热淋清制剂治疗单纯尿路感染有效性与安全性Meta分析
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摘要
目的针对应用热淋清制剂治疗单纯性尿路感染的临床疗效与安全性进行系统评价与Meta分析。方法计算机检索中国知网、万方、维普、Pubmed、Cochrane library等数据库(建库至2017年5月)。按照纳入与排除标准选择文献,提取资料和评价纳入研究的方法学质量后,采用Rev Man5. 3. 5进行Meta分析。结果全数文献中,试验组患者988例,总有效928例,对照组合计981例,总有效737例。所有符合要求的文献均报告了有效率,9篇文献报告了不良反应。Meta分析显示,热淋清制剂联合抗生素治疗单纯性尿路感染有效率优于单用抗生素治疗[合并RR及95%CI为1. 23(1. 18～1. 27),P=0. 45,I2=0%];热淋清联合西医常规治疗治疗单纯性尿路感染与单用抗生素治疗组的不良反应发生率比较差异无统计学意义(P=0. 42> 0. 05),说明热淋清制剂联合抗生素治疗单纯性尿路感染不会增加不良反应的发生率,安全性很高。结论热淋清制剂联合抗生素治疗单纯性尿路感染的疗效优于单用抗生素,热淋清制剂联合抗生素治疗单纯性尿路感染不会增加不良反应的发生率,安全性较高。
Objective To carry out the Meta-analysis on the effectiveness and safety of relinqing preparation in treatment of simple urinary infection. Methods The data were retrieved from CNKI,Wanfang,VIP,Pub Med and Cochrane Library databases from the time of database establishment to May 2017. According to the inclusion and exclusion criteria,the articles were screened. After extracting the data and evaluating the quality of the methodology of the included studied,Rev Man 5. 3. 5 software was adopted for the Meta-analysis. Results Of the fulltext articles,there were 988 cases in the trial group and 928 cases of them effective; 981 cases in the control group and 737 cases of them effective. All of the eligible articles had reported the effective rates and 9 articles reported the adverse reactions. Meta-analysis showed that relinqing preparation combined with antibiotics achieved the better effective rate on simple urinary infection as compared with simple use of antibiotics[Combined RR and 95% CI 1. 23( 1. 18 ～ 1. 27),P = 0. 45,I2= 0%]. In comparison of the combined treatment with relinqing and western medicine and the simple use of antibiotics,the difference in the cases of adverse reaction was not significant( P = 0. 42 > 0. 05). It was indicated that relinqing preparation combined with antibiotics did not increase the incidence of adverse reaction and the safety was higher in the treatment. Conclusion The combined therapy with relinqing preparation and antibiotics achieves the better effects on simple urinary infection as compared with the simple use of antibiotics. This combined treatment cannot increase the incidence of adverse reaction is quite high in the safety.
Objective To carry out the Meta-analysis on the effectiveness and safety of relinqing preparation in treatment of simple urinary infection. Methods The data were retrieved from CNKI,Wanfang,VIP,Pub Med and Cochrane Library databases from the time of database establishment to May 2017. According to the inclusion and exclusion criteria,the articles were screened. After extracting the data and evaluating the quality of the methodology of the included studied,Rev Man 5. 3. 5 software was adopted for the Meta-analysis. Results Of the fulltext articles,there were 988 cases in the trial group and 928 cases of them effective; 981 cases in the control group and 737 cases of them effective. All of the eligible articles had reported the effective rates and 9 articles reported the adverse reactions. Meta-analysis showed that relinqing preparation combined with antibiotics achieved the better effective rate on simple urinary infection as compared with simple use of antibiotics[Combined RR and 95% CI 1. 23( 1. 18 ～ 1. 27),P = 0. 45,I2= 0%]. In comparison of the combined treatment with relinqing and western medicine and the simple use of antibiotics,the difference in the cases of adverse reaction was not significant( P = 0. 42 > 0. 05). It was indicated that relinqing preparation combined with antibiotics did not increase the incidence of adverse reaction and the safety was higher in the treatment. Conclusion The combined therapy with relinqing preparation and antibiotics achieves the better effects on simple urinary infection as compared with the simple use of antibiotics. This combined treatment cannot increase the incidence of adverse reaction is quite high in the safety.
引文
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[17]王萍.热淋清颗粒联合盐酸左氧氟沙星胶囊对老年人尿路感染的影响[J].大家健康:学术版,2015(2):151-152.
[18]牛卫东.中西医结合治疗泌尿道感染的疗效及安全性观察[J].中西医结合心血管病杂志,2015(7):38-39.
[19]蒲翔,张丽艳,杨丰文,等.热淋清制剂治疗单纯性尿路感染随机对照试验的系统评价[J].天津医药,2016(8):1048-1052.
[20]黄楠.中药现代化系列报道之九:热淋清颗粒的药效和毒理研究[J].中国医院用药评价与分析,2007,7(6):443.
[21]曹芳,谭辉,邓先扩.头花蓼化学成分及其黄酮类化合物含量的研究进展[J].黔南民族医专学报,2012,25(2):121-125.
[22]徐丹,赵菲菲,杨馨,等.苗药头花蓼含药血清对巨噬细胞释放炎症因子的影响[J].贵州医科大学学报,2016,41(6):635-639,652.
[23]刘瑜新,宋晓勇,康文艺,等.头花蓼对多重耐药金黄色葡萄球菌抗菌作用研究[J].中成药,2014(9):1817-1821.
[24]张姝,罗昭逊,莫非,等.头花蓼对幽门螺杆菌抗菌作用分析[J].中国医院药学杂志,2015(2):113-118.
[25]李孟林,梁斌,姚强,等.苗药-头花蓼研究综述[J].中国医院用药评价与分析,2005(6):383-384.
[2]那彦群.中国泌尿外科疾病诊断治疗指南[M].北京:人民卫生出版社,2011:284.
[3]张予.苗药——头花蓼文献综述∥中国中西医结合学会中药专业委员会.全国中药研究学术讨论会论文集[C].北京:中国中西医结合学会中药专业委员会,2003:2.
[4]夏毓,张震,韩磊,等.多西环素联合热淋清颗粒治疗非淋菌性尿道炎临床观察[J].临床泌尿外科杂志,2004(2):109.
[5]欧阳小容,闵一果,江文学,等.热淋清颗粒联合克拉霉素治疗非淋菌性尿道炎临床观察[J].皮肤病与性病,2006(3):33-34.
[6]张晓群,汪正飞,郑石清.中西医结合治疗非淋菌性尿道炎41例观察[J].实用中医药杂志,2006(8):490.
[7]李国泉,王良平,陈明春.热淋清联合加替沙星治疗非淋球菌性尿道炎62例疗效观察[J].岭南皮肤性病科杂志,2007(3):175,177.
[8]李小玲,缪娟.头孢克肟联合热淋清胶囊治疗女性尿路感染疗效观察[J].临床合理用药杂志,2012(16):93-94.
[9]马杰,武进峰,兰晓煦,等.热淋清颗粒联合洛美沙星治疗女性急性膀胱炎36例临床观察[J].中国医疗前沿,2012(3):57.
[10]周燕萍,白海燕.热淋清片联合诺氟沙星片治疗单纯性尿路感染的疗效观察[J].中国药师,2013(4):580-581.
[11]舒则荣,刘兰芹.热淋清颗粒联合左氧氟沙星治疗泌尿系感染的疗效观察[J].海峡药学,2013(5):159-160.
[12]谢平松,周佳伟.头孢克肟联合热淋清胶囊治疗126例女性尿路感染临床疗效观察[J].中国药物经济学,2013(5):260-261.
[13]胡叶成,莫俏峰.热淋清联合头孢泊肟酯干混悬剂治疗儿童期尿道炎的临床效果观察[J].临床和实验医学杂志,2013(16):1311-1312.
[14]赵旭东,谢红林,高文君,等.头孢地尼联合热淋清胶囊治疗泌尿道感染100例临床观察[J].浙江中医杂志,2014(10):732.
[15]沈银奎.热淋清颗粒联合左氧氟沙星治疗泌尿系感染56例[J].中国药业,2014(8):66-67.
[16]房辉,钱辉军.热淋清联合左氧氟沙星治疗泌尿系感染的疗效临床研究[J].时珍国医国药,2014(4):899-900.
[17]王萍.热淋清颗粒联合盐酸左氧氟沙星胶囊对老年人尿路感染的影响[J].大家健康:学术版,2015(2):151-152.
[18]牛卫东.中西医结合治疗泌尿道感染的疗效及安全性观察[J].中西医结合心血管病杂志,2015(7):38-39.
[19]蒲翔,张丽艳,杨丰文,等.热淋清制剂治疗单纯性尿路感染随机对照试验的系统评价[J].天津医药,2016(8):1048-1052.
[20]黄楠.中药现代化系列报道之九:热淋清颗粒的药效和毒理研究[J].中国医院用药评价与分析,2007,7(6):443.
[21]曹芳,谭辉,邓先扩.头花蓼化学成分及其黄酮类化合物含量的研究进展[J].黔南民族医专学报,2012,25(2):121-125.
[22]徐丹,赵菲菲,杨馨,等.苗药头花蓼含药血清对巨噬细胞释放炎症因子的影响[J].贵州医科大学学报,2016,41(6):635-639,652.
[23]刘瑜新,宋晓勇,康文艺,等.头花蓼对多重耐药金黄色葡萄球菌抗菌作用研究[J].中成药,2014(9):1817-1821.
[24]张姝,罗昭逊,莫非,等.头花蓼对幽门螺杆菌抗菌作用分析[J].中国医院药学杂志,2015(2):113-118.
[25]李孟林,梁斌,姚强,等.苗药-头花蓼研究综述[J].中国医院用药评价与分析,2005(6):383-384.