弥散张量成像对遗忘型轻度认知障碍的诊断及预后评估价值
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摘要
目的:探讨遗忘型轻度认知障碍的DTI图像表现,并判断其预后。资料与方法:选取2012年至2015年来我院就诊的轻度认知障碍的患者61例,其中男32例,女29例。在社区招募健康受试者60例,男34例,女26例。对两组病人做神经心理测试,MRI一般序列扫描及DTI,测定期FA值,并随访一年,观察aMCI患者的转归情况。运用SPSS软件对FA值进行X2检验,观察其有无统计学差异。结果:61例aMCI患者中有15例12个月后转化为AD,正常组与aMCI组的额叶、颞叶、顶叶、枕叶、海马、下额枕部纤维束、胼胝体膝部、胼胝体压部、上纵束的FA值,没有显著地统计学差异;在扣带束的FA值的差异具有统计学意义。发展为AD的aMCI组与未发展为AD的aMCI组,在额叶、颞叶、海马、下额枕部纤维束、胼胝体膝部、扣带束的FA值的差异具有统计学意义;在顶叶、枕叶、胼胝体压部、上纵束的FA值无显著统计学意义。结论:DTI对区分aMCI类型及判断其预后具有重要价值。
引文
[1]郭龙军,李坤成,陈忠伟.磁共振检查技术DTI在阿尔茨海默病与轻度认知障碍中的应用[J].中国CT和MRI杂志,2015(11).
[2]李亚迪,董海波,谢国民,等.基于纤维束空间统计分析多参数DTI在遗忘型轻度认知障碍的应用[J].放射学实践,2012(06).
[3]李香春,刘红江,王海平,等.弥散张量成像对遗忘型轻度认知障碍诊断和预后评估的价值[J].中国全科医学,2016(11).
[4]Fu,J.L.,et al.,Use of diffusion tensor imaging for evaluating changes in the microstructural integrity of white matter over 3 years in patients with amnesic-type mild cognitive impairment converting to Alzheimer's disease.J Neuroimaging,2014.24(4):p.343-8.
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[6]Sali,D.,et al.,Diffusion tensor imaging(DTI)in the detection of white matter lesions in patients with mild cognitive impairment(MCI).Acta Neurol Belg,2013.113(4):p.441-51.
[7]Remy,F.,et al.,White matter disruption at the prodromal stage of Alzheimer's disease:relationships with hippocampal atrophy and episodic memory performance.Neuroimage Clin,2015.7:p.482-92.
[8]Wang,P.N.,et al.,Callosal degeneration topographically correlated with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease dementia.Hum Brain Mapp,2014.35(4):p.1529-43.
[9]Bosch,B.,et al.,Multiple DTI index analysis in normal aging,amnestic MCI and AD.Relationship with neuropsychological performance.Neurobiol Aging,2012.33(1):p.61-74.
[10]Garces,P.,et al.,The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment-a bimodal MEG-DTIstudy.Neuroimage Clin,2014.6:p.214-21.
[2]李亚迪,董海波,谢国民,等.基于纤维束空间统计分析多参数DTI在遗忘型轻度认知障碍的应用[J].放射学实践,2012(06).
[3]李香春,刘红江,王海平,等.弥散张量成像对遗忘型轻度认知障碍诊断和预后评估的价值[J].中国全科医学,2016(11).
[4]Fu,J.L.,et al.,Use of diffusion tensor imaging for evaluating changes in the microstructural integrity of white matter over 3 years in patients with amnesic-type mild cognitive impairment converting to Alzheimer's disease.J Neuroimaging,2014.24(4):p.343-8.
[5]Thillainadesan,S.,et al.,Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging.Int Psychogeriatr,2012.24(9):p.1483-93.
[6]Sali,D.,et al.,Diffusion tensor imaging(DTI)in the detection of white matter lesions in patients with mild cognitive impairment(MCI).Acta Neurol Belg,2013.113(4):p.441-51.
[7]Remy,F.,et al.,White matter disruption at the prodromal stage of Alzheimer's disease:relationships with hippocampal atrophy and episodic memory performance.Neuroimage Clin,2015.7:p.482-92.
[8]Wang,P.N.,et al.,Callosal degeneration topographically correlated with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease dementia.Hum Brain Mapp,2014.35(4):p.1529-43.
[9]Bosch,B.,et al.,Multiple DTI index analysis in normal aging,amnestic MCI and AD.Relationship with neuropsychological performance.Neurobiol Aging,2012.33(1):p.61-74.
[10]Garces,P.,et al.,The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment-a bimodal MEG-DTIstudy.Neuroimage Clin,2014.6:p.214-21.