幽门螺杆菌感染与肝硬化患者胃粘膜病变的相关性及其价值分析
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摘要
目的探讨幽门螺杆菌感染与肝硬化患者胃粘膜病变的相关性及其价值分析。方法选取2016年2月—2017年6月该院收治的肝硬化患者57例为肝硬化组,另选取2016年2月—2017年6月该院收治的排除肝部疾病的胃部疾病患者57例为对照组。观察比较肝硬化组及对照组的一般资料、胃粘膜中的HP检出率、胃镜检查结果、胃粘膜特点。结果肝硬化组和对照组的一般资料比较差异无统计学意义(P>0.05);肝硬化组的HP检出率显著高于对照组(P<0.05);肝硬化组的胃部疾病显著高于对照组(P<0.05);对照组患者的胃粘膜大部分呈现不规则状充血;肝硬化组患者的胃粘膜多呈现为圆状斑点充血及弥漫性粘膜充血,二者胃粘膜充血状态差异有统计学意义(P<0.05)。结论与对照组比较肝硬化组患者的HP阳性检出率更高,且二组患者的胃粘膜充血状态也各不相同,差异有统计学意义,临床中加强对患者HP的检测及治疗能够有效地减少患者出现胃粘膜病变,值得临床应用及推广。
Objective To explore the correlation between helicobacter pylori infection and gastric mucosal lesions in patients with liver cirrhosis and its value analysis.Methods From February 2016 to June 2017,fiftyseven patients with cirrhosis treated in Second Central Hospital of Baoding were selected as the cirrhosis group,and 57 patients with gastric diseases excluding liver diseases at the same period were selected as the control group.The general data,HP detection rate in gastric mucosa,gastroscopy results and characteristics of gastric mucosa in cirrhosis group and control group were observed and compared.Results There was no significant difference in general data between cirrhosis group and control group(P>0.05);the detection rate of HP in cirrhosis group was significantly higher than that in control group(P<0.05);gastric diseases in cirrhosis group were significantly higher than that in control group(P<0.05);most of the gastric mucosa in control group showed irregular hyperemia;most of the gastric mucosa in cirrhosis group showed round spot hyperemia and diffuse hyperemia.There was a significant difference in the status of gastric mucosal congestion between the two groups(P<0.05).Conclusion Compared with the control group,the positive detection rate of HP in cirrhosis group is higher,and the gastric mucosal congestion status of the two groups is different,with significant difference.Strengthening the detection and treatment of HP in patients can effectively reduce the occurrence of gastric mucosal lesions,which is worthy of clinical application and promotion.
Objective To explore the correlation between helicobacter pylori infection and gastric mucosal lesions in patients with liver cirrhosis and its value analysis.Methods From February 2016 to June 2017,fiftyseven patients with cirrhosis treated in Second Central Hospital of Baoding were selected as the cirrhosis group,and 57 patients with gastric diseases excluding liver diseases at the same period were selected as the control group.The general data,HP detection rate in gastric mucosa,gastroscopy results and characteristics of gastric mucosa in cirrhosis group and control group were observed and compared.Results There was no significant difference in general data between cirrhosis group and control group(P>0.05);the detection rate of HP in cirrhosis group was significantly higher than that in control group(P<0.05);gastric diseases in cirrhosis group were significantly higher than that in control group(P<0.05);most of the gastric mucosa in control group showed irregular hyperemia;most of the gastric mucosa in cirrhosis group showed round spot hyperemia and diffuse hyperemia.There was a significant difference in the status of gastric mucosal congestion between the two groups(P<0.05).Conclusion Compared with the control group,the positive detection rate of HP in cirrhosis group is higher,and the gastric mucosal congestion status of the two groups is different,with significant difference.Strengthening the detection and treatment of HP in patients can effectively reduce the occurrence of gastric mucosal lesions,which is worthy of clinical application and promotion.
引文
[1]王娟,杨兵,戴可可,等.幽门螺杆菌感染对慢性乙型肝炎及乙肝肝硬化患者消化道溃疡的临床影响[J].中华医院感染学杂志,2017,27(14):3200-3203
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[6]朱俊,袁玉林,陈敏,等.慢性肝病幽门螺杆菌感染患者白细胞介素水平测定的临床研究[J].中华医院感染学杂志,2016,26(16):3638-3639
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[11]王盖昊,戴飞,赵红珍,等.幽门螺杆菌致病机制的分子免疫学研究进展[J].中华医学杂志,2016,96(44):3609-3613
[12]Liou J M,Bair M J,Chen C C,et al.Levofloxacin Sequential Therapy vs Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori:A Randomized Trial[J].American Journal of Gastroenterology,2016,111(3):381-387
[13]陈洁.客观评价和正确认识幽门螺杆菌感染的“有益性”[J].中国实用儿科杂志,2016,31(7):494-496
[14]胡珍,陈兰芳,陈文生.幽门螺杆菌与胆囊疾病关系的Meta分析[J].重庆医学,2016,45(27):3817-3820
[15]刘奕婷,王巍,于晓松.幽门螺杆菌感染与甲状腺疾病的相关性研究[J].现代预防医学,2016,43(13):2423-2426
[16]Xin Y,Bo T,Xiao Y F,et al.Helicobacter pylori,upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer[J].Cancer Letters,2016,374(2):292-303
[17]陶智,王梦旻,吕惠芳.3种用药方案治疗幽门螺杆菌感染活动性慢性胃炎的临床观察[J].中国药房,2016,27(30):4224-4226
[18]李伟鹏,周鸿科,柏小芬,等.幽门螺杆菌感染与胃肠外疾病关系的研究进展[J].广东医学,2016,37(11):1731-1733
[19]Moonens K,Subedi S,Bugaytsova J,et al.Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori[J].Cell Host&Microbe,2016,19(1):55-66
[20]牟海军,陈小燕,化伟利,等.胃癌患者幽门螺杆菌的感染与预后的关系[J].中华医院感染学杂志,2016,26(16):3643-3644
[21]张铁民,张天哲,朱红丽,等.我国儿童HLA-DQB1基因多态性与幽门螺杆菌感染关系的Meta分析[J].中国煤炭工业医学杂志,2015,18(08):1368-1374
[22]秦耿,王慧芬,白如雪,等.消化性溃疡临床病理特征及其与幽门螺杆菌感染的关系[J].中国医药,2017,12(10):1549
[2]Tucci A,Poli L,Paparo G F,et al.Weekend therapy for the treatment of Helicobacter pylori infection.[J].American Journal of Gastroenterology,2016,93(5):737-742
[3]刘婷婷,张颖秋,朱樑.幽门螺旋杆菌与肝病的研究进展[J].第二军医大学学报,2016,37(6):744-749
[4]王雷,李成安.幽门螺杆菌感染对鹿城区高氨血症和肝性脑病发病的影响分析[J].中国地方病防治杂志,2016,31(2):150-152
[5]陈轶,陈益耀,韩向阳,等.幽门螺杆菌与乙型肝炎病毒对乙型病毒性肝炎患者胃黏膜病变的相关分析[J].中华医院感染学杂志,2016,26(14):3184-3186
[6]朱俊,袁玉林,陈敏,等.慢性肝病幽门螺杆菌感染患者白细胞介素水平测定的临床研究[J].中华医院感染学杂志,2016,26(16):3638-3639
[7]Thung I,Crowe S E,Valasek M A.Letter:global emergence of Helicobacter pylori antibiotic resistance-unanswered questions.Authors’reply[J].Alimentary Pharmacology&Therapeutics,2016,43(11):1249-1250
[8]李琳,肖淑萍,周晓颖,等.十二指肠球部溃疡患者38例根除幽门螺杆菌后胃肠道微生物菌群的改变[J].中华消化杂志,2016,36(1):41-43
[9]骆泉,赵洁,徐关根,等.幽门螺杆菌感染与不同胃炎及病理之间的关系[J].中华医院感染学杂志,2016,26(11):2476-2478
[10]张玲,高峰.非酒精性脂肪性肝病与幽门螺杆菌感染的相关性[J].中华消化杂志,2017,37(1):43-45
[11]王盖昊,戴飞,赵红珍,等.幽门螺杆菌致病机制的分子免疫学研究进展[J].中华医学杂志,2016,96(44):3609-3613
[12]Liou J M,Bair M J,Chen C C,et al.Levofloxacin Sequential Therapy vs Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori:A Randomized Trial[J].American Journal of Gastroenterology,2016,111(3):381-387
[13]陈洁.客观评价和正确认识幽门螺杆菌感染的“有益性”[J].中国实用儿科杂志,2016,31(7):494-496
[14]胡珍,陈兰芳,陈文生.幽门螺杆菌与胆囊疾病关系的Meta分析[J].重庆医学,2016,45(27):3817-3820
[15]刘奕婷,王巍,于晓松.幽门螺杆菌感染与甲状腺疾病的相关性研究[J].现代预防医学,2016,43(13):2423-2426
[16]Xin Y,Bo T,Xiao Y F,et al.Helicobacter pylori,upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer[J].Cancer Letters,2016,374(2):292-303
[17]陶智,王梦旻,吕惠芳.3种用药方案治疗幽门螺杆菌感染活动性慢性胃炎的临床观察[J].中国药房,2016,27(30):4224-4226
[18]李伟鹏,周鸿科,柏小芬,等.幽门螺杆菌感染与胃肠外疾病关系的研究进展[J].广东医学,2016,37(11):1731-1733
[19]Moonens K,Subedi S,Bugaytsova J,et al.Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori[J].Cell Host&Microbe,2016,19(1):55-66
[20]牟海军,陈小燕,化伟利,等.胃癌患者幽门螺杆菌的感染与预后的关系[J].中华医院感染学杂志,2016,26(16):3643-3644
[21]张铁民,张天哲,朱红丽,等.我国儿童HLA-DQB1基因多态性与幽门螺杆菌感染关系的Meta分析[J].中国煤炭工业医学杂志,2015,18(08):1368-1374
[22]秦耿,王慧芬,白如雪,等.消化性溃疡临床病理特征及其与幽门螺杆菌感染的关系[J].中国医药,2017,12(10):1549