含七氟异丙基的吡嗪酰胺的合成与活性研究
|
摘要
以专利JP2006290883报道的具有杀螨虫活性的化合物C为基础,设计一种含七氟异丙基的吡嗪酰胺类化合物,以吡嗪-2-甲酸和2-甲基-七氟异丙基苯胺为原料,进行一步缩合反应合成目标化合物,其化学结构经~1H NMR,ESI-MS和熔点确证。对其缩合反应的条件进行了探讨。初步的杀螨活性表明,该化合物对朱砂叶螨有一定抑制活性。
The novel pyrazine derivatives containing fluoroisopropyl group were synthesized based on the structure of compound which was reported on JP2006290883.The structures were confirmed by ~1H NMR,ESI-MS.The reaction condition were also discussed.The prelimary bioasssay indicated that the compound 1 had acaricidal activity.
The novel pyrazine derivatives containing fluoroisopropyl group were synthesized based on the structure of compound which was reported on JP2006290883.The structures were confirmed by ~1H NMR,ESI-MS.The reaction condition were also discussed.The prelimary bioasssay indicated that the compound 1 had acaricidal activity.
引文
[1]张一宾.世界农药新进展(四)[J].北京:化学工业出版社,2017.
[2]Tumova L,Gallova K,Rimakova J.The effect of substituted amides of pyrazine-2-carboxylic acids on flavonolignan production in silybum marianum culture in vitro[J].Acta Physiogate Plantarum,2005,27(3B):357-362.
[3]Masatsugu O,Yoshihro M,Koji T,et al.Preparation of N-2-(hetero)arylethylcarboxamide derivatives as pest-controlling agents:WO,2007108483[P].2007-10-23.
[4]Fukuda K,Kondo Y,Makabe T,et al.Synthesis and acaricidal activities of pyrazine derivatives:JP,2006290883[P].2006-08-20.
[5]刘长令,柴宝山.新农药创制与合成[M].北京:化学工业出版社,2013.
[2]Tumova L,Gallova K,Rimakova J.The effect of substituted amides of pyrazine-2-carboxylic acids on flavonolignan production in silybum marianum culture in vitro[J].Acta Physiogate Plantarum,2005,27(3B):357-362.
[3]Masatsugu O,Yoshihro M,Koji T,et al.Preparation of N-2-(hetero)arylethylcarboxamide derivatives as pest-controlling agents:WO,2007108483[P].2007-10-23.
[4]Fukuda K,Kondo Y,Makabe T,et al.Synthesis and acaricidal activities of pyrazine derivatives:JP,2006290883[P].2006-08-20.
[5]刘长令,柴宝山.新农药创制与合成[M].北京:化学工业出版社,2013.