“十九畏”同方配伍应用分析
|
摘要
整理古今"十九畏"同方配伍应用文献并进行分析,探讨"十九畏"古今同方应用情况及配伍特点。收集"十九畏"同方应用方剂共1600首(古代方剂602首、现代方剂998首),其中以肉桂-赤石脂最为常见(35. 00%),其次为人参-五灵脂(31. 56%)、丁香-郁金(17. 00%);乌头类-犀角(8. 88%)及巴豆-牵牛(7. 00%)应用较少,水银-砒霜、三棱-牙硝、硫黄-朴硝、狼毒-密陀僧古今均极少同方配伍应用。肉桂-赤石脂多配伍补气药、温里药和清热药,常用于腹泻、腹痛等脾胃疾病及痛经等妇科疾病;人参-五灵脂多配伍补气健脾药、活血化瘀药,用于妇女经产诸疾、小儿惊风、恶性肿瘤及心血管疾病等;丁香-郁金多配伍健脾药、理气药、化痰止咳药,常用于呃逆、胃痛等脾胃疾病。提示配伍禁忌"十九畏"中肉桂-赤石脂、人参-五灵脂、丁香-郁金古今均有应用,但具有一定病证特点和配伍环境特点,其安全性及组方规律值得进一步研究。
In order to discuss the features of compatibility and application of prescriptions containing drugs of"nineteen incompatibilities" in ancient and modern times,literatures including "nineteen incompatibilities"from ancient and modern times were collected and analyzed.A total of 1,600 prescriptions were collected including 602 ancient prescriptions and 998 modern prescriptions,among which the frequency of use of Rougui(Cortex Cinnamomi)with Chishizhi(Halloysitum Rubrum) was the highest(35.00%),followed by Renshen(Radix Ginseng) with Wulingzhi(Faeces Togopteri)(31.56%),Dingxiang(Flos Caryophylli) with Yujin(Radix Curcumae)(17.00%),Wutou(Radix Aconiti/Radix Aconiti Kusnezoffii) with Xijiao(Cornu Bubali)(8.88%),and Badou(Fructus Crotonis) with Qianniu(Semen Pharbitidis)(7.00%).Besides,the combinations of mecury with arsenic,Sanleng(Rhizoma Sparganii) with Yaxiao(Natrii Sulfas),Sulfur with Puxiao(Natrii Sulfas),Langdu(Stellera chamaejasme Linn) with litharge are rarely used either ancient or modern.The combination of Cortex Cinnamomi with Halloysitum Rubrum is commonly used with medicines of tonifying qi,warmimg the interior and clearing heat to treat diseases of spleen and stomach including diarrhea and abdominal pain,as well as gynecologic diseases like dysmenorrhea.The combination of Radix Ginseng with Faeces Togopteri is used with medicines of invigorating qi and strengthening the spleen,activating blood to remove stasis to treat obstetrical and gynecological diseases,malignant tumors,infantile convulsion,cardiovascular diseases,etc.The combination of Flos Caryophylli with Radix Curcumae is used with medicines of strengthening the spleen,regulating the flow of qi,resolving phlegm,and stopping coughing to treat diseases of spleen and stomach,such as hiccups and stomachaches.The results showed that under such circumstances as special symptoms and synergies,the prescription containing drugs of"nineteen incompatibilities"were used in both ancient and modern times.Therefore,the safety and compatible principles of the "nineteen incompatibilities"need further study.
In order to discuss the features of compatibility and application of prescriptions containing drugs of"nineteen incompatibilities" in ancient and modern times,literatures including "nineteen incompatibilities"from ancient and modern times were collected and analyzed.A total of 1,600 prescriptions were collected including 602 ancient prescriptions and 998 modern prescriptions,among which the frequency of use of Rougui(Cortex Cinnamomi)with Chishizhi(Halloysitum Rubrum) was the highest(35.00%),followed by Renshen(Radix Ginseng) with Wulingzhi(Faeces Togopteri)(31.56%),Dingxiang(Flos Caryophylli) with Yujin(Radix Curcumae)(17.00%),Wutou(Radix Aconiti/Radix Aconiti Kusnezoffii) with Xijiao(Cornu Bubali)(8.88%),and Badou(Fructus Crotonis) with Qianniu(Semen Pharbitidis)(7.00%).Besides,the combinations of mecury with arsenic,Sanleng(Rhizoma Sparganii) with Yaxiao(Natrii Sulfas),Sulfur with Puxiao(Natrii Sulfas),Langdu(Stellera chamaejasme Linn) with litharge are rarely used either ancient or modern.The combination of Cortex Cinnamomi with Halloysitum Rubrum is commonly used with medicines of tonifying qi,warmimg the interior and clearing heat to treat diseases of spleen and stomach including diarrhea and abdominal pain,as well as gynecologic diseases like dysmenorrhea.The combination of Radix Ginseng with Faeces Togopteri is used with medicines of invigorating qi and strengthening the spleen,activating blood to remove stasis to treat obstetrical and gynecological diseases,malignant tumors,infantile convulsion,cardiovascular diseases,etc.The combination of Flos Caryophylli with Radix Curcumae is used with medicines of strengthening the spleen,regulating the flow of qi,resolving phlegm,and stopping coughing to treat diseases of spleen and stomach,such as hiccups and stomachaches.The results showed that under such circumstances as special symptoms and synergies,the prescription containing drugs of"nineteen incompatibilities"were used in both ancient and modern times.Therefore,the safety and compatible principles of the "nineteen incompatibilities"need further study.
引文
[1]刘纯.医经小学[M].北京:中国中医药出版社,2015:17.
[2]黑峥峥.十九畏之肉桂与赤石脂同方配伍规律研究[D].南京:南京中医药大学,2017.
[3]王怀隐.太平圣惠方[M].郑金生,汪惟刚,董志珍,点校.北京:人民卫生出版社,2016.
[4]孙思邈.备急千金要方[M].太原:山西科学技术出版社,2010:93,455.
[5]王斌,姜波.中药治疗肠道易激综合征65例[J].中国中医药科技,2002,9(4):256.
[6]李梦雯,范欣生,张泠杉,等.基于复杂网络等方法的十九畏人参-五灵脂同方配伍探析[J].中国中药杂志,2017,42(18):3623-3627.
[7]吴瑭.温病条辨[M].孙志波,点校.北京:中医古籍出版社,2010:55
[8]龚信.古今医鉴[M].北京:中国医药科技出版社,2014:195.
[9]任应秋.疼痛的病机和证治[J].中医杂志,1980,21(10):19-23.
[10]肖晓光,王淑静,何光照,等.回生口服液联合化疗治疗晚期肺癌的临床观察[J].药物流行病学杂志,2016,25(4):216-220.
[11]费伯雄.医醇賸义[M].王新华,点校.南京:江苏科学技术出版社,1982:165-166.
[12]刘树华,李彦龙.自拟郁金丁香汤治疗非中枢顽固性呃逆69例[J].辽宁中医药大学学报,2013,15(5):13-14.
[13]王焘.外台秘要方[M].北京:中国医药科技出版社,2011:550.
[14]赵佶.圣济总录[M].郑金生,汪惟刚,点校.北京:人民卫生出版社,2013.
[15]唐自明,李树帜.水银与砒霜配伍的化学成分探索[J].云南中医学院学报,1998,21(S1):9,12.
[16]卫仲河,孟宪生,包永睿,等. HPLC三波长融合法对芒硝三棱相畏物质基础研究[J].中药材,2011,34(6):914-916.
[17]李树帜,唐自明,肖庆慈.三棱、芒硝配伍后化学成分的研究[J].云南中医学院学报,1998,21(S1):16-17.
[18]毛小平,旷春梅,肖庆慈,等.三棱与芒硝配伍的实验研究[J].云南中医中药杂志,1996,17(1):30-35.
[19]萧庆慈,李云森,毛小平,等.硫黄芒硝配伍的研究[J].云南中医学院学报,1998,21(S1):4-7.
[20]毛晓健,毛小平,肖庆慈.瑞香狼毒、狼毒大戟与密陀僧配伍的实验研究[J].云南中医学院学报,1998,21(S1):10-12.
[21]沈金鳌.妇科玉尺[M].郭瑞华,点校.天津:天津科学技术出版社,2000:127.
[22]陈素庵.陈素庵妇科补解[M].杜惠芳,注.北京:人民军医出版社,2012:223.
[2]黑峥峥.十九畏之肉桂与赤石脂同方配伍规律研究[D].南京:南京中医药大学,2017.
[3]王怀隐.太平圣惠方[M].郑金生,汪惟刚,董志珍,点校.北京:人民卫生出版社,2016.
[4]孙思邈.备急千金要方[M].太原:山西科学技术出版社,2010:93,455.
[5]王斌,姜波.中药治疗肠道易激综合征65例[J].中国中医药科技,2002,9(4):256.
[6]李梦雯,范欣生,张泠杉,等.基于复杂网络等方法的十九畏人参-五灵脂同方配伍探析[J].中国中药杂志,2017,42(18):3623-3627.
[7]吴瑭.温病条辨[M].孙志波,点校.北京:中医古籍出版社,2010:55
[8]龚信.古今医鉴[M].北京:中国医药科技出版社,2014:195.
[9]任应秋.疼痛的病机和证治[J].中医杂志,1980,21(10):19-23.
[10]肖晓光,王淑静,何光照,等.回生口服液联合化疗治疗晚期肺癌的临床观察[J].药物流行病学杂志,2016,25(4):216-220.
[11]费伯雄.医醇賸义[M].王新华,点校.南京:江苏科学技术出版社,1982:165-166.
[12]刘树华,李彦龙.自拟郁金丁香汤治疗非中枢顽固性呃逆69例[J].辽宁中医药大学学报,2013,15(5):13-14.
[13]王焘.外台秘要方[M].北京:中国医药科技出版社,2011:550.
[14]赵佶.圣济总录[M].郑金生,汪惟刚,点校.北京:人民卫生出版社,2013.
[15]唐自明,李树帜.水银与砒霜配伍的化学成分探索[J].云南中医学院学报,1998,21(S1):9,12.
[16]卫仲河,孟宪生,包永睿,等. HPLC三波长融合法对芒硝三棱相畏物质基础研究[J].中药材,2011,34(6):914-916.
[17]李树帜,唐自明,肖庆慈.三棱、芒硝配伍后化学成分的研究[J].云南中医学院学报,1998,21(S1):16-17.
[18]毛小平,旷春梅,肖庆慈,等.三棱与芒硝配伍的实验研究[J].云南中医中药杂志,1996,17(1):30-35.
[19]萧庆慈,李云森,毛小平,等.硫黄芒硝配伍的研究[J].云南中医学院学报,1998,21(S1):4-7.
[20]毛晓健,毛小平,肖庆慈.瑞香狼毒、狼毒大戟与密陀僧配伍的实验研究[J].云南中医学院学报,1998,21(S1):10-12.
[21]沈金鳌.妇科玉尺[M].郭瑞华,点校.天津:天津科学技术出版社,2000:127.
[22]陈素庵.陈素庵妇科补解[M].杜惠芳,注.北京:人民军医出版社,2012:223.