烷氧基桥的双核Co(II)配合物的合成和性质研究[J]．南开大学学报(自然科学)，1996，29(3)：101-103．
[44] Gembicky M．，et al．，Inorg. Chim. Acta，2005，305(1)：75．
[45] Liang H．，Yu Q．，Hu R.X．，zhou Z.Y．，zhou X.G．，Synthesis，crystal structure andspectroscpicpropereies of a copper(II) complex of the Schiff-base derived frompicolinade N-oxide and 4-aminoantipyrine[J]．Transition Metal Chemistry，2002，27(4)：454-457．
[46] 梁宏，陈雄斌，胡瑞祥，陈振锋，郁开北．Schiff 碱N-氧化吡啶-2-甲醛缩氨基脲及其铜配合物的合成晶体结构及谱学性质的研究[J]．化学学报，2002，60(5)：939-946．
[47] 于青，胡瑞祥，梁宏．希夫碱钼(VI)配合物的合成表征与生物活性研究[J]．广西师范大学学报（自然科学版），2001，19(1)：63-66．
[48] 于青，胡瑞祥.N-氧化吡啶-2-甲醛缩对苯二胺合成及表征[J]．广西师范大学学报（自然科学版），1999，17(4)：68-70．
[49] 胡瑞祥，于青，梁宏，等．Schiff 碱6-甲基-N-氧化吡啶-2-甲醛缩硫代氨基脲的合成及晶体结构[J]．结构化学，2001，20(4)：286-289．
[50] 从彦丽，罗济文，王修建，卢泽勤，梁宏．双(N-氧化吡啶-2-甲醛)缩1，3-二氨基-2-丙醇钼(VI)配合物的合成与活性[J]．广西科学，1996，3(4)：6-8．
[51] 宋会花，王修建，从彦丽，梁宏．钼-氮氧化吡啶系列Schiff 碱配合物的研究．I．N-氧化吡啶-2-甲醛氨基酸类Schiff 碱钼(VI)配合物的合成与表征[J]．合成化学，1998，6(2)：188-195．
[52] 宋会花，王修建，从彦丽，梁宏．N-氧化吡啶-2-甲醛缩邻苯二胺钼(VI)的合成与表征[J]．广西师范大学学报（自然科学版），1997，15(2)：56-60．
[53] 李冬青，从彦丽，王修建，梁宏．N-氧化吡啶-2-甲醛缩氨基硫脲钼(VI)的合成与表征[J]．广西师范大学学报（自然科学版），1996，14(3)：47-51．
[54] 陈雄斌，陈振锋，胡瑞祥，梁宏，周忠远．N-氧化吡啶-2-甲醛缩苯肼的晶体结构[J]．广西师范大学学报（自然科学版），2002，20(2)：43-46．
[55] 刘斌，胡瑞祥，梁宏，郁开北．Schiff 碱N-氧化吡啶-2-甲醛缩氨基硫脲的晶体结构[J]．结构化学，1999，18(6)：414-417．
[56] 陈雄斌，胡瑞祥，陈振锋，梁宏，郁开北．2-(2-氮氧化吡啶基)苯并噻唑的合成与晶体结构[J]．广西师范大学学报（自然科学版），2004，22(4)：45-48．
[57] 陈振锋，王修建，梁宏．双(N-氧化吡啶-2-甲醛)缩对苯二胺的合成与表征[J]．广西师范大学学报（自然科学版），1998，16(1)：79
[58] Lu Q．，et al．，XXV ICCC，Book of Abstract，1987，C2-492．
[59] 周健．广西师范大学硕士学位论文，2004．
[60] 龚钰秋，陈成刚，黄晓峰．金与铂和N-氧化吡啶-2-甲醛半卡巴腙配盐的合成及其晶体结构[J]．杭州大学学报（自然科学版），1993，20(4)：438-442．
[61] Gong Y.Q．，Chen C.G．，Huan X.F．，et al．，Synth. React. Inorg. Met.-Org. Chem.，1994，24(6)：877．
[62] 陆勤，王国雄，臧焰，尹湛峰，曾成，周忠远．N-氧化吡啶-2-甲醛衍生物的配合物研究．III．N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J]．化学学报，1989，47：1065-1070．
[63] 陆勤，王国雄，尹湛峰，曾成．N-氧化吡啶-2-甲醛缩氨基硫脲钴配合物的研究[J]．无机化学学报，1991，7(1)：65-68．
[64] 阎世平，等．N-氧化吡啶-2-甲醛单缩1，2-丙二胺Schiff 碱镍配合物的晶体结构[J]．高等学校化学学报，1992，13(11)：1355-1357．
[65] 王伯康，张世华，孙东，刘永江，曾成．N-氧化吡啶-2-甲醛缩二胍合铜配合物的合成、表征及磁性[J]．无机化学学报，1993，9(3)：244-248．
[66] Vrbova M．，et al．，Preparation and structure of 2-(2-benzimidazol-2-yl)pyridine N-oxideand its complexes．Polyhedron，2000，19：2195-2201．
[67] Boca M．，et al．，CuII complexes with the new Schiff base ligands as a mono- andbis-condensation products of 2-pyridinecarboxaldehyde-N-oxide with diethyllenetriamine．Inorg. Chim. Acta，2003，349：111-121．
[68] Gou S.H．，et al．，Transition metal complexes of the Schiff bases derived fromS-alkyldirhiocarbazate with 2-pyridinecarboxaldehyde N-oxide-I. Synthesis，propertiesand structure of four-coordinate copper(II) complexes．Polyhedron，1990，9(24)：2981-2985．
[69] Gou S.H．，et al．，Transition metal complexes of the Schiff bases derived fromS-alkyldithiocarbazate with 2-pyridinecarboxaldehyde-N-oxide-H.Synthesis，propertiesand X-ray crystal structure of five-coordinate copper(II) complexes．Polyhedron，1991，10(12)：1363-1366．
[70] Eariati，et al．，X-ray Structures of Cu(poph)Cl2，[Cu(pxo)Cl2]2 and [Cu(pxo)(pxo-H)Cl](poph=2-pyridinecarboxaldehyde 1-oxide-2′-pyridiny lhydrazone；pxo = 2-acetylpyridine–1-oxide oxime) one monomeric structure and two N-oxide-bridged dimeric structures，involving multidentepyridine N-oxide ligands．Inorg. Chim. Acta，1998，268：135-140．
[71] Chiumia G.C．，et al．，Terminal S-coordinaed thiocyanate in a nickel(II) complex.X-raystructures of Ni(poph)(H2O)(SCN)(NCS) and Ni(poqh)(H2O)(NCS)2．Inorg. Chim. Acta，1999，285：297-300．
[72] Baran P．，et al．，The spectroscopic and structural properties of copper(II) complexes ofthe novel tridentate(ONO) pyridine N-oxide ligand Hpoxap．Polyhedron，2002，21：1561-1571．
[73] Gou S.H．，et al．，Synthesis and characterization of a series of tripodal transition metalcomplexes with the schiff base of 2 ， 2′ ， 2″-triaminoethylamine and 2-pyridinecarboxaldehyde N-oxide crystal structure of heptacoordinate complexes of a sevencoordinateligand．Inorg. Chem.，1993，32：1883-1890．
[74] 尹湛峰，等．第一届全国配位化学会议论文摘要集，1989，A1，44．
[75] 龚钰秋，孙鑫泉，黄肖峰．N-氧化吡啶-2-甲醛肟与钯(II)、铂(IV)配合物的研究[J]．杭州大学学报（自然科学版），1994，21(4)：418-421．
[76] 于青．兰州大学博士学位论文，2003．
[77] 尹湛峰，臧焰，王国雄，曾成．N-氧化吡啶-2-甲醛双希夫碱配合物的研究[J]．无机化学学报，1990，6(2)：181-186．
[78] 王国雄，尹湛峰，臧焰，陆勤，曾成．N-氧化吡啶-2-甲醛衍生物的配合物研究(II)与二胺生成的双希夫碱铜配合物的电子结构[J]．物理化学学报，1989，5(3)：305-309．
[79] 臧焰，陆勤，尹湛峰，曾成，戴安邦，周忠远．N-氧化吡啶-2-甲醛衍生物的配合物研究(I)—与二胺生成的双Schiff 碱铜配合物的合成和晶体结构[J]．高等学校化学学报，1989，10(1)：1-5．
[80] Boca R ．， et al ．，Tetrahydropoxen: 2 ， 2′-(1 ， 2-ethanediylbis(iminomethylene))bis(pyridine N-oxide) and its complexes．X-ray structure of [Cu(H4-poxen)H2O](ClO4)2.H2O and [Co(poxen)H2O](ClO4)2. Polyhedron，2000，19：835-839．
[81] 崔爱莉，王凤山，于英.双N-氧化吡啶-2-甲醛丙二胺合锌配合物的合成、晶体结构和分子结构[J]．吉林大学自然科学学报，1994，2：81-86．
[82] Castineiras A., et al., Inorg. Chim. Acta，1994，216，229.
[83] 阎世平，等.结构化学，1992，11(2)：160.
[84] Cheng P．，et al．，Z. Anorg. Allg. Chem．，2003，629：1996．
[85] Boca M．，et al．，Selective Incidazolidine Ring Opening during Complex Formation ofIron(III) ， Copper(II) ， and Zinc(II) with a Multidentate Ligand obtained from2-pyridinecarboxaldehyde N-oxide and Triethylenetetramine.Inorg. Chem．，2000，39：3205-3212．
[86] Gou S.H．，et al．，Acta Crystallogr，Sect. C，1991，47：708．
[87] Yu Q．，Chen K．，Tan M Y．，Polish Journal of Chemistry，2003，77(7)：917．
[88] 尹湛峰，王国雄，叶玲，王凤山，樊玉国.双希夫碱镍(II)配合物的合成及晶体结构[J]．南京大学学报，1990，26(2)：256-262．.
[89] YU Qing，ZHU Li-Gang， BIAN He-Dong，et al.，Synthesis and Crystal Structure of aZinc(II) Complex Salt with the Schiff Base of Picolinaldehyde N-oxide andSemicarbazone．J. Struct. Chem．，2005，24：1271-1275．
[90] 朱立刚．广西师范大学硕士学位论文，2005．
[91] Karunaker G.V．，Sangeetha N.R．，Susila V．，Pal S．，J. Coord. Chem．，2000，50：51．
[92] Ali M.A．，et al．，Synthetic，spectroscopic and X-ray crystallographic structural studyof the monomeric [Cu(pysme)(sac)(MeOH)] and dimeric [Cu(6mptsc)(sac)]2complexes．Polyhedron，2004，23：2031-2036．
[93] Cheng Yong S.，et al．，J. Chem. Cryst.，1998，28：871．
[94] Domiano P．，et al．，Transition Met. Chem．，1980，5：172．
[95] Domiano P ．， et al ．， Crystal and moleaular structure of (N-picolinylidene-N’salicyloylhydrazinato)(N-picolinylidene-N’-salicyloylhydrazine) copper(II) perxhlorate-ethanlol.J. Chem. Soc，Dalton Trans：1979，8：1266-1269．
[96] Domiano P.，et al.，J. Chem. Soc，Dalton Trans.1974，3：531．
[97] Tojal G.J.，et al.，Spectroscopic ang magnetic properties of the pyridine-2-carbaldehydethiosemicarbazonateiron(III) complexes：[Fe(C7H7N4S)2]X.nH2O (X = Cl，ClO4，NO3，PF6). J. Inorg. Biochem．2001，84：271-278．
[98] Demertzi K.D．，Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehydethiosemicarbazone with potential biological activity.Synthesis，structure and spectralproperties. Extended network via hydrogen bond kinkages of [Pd(PyTsc)Cl]．Polyhedron，1999，18：1005-1013．
[99] Tojal G.J．，Spectroscopic and magnetic properties of the pyridine-2-carbaldehydethiosemicarbazonateiron(III) complexes：[Fe(C7H7N4S)2]X?nH2O(X = Cl，ClO4，NO3，PF6)．Inorg. Chim. Acta，1998，278：150-158．
[100] Casas J.S．，et a．，Synthesis，structure，spectroscopic properties and biological activityof mixed diorganotin(IV) complexes containing pyridine-2-carbaldehyde thiosemicarbazonato and diphenyldithiophosphinato ligands．J. Inorg. Biochem．1999，76：277-284．
[101] Labib L．，et al．，Organotin(IV) complexes with tridentate ligands-III. Synthesis andcharacterization of some organotin(IV) complexes with N-(2-pyridinyl methylene)hydrazinecarbothioamide ： The X-ray crystal structute of dimethylmonochloro[(N-(2-pyridinylmethylene) hydrazinecarbothioamidato) NS(-1)] tin(IV) hemihydrate．Polyhedron，1996，15：349-357．
[102] Barbieri R.S．，The reaction of 2-formylpyridine thiosemicarbazone (HFPT) with tintetrahalides.Crystal and molecular structure of [SnCl3(FPT)]．Inorg. Chim. Acta，1993，206：169-172．
[103] Lobana T.S ．， et al ．， Diphenylthallium(III) thiosemicarbazonates:flexibility ofcoordination in the solid state and polymorphism in chloroform solution．Inorg. Chim.Acta，2003，347：23-32．
[104] Casas J.S., Dimethylthallium(III) and methylmercury(II) derivatives ofpyridine-2-carbaldehyde thiosemicarbazone:synthesis and structure．J. Chem. Soc.，Dalton，Trans.，1993，8：1253-1259．
[105] Bingham A.G.，et al.，Synthertic，spectroscopic and X-ray crystrallographic studies onbinuclear copper(II) complexes with a tridentate NNS-bonding 2-formylpyridinethiosemicarbazone ligand.The characterization of both neutral and deprotonatedcoordinated ligand structures.J. Chem. Soc.，Dalton，Trans.，1987，3: 493-499.
[106] Tojal G.J.，et al.，Spectroscopic and magnetic properties of copper(II) complexesderived from pyridine-2-carbaldehyde thiosemicarbazone.Structures of [Cu(NO3)(C7H8N4S)(H2O)](NO3) and [{Cu(NCS)(C7H7N4S)}2].Polyhedron，1999，18：703-3711．
[107] Tojal G.J.，et al.，Synthesis，structures，spectroscopic and magnetic properties of twocopper(II) dimmers cononining pyridine-2-carbaldehyde thiosemicarbazonate (L)．J.Chem. Soc.，Dalton，Trans.，1994，15：2233-2238．
[108] Ainscough E.W.，et al.，Reaction of nitrogen and sulphur donor ligands with theantitumour complex [{CuL(MeCO2)}2] (HL = 2-formyl pyridine thiosemicarbazone) andthe single-crystal X-ray structure of [CuL(bipy)]ClO4 (bipy = 2，2′-bipyridyl). J. Chem.Soc.，Dalton，Trans.，1991，7：1737-1742．
[109] Tojal G.J. ， et al. ， Synthesis and spectroscopic properties of two pyridine-2-carbaldehyde thiosemicarbazone copper(II) compounds：[CuX2(C7H8N4S)]. H2O(X =Br，Cl).Inorg. Chim. Acta，1996，249：25-32．
[110] Smith H.W．，Acta Crystallogr，Sect B.，1975，31：2701．
[111] Mesa J.L.，et al．，Crystal structure and properties of the [Cu(C11H10N4)] compoundstereochemistry of [Cu(planar tridentate ligand)(unidentate ligand)2] complexes．Polyhedron，1988，7(15)：1383-1388．
[112] Baraniak E．，Structure and Properties of a Dimeriz nydroto-Bridged Ytterbium(III)Complex ， Di-H-hydroxo-bistriaquo(pyridine-2-carboxaldehyde 2’-pyridylhydrazone)ytterbiuni(III)] Tetrachloride Tetrahydrate．Inorg. Chem．，1976，15：2226-2230．
[113] Christidis C.P．，et al．，Acta. Crystallogr，Sect C，1999，55：707．
[114] Khalil T.E．，et al．，Organotin(IV) complex with tridentate ligands- II.synthesis andcharacterization of mono- and dimethyltin(IV)complexes with N-(2-pyridinylmethylene)benzoylhydrazine the crystal and molecular structure of monomethyldichloro[N-(2-pyridinylmethylene) benzoylhydrazinate NNO(-1)] Tin(IV)．Polyhedron，1994，13(17)：2569-2578．
[115] Pelagatti P．，et al．，Eur. J. Inorg. Chem．，2000：463．
[116] Paschaliclis G.D．，et al．，Synthesis，characterization and spectra of lanthanide(III)hydrazone complexes The X-ray molecular structures of the erbium(III) complex and theligand．Polyhedron，2000，19：2629-2637．
[117] Sangeetha N.R．，Pal S．，Dimeric and polymeric square-pyramidal copper(II) complexescontaining equatorial-apical chloride or acetatebridges ． Polyhedron ， 2000 ， 19 ：1593-1600．
[118] Pal S．，J. Chem. Soc.，Dalton，Trans.，2002：2102．
[119] Sulivan D.A.，Palenik G.J.，Magnetic and Spin LIFETIME studies in Solution of a △S = 1 spin-Equilibriumprocess for some Six-Coordinate Bis(N-R-2，6-pyridinedicarboxaldimine) Cobalt(II) Complexes. Inorg.Chem.，1997，16：1127．
[120] Mandal S.K．，Chakravarty A.R．，Synthesis，X-ray structure and properities of(?5-cyclopentadienyl) ruthenium(II) complexes of pyridyl-2-hydrazone ligands．Polyhedron，1991，10：2483-2486．
[121] Mondal B．，Puranik G.V．，Lahirl G.K．，examplex of highly stereoregulated rutheniumamidine copmplex formation: synthesis，crystal structures and spectral and redoxproperties of the complexes．Inorg. Chem．，2002，41：5831-5836．
[122] Sangeetha N.R．，et al．，A one-dimensional assembly of copper(II) polyhedra via dualuse of hydrogen-bonding and л-л interaxtion．Inorg. Chem. Comm．，2000，3：415-419．
[123] Ali M.A．，et al．，Trans. Met. Chem．，2002，27：262．
[124] Saiz G.P．，et al．，Evidence of Desulfurization in the Oxidative Cyclization ofThiosemicarbazones．Conversion to 1，3，4-Oxadiazole Derivatives．Inorg. Chem．，2002，41：1345-1347．
[125] Tarafder T.M．，Synthesis and charaterization of Zn(II) and Cd(II) complexes ofS-benzyl-β-N-(2-pyridyl) methylenedithiocarbazate (HNNS)：bioactivity of the HNNSSchiff base and its Zn(II)，Cu(II) and Cd(II) complexes and the X-ray structure of the[Zn(NNS)2] complex．Polyhedron，2001，20：2363-2370．
[126] Armstrong M.C．，Bernhardt P.V．，Pichardson D.R．，Eur. J. Inorg. Chem．，2003：1145．
[127] 蔡铁军，彭振山，邓谦，龙云飞，邓彤彤，郁开北．Schiff 碱铜(I)配合物的合成、结构及其与DNA 相互作用的研究[J]．无机化学学报，2004，20：731-733．
[128] Karuriaker V.G．，et al．，J. Coord. Chem．，2000，50：51．
[129] Zhou J．，et al，，Acta Crystallogr，Sect E．，2004，60：m586．
[130] Saiz G.P．，et al．，Eur. J. Inorg. Chem 2003：2639．
[131] Liang H．，Wang X.W．，Chen Z.F．，Acta，crys．2004，294：60．
[1] Labouta I.M., Hasscm A.M., Abouiwafa M.,et al.,Monatshefte Fur. Chin.,1989,120:571-573.
[2] Molina P.,Alnendros O.,Fresneda P.M.,Crystal and molecular structure of (N-picolinylidene-N′-salicyloylhydrazinato)(N-picolihylidene-N′-salicyloylhydrazine) copper(II) perchlorate-ethanol. Tetrahedron,1994,50(7):2241-2254.
[3] Sato H.,Tsuda M.,Watanabe K.,et al.,rhopaladins A-D,new indole alkaloids from marine tunicate rhopalaea sp. Tetrahedron,1998,54:8687-8690.
[4] Yang JG..,Pan FY.,Acta Cryst,2004,E60:o2009-o2010.
[5] 仉文升,李安良.药物化学,1999:458-464.
[6] King R.B.,Encyclopedia of Inorganic Chemistry,John Wiley&sons Ltd:New York[M].1994:p829.
[7] Singh B.,Sahai P.,Lanthanide complexes of 2-aminobenzophenone 2-thenoylhy drazone:synthesis and structural characterization. Synth React. Inorg. Met. Org. Chem.,1996,26(1):157-167.
[8] 杨正银,杨汝栋,郁开北.2-羰基丙酸(4-吡啶甲酰基)腙与碱土金属配合物的晶体结构及热稳定性[J].化学学报,1999,57(3):236-243.
[9] Duggal H.K.,Agarwala B.V.,Synthesis and characterization of nickel(II) and palladium(II) complexes of novel tetrauza annulene tetracarbonitrile. Synth. React. Inorg. Met. Org. Chem.,1992,22(8):871-882.
[10] Yang Z.Y.,Yang R.D.,Li F.S.,Yu K.B.,Crystal structure and antitumor activity of some rare earth metal complexes with schiff base.Polyhedron,2000,19:2599-2604.
[11] 何水样,曹文凯,陈军利,等.铜(II)与 2-羧基丙酸水杨酰腙配合物的合成、晶体结构和抑菌活性[J].高等学校化学学报,2002,6:991-993.
[12] 樊能廷著,有机合成事典,北京理工大学出版社[M].北京,1972:214.
[13] Ckalheide C.V.,J.Am.Chem.Soc.,1954,76:1286.
[14] 袁环.N-氧化吡啶工艺路线的改进[J].化学世界,1995,36(11):580-581.
[15] Peplinski Z.,Brown D.B.,et al.,Electrical properties of Na3Cu4S4,a mixed-valence one-dimensional metal.Inorg. Chem.,1982,21:1752.
[16] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,Crystal and molecular structure of (N-picolinylidene-N′-salicyloylhydrazinato) (N-picolinylidene-N′-salicyloyl hydrazine) copper(II) perchlorate-ethanol.JCS Dalton,1979:1266-1269.
[17] 于青,兰州大学博士学位论文,2003:48-53.
[1] Domagk G.,Naturwissenschanften,1964,33:315.
[2] Wilson H.R.,et al.,J. med. Chem.,1974,17:760.
[3] Winkelmann E.,Arzneim-Forsch,1977,27:950.
[4] Klayman D.L.,et al.,J. Med. Chem. Ther.,1981,16:317.
[5] 张来新,杨琼.新取代冠醚及其缩氨硫脲和缩氨脲化合物的合成[J].新疆大学学报,2001,18(1):69-71.
[6] 臧焰,王国雄,等.科学通报,1989,34(17):1316.
[7] 李冬青,从彦丽,王修建,梁宏.N-氧化吡啶-2-甲醛缩氨基硫脲钼(VI)的合成与表征[J].广西师范大学学报(自然科学版),1996,14(3):47-51.
[8] 陆勤,王国雄,臧焰,尹湛峰,曾成,周忠远.N-氧化吡啶-2-甲醛衍生物的配合物研究.III.N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J].化学学报,1989,47:1065-1070.
[9] Lu Q.,et al.,XXV ICCC,Book of Abstract,1987:C2-492.
[10] 刘斌,胡瑞祥,梁宏,郁开北.Schiff碱N-氧化吡啶-2-甲醛缩氨基硫脲的晶体结构[J].结构化学,1999,18(6):414-417.
[11] 陆勤,王国雄,尹湛峰,曾成.N-氧化吡啶-2-甲醛缩氨基硫脲钴配合物的研究[J].无机化学学报,1991,7(1):65-68.
[12] Janiak C.,A critical account on π-π stacking in metal complexes with aromatic nitrogen-coutaining ligands.J. Chem. Soc.,Dalton Trans.2000:3885-3896.
[13] 梁宏,陈雄斌,胡瑞祥,陈振锋,郁开北.Schiff碱N-氧化吡啶-2-甲醛缩氨基脲及其铜配合物的合成晶体结构及谱学性质的研究[J].化学学报,2002,60(5):939-946.
[14] Bindu P.,Kurup M.R.P.,Satyakeerty T.R.,EPR,cyclic voltammetric and biological activities of copper(II) complexes of salicylaldehyde N(4)-substituted thiosemicarbazone and heterocyclic bases. Polyhedron,1998,18:321-331.
[15] Jouad E.M.,Riou A.,Allain M.,Khan M.A.,Bouet G.M.,Synthesis,structural and spectral studies of 5-methyl 2-furaldehyde thiosemicarbazone and its Co,Ni,Cu and Cd complexes.Polyhedron,2001,20:67-74.
[16] Jouad E.M.,Larcher G.,Allain M.,et al.,Synthesis,structure and biological activity of nickel(II) complexes of 5-methyl 2-furfural thiosemicarbazone.J. Inorg. Biochem. 2001,86:565.
[17] Yu Q.,Tang Y.,Tan MY.,J. Rare Earths,2002,20:385.
[1] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,Crystal and molecular structure of catena-μ-isothiocyanato (N’-pyridyl-methylene-N″ salicyloylhydrazinato-NN’ O) copper(II).JCS Dalton,1975:2357-2360.
[2] Domiano P.,Musatti A.,Nardelli M.,Pelizzi C.,Predieri G.,JCS Dalton,1979:1266.
[3] Domiano P.,Musatti A.,Pelizzi C.,Predieri G..,Rhodium(I) complexes with pyidazine 4,6-dimethyl-pyrimidine,4,6-bis(3,5-dimethylpyrazol-1-yl) pyrimidine,3,6-bis(3,5-di methylpyrazol-1-yl) pyrimidine and 3-(3,5-dimethylpyrazol-1-yl)-6-chloropyridazine. Polyhedron,1984,3(2):213-221.
[4] Sheldrick G.M.,SHELXS-97 and SHELXL-97[CP/CD].Gottingen,Gremany:University of Gottingen,1997.
[5] 陈敏堂,廖代正,张若桦,等.烯醇式异桥双铜配合物的合成及磁换作用的研究[J].高等学校化学学报,1993,14(12):1638-1641.
[6] Sujittra Y.,Narongsak C.,Chaveng P.,Saksit B.,The coordination chemistry of mono and bis(di-2-pyridylamine)copper(II) complexes:preparation,characterization and crystal structures of [Cu(L)(NO3)2],[Cu(L)(H2O)2(SO4)],[Cu(L)2(NCS)](SCN)·0.5DMSO and [Cu(L)2(SCN)2].Polyhedron,2002,21:1279-1288.
[7] 王伟,张逢星,李珺,李恒欣,霍涌前,村桂香.Zn(II)-双呋喃甲醛缩二胺配合物的合成、结构和性质[J].化学学报,2004,64(16):1529-1532.
[8] 牛淑云,迟玉贤,金晶,杨我第,叶玲,两个二维Cd(II)配位聚合物的合成、晶体结构和荧光性质[J].高等学校化学学报,2004,25(10):1804-1806.
[1] Dey,K.,J. Scient. Ind. Res.,1974,33:39.
[2] Durga,N.D.,J. Scient. Ind. Res.,1982,41:501.
[3] 王耕霖,李盛荣,姜宗慧,王士贤.一价铜的缩氨基硫脲配合物及其抗癌活性的研究[J].化学通报,1988,11:37-38.
[4] Lumd,P.,Hannu,E.,Inorg Chim. Acta,1984,92:24.
[5] Dashora,R.,Singh,R.V.,Tandon,J.P.,Synth. React. Inorg. Met-Org. Chem.,1983,13:209.
[6] Chandra,S.,Snyth. React. Inorg. Met-Org. Chem.,1982,12(6):642.
[7] 吴自慎.华中师大学报(自然科学版),1983,1:61.
[8] Zhen-Feng Cheng,Jian Zhou,Hong Liang.,et al.,Acta Cryst.E. 60.
[9] France,H.C.,J. Chem. Eng. Data.,1980,25:404.
[10] 陆勤,王国雄,藏焰,尹湛峰,曾成,周忠远.N-氧化吡啶-2-甲醛衍生物的配合物研究.III.N-氧化吡啶-2-甲醛缩氨基硫脲的双核铜配合物的晶体结构和电子结构[J].化学学报,1989,47:1065-1070.
[11] 周健,广西师范大学硕士论文,2004.
[12] 中本一雄著,黄德如,汪仁庆译,无机和配位化合物的红外和拉曼光谱,化学工业出版社,北京,1986.
[1] Buu- Hoi N.P.,Huong N.D.,Ham N.H.,et al.,J. Chem. Soc.,1953:1358.
[2] Sayed L.E.,Iskander M.F.,J. Inorg. Nucl. Chem.,1971,35:435.
[3] 杨正银,杨汝栋.邻羧基苯甲醛苯甲酰腙稀土配合物的合成和抗氧化活性[J].中国稀土学报,2002,20( 4):366-369.
[4] Yang Z.Y.,Yang R.D.,Li F.S.,Synth React Inorg Met-org Chem.,1999,29(2):205.
[5] Yang Z.Y.,Synth React Inorg Met-Org Chem.,2000,30(7):1265.
[6] Yang Z.Y.,Yang R.D.,J. Chem. Intemet.2001,3(4):034 018 pc.
[7] Yang Z.Y.,Yang R.D.,Li F.S.,Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base.Polyhedron,2000,19:2599-2604.
[8] 何水样,曹文凯,陈利军,等.铜(II)与 2-羰基丙酸水杨酰腙配合物的合成、晶体结构和抑菌活性[J].高等学校化学学报,2002,23( 6):991.
[9] 范能廷.有机合成事典[M].北京:科学技术出版社,1992:214.
[10] Marzilli L.G.,Summers M.F.,Brescian P.N.,Charland J.P.,Randaccio L.,J. Am. Chem. Soc.,1985,107:6680.
[11] 郑昊,沈应中,等.N-(2-吡啶基)-伯胺二甲基合镓(III)的制备及表征[J].无机化学学报,1999,3:336.
[12] Trofimenko S.,Calabrese J.C.,Kochi J.K.,Wolowic S.,Hulsgen F B.,Reedijk J.,spectroscopic analysis, coordination geometry, and X-ray structures of Nickel(II) compounds with sterically demanding tris(pyrazoly)borate ligands and azide or (this)cyanate anions. Inorg. Chem.1992,31(17):3943-3950.
[13] Rojo T.,Cortes R.,Lezama L.,Arrortua M.I.,Urtiaga K.,Villeneuve G. Spectroscopic and magnetic properties of two ferromagnetically coupled nickel(II) dimmers [{Ni(terpy)(NCX)2}2](terpy = 2,2′:6′2″-terpyridine, X = S or Se).J.Chem. Soc.,Dalton Trans.1991:1779-1783.
[14] Garcia-Tojal J.,Garcia-Orad A.,Diaz A.A.,Biological activity of complexes derived from pyridine-2-carbaldehyde thiosemicarbazone:Structure of [Co(C7H7N4S)2][NCS].J. Inorg. Biochem.,2001,84:271-278.