注射用兰索拉唑治疗十二指肠溃疡出血的临床效果研究
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摘要
目的:探讨注射用兰索拉唑治疗十二指肠溃疡出血的临床疗效。方法:将65例十二指肠溃疡出血患者分为对照组和观察组。对照组32例患者给予奥美拉唑钠治疗,观察组33例患者给予注射用兰索拉唑治疗。观察两组患者临床疗效、不良反应、止血时间及腹痛消失时间。结果:观察组临床有效率96.97%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);观察组不良反应发生率为6.06%,显著低于对照组的12.50%(P<0.05)。观察组止血时间(28.21±8.52)h,腹痛消失时间(2.03±0.58)d,较对照组更短,差异有统计学意义(P<0.05)。结论:采取注射用兰索拉唑治疗十二指肠溃疡出血的临床疗效确切,不良反应少,能有效缩短患者止血时间及腹痛消失时间,在临床治疗中具有重要价值。
Objective:To investigate the clinical efficacy of Lansoprazole for Injection in the treatment of duodenal ulcer bleeding.Method:65 cases of patients with duodenal ulcer bleeding were divided into control group and observation group.The control group 32 cases were treated with Omeprazole Sodium and the observation group 33 cases were treated with Lansoprazole for Injection.The clinical efficacy and adverse reactions of the two groups were observed.Result:The clinical effective rate of the observation group was 97.22%,significantly higher than 73.33% of the control group,there was statistical significance(P<0.05).The incidence of adverse reactions in the observation group was 5.56%,significantly lower than 13.33% of the control group(P<0.05).The hemostasis time(28.21±8.52)h and the disappearance time of abdominal pain(2.03±0.58)d in the observation group were shorter than those in the control group(P<0.05).Conclusion:Lansoprazole for injection is effective in the treatment of duodenal ulcer hemorrhage with few adverse reactions,which is of great value in clinical treatment.
Objective:To investigate the clinical efficacy of Lansoprazole for Injection in the treatment of duodenal ulcer bleeding.Method:65 cases of patients with duodenal ulcer bleeding were divided into control group and observation group.The control group 32 cases were treated with Omeprazole Sodium and the observation group 33 cases were treated with Lansoprazole for Injection.The clinical efficacy and adverse reactions of the two groups were observed.Result:The clinical effective rate of the observation group was 97.22%,significantly higher than 73.33% of the control group,there was statistical significance(P<0.05).The incidence of adverse reactions in the observation group was 5.56%,significantly lower than 13.33% of the control group(P<0.05).The hemostasis time(28.21±8.52)h and the disappearance time of abdominal pain(2.03±0.58)d in the observation group were shorter than those in the control group(P<0.05).Conclusion:Lansoprazole for injection is effective in the treatment of duodenal ulcer hemorrhage with few adverse reactions,which is of great value in clinical treatment.
引文
[1]毛东东,张磊,李会娜,等.注射用兰索拉唑与注射用奥美拉唑钠治疗十二指肠溃疡出血的临床疗效对比[J].临床合理用药杂志,2016,9(9):58-59.
[2]夏扣平.注射用兰索拉唑治疗十二指肠溃疡出血的疗效评价[J].江西医药,2016,51(6):540-542.
[3]刘浏,陈葵祖,徐林华,等.注射用兰索拉唑治疗消化道出血临床疗效及安全性研究[J].亚太传统医药,2014,10(1):97-98.
[4]梁燕.兰索拉唑联合奥曲肽治疗消化道出血的临床疗效分析[J].临床医学研究与实践,2017,2(28):33-34.
[5]刘宁,许树长.奥美拉唑、泮托拉唑与兰索拉唑预防应激性溃疡疗效比较[J].中国药业,2014,47(23):21-22.
[6]田邦妮,黄盖,陈五一,等.兰索拉唑、奥曲肽、血凝酶三药联用治疗老年急性上消化道出血疗效分析[J].现代中西医结合杂志,2015,12(6):613-615.
[7]罗金键.泮托拉唑治疗消化性溃疡合并上消化道出血的临床观察[J].中国医院用药评价与分析,2015,15(3):301-304.
[8]蒋晓燕.兰索拉唑治疗消化道溃疡上消化道出血的综合治疗效果分析[J].中国医药科学,2014,53(21):80-81,119.
[9]胡贵香.兰索拉唑与奥美拉唑钠治疗十二指肠溃疡出血的疗效对比分析[J].现代诊断与治疗,2014,3(1):90-91.
[10]丁阿亮,于栋伟.注射用兰索拉唑治疗应激性溃疡所致上消化道出血安全性研究[J].中国药业,2016,25(6):23-25.
[11]李雷,史佳.注射用血凝酶联合兰索拉唑治疗老年消化道溃疡伴出血的临床分析[J].中华全科医学,2015,13(3):410-412.
[12]刁依娜,杨正兵,蒋学华,等.注射用兰索拉唑治疗65例十二指肠溃疡伴出血患者的疗效[J].华西药学杂志,2014,29(5):611-612.
[2]夏扣平.注射用兰索拉唑治疗十二指肠溃疡出血的疗效评价[J].江西医药,2016,51(6):540-542.
[3]刘浏,陈葵祖,徐林华,等.注射用兰索拉唑治疗消化道出血临床疗效及安全性研究[J].亚太传统医药,2014,10(1):97-98.
[4]梁燕.兰索拉唑联合奥曲肽治疗消化道出血的临床疗效分析[J].临床医学研究与实践,2017,2(28):33-34.
[5]刘宁,许树长.奥美拉唑、泮托拉唑与兰索拉唑预防应激性溃疡疗效比较[J].中国药业,2014,47(23):21-22.
[6]田邦妮,黄盖,陈五一,等.兰索拉唑、奥曲肽、血凝酶三药联用治疗老年急性上消化道出血疗效分析[J].现代中西医结合杂志,2015,12(6):613-615.
[7]罗金键.泮托拉唑治疗消化性溃疡合并上消化道出血的临床观察[J].中国医院用药评价与分析,2015,15(3):301-304.
[8]蒋晓燕.兰索拉唑治疗消化道溃疡上消化道出血的综合治疗效果分析[J].中国医药科学,2014,53(21):80-81,119.
[9]胡贵香.兰索拉唑与奥美拉唑钠治疗十二指肠溃疡出血的疗效对比分析[J].现代诊断与治疗,2014,3(1):90-91.
[10]丁阿亮,于栋伟.注射用兰索拉唑治疗应激性溃疡所致上消化道出血安全性研究[J].中国药业,2016,25(6):23-25.
[11]李雷,史佳.注射用血凝酶联合兰索拉唑治疗老年消化道溃疡伴出血的临床分析[J].中华全科医学,2015,13(3):410-412.
[12]刁依娜,杨正兵,蒋学华,等.注射用兰索拉唑治疗65例十二指肠溃疡伴出血患者的疗效[J].华西药学杂志,2014,29(5):611-612.