石斛在糖尿病等代谢性疾病中的作用及机制研究进展
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摘要
石斛是历代中医治疗"消渴证"的要药。近年来,随着代谢相关疾病的高发,其在防治糖尿病、高血压等相关代谢性疾病中的作用逐渐被挖掘,也越来越受到关注。综述不同石斛对糖尿病、高血压、高脂血症等相关代谢性疾病的作用及其共同作用机制,并从传统功效入手,总结提出石斛"益胃生津、滋阴清热"治疗"脾瘅——中满内热"是其改善糖尿病等相关代谢性疾病的关键,为石斛在防治糖尿病等相关代谢性疾病研究及临床应用中提供参考。
Life style changes with economic and social development, including a improper diet, cause diabetes, dyslipidemia,hypertension and other metabolic disturbances, which has become a major threat to the health of people around the world. Dendrobii Caulis, a traditional Chinese herbal medicine with various medicinal and health-care effects, is derived from different species of Dendrobium, which is traditionally used for "consumptive thirst syndrom". In recent years, its preventive effects on metabolic disturbances have been attracting more and more attention with the high incidence of metabolic disturbances. This paper aims to review the recent achievements of different Dendrobium species in preventive and therapeutic effects and its traditional functions on metabolic disturbances, mainly in diabetes, hypertension and dyslipidemia. Furthermore, probable mechanisms were summarized based on its traditional functions. Dendrobii Caulis was effective on metabolic disturbances primarily relevant to its conventional functions including replenishing yin for maintaining gastric tonicity, promoting body fluid production, nourishing yin and clearing heat, which is helpful for treatment of spleen impediment with abdominal flatulence and interior heat, the source of various metabolic disturbances in traditional medicine. This review provids reference for mechanism research and clinical application of Dendrobium in metabolic disturbances prevention and treatment.
Life style changes with economic and social development, including a improper diet, cause diabetes, dyslipidemia,hypertension and other metabolic disturbances, which has become a major threat to the health of people around the world. Dendrobii Caulis, a traditional Chinese herbal medicine with various medicinal and health-care effects, is derived from different species of Dendrobium, which is traditionally used for "consumptive thirst syndrom". In recent years, its preventive effects on metabolic disturbances have been attracting more and more attention with the high incidence of metabolic disturbances. This paper aims to review the recent achievements of different Dendrobium species in preventive and therapeutic effects and its traditional functions on metabolic disturbances, mainly in diabetes, hypertension and dyslipidemia. Furthermore, probable mechanisms were summarized based on its traditional functions. Dendrobii Caulis was effective on metabolic disturbances primarily relevant to its conventional functions including replenishing yin for maintaining gastric tonicity, promoting body fluid production, nourishing yin and clearing heat, which is helpful for treatment of spleen impediment with abdominal flatulence and interior heat, the source of various metabolic disturbances in traditional medicine. This review provids reference for mechanism research and clinical application of Dendrobium in metabolic disturbances prevention and treatment.
引文
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[9]金徽,杨贵忠,李小琼,等.金钗石斛对糖尿病大鼠肾组织中糖基化终产物表达的干预作用[J].中国生化药物杂志,2011,32(3):209-212.
[10]金徽,陶凤,唐彦萍.金钗石斛对糖尿病肾病大鼠肾组织N F-κB、IL-6表达的影响[J].重庆医学,2014,43(8):946-948.
[11]李菲,黄琦,李向阳,等金钗石斛提取物对肾上腺素所致血糖升高的影响[J].遵义医学院学报,2008,31(1):11-12.
[12]刘莹莹,武俊紫,李伟,等.金钗石斛多糖对II型糖尿病大鼠心肌组织中MMP-1和MMP-9表达的影响[J].西部医学,2017,29(10):1346-1351.
[13]刘莹莹,武俊紫,李伟,等.金钗石斛多糖对2型糖尿病大鼠心肌组织中RIP蛋白表达影响[J].辽宁中医药大学学报,2017,19(12):44-48.
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[15]黄琦,廖鑫,吴芹,等.金钗石斛生物总碱对糖尿病大鼠血糖及肝脏组织IRS-2 m RNA,IGF-1 m RNA表达的影响[J].中国实验方剂学杂志,2014,20(19):155-158.
[16]吴昊姝,徐建华,陈立钻,等.铁皮石斛降血糖作用及其机制的研究[J].中国中药杂志,2004,29(2):160-163.
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[19]汤志远,周晓宇,冯健,等.铁皮石斛多糖降血糖作用研究[J].南京中医药大学学报,2016,32(6):566-570.
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