血浆同型半胱氨酸水平与急性缺血性脑卒中患者卒中复发及死亡的关系分析
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摘要
目的分析血浆同型半胱氨酸水平与急性缺血性脑卒中患者卒中复发及死亡的关系。方法回顾性分析我院2018年1月-2018年12月收治的150例急性缺血性脑卒中患者临床资料,依据是否首次发病以及预后将其分为首次发病组100例、复发组40例、死亡组5例,对三组血浆同型半胱氨酸水平进行对比,分析该指标数值与急性缺血性脑卒中复发及死亡的关系。结果三组血浆同型半胱氨酸水平相比较,首次发病组<复发组<死亡组,差异有统计学意义(P<0.05);首次发病组16μmol/L-30μmol/L占比高于复发组及死亡组,复发组31μmol/L-100μmol/L占比高于首次发病组及死亡组,死亡组>100μmol/L占比高于首次发病组及复发组,差异均有统计学意义(P<0.05)。结论血浆同型半胱氨酸水平与急性缺血性脑卒中患者卒中复发及死亡密切相关,可作为急性缺血性脑卒复发及死亡的预测指标。
Objective To analyze the relationship between plasma homocysteine level and stroke recurrence and death in patients with acute ischemic stroke. Methods The clinical data of 150 patients with acute ischemic stroke admitted to our hospital from January 2018 to December 2018 were retrospectively analyzed. According to whether the?rst onset and prognosis were divided into 100 cases in the ?rst episode group and 40 cases in the recurrent group. Five patients in the death group were compared with the plasma homocysteine levels of the three groups, and the relationship between the index value and the recurrence and death of acute ischemic stroke was analyzed. Results The plasma levels of homocysteine in the three groups were signi?cantly higher in the ?rst-onset group than in the relapse group(P<0.05). The proportion of 16 μmol/L to 30 μmol/L in the ?rst-onset group was higher than that in the recurrent group.In the death group, the proportion of 31 μmol/L-100 μmol/L in the recurrent group was higher than that in the ?rst-incidence group and the death group. The proportion of death group >100 μmol/L was higher than that in the ?rst-onset group and the recurrence group, and the difference was statistically signi?cant(P<0.05). Conclusion Plasma homocysteine level is closely related to stroke recurrence and death in patients with acute ischemic stroke, and can be used as a predictor of acute ischemic stroke recurrence and death.
Objective To analyze the relationship between plasma homocysteine level and stroke recurrence and death in patients with acute ischemic stroke. Methods The clinical data of 150 patients with acute ischemic stroke admitted to our hospital from January 2018 to December 2018 were retrospectively analyzed. According to whether the?rst onset and prognosis were divided into 100 cases in the ?rst episode group and 40 cases in the recurrent group. Five patients in the death group were compared with the plasma homocysteine levels of the three groups, and the relationship between the index value and the recurrence and death of acute ischemic stroke was analyzed. Results The plasma levels of homocysteine in the three groups were signi?cantly higher in the ?rst-onset group than in the relapse group(P<0.05). The proportion of 16 μmol/L to 30 μmol/L in the ?rst-onset group was higher than that in the recurrent group.In the death group, the proportion of 31 μmol/L-100 μmol/L in the recurrent group was higher than that in the ?rst-incidence group and the death group. The proportion of death group >100 μmol/L was higher than that in the ?rst-onset group and the recurrence group, and the difference was statistically signi?cant(P<0.05). Conclusion Plasma homocysteine level is closely related to stroke recurrence and death in patients with acute ischemic stroke, and can be used as a predictor of acute ischemic stroke recurrence and death.
引文
[1]侯永革,王冬欣,张志涛,等.血浆同型半胱氨酸水平对脑梗死复发及中国缺血性卒中亚型分型的影响[J].临床误诊误治, 2018,31(11):86-89.
[2]方明.急性脑卒中病因学分型和病变部位与血浆同型半胱氨酸水平的临床关系[J].中国当代医药, 2018, 25(28):62-65.
[3]张丽,杨君素,朱红雯,等.同型半胱氨酸水平与急性缺血性脑卒中老老年患者溶栓预后相关性分析[J].河北医科大学学报,2018, 39(8):872-876.
[4]孟晓轲.急性缺血性脑卒中患者血浆同型半胱氨酸水平的变化[J].慢性病学杂志, 2018, 19(3):294-295.
[5]程国辉,钱剑宁,李友健.动脉粥样硬化性脑梗死急性期患者血浆脂蛋白相关磷脂酶A2与同型半胱氨酸水平的变化及临床相关性分析[J].中国医药科学, 2018, 8(4):203-245.
[6]范荣.缺血性心脑血管病患者血浆同型半胱氨酸水平的变化分析[J].中国医药指南, 2017, 15(12):84-85.
[2]方明.急性脑卒中病因学分型和病变部位与血浆同型半胱氨酸水平的临床关系[J].中国当代医药, 2018, 25(28):62-65.
[3]张丽,杨君素,朱红雯,等.同型半胱氨酸水平与急性缺血性脑卒中老老年患者溶栓预后相关性分析[J].河北医科大学学报,2018, 39(8):872-876.
[4]孟晓轲.急性缺血性脑卒中患者血浆同型半胱氨酸水平的变化[J].慢性病学杂志, 2018, 19(3):294-295.
[5]程国辉,钱剑宁,李友健.动脉粥样硬化性脑梗死急性期患者血浆脂蛋白相关磷脂酶A2与同型半胱氨酸水平的变化及临床相关性分析[J].中国医药科学, 2018, 8(4):203-245.
[6]范荣.缺血性心脑血管病患者血浆同型半胱氨酸水平的变化分析[J].中国医药指南, 2017, 15(12):84-85.