基于析因设计的中药熏蒸治疗血热型银屑病研究
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摘要
[目的]通过析因设计探究中药熏蒸治疗血热型银屑病的临床疗效。[方法]按两因素三水平的析因设计方法进行分析,两因素即温度组、时间组,三水平即温度组(38、40、42℃)、时间组(20、25、30 min),采集90例住院患者,随机分为9组进行试验,疗程均为2周。[结果]不同温度、时间组合对中药熏蒸治疗血热型银屑病的疗效影响大小为:42℃×25 min>42℃×30 min>42℃×20 min>40℃×25 min>40℃×20 min>38℃×30 min>40℃×30 min>38℃×20 min>38℃×25 min。在时间与温度的交互作用统计分析结果中,提示时间、温度之间的交互作用无统计学意义(P>0.05),但就温度的单独效应结果来看,差异有统计学意义(P<0.05),即不同的温度对银屑病面积与严重性指数(PASI)评分下降值具有显著影响。进一步分析,42℃温度条件下对PASI评分降低影响更为显著。[结论]中药熏蒸对血热型银屑病有良好的治疗效果,42℃×25 min组合的疗效明显优于其他组合,且无明显不良反应。
[Objective] To explore the clinical effects of herbal steaming therapy in treating blood-heat-type psoriasis based on factorial design. [Methods] Totally 90 patients were randomly divided into 9 groups to conduct a two-factor(temperature,time) three-level(temperature:38 ℃,40 ℃,42 ℃;time:20 min,25 min,30 min) factorial design.[Results] Combined the factor of temperature with time,there are different effect in treating blood-heat-type psoriasis with herbal steaming therapy:42 ℃×25 min>42 ℃×30 min>42 ℃×20 min>40 ℃×25 min>40 ℃×20 min>38 ℃×30 min>40 ℃×30 min>38 ℃×20 min>38 ℃×25 min. The interaction of the statistical analysis results between time and temperature has no statistical significance(P>0.05). However,there is statistical significance(P<0.05)considering the single effect of temperature which means different value of temperature has remarkable influence on the decreasing PASI score. Furthermore,the PASI score decreases significantly when the temperature at 42 ℃.[Conclusion] In treating blood-heat-type psoriasis with herbal steaming therapy,the group of 42 ℃ ×25 min produces the highest curative effect and without any side effect.
[Objective] To explore the clinical effects of herbal steaming therapy in treating blood-heat-type psoriasis based on factorial design. [Methods] Totally 90 patients were randomly divided into 9 groups to conduct a two-factor(temperature,time) three-level(temperature:38 ℃,40 ℃,42 ℃;time:20 min,25 min,30 min) factorial design.[Results] Combined the factor of temperature with time,there are different effect in treating blood-heat-type psoriasis with herbal steaming therapy:42 ℃×25 min>42 ℃×30 min>42 ℃×20 min>40 ℃×25 min>40 ℃×20 min>38 ℃×30 min>40 ℃×30 min>38 ℃×20 min>38 ℃×25 min. The interaction of the statistical analysis results between time and temperature has no statistical significance(P>0.05). However,there is statistical significance(P<0.05)considering the single effect of temperature which means different value of temperature has remarkable influence on the decreasing PASI score. Furthermore,the PASI score decreases significantly when the temperature at 42 ℃.[Conclusion] In treating blood-heat-type psoriasis with herbal steaming therapy,the group of 42 ℃ ×25 min produces the highest curative effect and without any side effect.
引文
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[2]黄香娇,陶锡东.银屑病关节炎治疗分析[J].浙江临床医学,2003,31(8):588.
[3]段茜,程燕,储蕾,等.中药药浴联合NB-UVB照射治疗寻常性银屑病疗效及安全性的系统评价[J].中国皮肤性病学杂志,2013,27(2):192-195.
[4]李梅,王素玲,李欣,等.复方甘草酸苷联合维胺酯胶囊治疗寻常性银屑病34例[J].陕西中医,2013,33(10):1372-1373.
[5]刘云贞,李春鸟.清热消肿洗剂熏蒸联合中医辨证论治口服中药治疗寻常性银屑病的疗效分析[J].陕西中医,2016,37(7):897-898.
[6]薛冰心,吴纯洁.影响药物经皮吸收的客观因素[J].中国现代医学杂志,2010,20(16):2479-2483,2487.
[7]刘承煌.皮肤的屏障作用和吸收作用[J].国外医学参考资料·皮肤病学分册,1977(1):9-15.
[8] Caterina MJ. Transient receptor potential ion channels as participants in thermosensation and thermoregulation[J]. Am J Physiol Regul Integr Comp Physiol,2007,292(1):R64-R76.
[9] Baylie RL,Brayden JE. TRPV channels and vascular function[J]. Acta Physiol(Oxf),2011,203(1):99-116.