Sirtuins与自噬在卵母细胞老化中的作用
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摘要
长时间未受精的卵母细胞不可避免地发生细胞核与细胞质的老化,并伴有受精率的降低、胚胎发育缺陷等问题。Sirtuins是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)依赖组蛋白去乙酰酶,通过调控代谢对细胞的老化有延缓和抑制的作用。该文综述了老化的卵母细胞中细胞核、细胞质、细胞器和乙酰化的改变。阐述了sirtuins的功能、sirtuins与卵母细胞老化之间的关系及与自噬之间的关系。讨论了通过调控sirtuins延缓和改善卵母细胞老化的可行性。
Long-term unfertilized oocytes inevitably undergo nuclear and cytoplasmic aging, which will lead to fertilization and development defects. Sirtuins is a NAD+-dependent histone deacetylase, through regulating the metabolism of cells aging delaying and inhibiting effects. In this review, we summarized the changes of aging oocytes in nucleus and cytoplasm. In addition, the functions of sirtuins, the relationship between sirtuins and postovulatory aging, and relationship between sirtuins and autophagy. It is also discussed that the regulation of sirtuins may delay and improve the aging of oocytes.
Long-term unfertilized oocytes inevitably undergo nuclear and cytoplasmic aging, which will lead to fertilization and development defects. Sirtuins is a NAD+-dependent histone deacetylase, through regulating the metabolism of cells aging delaying and inhibiting effects. In this review, we summarized the changes of aging oocytes in nucleus and cytoplasm. In addition, the functions of sirtuins, the relationship between sirtuins and postovulatory aging, and relationship between sirtuins and autophagy. It is also discussed that the regulation of sirtuins may delay and improve the aging of oocytes.
引文
1 Lee SE,Kim EY,Choi HY,Moon JJ,Park MJ,Lee JB,et al.Rapamycin rescues the poor developmental capacity of aged porcine oocytes.Asian-Australas J Anim Sci 2014;27(5):635-47.
2 Wang H,Jo YJ,Oh JS,Kim NH.Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPFactivity.Oncotarget 2017;8(24):38631-41.
3 Boya P,Reggiori F,Codogno P.Emerging regulation and functions of autophagy.Nat Cell Biol 2013;15(7):713-20.
4 Miao YL,Kikuchi K,Sun QY,Schatten H.Oocyte aging:cellular and molecular changes,developmental potential and reversal possibility.Hum Reprod Update 2009;15(5):573-85.
5 Miao Y,Zhou C,Cui Z,Zhang M,ShiYang X,Lu Y,et al.Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress.FASEB J 2018;32(3):1328-37
6 Prasad S,Koch B,Chaube SK.RO-3306 prevents postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro.Biomed Pharmacother 2016;78:216-25.
7 Huang JC,Yan LY,Lei ZL,Miao YL,Shi LH,Yang JW,et al.Changes in histone acetylation during postovulatory aging of mouse oocyte.Biol Reprod 2007;77(4):666-70.
8 Guarente L.Sirtuins,aging,and metabolism.Cold Spring Harb Symp Quant Biol 2011;76:81-90.
9 Park SK,Seong RK,Kim JA,Son SJ,Kim Y,Yokozawa T,et al.Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.Nutr Res Pract 2016;10(1):3-10.
10 Ou X,Lee MR,Huang X,Messina-Graham S,Broxmeyer HE.SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress.Stem cells 2014;32(5):1183-94.
11 Zhang T,Zhou Y,Li L,Wang HH,Ma XS,Qian WP,et al.SIRT1,2,3 protect mouse oocytes from postovulatory aging.Aging(Albany NY)2016;8(4):685-96.
12 Tsukamoto S,Kuma A,Murakami M,Kishi C,Yamamoto A,Mizushima N.Autophagy is essential for preimplantation development of mouse embryos.Science 2008;321(5885):117-20.
13 Tarin JJ,Perez-Albala S,Perez-Hoyos S,Cano A.Postovulatory aging of oocytes decreases reproductive fitness and longevity of offspring.Biol Reprod 2002;66(2):495-9.
14 Lord T,Aitken RJ.Oxidative stress and ageing of the post-ovulatory oocyte.Reproduction 2013;146(6):R217-27.
15 Eichenlaub-Ritter U.Oocyte ageing and its cellular basis.Int JDev Biol 2012;56(10-12):841-52.
16 Riepsamen A,Wu L,Lau L,Listijono D,Ledger W,Sinclair D,et al.Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.PloS one 2015;10(5):e0126194.
17 Kikuchi K,Naito K,Noguchi J,Shimada A,Kaneko H,Yamashita M,et al.Maturation/M-phase promoting factor:a regulator of aging in porcine oocytes.Biol Reprod 2000;63(3):715-22.
18 Zhang CX,Cui W,Zhang M,Zhang J,Wang TY,Zhu J,et al.Role of Na+/Ca2+exchanger(NCX)in modulating postovulatory aging of mouse and rat oocytes.PloS one 2014;9(4):e93446.
19 Zhao XM,Hao HS,Du WH,Zhao SJ,Wang HY,Wang N,et al.Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes.J Pineal Res 2016;60(2):132-41.
20 Morris BJ.Seven sirtuins for seven deadly diseases of aging.Free Radic Biol Med 2013;56:133-71.
21 Singh CK,Chhabra G,Ndiaye MA,Garcia-Peterson LM,Mack NJ,Ahmad N.The Role of Sirtuins in Antioxidant and Redox Signaling.Antioxid Redox Signal 2018;28(8):643-61.
22 Bosch-Presegue L,Vaquero A.The dual role of sirtuins in cancer.Genes Cancer 2011;2(6):648-62.
23 Grabowska W,Sikora E,Bielak-Zmijewska A.Sirtuins,a promising target in slowing down the ageing process.Biogerontology2017;18(4):447-76.
24 Salminen A,Kaarniranta K,Kauppinen A.Crosstalk between oxidative stress and SIRT1:Impact on the aging process.Int JMol Sci 2013;14(2):3834-59.
25 Zhang L,Hou X,Ma R,Moley K,Schedl T,Wang Q.Sirt2functions in spindle organization and chromosome alignment in mouse oocyte meiosis.FASEB J 2014;28(3):1435-45.
26 Mc Glynn LM,Zino S,MacDonald AI,Curle J,Reilly JE,Mohammed ZM,et al.SIRT2:tumour suppressor or tumour promoter in operable breast cancer?Eur J Cancer 2014;50(2):290-301.
27 Someya S,Yu W,Hallows WC,Xu J,Vann JM,Leeuwenburgh C,et al.Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.Cell 2010;143(5):802-12.
28 Rangarajan P,Karthikeyan A,Lu J,Ling EA,Dheen ST.Sirtuin3 regulates Foxo3a-mediated antioxidant pathway in microglia.Neuroscience 2015;311:398-414.
29 Finley LW,Haas W,Desquiret-Dumas V,Wallace DC,Procaccio V,Gygi SP,et al.Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.PloS one 2011;6(8):e23295.
30 Chen Y,Zhang J,Lin Y,Lei Q,Guan KL,Zhao S,et al.Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.EMBO Rep 2011;12(6):534-41.
31 Carafa V,Rotili D,Forgione M,Cuomo F,Serretiello E,Hailu GS,et al.Sirtuin functions and modulation:from chemistry to the clinic.Clin Epigenetics 2016;8:61.
32 Liu B,Che W,Zheng C,Liu W,Wen J,Fu H,et al.SIRT5:a safeguard against oxidative stress-induced apoptosis in cardiomyocytes.Cell Physiol Biochem 2013;32(4):1050-9.
33 Etchegaray JP,Chavez L,Huang Y,Ross KN,Choi J,Martinez-Pastor B,et al.The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of5-hydroxymethylcytosine.Nat Cell Biol 2015;17(5):545-57.
34 He J,Zhang G,Pang Q,Yu C,Xiong J,Zhu J,et al.SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.FEBS J 2017;284(9):1324-37.
35 Kawamura Y,Uchijima Y,Horike N,Tonami K,Nishiyama K,Amano T,et al.Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.J Clin Invest 2010;120(8):2817-28.
36 Ma R,Zhang Y,Zhang L,Han J,Rui R.Sirt1 protects pig oocyte against in vitro aging.Anim Sci J 2015;86(9):826-32.
37 Di Emidio G,Falone S,Vitti M,D’Alessandro AM,Vento M,Di Pietro C,et al.SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging.Hum Reprod2014;29(9):2006-17.
38 Qiu D,Hou X,Han L,Li X,Ge J,Wang Q.Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality.Aging cell 2018;doi:10.1111/acel.12698.
39 Robinson PJ,An W,Routh A,Martino F,Chapman L,Roeder RG,et al.30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction.J Mol Biol 2008;381(4):816-25.
40 Liu M,Yin Y,Ye X,Zeng M,Zhao Q,Keefe DL,et al.Resveratrol protects against age-associated infertility in mice.Hum Reprod 2013;28(3):707-17.
41 Lim HJ,Song H.Evolving tales of autophagy in early reproductive events.Int J Dev Biol 2014;58(2-4):183-7.
42 Lee GK,Shin H,Lim HJ.Rapamycin influences the efficiency of in vitro fertilization and development in the mouse:A role for autophagic activation.Asian-Australas J Anim Sci 2016;29(8):1102-10.
43 Matsui A,Kamada Y,Matsuura A.The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.PLoS Genet 2013;9(1):e1003245.
44 Mihalas BP,Redgrove KA,McLaughlin EA,Nixon B.Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage.Oxid Med Cell Longev 2017;2017:4015874.
45 Zhang X,Yu L,Xu H.Lysosome calcium in ROS regulation of autophagy.Autophagy 2016;12(10):1954-5.
46 Lin FH,Zhang WL,Li H,Tian XD,Zhang J,Li X,et al.Role of autophagy in modulating post-maturation aging of mouse oocytes.Cell Death Dis 2018;9(3):308.
47 Rubinsztein DC,Marino G,Kroemer G.Autophagy and aging.Cell 2011;146(5):682-95.
48 Cohen HY,Miller C,Bitterman KJ,Wall NR,Hekking B,Kessler B,et al.Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.Science 2004;305(5682):390-2.
49 Martinez-Lopez N,Athonvarangkul D,Singh R.Autophagy and aging.Adv Exp Med Biol 2015;847:73-87.
50 Hariharan N,Maejima Y,Nakae J,Paik J,Depinho RA,Sadoshima J.Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes.Circ Res 2010;107(12):1470-82.
51 Puissant A,Robert G,Fenouille N,Luciano F,Cassuto JP,Raynaud S,et al.Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1expression and AMPK activation.Cancer Res 2010;70(3):1042-52.
52 Takasaka N,Araya J,Hara H,Ito S,Kobayashi K,Kurita Y,et al.Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.J Immunol 2014;192(3):958-68.
2 Wang H,Jo YJ,Oh JS,Kim NH.Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPFactivity.Oncotarget 2017;8(24):38631-41.
3 Boya P,Reggiori F,Codogno P.Emerging regulation and functions of autophagy.Nat Cell Biol 2013;15(7):713-20.
4 Miao YL,Kikuchi K,Sun QY,Schatten H.Oocyte aging:cellular and molecular changes,developmental potential and reversal possibility.Hum Reprod Update 2009;15(5):573-85.
5 Miao Y,Zhou C,Cui Z,Zhang M,ShiYang X,Lu Y,et al.Postovulatory aging causes the deterioration of porcine oocytes via induction of oxidative stress.FASEB J 2018;32(3):1328-37
6 Prasad S,Koch B,Chaube SK.RO-3306 prevents postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro.Biomed Pharmacother 2016;78:216-25.
7 Huang JC,Yan LY,Lei ZL,Miao YL,Shi LH,Yang JW,et al.Changes in histone acetylation during postovulatory aging of mouse oocyte.Biol Reprod 2007;77(4):666-70.
8 Guarente L.Sirtuins,aging,and metabolism.Cold Spring Harb Symp Quant Biol 2011;76:81-90.
9 Park SK,Seong RK,Kim JA,Son SJ,Kim Y,Yokozawa T,et al.Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway.Nutr Res Pract 2016;10(1):3-10.
10 Ou X,Lee MR,Huang X,Messina-Graham S,Broxmeyer HE.SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress.Stem cells 2014;32(5):1183-94.
11 Zhang T,Zhou Y,Li L,Wang HH,Ma XS,Qian WP,et al.SIRT1,2,3 protect mouse oocytes from postovulatory aging.Aging(Albany NY)2016;8(4):685-96.
12 Tsukamoto S,Kuma A,Murakami M,Kishi C,Yamamoto A,Mizushima N.Autophagy is essential for preimplantation development of mouse embryos.Science 2008;321(5885):117-20.
13 Tarin JJ,Perez-Albala S,Perez-Hoyos S,Cano A.Postovulatory aging of oocytes decreases reproductive fitness and longevity of offspring.Biol Reprod 2002;66(2):495-9.
14 Lord T,Aitken RJ.Oxidative stress and ageing of the post-ovulatory oocyte.Reproduction 2013;146(6):R217-27.
15 Eichenlaub-Ritter U.Oocyte ageing and its cellular basis.Int JDev Biol 2012;56(10-12):841-52.
16 Riepsamen A,Wu L,Lau L,Listijono D,Ledger W,Sinclair D,et al.Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.PloS one 2015;10(5):e0126194.
17 Kikuchi K,Naito K,Noguchi J,Shimada A,Kaneko H,Yamashita M,et al.Maturation/M-phase promoting factor:a regulator of aging in porcine oocytes.Biol Reprod 2000;63(3):715-22.
18 Zhang CX,Cui W,Zhang M,Zhang J,Wang TY,Zhu J,et al.Role of Na+/Ca2+exchanger(NCX)in modulating postovulatory aging of mouse and rat oocytes.PloS one 2014;9(4):e93446.
19 Zhao XM,Hao HS,Du WH,Zhao SJ,Wang HY,Wang N,et al.Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes.J Pineal Res 2016;60(2):132-41.
20 Morris BJ.Seven sirtuins for seven deadly diseases of aging.Free Radic Biol Med 2013;56:133-71.
21 Singh CK,Chhabra G,Ndiaye MA,Garcia-Peterson LM,Mack NJ,Ahmad N.The Role of Sirtuins in Antioxidant and Redox Signaling.Antioxid Redox Signal 2018;28(8):643-61.
22 Bosch-Presegue L,Vaquero A.The dual role of sirtuins in cancer.Genes Cancer 2011;2(6):648-62.
23 Grabowska W,Sikora E,Bielak-Zmijewska A.Sirtuins,a promising target in slowing down the ageing process.Biogerontology2017;18(4):447-76.
24 Salminen A,Kaarniranta K,Kauppinen A.Crosstalk between oxidative stress and SIRT1:Impact on the aging process.Int JMol Sci 2013;14(2):3834-59.
25 Zhang L,Hou X,Ma R,Moley K,Schedl T,Wang Q.Sirt2functions in spindle organization and chromosome alignment in mouse oocyte meiosis.FASEB J 2014;28(3):1435-45.
26 Mc Glynn LM,Zino S,MacDonald AI,Curle J,Reilly JE,Mohammed ZM,et al.SIRT2:tumour suppressor or tumour promoter in operable breast cancer?Eur J Cancer 2014;50(2):290-301.
27 Someya S,Yu W,Hallows WC,Xu J,Vann JM,Leeuwenburgh C,et al.Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.Cell 2010;143(5):802-12.
28 Rangarajan P,Karthikeyan A,Lu J,Ling EA,Dheen ST.Sirtuin3 regulates Foxo3a-mediated antioxidant pathway in microglia.Neuroscience 2015;311:398-414.
29 Finley LW,Haas W,Desquiret-Dumas V,Wallace DC,Procaccio V,Gygi SP,et al.Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.PloS one 2011;6(8):e23295.
30 Chen Y,Zhang J,Lin Y,Lei Q,Guan KL,Zhao S,et al.Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.EMBO Rep 2011;12(6):534-41.
31 Carafa V,Rotili D,Forgione M,Cuomo F,Serretiello E,Hailu GS,et al.Sirtuin functions and modulation:from chemistry to the clinic.Clin Epigenetics 2016;8:61.
32 Liu B,Che W,Zheng C,Liu W,Wen J,Fu H,et al.SIRT5:a safeguard against oxidative stress-induced apoptosis in cardiomyocytes.Cell Physiol Biochem 2013;32(4):1050-9.
33 Etchegaray JP,Chavez L,Huang Y,Ross KN,Choi J,Martinez-Pastor B,et al.The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of5-hydroxymethylcytosine.Nat Cell Biol 2015;17(5):545-57.
34 He J,Zhang G,Pang Q,Yu C,Xiong J,Zhu J,et al.SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.FEBS J 2017;284(9):1324-37.
35 Kawamura Y,Uchijima Y,Horike N,Tonami K,Nishiyama K,Amano T,et al.Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.J Clin Invest 2010;120(8):2817-28.
36 Ma R,Zhang Y,Zhang L,Han J,Rui R.Sirt1 protects pig oocyte against in vitro aging.Anim Sci J 2015;86(9):826-32.
37 Di Emidio G,Falone S,Vitti M,D’Alessandro AM,Vento M,Di Pietro C,et al.SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging.Hum Reprod2014;29(9):2006-17.
38 Qiu D,Hou X,Han L,Li X,Ge J,Wang Q.Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality.Aging cell 2018;doi:10.1111/acel.12698.
39 Robinson PJ,An W,Routh A,Martino F,Chapman L,Roeder RG,et al.30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction.J Mol Biol 2008;381(4):816-25.
40 Liu M,Yin Y,Ye X,Zeng M,Zhao Q,Keefe DL,et al.Resveratrol protects against age-associated infertility in mice.Hum Reprod 2013;28(3):707-17.
41 Lim HJ,Song H.Evolving tales of autophagy in early reproductive events.Int J Dev Biol 2014;58(2-4):183-7.
42 Lee GK,Shin H,Lim HJ.Rapamycin influences the efficiency of in vitro fertilization and development in the mouse:A role for autophagic activation.Asian-Australas J Anim Sci 2016;29(8):1102-10.
43 Matsui A,Kamada Y,Matsuura A.The role of autophagy in genome stability through suppression of abnormal mitosis under starvation.PLoS Genet 2013;9(1):e1003245.
44 Mihalas BP,Redgrove KA,McLaughlin EA,Nixon B.Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage.Oxid Med Cell Longev 2017;2017:4015874.
45 Zhang X,Yu L,Xu H.Lysosome calcium in ROS regulation of autophagy.Autophagy 2016;12(10):1954-5.
46 Lin FH,Zhang WL,Li H,Tian XD,Zhang J,Li X,et al.Role of autophagy in modulating post-maturation aging of mouse oocytes.Cell Death Dis 2018;9(3):308.
47 Rubinsztein DC,Marino G,Kroemer G.Autophagy and aging.Cell 2011;146(5):682-95.
48 Cohen HY,Miller C,Bitterman KJ,Wall NR,Hekking B,Kessler B,et al.Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.Science 2004;305(5682):390-2.
49 Martinez-Lopez N,Athonvarangkul D,Singh R.Autophagy and aging.Adv Exp Med Biol 2015;847:73-87.
50 Hariharan N,Maejima Y,Nakae J,Paik J,Depinho RA,Sadoshima J.Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes.Circ Res 2010;107(12):1470-82.
51 Puissant A,Robert G,Fenouille N,Luciano F,Cassuto JP,Raynaud S,et al.Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1expression and AMPK activation.Cancer Res 2010;70(3):1042-52.
52 Takasaka N,Araya J,Hara H,Ito S,Kobayashi K,Kurita Y,et al.Autophagy induction by SIRT6 through attenuation of insulinlike growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.J Immunol 2014;192(3):958-68.