奥氮平治疗伴肿瘤相关性焦虑抑郁的临床效果研究
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摘要
目的探讨奥氮平治疗伴肿瘤相关性焦虑抑郁患者的临床疗效。方法本次研究中103例合并焦虑抑郁情绪的肿瘤患者,均为2014年1月~2015年6月期间来我院进行治疗的病例,将其按照随机数字表法分为两组,研究组51例采用奥氮平及常规肿瘤治疗,对照组52例采用常规肿瘤治疗。比较两组治疗前后的焦虑、抑郁情绪及患者的生活质量。结果治疗后研究组和对照组SDS及SAS评分均出现明显降低,与治疗前比较差异有统计学意义(P<0.05);研究组治疗后SDS、SAS评分与同期对照组比较明显较低,两组差异有统计学意义(P<0.05)。治疗后两组SF-36量表各维度评分均出现明显升高,研究组治疗后生理职能、活力、社会功能、情感职能评分与同期对照组比较明显升高,两组差异有统计学意义(P<0.05)。结论伴肿瘤相关性焦虑抑郁患者采用奥氮平治疗疗效显著,可有效缓解患者的焦虑、抑郁情绪,提高患者的生活质量,可在临床推广应用。
Objective To explore the clinical effect of olanzapine in treatment of tumor-relate anxiety and depression. Methods 103 tumor patients with anxiety and depression were all selected from January 2014 to June 2015 in our hospital,and they were divided into two groups according to random number table.51 cases in the study group were treated with olanzapine and conventional tumor therapy,and 52 cases in the control group were treated with conventional tumor therapy.The anxiety, depression and quality of life of two groups before treatment and after treatment were compared. Results SDS and SAS scores of the two groups after treatment were significantly lower than those before treatment,there were significant differences between before treatment and after treatment(P < 0.05).SDS,SAS score of the study group after treatment were lower than those of the control group on the same period,there were significant differences between the two groups(P < 0.05).All dimensions of SF-36 scores of the two groups after treatment were significantly increased.Physiological function,vitality,social function,emotional function score of the study group after treatment were higher than those of the control group on the same period,there were significant differences between the two groups(P < 0.05). Conclusion The clinical effect of olanzapine in treatment of tumor-relate anxiety and depression was significant.It could effectively alleviate the anxiety and depression of the patients,and improve the quality of life of patients.It could be widely used in clinical practice.
Objective To explore the clinical effect of olanzapine in treatment of tumor-relate anxiety and depression. Methods 103 tumor patients with anxiety and depression were all selected from January 2014 to June 2015 in our hospital,and they were divided into two groups according to random number table.51 cases in the study group were treated with olanzapine and conventional tumor therapy,and 52 cases in the control group were treated with conventional tumor therapy.The anxiety, depression and quality of life of two groups before treatment and after treatment were compared. Results SDS and SAS scores of the two groups after treatment were significantly lower than those before treatment,there were significant differences between before treatment and after treatment(P < 0.05).SDS,SAS score of the study group after treatment were lower than those of the control group on the same period,there were significant differences between the two groups(P < 0.05).All dimensions of SF-36 scores of the two groups after treatment were significantly increased.Physiological function,vitality,social function,emotional function score of the study group after treatment were higher than those of the control group on the same period,there were significant differences between the two groups(P < 0.05). Conclusion The clinical effect of olanzapine in treatment of tumor-relate anxiety and depression was significant.It could effectively alleviate the anxiety and depression of the patients,and improve the quality of life of patients.It could be widely used in clinical practice.
引文
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[12]王学燕,周玉珍,杨红梅,等.喹硫平与奥氮平对帕罗西汀治疗抑郁症伴焦虑障碍患者增效作用的比较[J].中国民康医学,2015,27(6):29-30.
[13]高平来,刘跃钢.西酞普兰联合奥氮平治疗躯体形式障碍对照研究[J].临床心身疾病杂志,2014,20(5):13-15.
[14]赖道丽,胡卫平,冯春萍.博乐欣联合奥氮平治疗焦虑合并抑郁的临床研究[J].当代医学,2014,20(32):135-136.
[15]黄建,左红英,杨惠,等.抗抑郁药物合奥氮平治疗伴躯体疼痛抑郁症40例临床观察[J].中国民族民间医药杂志,2015,24(20):40.
[16]刘锡亮,曲春晖,姜丽丽.氟西汀联合小剂量奥氮平治疗重度抑郁症的临床疗效评价[J].中国继续医学教育,7(23):147-148.
[2]魏立君.胃肠道恶性肿瘤患者焦虑抑郁状态及其影响因素[J].现代肿瘤医学,2015,23(19):2802-2804.
[3]李元娥.整体护理干预对肿瘤化疗患者疲乏及焦虑抑郁的影响[J].内科,2015,10(5):743-744.
[4]梁敏.心理干预对恶性肿瘤患者焦虑抑郁的影响[J].吉林医学,2013,34(12):2387-2388.
[5]李春波,何燕玲.健康状况调查问卷SF-36的介绍[J].国外医学精神病学分册,2002,29(2):116-119.
[6]赵兵,储文革,马嫣,等.米氮平与氟西汀治疗肿瘤化疗患者伴发焦虑抑郁障碍对照研究[J].临床心身疾病杂志,2015,21(5):33-35.
[7]Yang YL,Liu L,Wang Y,et al.The prevalence of depression and anxiety among Chinese adults with cancer:a systematic review and meta-analysis[J].BMC Cancer,2013,13:393.
[8]程和瑞,翟西菊,亓德美,等.奥氮平治疗伴肿瘤相关性焦虑抑郁肿瘤的疗效观察[J].社区医学杂志,2015,13(4):28-30.
[9]彭娟,周录娇,周航,等.100例肿瘤患者的抑郁焦虑情绪调查分析[J].重庆医学,2015,44(14):1949-1950.
[10]杨红,郑世利.社会支持对门诊化疗肿瘤患者焦虑抑郁情绪的影响[J].国际护理学杂志,2015,34(16):2167-2171.
[11]王金梅,邵长春,杜兴水.米氮平、艾司西酞普兰治疗恶性肿瘤伴发抑郁焦虑的临床对照研究[J].当代护士,2015(6):84-86.
[12]王学燕,周玉珍,杨红梅,等.喹硫平与奥氮平对帕罗西汀治疗抑郁症伴焦虑障碍患者增效作用的比较[J].中国民康医学,2015,27(6):29-30.
[13]高平来,刘跃钢.西酞普兰联合奥氮平治疗躯体形式障碍对照研究[J].临床心身疾病杂志,2014,20(5):13-15.
[14]赖道丽,胡卫平,冯春萍.博乐欣联合奥氮平治疗焦虑合并抑郁的临床研究[J].当代医学,2014,20(32):135-136.
[15]黄建,左红英,杨惠,等.抗抑郁药物合奥氮平治疗伴躯体疼痛抑郁症40例临床观察[J].中国民族民间医药杂志,2015,24(20):40.
[16]刘锡亮,曲春晖,姜丽丽.氟西汀联合小剂量奥氮平治疗重度抑郁症的临床疗效评价[J].中国继续医学教育,7(23):147-148.