猪12号染色体上10个新基因的分离、定位及其与部分性状的关联分析
|
摘要
本论文根据比较基因定位信息，并结合公共数据库中的EST资源，分离、定位猪12号染色体上的新基因，并对基因与部分性状进行了初步关联分析，取得了如下结果：
1．以人的17号染色体上的同源基因的cDNA为探针，从GeneBank中搜索猪的同源EST，由EST构成的连接群(contig)设计引物，从湖北白猪基因组中分离克隆了10个基因片段。这10个基因分别为：磷脂酶D2基因(PLD2)、生长因子受体结合蛋白7基因(GRB7)、颗粒蛋白基因(GRN)、Ⅰ型胶原蛋白α1亚基基因(COL1A1)、磷酸甘露糖长醇利用缺陷型基因(MPDU1)、微管蛋白特异的伴侣蛋白基因(TBCD)、组蛋白乙酰转移酶基因(GCN5L2)、MAC30蛋白基因(MAC30)、Tax模体作用蛋白1基因(TIP-1)、KIAA1582蛋白(KIAA1582)基因。
2．采用电脑克隆策略结合RACE技术，获得了MPDU1和GRN基因的全长cDNA，推导出了相应的氨基酸序列。将推导出的氨基酸序列与其它物种的对应序列进行同源性比较，发现猪的MPDU1氨基酸序列与人的该氨基酸序列同源性达91％，猪的GRN氨基酸序列与人的同源性达70％。
3．采用半定量RT-PCR方法检测了MPDU1基因和GRN基因在通城猪的肾脏、心脏、肺、脾脏和肝脏等5个组织中的表达情况，结果表明MPDU1基因在所检测的组织中广泛表达，且表达量无显著性差异，而GRN基因在不同组织中表达量不同，脾脏中表达量最高，而心脏中的表达水平最低。
4．用猪×啮齿类体细胞杂种板将新分离的8个基因进行染色体区域定位，定位结果如下：PLD2基因被定位于SSC12q11-q15(P=0.9862)，与该区域标记间的相关系数为1(Cor=1)；GRB7基因被定位于SSC12 p11-(2／3 p13)，P=0.8901，Cor=1；COL1A1基因被定位于SSC12 p11-(2／3 p13)，P=0.8901，Cor=1；MPDU1基因被定位于SSC12q11-q15，P=0.9862，Cor=1；TBCD基因被定位于SSC12p11-(2／3 p13)，P=0.4701，Cor=0.9177或12q11-q15，P=0.4701，Cor=0.9117；MAC30基因被定位于SSC12q11-q15，P=0.9862，Cor=1；TIP-1基因被定位于SSC12q11-q15，P=0.9862，Cor=1；KIAA1582基因被定位于12p11-(2／3 p13)，P=0.8901，Cor=1。
5．用猪×仓鼠辐射杂种板将新分离的9个基因进行染色体精细定位，表明这些基因均与猪12号染色体上的基因或标记紧密连锁。具体定位结果如下：PLD2基因与Swc23
猪12号染色体上10个新基因的分商、定位及其与部分性状的关联分析
紧密连锁，LOD=6.11;分万尸基因与及记习J紧密连锁，LOD二15.25;份私/基因与介石万7紧
密连锁，LOD二8.81;‘况劲了基因与及叮J夕口紧密连锁，LOD二21.28;留即基因与万心荃夕O
紧密连锁，LOD=4.96;义)朽乙2基因与万帕璧J紧密连锁，LOD二10.03;蒯c3口基因与介‘23
紧密连锁，LOD二巧.58;几甲可基因与万冲了刃占紧密连锁，LOD二10.95消大去心了压貂基因与
及松洲夕乎紧密连锁，LOD=9.47。
6.采用PCR一RFLP方法检测了分咨7、酬脚{‘优IAI、树叨艺口、蒯c3o、了丫尸一了等6个基
因9个位点的多态性和PL刃基因第21内含子万石飞万序列的插入、缺失造成的PCR产物长
度多态性，分析了不同猪品种中的基因型频率和基因频率，以及各等位基因在不同猪品
种中的分布差异。
7.在长白占X(大白X通城)早和大白占X(长白X通城)早的上下代个体中，分
析了PL刃、命公7、以动v、‘况俐了匆77尸一了基因上述多态位点的遗传方式，结果表明均呈
共显性遗传方式。
8.以本室与通城县畜牧局种畜场合作所建立的试验群体(含长白猪22头、通城猪
58头、大白猪23头、长大通23头、大长通21头)为材料，分析了前述7基因的DNA
多态位点与部分生产性状和免疫性状的关联，结果发现①G尺B7基因第163位点不同基因
型个体在屠宰率困P)、红细胞数(RBC)上差异显著(P<0.05)，CC基因型的个体与
TT基因型的个体的20周龄时血清中IgG的含量(I gG)差异极显著(P<0.01);在243位
点，不同基因型的个体之间肌肉pH值(MPH)、红细胞数(RBC)、红细胞压积(HCT)
差异显著(P<0.05);②G尺厅基因不同基因型的个体之间剪切力(Shear foree)、眼肌面
积(LMA)、板油率差异显著(P<0.05);③COLIA了基因第170位点GG基因型个体与
AA、AG基因型个体之间红细胞分布宽度(RDw)差异显著(P二0.0146);④MAc30
基因AG基因型个体与AA基因型个体之间第6、7肋间背膘厚(6一7BF)及三点平均背
膘厚(ABF)差异极显著(P<0.01);⑤7了P一了基因282位点TG基因型个体与TT基因型
个体屠宰率(DP%)差异显著(P=0.0404)，腿臀比率(Ham)差异极显著(P=0.0087)。
The objective of this thesis was to isolate, characterize and physically map the novel genes on pig chromosome 12 using information derived from comparative mapping and pig EST database. The association between genes and some economic traits is also studied. The main results are as follows:
1. Pig ESTs were identified through standard BLAST analysis by using cDNA sequences
of human homologous genes on chromosome 17. Highly conserved pig ESTs were assembled
to EST contigs. And primers selected from the contigs were used to isolate 10 novel porcine
gene fragments from Hubei White pigs genomic DNA. The 10 novel porcine genes were as
follows: phospholipase D2(PLD2),Growth factor receptor binding protein7(CRB7), granulins
(GRN) , collagen, type I, alpha 1 (COL1A1) , amnnose-p-dolichol utilization defect 1
(MPDU1) ,tubulin-specific chaperone d (TBCD) ,GCN5 general control of amino-acid
synthesis 5-like 2 (yeast) (GCN5L2) , MAC30 (.MAC30) , TIP-1 Tax interaction protein 1
(TIP-1) and KIAA1582 (KIAA1582) gene.
2. The full length cDNA of MPDU1 and GRN genes were obtained through in silico cloning together with RACE. The deduced amino acid sequences of MPDU1 and GRN proteins show 91% and 70% similarity to corresponding human sequences, respectively.
3. Expression profiles of MPDU1 and GRN genes of Tongcheng pigs were analysis by semi-quantitative RT-PCR assay. MPDU1 gene is widely expressed in tissues of kidney, heart, lung, spleen and liver and there is no significant difference between each tissue; while GRN gene is highly expressed in the spleen and lowly expressed in heart.
4. The pig rodent somatic cell hybrid panel (SCHP) was used for regional assignment of the 8 genes. The GRB7, COL1A1 and K1AA1582 genes were localized to SSC12pl 1- (2/3) pl3 with error risk <0.1%. The probability of regional localization and correlation for the 3 genes was 0.8901 and 1.0, respectively. The PLD2, MPDU1, MAC30 and TIP-1 genes were physically mapped to SSC12qll-ql5 with error risk <0.1%. The probability of regional localization and correlation for the 4 genes was 0.9862 and 1, respectively. The TBCD gene was physically mapped to SSC12p 11-(2/3 p13) (P=0.4701) or 12qll-ql5 (P= 0. 4701) with error risk <0.1%. The correlation of localization to the two regions of the gene was 0.9177 and 0.9117, respectively.
5. The INRA-University of Minnesota porcine radiation hybrid (IMpRH) panel was employed to determine the precise location of nine novel genes. Statistical analysis revealed that all the 9 genes were closely linked to genes or markers on pig chromosome 12. PLD2 and
MAC30 genes were both located closely to marker Swc23, with LOD score threshold 6.11 and 15.58, respectively. The GRB7 and GCN5L2 genes were both closely linked to Sw943, with LOD score threshold of 15.25 and 10.03, respectively. The GRN gene was closely linked to Sw957, with LOD score threshold of 8.81. The COLlAl gene was closely linked to Swr390, with LOD score threshold of 21.28. The TBCD gene was closely linked to Sw2490, with LOD score threshold of 4.96. The TIP-1 gene was closely linked to Swl936, with LOD score threshold of 10.96. The KIAA1582 gene was closely linked to Sw2494, with LOD score threshold of 9.47.
6. Studies on polymorphic sites of GRB7, GRN, COLlAl, MPDU1 > MAC30, TIP-1 genes by PCR-RFLP revealed nine polymorphic sites. Allele frequencies among different pig populations were determined. A SINE indel polymorphism was detected in the intron 21 of PLD2, and allele frequencies among different pig populations was determined, too.
7. Codominant inheritance of the above polymorphic sites were demonstrated in the Landracec (Large WhitexTongcheng) and Large Whitex (LandracexTongcheng) two-generation pedigrees.
8. The above polymorphic sites were genotyped in the experimental pig population constructed under the cooperation of our lab and animal husbandry bureau of Tongcheng county (include 22 Landrace pigs,58 Tongcheng pigs,23 Large White pigs,23 Landrace
(Large WhitexTongcheng) pigs and 21 Large White (LandracexTongcheng) pig
1．以人的17号染色体上的同源基因的cDNA为探针，从GeneBank中搜索猪的同源EST，由EST构成的连接群(contig)设计引物，从湖北白猪基因组中分离克隆了10个基因片段。这10个基因分别为：磷脂酶D2基因(PLD2)、生长因子受体结合蛋白7基因(GRB7)、颗粒蛋白基因(GRN)、Ⅰ型胶原蛋白α1亚基基因(COL1A1)、磷酸甘露糖长醇利用缺陷型基因(MPDU1)、微管蛋白特异的伴侣蛋白基因(TBCD)、组蛋白乙酰转移酶基因(GCN5L2)、MAC30蛋白基因(MAC30)、Tax模体作用蛋白1基因(TIP-1)、KIAA1582蛋白(KIAA1582)基因。
2．采用电脑克隆策略结合RACE技术，获得了MPDU1和GRN基因的全长cDNA，推导出了相应的氨基酸序列。将推导出的氨基酸序列与其它物种的对应序列进行同源性比较，发现猪的MPDU1氨基酸序列与人的该氨基酸序列同源性达91％，猪的GRN氨基酸序列与人的同源性达70％。
3．采用半定量RT-PCR方法检测了MPDU1基因和GRN基因在通城猪的肾脏、心脏、肺、脾脏和肝脏等5个组织中的表达情况，结果表明MPDU1基因在所检测的组织中广泛表达，且表达量无显著性差异，而GRN基因在不同组织中表达量不同，脾脏中表达量最高，而心脏中的表达水平最低。
4．用猪×啮齿类体细胞杂种板将新分离的8个基因进行染色体区域定位，定位结果如下：PLD2基因被定位于SSC12q11-q15(P=0.9862)，与该区域标记间的相关系数为1(Cor=1)；GRB7基因被定位于SSC12 p11-(2／3 p13)，P=0.8901，Cor=1；COL1A1基因被定位于SSC12 p11-(2／3 p13)，P=0.8901，Cor=1；MPDU1基因被定位于SSC12q11-q15，P=0.9862，Cor=1；TBCD基因被定位于SSC12p11-(2／3 p13)，P=0.4701，Cor=0.9177或12q11-q15，P=0.4701，Cor=0.9117；MAC30基因被定位于SSC12q11-q15，P=0.9862，Cor=1；TIP-1基因被定位于SSC12q11-q15，P=0.9862，Cor=1；KIAA1582基因被定位于12p11-(2／3 p13)，P=0.8901，Cor=1。
5．用猪×仓鼠辐射杂种板将新分离的9个基因进行染色体精细定位，表明这些基因均与猪12号染色体上的基因或标记紧密连锁。具体定位结果如下：PLD2基因与Swc23
猪12号染色体上10个新基因的分商、定位及其与部分性状的关联分析
紧密连锁，LOD=6.11;分万尸基因与及记习J紧密连锁，LOD二15.25;份私/基因与介石万7紧
密连锁，LOD二8.81;‘况劲了基因与及叮J夕口紧密连锁，LOD二21.28;留即基因与万心荃夕O
紧密连锁，LOD=4.96;义)朽乙2基因与万帕璧J紧密连锁，LOD二10.03;蒯c3口基因与介‘23
紧密连锁，LOD二巧.58;几甲可基因与万冲了刃占紧密连锁，LOD二10.95消大去心了压貂基因与
及松洲夕乎紧密连锁，LOD=9.47。
6.采用PCR一RFLP方法检测了分咨7、酬脚{‘优IAI、树叨艺口、蒯c3o、了丫尸一了等6个基
因9个位点的多态性和PL刃基因第21内含子万石飞万序列的插入、缺失造成的PCR产物长
度多态性，分析了不同猪品种中的基因型频率和基因频率，以及各等位基因在不同猪品
种中的分布差异。
7.在长白占X(大白X通城)早和大白占X(长白X通城)早的上下代个体中，分
析了PL刃、命公7、以动v、‘况俐了匆77尸一了基因上述多态位点的遗传方式，结果表明均呈
共显性遗传方式。
8.以本室与通城县畜牧局种畜场合作所建立的试验群体(含长白猪22头、通城猪
58头、大白猪23头、长大通23头、大长通21头)为材料，分析了前述7基因的DNA
多态位点与部分生产性状和免疫性状的关联，结果发现①G尺B7基因第163位点不同基因
型个体在屠宰率困P)、红细胞数(RBC)上差异显著(P<0.05)，CC基因型的个体与
TT基因型的个体的20周龄时血清中IgG的含量(I gG)差异极显著(P<0.01);在243位
点，不同基因型的个体之间肌肉pH值(MPH)、红细胞数(RBC)、红细胞压积(HCT)
差异显著(P<0.05);②G尺厅基因不同基因型的个体之间剪切力(Shear foree)、眼肌面
积(LMA)、板油率差异显著(P<0.05);③COLIA了基因第170位点GG基因型个体与
AA、AG基因型个体之间红细胞分布宽度(RDw)差异显著(P二0.0146);④MAc30
基因AG基因型个体与AA基因型个体之间第6、7肋间背膘厚(6一7BF)及三点平均背
膘厚(ABF)差异极显著(P<0.01);⑤7了P一了基因282位点TG基因型个体与TT基因型
个体屠宰率(DP%)差异显著(P=0.0404)，腿臀比率(Ham)差异极显著(P=0.0087)。
The objective of this thesis was to isolate, characterize and physically map the novel genes on pig chromosome 12 using information derived from comparative mapping and pig EST database. The association between genes and some economic traits is also studied. The main results are as follows:
1. Pig ESTs were identified through standard BLAST analysis by using cDNA sequences
of human homologous genes on chromosome 17. Highly conserved pig ESTs were assembled
to EST contigs. And primers selected from the contigs were used to isolate 10 novel porcine
gene fragments from Hubei White pigs genomic DNA. The 10 novel porcine genes were as
follows: phospholipase D2(PLD2),Growth factor receptor binding protein7(CRB7), granulins
(GRN) , collagen, type I, alpha 1 (COL1A1) , amnnose-p-dolichol utilization defect 1
(MPDU1) ,tubulin-specific chaperone d (TBCD) ,GCN5 general control of amino-acid
synthesis 5-like 2 (yeast) (GCN5L2) , MAC30 (.MAC30) , TIP-1 Tax interaction protein 1
(TIP-1) and KIAA1582 (KIAA1582) gene.
2. The full length cDNA of MPDU1 and GRN genes were obtained through in silico cloning together with RACE. The deduced amino acid sequences of MPDU1 and GRN proteins show 91% and 70% similarity to corresponding human sequences, respectively.
3. Expression profiles of MPDU1 and GRN genes of Tongcheng pigs were analysis by semi-quantitative RT-PCR assay. MPDU1 gene is widely expressed in tissues of kidney, heart, lung, spleen and liver and there is no significant difference between each tissue; while GRN gene is highly expressed in the spleen and lowly expressed in heart.
4. The pig rodent somatic cell hybrid panel (SCHP) was used for regional assignment of the 8 genes. The GRB7, COL1A1 and K1AA1582 genes were localized to SSC12pl 1- (2/3) pl3 with error risk <0.1%. The probability of regional localization and correlation for the 3 genes was 0.8901 and 1.0, respectively. The PLD2, MPDU1, MAC30 and TIP-1 genes were physically mapped to SSC12qll-ql5 with error risk <0.1%. The probability of regional localization and correlation for the 4 genes was 0.9862 and 1, respectively. The TBCD gene was physically mapped to SSC12p 11-(2/3 p13) (P=0.4701) or 12qll-ql5 (P= 0. 4701) with error risk <0.1%. The correlation of localization to the two regions of the gene was 0.9177 and 0.9117, respectively.
5. The INRA-University of Minnesota porcine radiation hybrid (IMpRH) panel was employed to determine the precise location of nine novel genes. Statistical analysis revealed that all the 9 genes were closely linked to genes or markers on pig chromosome 12. PLD2 and
MAC30 genes were both located closely to marker Swc23, with LOD score threshold 6.11 and 15.58, respectively. The GRB7 and GCN5L2 genes were both closely linked to Sw943, with LOD score threshold of 15.25 and 10.03, respectively. The GRN gene was closely linked to Sw957, with LOD score threshold of 8.81. The COLlAl gene was closely linked to Swr390, with LOD score threshold of 21.28. The TBCD gene was closely linked to Sw2490, with LOD score threshold of 4.96. The TIP-1 gene was closely linked to Swl936, with LOD score threshold of 10.96. The KIAA1582 gene was closely linked to Sw2494, with LOD score threshold of 9.47.
6. Studies on polymorphic sites of GRB7, GRN, COLlAl, MPDU1 > MAC30, TIP-1 genes by PCR-RFLP revealed nine polymorphic sites. Allele frequencies among different pig populations were determined. A SINE indel polymorphism was detected in the intron 21 of PLD2, and allele frequencies among different pig populations was determined, too.
7. Codominant inheritance of the above polymorphic sites were demonstrated in the Landracec (Large WhitexTongcheng) and Large Whitex (LandracexTongcheng) two-generation pedigrees.
8. The above polymorphic sites were genotyped in the experimental pig population constructed under the cooperation of our lab and animal husbandry bureau of Tongcheng county (include 22 Landrace pigs,58 Tongcheng pigs,23 Large White pigs,23 Landrace
(Large WhitexTongcheng) pigs and 21 Large White (LandracexTongcheng) pig
引文
1．王文君，陈克飞，任军，丁能水，林万华，高军，艾华水，黄路生．生长激素基因(GH2)多态与猪部分生产性能的关系．遗传学报，2002，29(2)：111-114
2．刘海峰，帅素容．pGH基因全序列ApaⅠ酶切位点多态性与生产性能的相关分析。四川师范学院学报：自然科学版，2003，24(3)：330-334
3．刘桂兰，蒋思文，熊远著，郑嵘，屈彦纯．IGF2基因PCR-RFLP多态性与脂肪沉积相关性状的关联分析。遗传学报，2003，30(12)：1107-1112
4．刘桂兰，蒋思文，熊远著，郑嵘，屈彦纯．猪资源家系MC4R基因扫描及其与脂肪性状的相关分析。遗传学报，2002，29(6)：497-501
5．刘榜．15个猪品种MHC Ⅱ类区4个基因的SNPs分析及与免疫性状的关联。(博士学位论文)，武汉，华中农业大学，2003
6．宋成义，经荣斌，陶勇，高波，张金存．陈华才，黄富林，杨元清．猪GH基因部分突变位点对生产性能的影响。遗传，2001，23(5)：427-430
7．李宁，吴常信．动物分子育种：一门发展中的新型学科．农业生物技术学报，1997，5(2)：144-147
8．李伟，印莉萍．基因组学相关概念及其研究进展。生物学通报，2000，35(11)：1-3
9．李加琪，陈赞谋，刘德武，刘小红，孙宝丽，凌飞，张豪，陈瑶生．IFG-1基因对长白×蓝塘猪资源群生产性能的遗传效应分析。遗传学报，2003，30(9)：835-839
10．余梅．猪12号染色体上四个新基因的分离、鉴定与物理定位。(博士学位论文)，武汉，华中农业大学，2002
11．张淑君，熊远著，邓昌彦，曾凡同，邱祥聘，肖森木，夏瑜，徐建祥，刘晓华．猪产仔数分子标记及其效应分析。生物技术通报，2003，2：36-40
12．张伟力，猪肉肉色与酸度测定方法，养猪，2002a(2)：33-34
13．张伟力，猪肉系水力测定方法，养猪，2002b(3)：25-26
14．张伟力．猪肉质地与风味测定，养猪，2002c(4)：33-35
15．陈润生，优质猪肉的指标及其度量方法，养猪业，2002(3)：1-5
16．陈克飞，黄路生，李宁，张勤，罗明，吴常信．猪雌激素受体(ESR)基因对产仔数性状的影响。遗传学报，2000，27(10)：853-857
17．施启顺，黄生强，柳小春，贺长青 蒋隽．不同猪种E．coli F18受体基因的多态性。遗传学报，2003，30(3)：221-224
18．赵要风，李宁，肖璐，曹更生，陈怡真，张顺，陈永福，吴常信，张建生，孙士铨，徐学清．猪FSH β亚基基因结构区逆转座子插入突变及其与猪产仔数关系的研究。中国科学，1999，1(1)：81-86
19．钟金城，陈智华．分子遗传学与动物育种。成都，四川大学出版社，2001。
20．徐宁迎，章胜乔，彭淑红．金华猪3个繁殖性状主基因的分布及其效应的研究。遗传学报，2003，
30(12)：1090-1096
21．彭中镇主编，猪的遗传改良，农业出版社，1994
22．戢福云．染色体显微操作技术应用于黄鳝基因定位研究。(博士学位论文)，武汉，武汉大学，2001
23. Alho HS, Inkinen KA, Salminen US, Maasilta PK, Taskinen EI, Glumoff V, Vuorio EI, Ikonen TS, Harjula AL. Collagens Ⅰ and Ⅲ in a porcine bronchial model of obliterative bronchiolitis. Am J Respir Crit Care Med, 2001, 164(8 Pt 1): 1519-1525.
24. Anand M, Rush JS, Ray S, Doucey MA, Weik J, Ware FE, Hofsteenge J, Waechter CJ, Lehrman MA. Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals. Mol Biol Cell, 2001, 12(2): 487-501.
25. Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson K, Andersson-Eklund L, et al. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science, 1994, 263(5154): 1771-1774.
26. Asano A, Ko JH, Morozumi T, Hamashima N, Watanabe T. Polymorphisms and the antiviral property of porcine Mx1 protein. J Vet Med Sci, 2002, 64(12): 1085-1089.
27. Atalay A, Crook T, Ozturk M, Yulug IG. Identification of genes induced by BRCAI in breast cancer cells. Biochem Biophys Res Commun, 2002, 299(5): 839-846.
28. Bertani GR, Johnson RK, Robic A, Pomp D. Mapping of porcine ESTs obtained from the anterior pituitary. Anim Genet, 2003, 34(2): 132-134.
29. Bertrand C, Bergounioux C, Domenichini S, Delarue M, Zhou DX. Arabidopsis histone acetyltransferase AtGCN5 regulates the floral meristem activity through the WUSCHEL/AGAMOUS pathway. J Biol Chem, 2003, 278(30): 28246-28251.
30. Bhandari V, Bateman A. Structure and chromosomal location of the human granulin gene. Biochem Biophys Res Commun, 1992, 188(1): 57-63.
31. Bhandari V, Palfree RG, Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc Natl Acad Sci USA, 1992, 89(5): 1715-1719.
32. Bidanel JP, Rothschild MF. Current status of quantitative trait locus mapping in pigs. pig news and information, 2002, 23: 39N-53N.
33. Brunsch C, Sternstein I, Reinecke P, Bieniek J. Analysis of associations of PIT1 genotypes with growth, meat quality and carcass composition traits in pigs. J Appl Genet, 2002, 43(1): 85-91.
34. Candau R, Berger SL. Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo. J Biol Chem, 1996, 271(9): 5237-5245.
35. Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol, 1996, 16(2): 593-602.
36. Candau R, Zhou JX, Allis CD, Berger SL. Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. Embo J, 1997, 16(3): 555-565.
37. Capone MC, Gorman DM, Ching EP, Zlotnik A. Identification through bioinformatics of cDNAs
encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family, J Immunol, 1996, 157(3): 969-973.
38. Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA. The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. Genomics, 1997, 40(3): 497-500.
39. Casas-Carrillo E, Prill-Adams A, Price SG, Clutter AC, Kirkpatrick BW. Relationship of growth hormone and insulin-like growth factor-1 genotypes with growth and carcass traits in swine. Anim Genet, 1997, 28(2): 88-93.
40. Cassady JP, Johnson RK, Pomp D, Rohrer GA, Van Vleck LD, Spiegel EK, Gilson KM. Identification of quantitative trait loci affecting reproduction in pigs. J Anim Sci, 2001, 79(3): 623-633.
41. Ciobanu D, Bastiaansen J, Malek M, Helm J, Woollard J, Plastow G, Rothschild M. Evidence for new alleles in the protein kinase adenosine monophosphate-activated gamma(3)-subunit gene associated with low glycogen content in pig skeletal muscle and improved meat quality. Genetics, 2001, 159(3): 1151-1162.
42. Cirera S, Jorgensen CB, Sawera M, Raudsepp T, Chowdhary BP, Fredholm M. Comparative mapping in the pig: localization of 214 expressed sequence tags. Mamm Genome, 2003, 14(6): 405-426.
43. Clop A, Ovilo C, Perez-Enciso M, Cercos A, Tomas A, Fernandez A, Coll A, et al. Detection of QTL affecting fatty acid composition in the pig. Mamm Genome, 2003, 14(9): 650-656.
44. consortium TMs. Complete sequence and gene map of a human major histocompatibility complex. Nature, 1999, 401(6756): 921-923.
45. Cox DR, Burmeister M, Price ER, Kim S, Myers RM. Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science, 1990, 250(4978): 245-250.
46. Davoli R, Fontanesi L, Zambonelli P, Bigi D, Gellin J, Yerle M, Milc J, et al. Isolation of porcine expressed sequence tags for the construction of a first genomic transcript map of the skeletal muscle in pig. Anim Genet, 2002, 33(1): 3-18.
47. de Koning DJ, Rattink AP, Harlizius B, van Arendonk JA, Brascamp EW, Groenen MA. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc Natl Acad Sci USA, 2000, 97(14): 7947-7950.
48. Dong LQ, Du H, Porter SG, Kolakowski LF, Jr., Lee AV, Mandarino LJ, Fan J, et al. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. J Biol Chem, 1997, 272(46): 29104-29112.
49. Drogemuller C, Hamann H, Distl O. Candidate gene markers for litter size in different German pig lines. J Anim Sci, 2001, 79(10): 2565-2570.
50. Edfors-Lilja I, Gustafsson U, Duval-Iflah Y, Ellergren H, Johansson M, Juneja RK, Marklund L, Andersson L. The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen. Anim Genet,
1995, 26(4): 237-242.
51. Ernst CW, Robic A, Yerle M, Wang L, Rothschild ME Mapping of calpastatin and three microsatellites to porcine chromosome 2q2.1-q2.4. Anim Genet, 1998, 29(3): 212-215.
52. Exton JH. Phospholipase D: enzymology, mechanisms of regulation, and function. Physiol Rev, 1997, 77(2): 303-320.
53. Fanning AS, Anderson JM. PDZ domains and the formation of protein networks at the plasma membrane. Curr Top Microbiol Immunol, 1998, 228: 209-233.
54. Fanning AS, Anderson JM. PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest, 1999, 103(6): 767-772.
55. Fisher S, Jagadeeswaran P, Halpern ME. Radiographic analysis of zebrafish skeletal defects. Dev Biol, 2003, 264(1): 64-76.
56. Francis DH, Erickson AK, Grange PA. K88 adhesins of enterotoxigenic Escherichia coli and their porcine enterocyte receptors. Advances in Experimental Medicine and Biology, 1999, 473:147-154
57. Fujii J, Otsu K, Zorzato F, de Leon S, Khanna VK, Weiler JE, O'Brien PJ, MacLennan DH. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science, 1991,253(5018): 448-451.
58. Geffrotin C, Popescu CP, Cribiu EP, Boscher J, Renard C, Chardon P, Vaiman M. Assignment of MHC in swine to chromosome 7 by in situ hybridization and serological typing. Ann Genet, 1984, 27(4): 213-219.
59. Geldermann H, Muller E, Beeckmann P, Knorr C, Yue G. Mapping of quantitative traits loci by means of marker genes in F2 generations of wild boar, Pietrain and Meishan pigs. J Anim Breed Genet, 1996, 113(6): 381-387.
60. Geldermann H, Muller E, Moser G, Reiner G, Bartenschlager H, Cepica S, Stratil A, et al. Genome-wide linkage and QTL mapping in porcine F2 families generated from Pietrain, Meishan and Wild Board crosses. Journal of Animal Breeding and Genetics, 2003, 120(6): 363-393.
61. Gerard GF, Fox DK, Nathan M, D'Alessio JM. Reverse transcriptase. The use of cloned Moloney murine leukemia virus reverse transcriptase to synthesize DNA from RNA. Mol Biotechnol, 1997, 8(1): 61-77.
62. Gerbens F, Jansen A, van Erp AJ, Harders F, Meuwissen TH, Rettenberger G, Veerkamp JH, te Pas MF. The adipocyte fatty acid-binding protein locus: characterization and association with intramuscular fat content in pigs. Mamm Genome, 1998, 9(12): 1022-1026.
63. Gerbens F, van Erp AJ, Harders FL, Verburg F J, Meuwissen TH, Veerkamp JH, te Pas MF. Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performance traits in pigs. J Anim Sci, 1999, 77(4): 846-852.
64. Goto T, Katada T, Kinoshita T, Kubota HY. Expression and characterization of Xenopus type Ⅰ collagen alpha 1 (COL1A1) during embryonic development. Dev Growth Differ, 2000, 42(3): 249-256.
65. Goureau A, Yerle M, Schmitz A, Riquet J, Milan D, Pinton P, Frelat G, Gellin J. Human and porcine correspondence of chromosome segments using bidirectional chromosome painting. Genomics, 1996, 36(2): 252-262.
66. Hamasima N, Suzuki H, Mikawa A, Morozumi T, Plastow G, Mitsuhashi T. Construction of a new porcine whole-genome framework map using a radiation hybrid panel. Anim Genet, 2003, 34(3): 216-220.
67. Hamilton DN, Ellis M, Miller KD, McKeith FK, Parrett DF. The effect of the Halothane and Rendement Napole genes on carcass and meat quality characteristics of pigs. J Anim Sci, 2000, 78(11): 2862-2867.
68. Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem, 1995, 270(50): 29640-29643.
69. Han DC, Shen TL, Miao H, Wang B, Guan JL. EphBl associates with Grb7 and regulates cell migration. J Biol Chem, 2002, 277(47): 45655-45661.
70. Harbitz I, Kristensen T, Bosnes M, Kran S, Davies W. DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg615——Cys615 mutation, associated with porcine malignant hyperthermia, in Norwegian landraee pigs. Anim Genet, 1992, 23(5): 395-402.
71. Hawken RJ, Murtaugh J, Flickinger GH, Yerle M, Robic A, Milan D, Gellin J, et al. A first-generation porcine whole-genome radiation hybrid map. Mamm Genome, 1999, 10(8): 824-830.
72. He Z, Ong CH, Halper J, Bateman A. Progranulin is a mediator of the wound response. Nat Med, 2003, 9(2): 225-229.
73. Hettmann C, Soldati D. Cloning and analysis of a Toxoplasma gondii histone acetyltransferase: a novel chromatin remodelling factor in Apicomplexan parasites. Nucleic Acids Res, 1999, 27(22): 4344-4352.
74. Hirooka H, de Koning DJ, Harlizius B, van Arendonk JA, Rattink AP, Groenen MA, Brascamp EW, Bovenhuis H. A whole-genome scan for quantitative trait loci affecting teat number in pigs. J Anim Sci, 2001, 79(9): 2320-2326.
75. Huerre C, Junien C, Weil D, Chu ML, Morabito M, Van Cong N, Myers JC, et al. Human type Ⅰ procollagen genes are located on different chromosomes. Proc Natl Acad Sci U S A, 1982, 79(21): 6627-6630.
76. Jansen JH, Hogasen K, Grondahl AM. Porcine membranoproliferative glomerulonephritis type Ⅱ: an autosomal recessive deficiency of factor H. Vet Rec, 1995, 137(10): 240-244.
77. Janzen MA, Kuhlers DL, Jungst SB, Louis CF. ARPP-16 mRNA is up-regulated in the longissimus muscle of pigs possessing an elevated growth rate. J Anim Sci, 2000, 78(6): 1475-1484.
78. Jiang YL, Li N, Plastow G, Liu ZL, Hu XX, Wu CX. Identification of three SNPs in the porcine myostatin gene (MSTN). Anim Biotechnol, 2002, 13(1): 173-178.
79. Jiang ZH, Gibson JP. Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mamm Genome, 1999, 10(2): 191-193.
80. Johansson M, Ellegren H, Andersson L. Comparative mapping reveals extensive linkage conservation--but with gene order rearrangements--between the pig and the human genomes. Genomics, 1995, 25(3): 682-690.
81. Johansson Moller M, Chaudhary R, Hellmen E, Hoyheim B, Chowdhary B, Andersson L. Pigs with
the dominant white coat color phenotype carry a duplication of the KIT gene encoding the mast/stem cell growth factor receptor. Mamm Genome, 1996, 7(11): 822-830.
82. Johnson RK, Nielsen MK, Casey DS. Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size. J Anim Sci, 1999, 77(3): 541-557.
83. Kelley LA, MacCallum RM, Sternberg MJ. Enhanced genome annotation using structural profiles in the program 3D-PSSM. J Mol Biol, 2000, 299(2): 499-520.
84. Kierstein S, Brenig B. Assignment of neuronal pentraxin Ⅰ(NPTX1) gene to porcine chromosome 12pter by somatic cell and radiation hybrid panel mapping. Cytogenet Genome Res, 2002, 98(1): 108C.
85. Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, et al. Functional genetic analysis of mouse chromosome 11. Nature, 2003, 425(6953): 81-86.
86. Kim KS, Larsen N, Short T, Plastow G, Rothschild MF. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome, 2000, 11(2): 131-135.
87. Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD. ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. J Biol Chem, 2003, 278(4): 2661-2668.
88. Knorr C, Moser G, Muller E, Geldermann H. Associations of GH gene variants with performance traits in F2 generations of European wild boar, Pietrain and Meishan pigs. Anim Genet, 1997, 28(2): 124-128.
89. Kodaki T, Yamashita S. Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain. J Biol Chem, 1997, 272(17): 11408-11413.
90. Korkko J, Ala-Kokko L, De Paepe A, Nuytinck L, Earley J, Prockop DJ, Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type Ⅰ: identification of common sequences of null-allele mutations. Am J Hum Genet, 1998, 62(1): 98-110.
91. Kuivaniemi H, Tromp G, Chu ML, Prockop DJ. Structure of a full-length cDNA clone for the prepro alpha 2(Ⅰ) chain of human type Ⅰ procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation. Biochem J, 1988, 252(3): 633-640.
92. Kumar KG, Ponsuksili S, Sehellander K, Wimmers K. Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits, Immunogenetics, 2004, 55(12): 811-817.
93. Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature, 1996, 383(6597): 269-272.
94. Kuo MH, Zhou J, Jambeck P, Churchill ME, Allis CD. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev, 1998, 12(5): 627-639.
95. Kuryl J, Pierzchala M. Association of POU1F1/Rsal genotypes with carcass traits in pigs. J Appl Genet, 2001,42(3): 309-316.
96. Kwun H J, Lee JH, Min do S, Jang KL. Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2. FEBS Lett, 2003, 544(1-3): 38-44.
97. Lahbib-Mansais Y, Tosser-Klopp G, Leroux S, Cabau C, Karsenty E, Milan D, Barillot E, et al. Contribution to high-resolution mapping in pigs with 101 type Ⅰ markers and progress in comparative map between humans and pigs. Mamm Genome, 2003, 14(4): 275-288.
98. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, et al. Initial sequencing and analysis of the human genome. Nature, 2001, 409(6822): 860-921.
99. Le Roy P, Naveau J, Elsen JM, Sellier P. Evidence for a new major gene influencing meat quality in pigs. Genet Res, 1990, 55(1): 33-40.
100. Levin B. Gene Ⅶ, Oxford University Press, New York,2000.
101. Lewis SA, Tian G, Vainberg IE, Cowan NJ. Chaperonin-mediated folding of actin and tubulin. J Cell Biol, 1996, 132(1-2): 1-4.
102. Liau LM, Lallone RL, Seitz RS, Buznikov A, Gregg JP, Kornblum HI, Nelson SF, Bronstein JM. Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption. Cancer Res, 2000, 60(5): 1353-1360.
103. Lin L, Liu B, Yu M, Yerle M, Fan B, Yang J, Li K. Radiation hybrid mapping of the pig ALDOA, ALDOB and ALDOC genes to SSC3, SSC1 and SSC12. Anim Genet, 2004, 35(1): 66-67.
104. Linville RC, Pomp D, Johnson RK, Rothschild MF. Candidate gene analysis for loci affecting litter size and ovulation rate in swine. J Anim Sci, 2001, 79(1): 60-67.
105. Lumsden JS, Kennedy BW, Mallard BA, Wilkie BN. The influence of the swine major histocompatibility genes on antibody and cell-mediated immune responses to immunization with an aromatic-dependent mutant of Salmonella typhimurium. Can J Vet Res, 1993, 57(1): 14-18.
106. Malek M, Dekkers JC, Lee HK, Baas TJ, Prusa K, Huff-Lonergan E, Rothschild MF. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. Ⅱ. Meat and muscle composition. Mamm Genome, 2001a, 12(8): 637-645.
107. Malek M, Dekkers JC, Lee HK, Baas TJ, Rothschild MF. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. Ⅰ. Growth and body composition. Mamm Genome, 2001b, 12(8): 630-636.
108. Malhotra K, Luehrsen KR, Costello LL, Raich TJ, Sim K, Foltz L, Davidson S, et al. Identification of differentially expressed mRNAs in human fetal liver across gestation. Nucleic Acids Res, 1999, 27(3): 839-847.
109. Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. Embo J, 1994, 13(20): 4807-4815.
110. Margolis B, Siivennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A, 1992, 89(19): 8894-8898.
111. Mariani P, Lundstrom K, Gustafsson U, Enfalt AC, Juneja RK, Andersson L. A major locus (RN) affecting muscle glycogen content is located on pig chromosome 15. Mamm Genome, 1996, 7(1): 52-54.
112. Martin L, Fanarraga ML, Aloria K, Zabala JC. Tubulin folding cofactor D is a microtubule destabilizing protein. FEBS Lett, 2000, 470(1): 93-95.
113. Meijerink E, Fries R, Vogeli P, Masabanda J, Wigger G, Stricker C, Neuenschwander S, Bertschinger HU, Stranzinger G. Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Mamm Genome, 1997, 8(10): 736-741.
114. Mekchay S, Ponsuksili S, Schellander K, Wimmers K. Association of the porcine C3 gene with haemolytic complement activity in the pig. Genet Sel Evol, 2003, 35 Suppl 1 : S83-96.
115. Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J. PCR amplification and physical localization of the genes for pig FSHB and LHB. Cytogenet Cell Genet, 1995, 70(3-4): 224-227.
116. Messer L, Wang L, C. L, Rothschild MF. Mapping and investigation of candidate genes for litter size in French Large White pigs. Anim Genet, 1996a, 27(suppl): 114.
117. Messer L, Wang L, Yelich J, Pomp D, Geisert R, Rothschild MF. Linkage mapping of the retinoic acid receptor-gamma gene to porcine chromosome 5. Anim Genet, 1996b, 27(3): 175-177.
118. Messer LA, Wang L, Yelich J, Pomp D, Geisert RD, Rothschild MF. Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine chromosome 14. Mamm Genome, 1996c, 7(5): 396.
119. Milan D, Woloszyn N, Yerle M, Le Roy P, Bonnet M, Riquet J, Lahbib-Mansais Y, et al. Accurate mapping of the "acid meat" RN gene on genetic and physical maps of pig chromosome 15. Mamm Genome, 1996, 7(1): 47-51.
120. Milan D, Jeon JT, Looft C, Amarger V, Robic A, Thelander M, Rogel-Gaitlard C, et al. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science, 2000, 288(5469): 1248-1251.
121. Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics, 2001, 74(2): 234-244.
122. Moller S, Croning MD, Apweiler R. Evaluation of methods for the prediction of membrane spanning regions. Bioinformatics, 2001, 17(7): 646-653.
123. Monson JM, Friedman J, McCarthy BJ. DNA sequence analysis of a mouse pro alpha 1 (Ⅰ) procollagen gene: evidence for a mouse B1 element within the gene. Mol Cell Biol, 1982, 2(11): 1362-1371.
124. Muller M, Brenig B, Winnacker EL, Brem G. Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene, 1992, 121 (2): 263-270.
125. Munoz G, Ovilo C, Noguera JL, Sanchez A, Rodriguez C, Silio L. Assignment of the fatty acid synthase (FASN) gene to pig chromosome 12 by physical and linkage mapping. Anita Genet, 2003, 34(3): 234-235.
126. Murphy M, Pykett MJ, Harnish P, Zang KD, George DL. Identification and characterization of genes differentially expressed in meningiomas. Cell Growth Differ, 1993, 4(9): 715-722.
127. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, et al. Prediction of the coding sequences of unidentified human genes. Ⅷ. The complete sequences of 100 new
cDNA clones from brain which code for large proteins in vitro. DNA Res, 1999, 6(1): 63-70.
128. Nezer C, Collette C, Moreau L, Brouwers B, Kim JJ, Giuffra E, Buys N, Andersson L, Georges M. Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene. Genetics, 2003, 165(1): 277-285.
129. Nutbrown RF, McEwen MR, Thomas RA, Duane S, Shipley DR. Comparison of conversion factors for x-ray beams from a Philips SL15 and the NPL linear accelerator. Phys Med Biol, 2001, 46(11): N245-252.
130. Park HB, Carlborg O, Marklund S, Andersson L. Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Anim Genet, 2002, 33(2): 155-157.
131. Park SK, Provost JJ, Bae CD, Ho WT, Exton JH. Cloning and characterization of phospholipase D from rat brain. J Biol Chem, 1997, 272(46): 29263-29271.
132. Paszek AA, Wilkie PJ, Flickinger GH, Miller LM, Louis CF, Rohrer GA, Alexander LJ, Beattie CW, Schook LB. Interval mapping of carcass and meat quality traits in a divergent swine cross. Anim Biotechnol, 2001, 12(2): 155-165.
133. Pita RH, Ramos AM, Lopes PS, Guimaraes SE, Rothschild MF. Assignment of the porcine peptide YY gene to chromosome 12. Anim Genet, 2003, 34(6): 469.
134 Plowman GD, Green JM, Neubauer MG, Buckley SD, McDonald VL, Todaro GJ, Shoyab M. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J Biol Chem, 1992, 267(18): 13073-13078.
135. Ponsuksili S, Wimmers K, Yerle M, Schellander K. Mapping of 93 porcine ESTs preferentially expressed in liver. Mamm Genome, 2001, 12(11): 869-872.
136. Pope FM, Nicholls AC, McPheat J, Talmud P, Owen R. Collagen genes and proteins in osteogenesis imperfecta. J Med Genet, 1985, 22(6): 466-478.
137. Reiner G, Heinricy L, Muller E, Geldermann H, Dzapo V. Indications of associations of the porcine FOS proto-oncogene with skeletal muscle fibre traits. Anim Genet, 2002, 33(1): 49-55.
138. Rothschild M, Jacobson C, Vaske D, Tuggle C, Wang L, Short T, Eekardt G, et al. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Natl Acad Sci U S A, 1996, 93(1): 201-205.
139. Rothschild MF. From a sow's ear to a silk purse: real progress in porcine genomics. Cytogenet Genome Res, 2003, 102(1-4): 95-99.
140. Sasaki S, Clutter AC, Pomp D. Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism. Mamm Genome, 1996, 7(6): 471-472.
141. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Korn-Lubetzki Ⅰ, et al. MPDUI mutations underlie a novel human congenital disorder of glycosylation, designated type If. J Clin Invest, 2001a, 108(11): 1687-1695.
142. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Raas-Rotschild A, et al. MPDUI mutations underlie a novel human congenital disorder of glycosylation, designated type If. J Clin Invest, 2001b, 108(11): 1687-1695.
143. Shackelford SD, Koohmaraie M, Cundiff LV, Gregory KE, Rohrer GA, Savell JW. Heritabilities and phenotypic and genetic correlations for bovine postrigor calpastatin activity, intramuscular fat content, Warner-Bratzler shear force, retail product yield, and growth rate. J Anim Sci, 1994, 72(4): 857-863.
144. Shen TL, Han DC, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J Biol Chem, 2002, 277(32): 29069-29077.
145. Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y, Allis CD. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res, 1998, 26(12): 2948-2954.
146. Smith TP, Rohrer GA, Alexander LJ, Troyer DL, Kirby-Dobbels K.R, Janzen MA, Comwell DL, et al. Directed integration of the physical and genetic linkage maps of swine chromosome 7 reveals that the SLA spans the centromere. Genome Res, 1995, 5(3): 259-271.
147. Southwood OI, Short TH, Plastow GS. Genetic markers for litter size in commercial lines of pigs. Proc 6th Wold Congr Appl Livest Prod, 1998, 26: 453-456.
148. Stover ML, Primorac D, Liu SC, McKinstry MB, Rowe DW. Defective splicing of mRNA from one COL1A1 allele of type Ⅰ collagen in nondeforming (type Ⅰ) osteogenesis imperfecta. J Clin Invest, 1993, 92(4): 1994-2002.
149. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA, 2002, 99(26): 16899-16903.
150. Syntichaki P, Thireos G. The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5. J Biol Chem, 1998, 273(38): 24414-24419.
150. Tanaka S, Sugimachi K, Kawaguchi H, Saeki H, Ohno S, Wands JR. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. J Cell Physiol, 2000, 183(3): 411-415.
152. te Pas MF, Soumillion A, Harders FL, Verburg FJ, van den Bosch TJ, Galesloot P, Meuwissen TH. Influences of myogenin genotypes on birth weight, growth rate, carcass weight, backfat thickness, and lean weight of pigs. J Anim Sci, 1999, 77(9): 2352-2356.
153. te Pas MF, Verburg FJ, Gerritsen CL, de Greef KH. Messenger ribonucleic acid expression of the MyoD gene family in muscle tissue at slaughter in relation to selection for porcine growth rate. J Anim Sci, 2000, 78(1): 69-77.
154. Thornton MA, Poncz M, Korostishevsky M, Yakobson E, Usher S, Seligsohn U, Peretz H. The human platelet alphaIIb gene is not closely linked to its integrin partner beta3. Blood, 1999, 94(6): 2039-2047.
155. Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ. Pathway leading to correctly folded beta-tubulin. Cell, 1996, 86(2): 287-296.
156. Tian G, Bhamidipati A, Cowan NJ, Lewis SA. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J Biol Chem, 1999, 274(34): 24054-24058.
157. Tromp G, Kuivaniemi H, Stacey A, Shikata H, Baldwin CT, Jaenisch R., Prockop DJ. Structure of a
full-length cDNA clone for the prepro alpha 1(Ⅰ) chain of human type Ⅰ procollagen. Biochem J, 1988, 253(3): 919-922.
158. Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Nucleic Acids Res, 2004, 32 Database issue: D484-488.
159. Van der Steen HA, Southwood OI, Vries AG, Short TH, McLaren DG, Wei M, Plastow GS. Evidence of a new genetic marker for litter size in Meishan Synthetic pigs, Proc Intern Conf Anima Biotech, 1997: 17-20.
160. Van Laere AS, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, Archibald AL, et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature, 2003, 425(6960): 832-836.
161. Vincent AL, Evans C, Short TH, Southwood OI, Plastow GS, Tuggle CK, Rothschild MF. The prolactin receptor gene is associate with increased litter size in pig. Proceedings of the 6th World congress on Genetics Applied to Livestock Production, 1998, 27: 15-18.
162. Vogeli P, Bertschinger HU, Stamm M, Stricker C, Hagger C, Fries R, Rapacz J, Stranzinger G. Genes specifying receptors for F18 fimhriated Escherichia coli, causing oedema disease and postweaning diarrhoea in pigs, map to chromosome 6. Anim Genet, 1996, 27(5): 321-328.
163. Wang L, Liu L, Berger SL. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev, 1998, 12(5): 640-653.
164. Wang YF, Yu M, Yerle M, Liu B, Zhao SH, Xiong TA, Fan B, Li K. Mapping of genes encoding four ATPase and three non-ATPase components of the pig 26S proteasome. Anim Genet, 2003, 34(5): 393-395.
165. Ware FE, Lehrman MA. Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells. J Biol Chem, 1996, 271(24): 13935-13938.
166. Wilmmers K, Ponsuksili S, Hardge T, Schellander K. Detection of candidate genes for functional traits in pigs. China-EU animal biotechnology conference proceedings, 2000: 45-57.
167. Wimmers K, Mekchay S, Schellander K, Ponsuksili S. Molecular characterization of the pig C3 gene and its association with complement activity. Immunogenetics, 2003, 54(10): 714-724.
168. Xia D, Zhao RQ, Wei XH, Xu QF, Chen J. Developmental patterns of GHr and SS mRNA expression in porcine gastric tissue. World J Gastroenterol, 2003, 9(5): 1058-1062.
169. Xu W, Edmondson DG, Roth SY. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol, 1998, 18(10): 5659-5669.
170. Yan XM, Ren J, Guo YM, Ding NS, Chen KF, Gao J, Ai HS, et al. Research on the genetic variations of al-fucosytransferase (FUT1) gene in 26 pig breeds, Yi Chuan Xue Bao, 2003, 30(9): 830-834.
171. Yang J, Li K, Liu B, Yerle M, Fan B, Xiong T, Yu M. Assignments of GRB7, GCN5L2, COL1A1 and TBCD to pig chromosome 12 by radiation hybrid mapping. Cytogenet Genome Res, 2003, 103(1-2): 204L.
172. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 1996, 382(6589): 319-324.
173. Yerle M, Echard G, Robic A, Mairal A, Dubut-Fontana C, Riquet J, Pinton P, et al. A somatic cell hybrid panel for pig regional gene mapping characterized by molecular cytogenetics. Cytogenet Cell Genet, 1996, 73(3): 194-202.
174. Yerle M, Pinton P, Robic A, Alfonso A, Palvadeau Y, Delcros C, Hawken R, et al. Construction of a whole-genome radiation hybrid panel for high-resolution gene mapping in pigs. Cytogenet Cell Genet, 1998, 82(3-4): 182-188.
175. Yerle M, Pinton P, Delcros C, Arnal N, Milan D, Robic A. Generation and characterization of a 12,000-rad radiation hybrid panel for fine mapping in pig. Cytogenet Genorae Res, 2002, 97(3-4): 219-228.
176. Yu M, Zhao S, Yerle M, Liu B, Xiong T, Li K. Isolation, physical mapping and polymorphism of the porcine ferredoxin reductase (FDXR) gene. Anim Genet, 2002, 33(5): 394-395.
177. Yu M, Liu B, Yerle M, Zhu M, Pan P, Fan B, Li K. Physical mapping of the rod cGMP-phosphodiesterase-subunit (PDE6G) gene to pig chromosome 12. Anim Genet, 2003, 34(1): 76-77.
178. Yu M, Wang Y, te Pas MF, Yerle M, Liu B, Fan B, Xiong T, Li K. Investigation of the porcine PA28 activator c-subunit (PSME3) gene: isolation, polymorphism and its chromosomal localization. Journal of Animal Breeding and Genetics, 2004, 121 (2): 142-148.
179. Yu TP, Tuggle CK, Schmitz CB, Rothschild MR Association of PIT1 polymorphisms with growth and carcass traits in pigs. J Anim Sci, 1995, 73(5): 1282-1288.
180. Yue G, Schroffel JR, Moser G, Bartenschlager H, Reiner G, Geldermann H. Linkage and QTL mapping for Sus scrofa chromosome 12. Journal of Animal Breeding and Genetics, 2003, 120(Suppl.1): 95-102.
2．刘海峰，帅素容．pGH基因全序列ApaⅠ酶切位点多态性与生产性能的相关分析。四川师范学院学报：自然科学版，2003，24(3)：330-334
3．刘桂兰，蒋思文，熊远著，郑嵘，屈彦纯．IGF2基因PCR-RFLP多态性与脂肪沉积相关性状的关联分析。遗传学报，2003，30(12)：1107-1112
4．刘桂兰，蒋思文，熊远著，郑嵘，屈彦纯．猪资源家系MC4R基因扫描及其与脂肪性状的相关分析。遗传学报，2002，29(6)：497-501
5．刘榜．15个猪品种MHC Ⅱ类区4个基因的SNPs分析及与免疫性状的关联。(博士学位论文)，武汉，华中农业大学，2003
6．宋成义，经荣斌，陶勇，高波，张金存．陈华才，黄富林，杨元清．猪GH基因部分突变位点对生产性能的影响。遗传，2001，23(5)：427-430
7．李宁，吴常信．动物分子育种：一门发展中的新型学科．农业生物技术学报，1997，5(2)：144-147
8．李伟，印莉萍．基因组学相关概念及其研究进展。生物学通报，2000，35(11)：1-3
9．李加琪，陈赞谋，刘德武，刘小红，孙宝丽，凌飞，张豪，陈瑶生．IFG-1基因对长白×蓝塘猪资源群生产性能的遗传效应分析。遗传学报，2003，30(9)：835-839
10．余梅．猪12号染色体上四个新基因的分离、鉴定与物理定位。(博士学位论文)，武汉，华中农业大学，2002
11．张淑君，熊远著，邓昌彦，曾凡同，邱祥聘，肖森木，夏瑜，徐建祥，刘晓华．猪产仔数分子标记及其效应分析。生物技术通报，2003，2：36-40
12．张伟力，猪肉肉色与酸度测定方法，养猪，2002a(2)：33-34
13．张伟力，猪肉系水力测定方法，养猪，2002b(3)：25-26
14．张伟力．猪肉质地与风味测定，养猪，2002c(4)：33-35
15．陈润生，优质猪肉的指标及其度量方法，养猪业，2002(3)：1-5
16．陈克飞，黄路生，李宁，张勤，罗明，吴常信．猪雌激素受体(ESR)基因对产仔数性状的影响。遗传学报，2000，27(10)：853-857
17．施启顺，黄生强，柳小春，贺长青 蒋隽．不同猪种E．coli F18受体基因的多态性。遗传学报，2003，30(3)：221-224
18．赵要风，李宁，肖璐，曹更生，陈怡真，张顺，陈永福，吴常信，张建生，孙士铨，徐学清．猪FSH β亚基基因结构区逆转座子插入突变及其与猪产仔数关系的研究。中国科学，1999，1(1)：81-86
19．钟金城，陈智华．分子遗传学与动物育种。成都，四川大学出版社，2001。
20．徐宁迎，章胜乔，彭淑红．金华猪3个繁殖性状主基因的分布及其效应的研究。遗传学报，2003，
30(12)：1090-1096
21．彭中镇主编，猪的遗传改良，农业出版社，1994
22．戢福云．染色体显微操作技术应用于黄鳝基因定位研究。(博士学位论文)，武汉，武汉大学，2001
23. Alho HS, Inkinen KA, Salminen US, Maasilta PK, Taskinen EI, Glumoff V, Vuorio EI, Ikonen TS, Harjula AL. Collagens Ⅰ and Ⅲ in a porcine bronchial model of obliterative bronchiolitis. Am J Respir Crit Care Med, 2001, 164(8 Pt 1): 1519-1525.
24. Anand M, Rush JS, Ray S, Doucey MA, Weik J, Ware FE, Hofsteenge J, Waechter CJ, Lehrman MA. Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals. Mol Biol Cell, 2001, 12(2): 487-501.
25. Andersson L, Haley CS, Ellegren H, Knott SA, Johansson M, Andersson K, Andersson-Eklund L, et al. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science, 1994, 263(5154): 1771-1774.
26. Asano A, Ko JH, Morozumi T, Hamashima N, Watanabe T. Polymorphisms and the antiviral property of porcine Mx1 protein. J Vet Med Sci, 2002, 64(12): 1085-1089.
27. Atalay A, Crook T, Ozturk M, Yulug IG. Identification of genes induced by BRCAI in breast cancer cells. Biochem Biophys Res Commun, 2002, 299(5): 839-846.
28. Bertani GR, Johnson RK, Robic A, Pomp D. Mapping of porcine ESTs obtained from the anterior pituitary. Anim Genet, 2003, 34(2): 132-134.
29. Bertrand C, Bergounioux C, Domenichini S, Delarue M, Zhou DX. Arabidopsis histone acetyltransferase AtGCN5 regulates the floral meristem activity through the WUSCHEL/AGAMOUS pathway. J Biol Chem, 2003, 278(30): 28246-28251.
30. Bhandari V, Bateman A. Structure and chromosomal location of the human granulin gene. Biochem Biophys Res Commun, 1992, 188(1): 57-63.
31. Bhandari V, Palfree RG, Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc Natl Acad Sci USA, 1992, 89(5): 1715-1719.
32. Bidanel JP, Rothschild MF. Current status of quantitative trait locus mapping in pigs. pig news and information, 2002, 23: 39N-53N.
33. Brunsch C, Sternstein I, Reinecke P, Bieniek J. Analysis of associations of PIT1 genotypes with growth, meat quality and carcass composition traits in pigs. J Appl Genet, 2002, 43(1): 85-91.
34. Candau R, Berger SL. Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo. J Biol Chem, 1996, 271(9): 5237-5245.
35. Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol, 1996, 16(2): 593-602.
36. Candau R, Zhou JX, Allis CD, Berger SL. Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. Embo J, 1997, 16(3): 555-565.
37. Capone MC, Gorman DM, Ching EP, Zlotnik A. Identification through bioinformatics of cDNAs
encoding human thymic shared Ag-1/stem cell Ag-2. A new member of the human Ly-6 family, J Immunol, 1996, 157(3): 969-973.
38. Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA. The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. Genomics, 1997, 40(3): 497-500.
39. Casas-Carrillo E, Prill-Adams A, Price SG, Clutter AC, Kirkpatrick BW. Relationship of growth hormone and insulin-like growth factor-1 genotypes with growth and carcass traits in swine. Anim Genet, 1997, 28(2): 88-93.
40. Cassady JP, Johnson RK, Pomp D, Rohrer GA, Van Vleck LD, Spiegel EK, Gilson KM. Identification of quantitative trait loci affecting reproduction in pigs. J Anim Sci, 2001, 79(3): 623-633.
41. Ciobanu D, Bastiaansen J, Malek M, Helm J, Woollard J, Plastow G, Rothschild M. Evidence for new alleles in the protein kinase adenosine monophosphate-activated gamma(3)-subunit gene associated with low glycogen content in pig skeletal muscle and improved meat quality. Genetics, 2001, 159(3): 1151-1162.
42. Cirera S, Jorgensen CB, Sawera M, Raudsepp T, Chowdhary BP, Fredholm M. Comparative mapping in the pig: localization of 214 expressed sequence tags. Mamm Genome, 2003, 14(6): 405-426.
43. Clop A, Ovilo C, Perez-Enciso M, Cercos A, Tomas A, Fernandez A, Coll A, et al. Detection of QTL affecting fatty acid composition in the pig. Mamm Genome, 2003, 14(9): 650-656.
44. consortium TMs. Complete sequence and gene map of a human major histocompatibility complex. Nature, 1999, 401(6756): 921-923.
45. Cox DR, Burmeister M, Price ER, Kim S, Myers RM. Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science, 1990, 250(4978): 245-250.
46. Davoli R, Fontanesi L, Zambonelli P, Bigi D, Gellin J, Yerle M, Milc J, et al. Isolation of porcine expressed sequence tags for the construction of a first genomic transcript map of the skeletal muscle in pig. Anim Genet, 2002, 33(1): 3-18.
47. de Koning DJ, Rattink AP, Harlizius B, van Arendonk JA, Brascamp EW, Groenen MA. Genome-wide scan for body composition in pigs reveals important role of imprinting. Proc Natl Acad Sci USA, 2000, 97(14): 7947-7950.
48. Dong LQ, Du H, Porter SG, Kolakowski LF, Jr., Lee AV, Mandarino LJ, Fan J, et al. Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma. J Biol Chem, 1997, 272(46): 29104-29112.
49. Drogemuller C, Hamann H, Distl O. Candidate gene markers for litter size in different German pig lines. J Anim Sci, 2001, 79(10): 2565-2570.
50. Edfors-Lilja I, Gustafsson U, Duval-Iflah Y, Ellergren H, Johansson M, Juneja RK, Marklund L, Andersson L. The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen. Anim Genet,
1995, 26(4): 237-242.
51. Ernst CW, Robic A, Yerle M, Wang L, Rothschild ME Mapping of calpastatin and three microsatellites to porcine chromosome 2q2.1-q2.4. Anim Genet, 1998, 29(3): 212-215.
52. Exton JH. Phospholipase D: enzymology, mechanisms of regulation, and function. Physiol Rev, 1997, 77(2): 303-320.
53. Fanning AS, Anderson JM. PDZ domains and the formation of protein networks at the plasma membrane. Curr Top Microbiol Immunol, 1998, 228: 209-233.
54. Fanning AS, Anderson JM. PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest, 1999, 103(6): 767-772.
55. Fisher S, Jagadeeswaran P, Halpern ME. Radiographic analysis of zebrafish skeletal defects. Dev Biol, 2003, 264(1): 64-76.
56. Francis DH, Erickson AK, Grange PA. K88 adhesins of enterotoxigenic Escherichia coli and their porcine enterocyte receptors. Advances in Experimental Medicine and Biology, 1999, 473:147-154
57. Fujii J, Otsu K, Zorzato F, de Leon S, Khanna VK, Weiler JE, O'Brien PJ, MacLennan DH. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science, 1991,253(5018): 448-451.
58. Geffrotin C, Popescu CP, Cribiu EP, Boscher J, Renard C, Chardon P, Vaiman M. Assignment of MHC in swine to chromosome 7 by in situ hybridization and serological typing. Ann Genet, 1984, 27(4): 213-219.
59. Geldermann H, Muller E, Beeckmann P, Knorr C, Yue G. Mapping of quantitative traits loci by means of marker genes in F2 generations of wild boar, Pietrain and Meishan pigs. J Anim Breed Genet, 1996, 113(6): 381-387.
60. Geldermann H, Muller E, Moser G, Reiner G, Bartenschlager H, Cepica S, Stratil A, et al. Genome-wide linkage and QTL mapping in porcine F2 families generated from Pietrain, Meishan and Wild Board crosses. Journal of Animal Breeding and Genetics, 2003, 120(6): 363-393.
61. Gerard GF, Fox DK, Nathan M, D'Alessio JM. Reverse transcriptase. The use of cloned Moloney murine leukemia virus reverse transcriptase to synthesize DNA from RNA. Mol Biotechnol, 1997, 8(1): 61-77.
62. Gerbens F, Jansen A, van Erp AJ, Harders F, Meuwissen TH, Rettenberger G, Veerkamp JH, te Pas MF. The adipocyte fatty acid-binding protein locus: characterization and association with intramuscular fat content in pigs. Mamm Genome, 1998, 9(12): 1022-1026.
63. Gerbens F, van Erp AJ, Harders FL, Verburg F J, Meuwissen TH, Veerkamp JH, te Pas MF. Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performance traits in pigs. J Anim Sci, 1999, 77(4): 846-852.
64. Goto T, Katada T, Kinoshita T, Kubota HY. Expression and characterization of Xenopus type Ⅰ collagen alpha 1 (COL1A1) during embryonic development. Dev Growth Differ, 2000, 42(3): 249-256.
65. Goureau A, Yerle M, Schmitz A, Riquet J, Milan D, Pinton P, Frelat G, Gellin J. Human and porcine correspondence of chromosome segments using bidirectional chromosome painting. Genomics, 1996, 36(2): 252-262.
66. Hamasima N, Suzuki H, Mikawa A, Morozumi T, Plastow G, Mitsuhashi T. Construction of a new porcine whole-genome framework map using a radiation hybrid panel. Anim Genet, 2003, 34(3): 216-220.
67. Hamilton DN, Ellis M, Miller KD, McKeith FK, Parrett DF. The effect of the Halothane and Rendement Napole genes on carcass and meat quality characteristics of pigs. J Anim Sci, 2000, 78(11): 2862-2867.
68. Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA. Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem, 1995, 270(50): 29640-29643.
69. Han DC, Shen TL, Miao H, Wang B, Guan JL. EphBl associates with Grb7 and regulates cell migration. J Biol Chem, 2002, 277(47): 45655-45661.
70. Harbitz I, Kristensen T, Bosnes M, Kran S, Davies W. DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg615——Cys615 mutation, associated with porcine malignant hyperthermia, in Norwegian landraee pigs. Anim Genet, 1992, 23(5): 395-402.
71. Hawken RJ, Murtaugh J, Flickinger GH, Yerle M, Robic A, Milan D, Gellin J, et al. A first-generation porcine whole-genome radiation hybrid map. Mamm Genome, 1999, 10(8): 824-830.
72. He Z, Ong CH, Halper J, Bateman A. Progranulin is a mediator of the wound response. Nat Med, 2003, 9(2): 225-229.
73. Hettmann C, Soldati D. Cloning and analysis of a Toxoplasma gondii histone acetyltransferase: a novel chromatin remodelling factor in Apicomplexan parasites. Nucleic Acids Res, 1999, 27(22): 4344-4352.
74. Hirooka H, de Koning DJ, Harlizius B, van Arendonk JA, Rattink AP, Groenen MA, Brascamp EW, Bovenhuis H. A whole-genome scan for quantitative trait loci affecting teat number in pigs. J Anim Sci, 2001, 79(9): 2320-2326.
75. Huerre C, Junien C, Weil D, Chu ML, Morabito M, Van Cong N, Myers JC, et al. Human type Ⅰ procollagen genes are located on different chromosomes. Proc Natl Acad Sci U S A, 1982, 79(21): 6627-6630.
76. Jansen JH, Hogasen K, Grondahl AM. Porcine membranoproliferative glomerulonephritis type Ⅱ: an autosomal recessive deficiency of factor H. Vet Rec, 1995, 137(10): 240-244.
77. Janzen MA, Kuhlers DL, Jungst SB, Louis CF. ARPP-16 mRNA is up-regulated in the longissimus muscle of pigs possessing an elevated growth rate. J Anim Sci, 2000, 78(6): 1475-1484.
78. Jiang YL, Li N, Plastow G, Liu ZL, Hu XX, Wu CX. Identification of three SNPs in the porcine myostatin gene (MSTN). Anim Biotechnol, 2002, 13(1): 173-178.
79. Jiang ZH, Gibson JP. Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds. Mamm Genome, 1999, 10(2): 191-193.
80. Johansson M, Ellegren H, Andersson L. Comparative mapping reveals extensive linkage conservation--but with gene order rearrangements--between the pig and the human genomes. Genomics, 1995, 25(3): 682-690.
81. Johansson Moller M, Chaudhary R, Hellmen E, Hoyheim B, Chowdhary B, Andersson L. Pigs with
the dominant white coat color phenotype carry a duplication of the KIT gene encoding the mast/stem cell growth factor receptor. Mamm Genome, 1996, 7(11): 822-830.
82. Johnson RK, Nielsen MK, Casey DS. Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size. J Anim Sci, 1999, 77(3): 541-557.
83. Kelley LA, MacCallum RM, Sternberg MJ. Enhanced genome annotation using structural profiles in the program 3D-PSSM. J Mol Biol, 2000, 299(2): 499-520.
84. Kierstein S, Brenig B. Assignment of neuronal pentraxin Ⅰ(NPTX1) gene to porcine chromosome 12pter by somatic cell and radiation hybrid panel mapping. Cytogenet Genome Res, 2002, 98(1): 108C.
85. Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, et al. Functional genetic analysis of mouse chromosome 11. Nature, 2003, 425(6953): 81-86.
86. Kim KS, Larsen N, Short T, Plastow G, Rothschild MF. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome, 2000, 11(2): 131-135.
87. Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD. ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. J Biol Chem, 2003, 278(4): 2661-2668.
88. Knorr C, Moser G, Muller E, Geldermann H. Associations of GH gene variants with performance traits in F2 generations of European wild boar, Pietrain and Meishan pigs. Anim Genet, 1997, 28(2): 124-128.
89. Kodaki T, Yamashita S. Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain. J Biol Chem, 1997, 272(17): 11408-11413.
90. Korkko J, Ala-Kokko L, De Paepe A, Nuytinck L, Earley J, Prockop DJ, Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type Ⅰ: identification of common sequences of null-allele mutations. Am J Hum Genet, 1998, 62(1): 98-110.
91. Kuivaniemi H, Tromp G, Chu ML, Prockop DJ. Structure of a full-length cDNA clone for the prepro alpha 2(Ⅰ) chain of human type Ⅰ procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation. Biochem J, 1988, 252(3): 633-640.
92. Kumar KG, Ponsuksili S, Sehellander K, Wimmers K. Molecular cloning and sequencing of porcine C5 gene and its association with immunological traits, Immunogenetics, 2004, 55(12): 811-817.
93. Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature, 1996, 383(6597): 269-272.
94. Kuo MH, Zhou J, Jambeck P, Churchill ME, Allis CD. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev, 1998, 12(5): 627-639.
95. Kuryl J, Pierzchala M. Association of POU1F1/Rsal genotypes with carcass traits in pigs. J Appl Genet, 2001,42(3): 309-316.
96. Kwun H J, Lee JH, Min do S, Jang KL. Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2. FEBS Lett, 2003, 544(1-3): 38-44.
97. Lahbib-Mansais Y, Tosser-Klopp G, Leroux S, Cabau C, Karsenty E, Milan D, Barillot E, et al. Contribution to high-resolution mapping in pigs with 101 type Ⅰ markers and progress in comparative map between humans and pigs. Mamm Genome, 2003, 14(4): 275-288.
98. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, et al. Initial sequencing and analysis of the human genome. Nature, 2001, 409(6822): 860-921.
99. Le Roy P, Naveau J, Elsen JM, Sellier P. Evidence for a new major gene influencing meat quality in pigs. Genet Res, 1990, 55(1): 33-40.
100. Levin B. Gene Ⅶ, Oxford University Press, New York,2000.
101. Lewis SA, Tian G, Vainberg IE, Cowan NJ. Chaperonin-mediated folding of actin and tubulin. J Cell Biol, 1996, 132(1-2): 1-4.
102. Liau LM, Lallone RL, Seitz RS, Buznikov A, Gregg JP, Kornblum HI, Nelson SF, Bronstein JM. Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption. Cancer Res, 2000, 60(5): 1353-1360.
103. Lin L, Liu B, Yu M, Yerle M, Fan B, Yang J, Li K. Radiation hybrid mapping of the pig ALDOA, ALDOB and ALDOC genes to SSC3, SSC1 and SSC12. Anim Genet, 2004, 35(1): 66-67.
104. Linville RC, Pomp D, Johnson RK, Rothschild MF. Candidate gene analysis for loci affecting litter size and ovulation rate in swine. J Anim Sci, 2001, 79(1): 60-67.
105. Lumsden JS, Kennedy BW, Mallard BA, Wilkie BN. The influence of the swine major histocompatibility genes on antibody and cell-mediated immune responses to immunization with an aromatic-dependent mutant of Salmonella typhimurium. Can J Vet Res, 1993, 57(1): 14-18.
106. Malek M, Dekkers JC, Lee HK, Baas TJ, Prusa K, Huff-Lonergan E, Rothschild MF. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. Ⅱ. Meat and muscle composition. Mamm Genome, 2001a, 12(8): 637-645.
107. Malek M, Dekkers JC, Lee HK, Baas TJ, Rothschild MF. A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. Ⅰ. Growth and body composition. Mamm Genome, 2001b, 12(8): 630-636.
108. Malhotra K, Luehrsen KR, Costello LL, Raich TJ, Sim K, Foltz L, Davidson S, et al. Identification of differentially expressed mRNAs in human fetal liver across gestation. Nucleic Acids Res, 1999, 27(3): 839-847.
109. Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. Embo J, 1994, 13(20): 4807-4815.
110. Margolis B, Siivennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A, 1992, 89(19): 8894-8898.
111. Mariani P, Lundstrom K, Gustafsson U, Enfalt AC, Juneja RK, Andersson L. A major locus (RN) affecting muscle glycogen content is located on pig chromosome 15. Mamm Genome, 1996, 7(1): 52-54.
112. Martin L, Fanarraga ML, Aloria K, Zabala JC. Tubulin folding cofactor D is a microtubule destabilizing protein. FEBS Lett, 2000, 470(1): 93-95.
113. Meijerink E, Fries R, Vogeli P, Masabanda J, Wigger G, Stricker C, Neuenschwander S, Bertschinger HU, Stranzinger G. Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. Mamm Genome, 1997, 8(10): 736-741.
114. Mekchay S, Ponsuksili S, Schellander K, Wimmers K. Association of the porcine C3 gene with haemolytic complement activity in the pig. Genet Sel Evol, 2003, 35 Suppl 1 : S83-96.
115. Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J. PCR amplification and physical localization of the genes for pig FSHB and LHB. Cytogenet Cell Genet, 1995, 70(3-4): 224-227.
116. Messer L, Wang L, C. L, Rothschild MF. Mapping and investigation of candidate genes for litter size in French Large White pigs. Anim Genet, 1996a, 27(suppl): 114.
117. Messer L, Wang L, Yelich J, Pomp D, Geisert R, Rothschild MF. Linkage mapping of the retinoic acid receptor-gamma gene to porcine chromosome 5. Anim Genet, 1996b, 27(3): 175-177.
118. Messer LA, Wang L, Yelich J, Pomp D, Geisert RD, Rothschild MF. Linkage mapping of the retinol-binding protein 4 (RBP4) gene to porcine chromosome 14. Mamm Genome, 1996c, 7(5): 396.
119. Milan D, Woloszyn N, Yerle M, Le Roy P, Bonnet M, Riquet J, Lahbib-Mansais Y, et al. Accurate mapping of the "acid meat" RN gene on genetic and physical maps of pig chromosome 15. Mamm Genome, 1996, 7(1): 47-51.
120. Milan D, Jeon JT, Looft C, Amarger V, Robic A, Thelander M, Rogel-Gaitlard C, et al. A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. Science, 2000, 288(5469): 1248-1251.
121. Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics, 2001, 74(2): 234-244.
122. Moller S, Croning MD, Apweiler R. Evaluation of methods for the prediction of membrane spanning regions. Bioinformatics, 2001, 17(7): 646-653.
123. Monson JM, Friedman J, McCarthy BJ. DNA sequence analysis of a mouse pro alpha 1 (Ⅰ) procollagen gene: evidence for a mouse B1 element within the gene. Mol Cell Biol, 1982, 2(11): 1362-1371.
124. Muller M, Brenig B, Winnacker EL, Brem G. Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene, 1992, 121 (2): 263-270.
125. Munoz G, Ovilo C, Noguera JL, Sanchez A, Rodriguez C, Silio L. Assignment of the fatty acid synthase (FASN) gene to pig chromosome 12 by physical and linkage mapping. Anita Genet, 2003, 34(3): 234-235.
126. Murphy M, Pykett MJ, Harnish P, Zang KD, George DL. Identification and characterization of genes differentially expressed in meningiomas. Cell Growth Differ, 1993, 4(9): 715-722.
127. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, et al. Prediction of the coding sequences of unidentified human genes. Ⅷ. The complete sequences of 100 new
cDNA clones from brain which code for large proteins in vitro. DNA Res, 1999, 6(1): 63-70.
128. Nezer C, Collette C, Moreau L, Brouwers B, Kim JJ, Giuffra E, Buys N, Andersson L, Georges M. Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene. Genetics, 2003, 165(1): 277-285.
129. Nutbrown RF, McEwen MR, Thomas RA, Duane S, Shipley DR. Comparison of conversion factors for x-ray beams from a Philips SL15 and the NPL linear accelerator. Phys Med Biol, 2001, 46(11): N245-252.
130. Park HB, Carlborg O, Marklund S, Andersson L. Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Anim Genet, 2002, 33(2): 155-157.
131. Park SK, Provost JJ, Bae CD, Ho WT, Exton JH. Cloning and characterization of phospholipase D from rat brain. J Biol Chem, 1997, 272(46): 29263-29271.
132. Paszek AA, Wilkie PJ, Flickinger GH, Miller LM, Louis CF, Rohrer GA, Alexander LJ, Beattie CW, Schook LB. Interval mapping of carcass and meat quality traits in a divergent swine cross. Anim Biotechnol, 2001, 12(2): 155-165.
133. Pita RH, Ramos AM, Lopes PS, Guimaraes SE, Rothschild MF. Assignment of the porcine peptide YY gene to chromosome 12. Anim Genet, 2003, 34(6): 469.
134 Plowman GD, Green JM, Neubauer MG, Buckley SD, McDonald VL, Todaro GJ, Shoyab M. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J Biol Chem, 1992, 267(18): 13073-13078.
135. Ponsuksili S, Wimmers K, Yerle M, Schellander K. Mapping of 93 porcine ESTs preferentially expressed in liver. Mamm Genome, 2001, 12(11): 869-872.
136. Pope FM, Nicholls AC, McPheat J, Talmud P, Owen R. Collagen genes and proteins in osteogenesis imperfecta. J Med Genet, 1985, 22(6): 466-478.
137. Reiner G, Heinricy L, Muller E, Geldermann H, Dzapo V. Indications of associations of the porcine FOS proto-oncogene with skeletal muscle fibre traits. Anim Genet, 2002, 33(1): 49-55.
138. Rothschild M, Jacobson C, Vaske D, Tuggle C, Wang L, Short T, Eekardt G, et al. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Natl Acad Sci U S A, 1996, 93(1): 201-205.
139. Rothschild MF. From a sow's ear to a silk purse: real progress in porcine genomics. Cytogenet Genome Res, 2003, 102(1-4): 95-99.
140. Sasaki S, Clutter AC, Pomp D. Assignment of the porcine obese (leptin) gene to chromosome 18 by linkage analysis of a new PCR-based polymorphism. Mamm Genome, 1996, 7(6): 471-472.
141. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Korn-Lubetzki Ⅰ, et al. MPDUI mutations underlie a novel human congenital disorder of glycosylation, designated type If. J Clin Invest, 2001a, 108(11): 1687-1695.
142. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Raas-Rotschild A, et al. MPDUI mutations underlie a novel human congenital disorder of glycosylation, designated type If. J Clin Invest, 2001b, 108(11): 1687-1695.
143. Shackelford SD, Koohmaraie M, Cundiff LV, Gregory KE, Rohrer GA, Savell JW. Heritabilities and phenotypic and genetic correlations for bovine postrigor calpastatin activity, intramuscular fat content, Warner-Bratzler shear force, retail product yield, and growth rate. J Anim Sci, 1994, 72(4): 857-863.
144. Shen TL, Han DC, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J Biol Chem, 2002, 277(32): 29069-29077.
145. Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y, Allis CD. Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res, 1998, 26(12): 2948-2954.
146. Smith TP, Rohrer GA, Alexander LJ, Troyer DL, Kirby-Dobbels K.R, Janzen MA, Comwell DL, et al. Directed integration of the physical and genetic linkage maps of swine chromosome 7 reveals that the SLA spans the centromere. Genome Res, 1995, 5(3): 259-271.
147. Southwood OI, Short TH, Plastow GS. Genetic markers for litter size in commercial lines of pigs. Proc 6th Wold Congr Appl Livest Prod, 1998, 26: 453-456.
148. Stover ML, Primorac D, Liu SC, McKinstry MB, Rowe DW. Defective splicing of mRNA from one COL1A1 allele of type Ⅰ collagen in nondeforming (type Ⅰ) osteogenesis imperfecta. J Clin Invest, 1993, 92(4): 1994-2002.
149. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA, 2002, 99(26): 16899-16903.
150. Syntichaki P, Thireos G. The Gcn5.Ada complex potentiates the histone acetyltransferase activity of Gcn5. J Biol Chem, 1998, 273(38): 24414-24419.
150. Tanaka S, Sugimachi K, Kawaguchi H, Saeki H, Ohno S, Wands JR. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. J Cell Physiol, 2000, 183(3): 411-415.
152. te Pas MF, Soumillion A, Harders FL, Verburg FJ, van den Bosch TJ, Galesloot P, Meuwissen TH. Influences of myogenin genotypes on birth weight, growth rate, carcass weight, backfat thickness, and lean weight of pigs. J Anim Sci, 1999, 77(9): 2352-2356.
153. te Pas MF, Verburg FJ, Gerritsen CL, de Greef KH. Messenger ribonucleic acid expression of the MyoD gene family in muscle tissue at slaughter in relation to selection for porcine growth rate. J Anim Sci, 2000, 78(1): 69-77.
154. Thornton MA, Poncz M, Korostishevsky M, Yakobson E, Usher S, Seligsohn U, Peretz H. The human platelet alphaIIb gene is not closely linked to its integrin partner beta3. Blood, 1999, 94(6): 2039-2047.
155. Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ. Pathway leading to correctly folded beta-tubulin. Cell, 1996, 86(2): 287-296.
156. Tian G, Bhamidipati A, Cowan NJ, Lewis SA. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J Biol Chem, 1999, 274(34): 24054-24058.
157. Tromp G, Kuivaniemi H, Stacey A, Shikata H, Baldwin CT, Jaenisch R., Prockop DJ. Structure of a
full-length cDNA clone for the prepro alpha 1(Ⅰ) chain of human type Ⅰ procollagen. Biochem J, 1988, 253(3): 919-922.
158. Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Nucleic Acids Res, 2004, 32 Database issue: D484-488.
159. Van der Steen HA, Southwood OI, Vries AG, Short TH, McLaren DG, Wei M, Plastow GS. Evidence of a new genetic marker for litter size in Meishan Synthetic pigs, Proc Intern Conf Anima Biotech, 1997: 17-20.
160. Van Laere AS, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, Archibald AL, et al. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature, 2003, 425(6960): 832-836.
161. Vincent AL, Evans C, Short TH, Southwood OI, Plastow GS, Tuggle CK, Rothschild MF. The prolactin receptor gene is associate with increased litter size in pig. Proceedings of the 6th World congress on Genetics Applied to Livestock Production, 1998, 27: 15-18.
162. Vogeli P, Bertschinger HU, Stamm M, Stricker C, Hagger C, Fries R, Rapacz J, Stranzinger G. Genes specifying receptors for F18 fimhriated Escherichia coli, causing oedema disease and postweaning diarrhoea in pigs, map to chromosome 6. Anim Genet, 1996, 27(5): 321-328.
163. Wang L, Liu L, Berger SL. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev, 1998, 12(5): 640-653.
164. Wang YF, Yu M, Yerle M, Liu B, Zhao SH, Xiong TA, Fan B, Li K. Mapping of genes encoding four ATPase and three non-ATPase components of the pig 26S proteasome. Anim Genet, 2003, 34(5): 393-395.
165. Ware FE, Lehrman MA. Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells. J Biol Chem, 1996, 271(24): 13935-13938.
166. Wilmmers K, Ponsuksili S, Hardge T, Schellander K. Detection of candidate genes for functional traits in pigs. China-EU animal biotechnology conference proceedings, 2000: 45-57.
167. Wimmers K, Mekchay S, Schellander K, Ponsuksili S. Molecular characterization of the pig C3 gene and its association with complement activity. Immunogenetics, 2003, 54(10): 714-724.
168. Xia D, Zhao RQ, Wei XH, Xu QF, Chen J. Developmental patterns of GHr and SS mRNA expression in porcine gastric tissue. World J Gastroenterol, 2003, 9(5): 1058-1062.
169. Xu W, Edmondson DG, Roth SY. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol, 1998, 18(10): 5659-5669.
170. Yan XM, Ren J, Guo YM, Ding NS, Chen KF, Gao J, Ai HS, et al. Research on the genetic variations of al-fucosytransferase (FUT1) gene in 26 pig breeds, Yi Chuan Xue Bao, 2003, 30(9): 830-834.
171. Yang J, Li K, Liu B, Yerle M, Fan B, Xiong T, Yu M. Assignments of GRB7, GCN5L2, COL1A1 and TBCD to pig chromosome 12 by radiation hybrid mapping. Cytogenet Genome Res, 2003, 103(1-2): 204L.
172. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature, 1996, 382(6589): 319-324.
173. Yerle M, Echard G, Robic A, Mairal A, Dubut-Fontana C, Riquet J, Pinton P, et al. A somatic cell hybrid panel for pig regional gene mapping characterized by molecular cytogenetics. Cytogenet Cell Genet, 1996, 73(3): 194-202.
174. Yerle M, Pinton P, Robic A, Alfonso A, Palvadeau Y, Delcros C, Hawken R, et al. Construction of a whole-genome radiation hybrid panel for high-resolution gene mapping in pigs. Cytogenet Cell Genet, 1998, 82(3-4): 182-188.
175. Yerle M, Pinton P, Delcros C, Arnal N, Milan D, Robic A. Generation and characterization of a 12,000-rad radiation hybrid panel for fine mapping in pig. Cytogenet Genorae Res, 2002, 97(3-4): 219-228.
176. Yu M, Zhao S, Yerle M, Liu B, Xiong T, Li K. Isolation, physical mapping and polymorphism of the porcine ferredoxin reductase (FDXR) gene. Anim Genet, 2002, 33(5): 394-395.
177. Yu M, Liu B, Yerle M, Zhu M, Pan P, Fan B, Li K. Physical mapping of the rod cGMP-phosphodiesterase-subunit (PDE6G) gene to pig chromosome 12. Anim Genet, 2003, 34(1): 76-77.
178. Yu M, Wang Y, te Pas MF, Yerle M, Liu B, Fan B, Xiong T, Li K. Investigation of the porcine PA28 activator c-subunit (PSME3) gene: isolation, polymorphism and its chromosomal localization. Journal of Animal Breeding and Genetics, 2004, 121 (2): 142-148.
179. Yu TP, Tuggle CK, Schmitz CB, Rothschild MR Association of PIT1 polymorphisms with growth and carcass traits in pigs. J Anim Sci, 1995, 73(5): 1282-1288.
180. Yue G, Schroffel JR, Moser G, Bartenschlager H, Reiner G, Geldermann H. Linkage and QTL mapping for Sus scrofa chromosome 12. Journal of Animal Breeding and Genetics, 2003, 120(Suppl.1): 95-102.