创伤后应激障碍同型半胱氨酸水平
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摘要
目的:探讨创伤后应激障碍(PTSD)患者早期的同型半胱氨酸水平。方法:汶川地震3个月后,对660例抗震志愿者进行PTSD问卷调查,对于可疑PTSD者给予结构性访谈,确诊53例PTSD。随机选取27例PTSD者(PTSD组),35例参加救灾的无PTSD人员(无PTSD组)及78例未参加抗震救灾的同单位人员(对照组),对其血浆同型半胱氨酸水平进行检测。结果:3组血浆同型半胱氨酸浓度均为非正态分布。运用等级资料检验发现,PTSD组与无PTSD组间以及无PTSD组与对照组间在同型半胱氨酸水平差异无显著性,而PTSD组与对照组间存在显著的统计学差异。结论:虽然目前仍不清楚同型半胱氨酸与PTSD间具体关系,但在PTSD的早期就存在血浆同型半胱氨酸水平的升高。
Objective:To study the early level of homocysteine in the rescuer with post-traumatic stress disorder. Method:Three months after earthquake of Wenchuan,660 volunteers of earthquake relief were screened by questionnaires for PTSD.53 PTSD patients were diagnosed by structured interview.Twenty seven rescuers with PTSD,35 rescuers without PTSD and 78 control peoples who did not participate in earthquake relief in the same unit of work were recruited,and their plasma homocysteine levels were researched. Results:The data of the plasma homocysteine in three groups were not normal distribution.Using ranked data analysis,there was a significant difference on the plasma homocysteine concentration between rescuers with PTSD group and control group,however,no statistical differneces were found between rescuers with PTSD group and rescuers without PTSD group,and between rescuers without PTSD group and control group. Conclusion:Elevated homocysteine levels are found in the rescuers with PTSD three months after earthquake relief,though the reason for elevated homocysteine levels in PTSD patients is not clear.
Objective:To study the early level of homocysteine in the rescuer with post-traumatic stress disorder. Method:Three months after earthquake of Wenchuan,660 volunteers of earthquake relief were screened by questionnaires for PTSD.53 PTSD patients were diagnosed by structured interview.Twenty seven rescuers with PTSD,35 rescuers without PTSD and 78 control peoples who did not participate in earthquake relief in the same unit of work were recruited,and their plasma homocysteine levels were researched. Results:The data of the plasma homocysteine in three groups were not normal distribution.Using ranked data analysis,there was a significant difference on the plasma homocysteine concentration between rescuers with PTSD group and control group,however,no statistical differneces were found between rescuers with PTSD group and rescuers without PTSD group,and between rescuers without PTSD group and control group. Conclusion:Elevated homocysteine levels are found in the rescuers with PTSD three months after earthquake relief,though the reason for elevated homocysteine levels in PTSD patients is not clear.
引文
[1]Bottiglieri T,Laundy M,Crellin R,et al.Homocysteine,folate,methylation,and monoamine metabolism in depression[J].Neurol Neurosurg Psychiatry,2000,69:228-232.
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[4]Levine J,Timinsky I,Vishne T,et al.Elevated serum homocysteine levels in male patients with PTSD[J].Depression and Anxiety,2005,25:154-157.
[5]de Souza FG,Rodrigues MD,Tufik S,et al.Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats[J].Pharmacol Biochem Behav,2006,85:400-407.
[6]Mattson MP,Shea TB.Folate and homocysteine metabolism in neu-ral plasticity and neurodegenerative disorders[J].Trends Neurosci,2003,26:137-146.
[7]Bottiglieri T,Hyland K,Reynolds EH.The clinical potential of ademetionine in neurological disorders[J].Drugs,1994,48:137-152.
[8]Chambers RA,Bremner JD,Moghaddam B,et al.Glutamate and post-traumatic stress disorder:toward a psychobiology of dissocia-tion[J].Semin Clin Neuropsychiatry,1999,4:274-281.
[9]Garakani A,MathewSJ,Charney DS.Neurobiology of anxiety disor-ders and implications for treatment[J].Mt Sinai J Med,2006,73:941-949.
[10]Atmaca M,Tezcan E,Kuloglu M,et al.Serum folate and homocys-teine levels in patients with obsessive compulsive disorder[J].Psychiatry Clin Neurosci,2005,59:616-620.
[11]Tiemeier H,van Tuijl HR,Hofman A,et al.Vitamin B12,folate,and homocysteine in depression:the Rotterdam Study[J].Am J Psychiatry,2002,159:2099-2101.
[12]Bjelland I,Tell GS,Vollset SE,et al.Folate,Vitamin B12,homo-cysteine,and the MTHFR677C→T polymorphism in anxiety and depression:The Hordaland homocysteine study[J].Arch Gen Psy-chiatry,2003,60:618-626.
[2]Levine J,Cole DP,Chengappa KN,et al.Anxiety disorders and ma-jor depression,together or apart[J].Depress Anxiety,2001,14:94-104.
[3]Stahl Z,Belmaker RH,Friger M,et al.Nutritional and life style de-terminants of plasma homocysteine in schizophrenia patients[J].Eur Neuropsychopharmacol,2005,15:291-295.
[4]Levine J,Timinsky I,Vishne T,et al.Elevated serum homocysteine levels in male patients with PTSD[J].Depression and Anxiety,2005,25:154-157.
[5]de Souza FG,Rodrigues MD,Tufik S,et al.Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats[J].Pharmacol Biochem Behav,2006,85:400-407.
[6]Mattson MP,Shea TB.Folate and homocysteine metabolism in neu-ral plasticity and neurodegenerative disorders[J].Trends Neurosci,2003,26:137-146.
[7]Bottiglieri T,Hyland K,Reynolds EH.The clinical potential of ademetionine in neurological disorders[J].Drugs,1994,48:137-152.
[8]Chambers RA,Bremner JD,Moghaddam B,et al.Glutamate and post-traumatic stress disorder:toward a psychobiology of dissocia-tion[J].Semin Clin Neuropsychiatry,1999,4:274-281.
[9]Garakani A,MathewSJ,Charney DS.Neurobiology of anxiety disor-ders and implications for treatment[J].Mt Sinai J Med,2006,73:941-949.
[10]Atmaca M,Tezcan E,Kuloglu M,et al.Serum folate and homocys-teine levels in patients with obsessive compulsive disorder[J].Psychiatry Clin Neurosci,2005,59:616-620.
[11]Tiemeier H,van Tuijl HR,Hofman A,et al.Vitamin B12,folate,and homocysteine in depression:the Rotterdam Study[J].Am J Psychiatry,2002,159:2099-2101.
[12]Bjelland I,Tell GS,Vollset SE,et al.Folate,Vitamin B12,homo-cysteine,and the MTHFR677C→T polymorphism in anxiety and depression:The Hordaland homocysteine study[J].Arch Gen Psy-chiatry,2003,60:618-626.
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