摘要
目的:探讨复方消化酶片联合埃索美拉唑肠溶胶囊治疗伴有腹胀上腹痛综合征(EPS)型功能性消化不良(FD)的临床效果。方法:选择EPS型FD患者157例,随机分为观察组(n=79)、对照组(n=78)。对照组予以埃索美拉唑肠溶胶囊治疗,观察组予以复方消化酶片联合埃索美拉唑肠溶胶囊治疗。观察2组治疗前及治疗1个疗程后胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平、胃窦收缩幅度、疗效及不良反应。结果:治疗后,观察组PGⅠ[(94.01±8.65) ng/mL]、PGⅡ[(5.98±1.77) ng/mL]水平分别低于对照组的[(124.98±10.02) ng/mL、(9.02±1.58) ng/mL](P<0.05),胃窦收缩幅度[(0.29±0.03)%]高于对照组[(0.25±0.02)%],总有效率(97.47%)高于对照组(83.33%)(P <0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:复方消化酶片联合埃索美拉唑肠溶胶囊治疗EPS型FD疗效显著,能有效改善消化功能,且不良反应少。
Objective:To investigate the clinical effect of compound digestive enzyme tablets combined with esomeprazole enteric-coated capsules in the treatment of functional dyspepsia(FD) with abdominal distension and upper abdominal pain syndrome(EPS).Methods:A total of 157 patients with EPS type FD were randomly divided into observation group(n=79) and control group(n=78).The control group was treated with esomeprazole enteric-coated capsules,and the observation group was treated with compound digestive enzyme tablets combined with esomeprazole enteric-coated capsules.PepsinogenⅠ(PGⅠ),pepsinogen Ⅱ(PGⅡ) levels,gastric sinus contraction amplitude,efficacy and adverse reactions were observed before and after 1 course of treatment.Results:After treatment,the levels of PGⅠ[(94.01±8.65) ng/mL]and PGⅡ[(5.98±1.77) ng/mL]in the observation group were lower than those in the control group [(124.98±10.02) ng/mL,(9.02±1.58) ng/mL](P<0.05),the amplitude of gastric antrum contraction [(0.29±0.03) %]was higher than that of the control group [(0.25± 0.02) %],the total effective rate(97.47%) was higher than that of the control group(83.33%)(P<0.05);the incidence of adverse reactions in the observation group was not significantly different from that in the control group(P>0.05).Conclusion:Compound digestive enzyme tablets combined with esomeprazole enteric-coated capsules have significant curative effect on EPS type FD,which can effectively improve gastric digestive function and less adverse reactions.
引文
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