宁泌泰胶囊在男科疾病中的研究进展
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摘要
宁泌泰胶囊是治疗泌尿、生殖系感染的经典专利苗药,富含多种中草药有效成分,具有广泛的生物学活性,对于泌尿生殖系统感染效果显著。宁泌泰胶囊面世至今已有近20年,回顾近年来国内相关研究发现,宁泌泰胶囊在泌尿男科疾病中的应用较多,尤其在慢性前列腺炎方面应用非常广泛,取得了理想的疗效。此外,宁泌泰胶囊对男性生殖系统无明显不良反应,在糖尿病尿路感染、非淋菌性尿道炎、精囊炎、急性附睾炎、膀胱过度活动症、血尿、精液不液化等方面也正逐步推广应用。未来尚需要大样本、多中心、随机对照研究以进一步验证宁泌泰胶囊的确切疗效。同时,需要开展更多分子生物学方面的实验研究,以便更深入的探讨宁泌泰胶囊的药理学作用机制。因此,本文就近年来国内关于宁泌泰胶囊在泌尿男科疾病中的应用及研究进展作一综述。
Ningmitai Capsule is a classical patent medicine prepared from multiple effective ingredients of Chinese herbal medicine,with a wide range of biological activities and a significant efficacy in the treatment of urogenital diseases. Ningmitai Capsule has been widely applied in the management of urological and andrological diseases,with a particularly ideal effect on chronic prostatitis,since its first introduction nearly 20 years ago. With no obvious adverse effect on the male reproductive system,it has also been gaining a gradual application in the treatment of such diseases as urinary tract infections,diabetes,non-gonococcal urethritis,seminal vesiculitis,acute epididymitis,overactive bladder,hematuria,and semen non-liquefaction. However,the definite efficacy of Ningmitai Capsule needs to be further verified with more large-scale multi-centered randomized controlled trials,and its pharmacological mechanism remains to be further explored via more biomolecular experiments. The present article focuses on the recent advances in the application and studies of Ningmitai Capsule in the treatment of urological and andrological diseases.
Ningmitai Capsule is a classical patent medicine prepared from multiple effective ingredients of Chinese herbal medicine,with a wide range of biological activities and a significant efficacy in the treatment of urogenital diseases. Ningmitai Capsule has been widely applied in the management of urological and andrological diseases,with a particularly ideal effect on chronic prostatitis,since its first introduction nearly 20 years ago. With no obvious adverse effect on the male reproductive system,it has also been gaining a gradual application in the treatment of such diseases as urinary tract infections,diabetes,non-gonococcal urethritis,seminal vesiculitis,acute epididymitis,overactive bladder,hematuria,and semen non-liquefaction. However,the definite efficacy of Ningmitai Capsule needs to be further verified with more large-scale multi-centered randomized controlled trials,and its pharmacological mechanism remains to be further explored via more biomolecular experiments. The present article focuses on the recent advances in the application and studies of Ningmitai Capsule in the treatment of urological and andrological diseases.
引文
[1]刘左成,李广宇,黄伟,等.宁泌泰联合盐酸坦索罗辛缓释胶囊治疗慢性非细菌性前列腺炎疗效观察.临床合理用药杂志,2010,(16):26-27.
[2]黄秀英,仇让学.宁泌泰胶囊联合罗红霉素缓释胶囊治疗慢性前列腺炎229例.哈尔滨医药,2011,31(3):177.
[3]殷崎.宁泌泰胶囊对大鼠实验性前列腺炎的药效学研究.贵州医药,2000,24(1):43-44.
[4]杨晨涛,张飞,窦圣姗,等.宁泌泰胶囊对金黄色葡萄球菌抑制作用的研究.中华男科学杂志,2016,22(4):376-378.
[5]汤京华.宁泌泰胶囊治疗女性尿道综合征53例.上海中医药杂志,2003,37(2):25-26.
[6]范祎,周光军,於裕福.宁泌泰胶囊治疗慢性前列腺炎500例临床观察.浙江中医杂志,2008,45(12):736.
[7]张飞,窦圣姗,张杰.宁泌泰胶囊的抗炎作用研究.现代药物与临床,2015,30(11):1317-1319.
[8]刘蕾,田明清,黄文杰.宁泌泰胶囊治疗糖尿病尿路感染的临床疗效观察.中国中西医结合急救杂志,2014,21(5):368-371.
[9]赵润璞,琚保军.宁泌泰胶囊联合阿奇霉素治疗非淋菌性尿道炎110例临床观察.中国综合临床,2006,22(10):948.
[10]杨文涛,梁文涛,金鑫,等.非常见致病菌引起的非淋菌性尿道炎13例治疗体会.长春中医药大学学报,2011,27(1):102-103.
[11]任知良,刘崇恺,江志强.宁泌泰胶囊治疗慢性前列腺炎320例.上海中医药杂志,2003,37(9):26.
[12]周海滨,廖鑫鑫,蔡军,等.宁泌泰联合盐酸坦索罗辛治疗Ⅲ型前列腺炎的疗效.实用临床医学,2014,15(3):46-48.
[13]种庆贵,宋爱君,郭艳,等.宁泌泰胶囊治疗慢性前列腺炎临床观察.中国中西医结合外科杂志,2014,20(2):178-180.
[14]黄宝星,宿恒川,孙福康.复方环丙沙星栓联合云南白药、宁泌泰治疗组织学前列腺炎伴PSA升高患者的疗效评价.中华男科学杂志,2012,18(11):986-990.
[15]陈思达,刘步平,钱丽欢,等.宁泌泰治疗慢性前列腺炎Meta分析.现代医院,2015,15(12):8-12,17.
[16]夏明康,胡珍真,杨素娜,等.宁泌泰胶囊联合抗生素治疗慢性前列腺炎的Meta分析.中草药,2015,46(11):1704-1709.
[17]唐富荣,余金明,唐证,等.单用左氧氟沙星及其联用宁泌泰胶囊治疗慢性前列腺炎的药物经济学评价.中国中西医结合外科杂志,2016,22(1):28-31.
[18]Furuya R,Takahashi S,Furuya S,et al.Is urethritis accompanied by seminal vesiculitis?Int J Urol,2009,16(7):628-631.
[19]Park SH,Ryu JK,Choo GY,et al.Chronic bacterial seminal vesiculitis as a potential disease entity in men with chronic prostatitis.Int J Urol,2015,22(5):508-512.
[20]杨介礼,陈庆存,李祖能.宁泌泰胶囊治疗慢性精囊炎临床观察.中国乡村医药,2010,17(9):41.
[21]蔡健,陈熙猛,汪广兵.宁泌泰胶囊治疗精囊炎所致血精症的疗效观察.中草药,2014,45(23):3440-3442.
[22]胡斌,郑典宝,刘汀.宁泌泰胶囊治疗急性附睾炎97例临床体会.生物技术世界,2013,7(4):77.
[23]贾民,张晓宇,刘铄,等.宁泌泰胶囊联合托特罗治疗经尿道前列腺电切术后膀胱过度活动症临床研究.国际中医中药杂志,2015,(8):695-698.
[24]车福驷,赵树学.宁泌泰胶囊治疗前列腺性血尿430例临床研究.上海中医药杂志,2006,40(6):55-55.
[25]Wilson VB,Bunge RG.Infertility and semen non-liquefaction.J Urol,1975,113(4):509-510.
[26]郑德全,郑毅春.宁泌泰胶囊治疗精液不液化症120例报告.临床泌尿外科杂志,2006,21(9):714-715.
[27]钟邦兴.观察宁泌泰胶囊针对精液不液化症的临床效果.医药前沿,2012,18(2):143-143.
[28]张翼飞,梁朝朝.精液延迟液化与慢性前列腺炎的研究进展.中华男科学杂志,2007,13(1):53-56.
[29]张新东,金保方,周玉春,等.前列倍喜胶囊治疗精液不液化180例临床研究.中华男科学杂志,2009,15(7):665-668.
[30]王向东,刘胜,孙鹏宇,等.宁泌泰胶囊治疗156例精液不液化症疗效观察.现代医院,2014,14(3):35-36.
[31]赵金辉.宁泌泰胶囊联合中医辨证治疗精液不液化症50例临床研究.中国实用医药,2010,5(28):129.
[32]姜辉,邓春华,商学军,等.左卡尼汀在男性不育中临床应用专家共识(2014版).中华男科学杂志,2015,21(1):82-85.
[33]聂富高,孙荣生,侯万里.宁泌泰胶囊治疗炎性弱精症143例临床观察.上海中医药杂志,2008,42(10):44-45.
[34]陈淑敏,于忠建.宁泌泰胶囊治疗伴慢性前列腺炎的不育患者58例.中国药业,2009,18(14):79.
[35]韩伟,张喜庄,杨永军,等.单用宁泌泰胶囊治疗BPH疗效观察.临床泌尿外科杂志,2012,27(11):853-854.
[36]朱建国.宁泌泰联合坦索罗辛对双J管综合征的预防作用.中国中西医结合急救杂志,2015,22(1):98-100.
[2]黄秀英,仇让学.宁泌泰胶囊联合罗红霉素缓释胶囊治疗慢性前列腺炎229例.哈尔滨医药,2011,31(3):177.
[3]殷崎.宁泌泰胶囊对大鼠实验性前列腺炎的药效学研究.贵州医药,2000,24(1):43-44.
[4]杨晨涛,张飞,窦圣姗,等.宁泌泰胶囊对金黄色葡萄球菌抑制作用的研究.中华男科学杂志,2016,22(4):376-378.
[5]汤京华.宁泌泰胶囊治疗女性尿道综合征53例.上海中医药杂志,2003,37(2):25-26.
[6]范祎,周光军,於裕福.宁泌泰胶囊治疗慢性前列腺炎500例临床观察.浙江中医杂志,2008,45(12):736.
[7]张飞,窦圣姗,张杰.宁泌泰胶囊的抗炎作用研究.现代药物与临床,2015,30(11):1317-1319.
[8]刘蕾,田明清,黄文杰.宁泌泰胶囊治疗糖尿病尿路感染的临床疗效观察.中国中西医结合急救杂志,2014,21(5):368-371.
[9]赵润璞,琚保军.宁泌泰胶囊联合阿奇霉素治疗非淋菌性尿道炎110例临床观察.中国综合临床,2006,22(10):948.
[10]杨文涛,梁文涛,金鑫,等.非常见致病菌引起的非淋菌性尿道炎13例治疗体会.长春中医药大学学报,2011,27(1):102-103.
[11]任知良,刘崇恺,江志强.宁泌泰胶囊治疗慢性前列腺炎320例.上海中医药杂志,2003,37(9):26.
[12]周海滨,廖鑫鑫,蔡军,等.宁泌泰联合盐酸坦索罗辛治疗Ⅲ型前列腺炎的疗效.实用临床医学,2014,15(3):46-48.
[13]种庆贵,宋爱君,郭艳,等.宁泌泰胶囊治疗慢性前列腺炎临床观察.中国中西医结合外科杂志,2014,20(2):178-180.
[14]黄宝星,宿恒川,孙福康.复方环丙沙星栓联合云南白药、宁泌泰治疗组织学前列腺炎伴PSA升高患者的疗效评价.中华男科学杂志,2012,18(11):986-990.
[15]陈思达,刘步平,钱丽欢,等.宁泌泰治疗慢性前列腺炎Meta分析.现代医院,2015,15(12):8-12,17.
[16]夏明康,胡珍真,杨素娜,等.宁泌泰胶囊联合抗生素治疗慢性前列腺炎的Meta分析.中草药,2015,46(11):1704-1709.
[17]唐富荣,余金明,唐证,等.单用左氧氟沙星及其联用宁泌泰胶囊治疗慢性前列腺炎的药物经济学评价.中国中西医结合外科杂志,2016,22(1):28-31.
[18]Furuya R,Takahashi S,Furuya S,et al.Is urethritis accompanied by seminal vesiculitis?Int J Urol,2009,16(7):628-631.
[19]Park SH,Ryu JK,Choo GY,et al.Chronic bacterial seminal vesiculitis as a potential disease entity in men with chronic prostatitis.Int J Urol,2015,22(5):508-512.
[20]杨介礼,陈庆存,李祖能.宁泌泰胶囊治疗慢性精囊炎临床观察.中国乡村医药,2010,17(9):41.
[21]蔡健,陈熙猛,汪广兵.宁泌泰胶囊治疗精囊炎所致血精症的疗效观察.中草药,2014,45(23):3440-3442.
[22]胡斌,郑典宝,刘汀.宁泌泰胶囊治疗急性附睾炎97例临床体会.生物技术世界,2013,7(4):77.
[23]贾民,张晓宇,刘铄,等.宁泌泰胶囊联合托特罗治疗经尿道前列腺电切术后膀胱过度活动症临床研究.国际中医中药杂志,2015,(8):695-698.
[24]车福驷,赵树学.宁泌泰胶囊治疗前列腺性血尿430例临床研究.上海中医药杂志,2006,40(6):55-55.
[25]Wilson VB,Bunge RG.Infertility and semen non-liquefaction.J Urol,1975,113(4):509-510.
[26]郑德全,郑毅春.宁泌泰胶囊治疗精液不液化症120例报告.临床泌尿外科杂志,2006,21(9):714-715.
[27]钟邦兴.观察宁泌泰胶囊针对精液不液化症的临床效果.医药前沿,2012,18(2):143-143.
[28]张翼飞,梁朝朝.精液延迟液化与慢性前列腺炎的研究进展.中华男科学杂志,2007,13(1):53-56.
[29]张新东,金保方,周玉春,等.前列倍喜胶囊治疗精液不液化180例临床研究.中华男科学杂志,2009,15(7):665-668.
[30]王向东,刘胜,孙鹏宇,等.宁泌泰胶囊治疗156例精液不液化症疗效观察.现代医院,2014,14(3):35-36.
[31]赵金辉.宁泌泰胶囊联合中医辨证治疗精液不液化症50例临床研究.中国实用医药,2010,5(28):129.
[32]姜辉,邓春华,商学军,等.左卡尼汀在男性不育中临床应用专家共识(2014版).中华男科学杂志,2015,21(1):82-85.
[33]聂富高,孙荣生,侯万里.宁泌泰胶囊治疗炎性弱精症143例临床观察.上海中医药杂志,2008,42(10):44-45.
[34]陈淑敏,于忠建.宁泌泰胶囊治疗伴慢性前列腺炎的不育患者58例.中国药业,2009,18(14):79.
[35]韩伟,张喜庄,杨永军,等.单用宁泌泰胶囊治疗BPH疗效观察.临床泌尿外科杂志,2012,27(11):853-854.
[36]朱建国.宁泌泰联合坦索罗辛对双J管综合征的预防作用.中国中西医结合急救杂志,2015,22(1):98-100.