依达拉奉注射液对颅脑外伤脑出血患者血浆NOET水平及血液流变学的影响
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摘要
目的:研究依达拉奉注射液对颅脑外伤脑出血患者血浆NO、ET水平及血液流变学的影响。方法:将本院2015年11月至2017年2月共80例颅脑外伤脑出血患者以随机数字表法均分为观察组和对照组,每组各40例。入组患者进行常规止血、补液、降颅压、营养、抗炎、脱水、利尿等对症治疗;观察组则在此基础上给予依达拉奉注射液。观察记录两组患者临床治疗效果,比较两组患者治疗前后FMA评分和ADL评分;并对血液流变学指标及NO、ET水平进行检测比较。结果:两组患者治疗后,观察组患者临床总有效率(95.00%),明显高于对照组(72.50%),观察组全血粘度(高切、低切)、血浆粘度血沉、血小板黏附率及红细胞聚集指数、血浆ET水平均明显低于对照组,而NO水平、患者FMA和ADL评分明显高于对照组,差异有统计学意义(P<0.05)。结论:依达拉奉注射液治疗颅脑外伤脑出血患者具有较好的临床效率,可有效改善其血液流变学指标及血浆NO、ET水平。
Objective: To study the effect of Edaravone Injection on plasma NO,ET and hemorheology in patients with cerebral hemorrhage. Methods: From November 2015 to February 2017,a total of 80 patients with traumatic brain hemorrhage in our hospital were randomly divided into observation group and control group,40 cases in each group. The patients were treated with routine hemostasis,fluid infusion,intracranial pressure reduction,nutrition,anti-inflammatory,dehydration,diuresis and other symptomatic treatment; the observation group was given Edaravone Injection on this basis. Observe and record the clinical treatment effect of two groups of patients,compare the two groups of patients before and after treatment FMA score and ADL score; and the nemorheological indexes and NO,ET levels were detected and compared. Results: The total effective rate of the observation group was 95%,which was significantly higher than that of the control group(72.50%),and the difference was statistically significant(P<0.05). After treatment,the scores of FMA and ADL in the observation group were significantly higher than those in the control group,the difference was statistically significant(P < 0.05). Two groups of patients after treatment,the observation group of whole blood viscosity(high and low shear),plasma viscosity,erythrocyte sedimentation rate,platelet adhesion rate and erythrocyte aggregation index were significantly lower than the control group,the difference was statistically significant(P <0. 05). After treatment,the level of plasma ET in the observation group was significantly lower than that in the control group,while the level of NO was significantly higher than that of the control group,and the difference was statistically significant(P <0.05). Conclusion: Edaravone Injection has good clinical efficiency in the treatment of cerebral hemorrhage patients with craniocerebral trauma,which can effectively improve the hemorheological indexes and plasma NO and ET levels.
Objective: To study the effect of Edaravone Injection on plasma NO,ET and hemorheology in patients with cerebral hemorrhage. Methods: From November 2015 to February 2017,a total of 80 patients with traumatic brain hemorrhage in our hospital were randomly divided into observation group and control group,40 cases in each group. The patients were treated with routine hemostasis,fluid infusion,intracranial pressure reduction,nutrition,anti-inflammatory,dehydration,diuresis and other symptomatic treatment; the observation group was given Edaravone Injection on this basis. Observe and record the clinical treatment effect of two groups of patients,compare the two groups of patients before and after treatment FMA score and ADL score; and the nemorheological indexes and NO,ET levels were detected and compared. Results: The total effective rate of the observation group was 95%,which was significantly higher than that of the control group(72.50%),and the difference was statistically significant(P<0.05). After treatment,the scores of FMA and ADL in the observation group were significantly higher than those in the control group,the difference was statistically significant(P < 0.05). Two groups of patients after treatment,the observation group of whole blood viscosity(high and low shear),plasma viscosity,erythrocyte sedimentation rate,platelet adhesion rate and erythrocyte aggregation index were significantly lower than the control group,the difference was statistically significant(P <0. 05). After treatment,the level of plasma ET in the observation group was significantly lower than that in the control group,while the level of NO was significantly higher than that of the control group,and the difference was statistically significant(P <0.05). Conclusion: Edaravone Injection has good clinical efficiency in the treatment of cerebral hemorrhage patients with craniocerebral trauma,which can effectively improve the hemorheological indexes and plasma NO and ET levels.
引文
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[3]姚广明,刘朋飞,李鹏亮,等.补阳还五汤对脑缺血治疗作用机制[J].中国老年学杂志,2016,36(6):1533~1535.
[4]全国第四次脑血管病学术会议.各类脑血管疾病诊断要点[J].中华神经科杂志,1997,29(6):379.
[5]Bansari Patel,Sonia Elguero,Suruchi Thakore.Role of nuclear progesterone receptor isoforms in uterine pathophysiology[J].Hum Reprod Update,2015,21(2):155~173.
[6]于朝旭,武焕颖,孙实安,等.复方麝香注射液联合依达拉奉对颅脑外伤患者凝血和神经功能的影响[J].中国药房,2017,28(20):2827~2830.
[7]罗银河,葛金文,刘林,等.补阳还五汤治疗缺血性中风临床应用进展[J].中西医结合心脑血管病杂志,2016,14(3):278~281.
[8]杨文强,张斌,梁剑锋,等.丹红注射液对Ⅰ型糖尿病大鼠周围神经病变的作用研究[J].中华神经医学杂志,2015,14(5):460-463.
[9]李积军.丹红注射液联合依达拉奉治疗急性脑梗死的疗效观察[J].中国中西医结合急救杂志,2015,17(2):178~180.
[10]Caroline H.Diep,Andrea R.Daniel,Laura J.Progesterone action in breast,uterine,and ovarian cancers[J].Mol Endocrinol,2015,54(2):R31~R53.
[11]李宝东,陈冬云,谢建勤,等.大剂量维生素C和E对颅脑外伤急性期脑保护作用的研究[J].中华临床医师杂志(电子版),2016,10(13):2015~2018.
[12]程火星.颅脑外伤引起的迟发性脑出血与凝血功能障碍的临床研究[J].哈尔滨医药,2016,36(3):217~218.