创伤后应激障碍患者血清丙二醛及血浆超氧化物歧化酶水平研究
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摘要
目的:通过测定创伤后应激障碍(PTSD)患者血清丙二醛(MDA)及血浆超氧化物歧化酶(SOD)水平,探讨PTSD患者是否存在显著的脂质过氧化。方法:地震灾后1年,对596例参加抗震救灾的志愿者进行PTSD问卷调查,确诊为PTSD者24例,对其中18例(PTSD组)和32名未参加抗震救灾的健康招募者(对照组)进行血清MDA浓度及血浆总SOD活性检测。结果:两组血清MDA浓度及血浆SOD活性均为非正态分布资料;运用等级资料检验,两组血清MDA浓度及血浆SOD活性水平差异均存在显著的统计学意义(P=0.008,0.007)。结论:PTSD患者存在显著的脂质过氧化。
Objective:To determine whether there is significantly lipid peroxidation in post-traumatic stress disorder(PDST)by assessing serum malondialdehyole(MDA)level and plasma activity of total superoxide dismutase(SOD)in a group of PTSD patients.Method:One year after earthquake relief,596 volunteers of earthquake relief were screened by questionnaires for PTSD.Twenty-four PTSD patients were diagnosed by structured interview.Blood samples were drawn from 18 PTSD patients and 32 control peoples who did not participate in earthquake relief,and serum MDA level and plasma activity of total SOD were detected.Results:The data of serum MDA level and plasma activity of total SOD in the two groups were abnormal distribution.There were significant differnece on serum MDA level and plasma activity of total SOD between PTSD group and control group.Conclusion:Our results suggest that marked lipid peroxidation seems to be related to PTSD.
Objective:To determine whether there is significantly lipid peroxidation in post-traumatic stress disorder(PDST)by assessing serum malondialdehyole(MDA)level and plasma activity of total superoxide dismutase(SOD)in a group of PTSD patients.Method:One year after earthquake relief,596 volunteers of earthquake relief were screened by questionnaires for PTSD.Twenty-four PTSD patients were diagnosed by structured interview.Blood samples were drawn from 18 PTSD patients and 32 control peoples who did not participate in earthquake relief,and serum MDA level and plasma activity of total SOD were detected.Results:The data of serum MDA level and plasma activity of total SOD in the two groups were abnormal distribution.There were significant differnece on serum MDA level and plasma activity of total SOD between PTSD group and control group.Conclusion:Our results suggest that marked lipid peroxidation seems to be related to PTSD.
引文
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[8]Tezcan E,Atnaca M,Kuloglu M,et al.Free radicals in patients with post-traumatic stress disorde[J].Eur Arch Psychiatry Cli Neuros-ci,2003,253:89-91.
[2]Andreazza AC,Kauer-Sant'anna M,Frey BN,et al.Oxidative stress markers in bipolar disorder:A meta-analysis[J].J Affect Disord,2008,111:135-144.
[3]Ozdemir E,Cetinkaya S,Ersan S,et al.Serum selenium and plasma malondialdehyde levels and antioxidant enzyme activities in patients with obsessive-compulsive disorder[J].Prog Neuropsychopharma-col Biol Psychiatry,2009,33:62-65.
[4]Krystal JH,Neumeister A.Noradrenergic and serotonergic mecha-nisms in the neurobiology of posttraumatic stress disorder and resili-ence[J].Brain Res,2009,1293:13-23.
[5]Sher L,Oquendo MA,Li S,et al.Higher cerebrospinal fluid ho-movanillic acid levels in depressed patients with comorbid posttrau-matic stress disorder[J].Eur Neuropsychopharmacol,2005,15:203-209.
[6]Levine J,Timinsky I,Vishne T,et al.elevated serum homocysteine levels in male patients with PTSD[J].Depression and Anxiety,2005,25:154-157.
[7]卜甜甜,吴士文,侯世科.创伤后应激障碍同型半胱氨酸水平[J].临床精神医学杂志,2009,19:312-314.
[8]Tezcan E,Atnaca M,Kuloglu M,et al.Free radicals in patients with post-traumatic stress disorde[J].Eur Arch Psychiatry Cli Neuros-ci,2003,253:89-91.
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