光电化学生物传感器研究
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摘要
光电化学法是在光照射下,将化学能转换为电能的低成本方法。而光电化学生物传感技术由于具有通过生物分子氧化产生的光电流来检测生物分子的能力而引起了广泛的关注。光电化学生物传感器具有低成本、高灵敏度、高特异性、仪器操作简单以及检测背景信号低等特点,在免疫检测和生物技术等重要领域具有广泛应用前景。近年来,对于光电化学生物传感器性能和检测方法的研究也取得了颇丰的成果。本文主要介绍光电化学生物传感器的概念及基本原理、分类应用及对其未来的展望。
The photoelectrochemical( PEC) process is a low-cost approach to convert chemical energy to electricity under light illumination. The photoelectrochemical biosensing has attracted huge attention because of its ability to detect biomolecules through the photocurrent generated from biomolecule oxidation. The photoelectrochemical biosensors have extensive application prospect in the immunodetection,biotechnology and other important fields for their characteristics of low cost,high sensitivity,high specificity,simple operation,low detection background signal and so on. In recent years,the research of the performance and detection methods of photoelectrochemical biosensors have been made many achievements. This paper mainly introduces the concept,basic principle,classification,application and prospect of the photoelectrochemical biosensors.
The photoelectrochemical( PEC) process is a low-cost approach to convert chemical energy to electricity under light illumination. The photoelectrochemical biosensing has attracted huge attention because of its ability to detect biomolecules through the photocurrent generated from biomolecule oxidation. The photoelectrochemical biosensors have extensive application prospect in the immunodetection,biotechnology and other important fields for their characteristics of low cost,high sensitivity,high specificity,simple operation,low detection background signal and so on. In recent years,the research of the performance and detection methods of photoelectrochemical biosensors have been made many achievements. This paper mainly introduces the concept,basic principle,classification,application and prospect of the photoelectrochemical biosensors.
引文
[1]JIANG Y D,LIU D L,YANG Y D,et al.. Photoelectrochemical detection of alpha-fetoprotein based on Zn O inverse opals structure electrodes modified by Ag2S nanoparticles[J]. Sci. Rep.,2016,6:38400-1-8.
[2]XIA L,SONG J,XU R,et al.. Zinc oxide inverse opal electrodes modified by glucose oxidase for electrochemical and photoelectrochemical biosensor[J]. Biosens. Bioelectron.,2014,59:350-357.
[3]XIA L,XU L,SONG J,et al.. Cd S quantum dots modified Cu O inverse opal electrodes for ultrasensitive electrochemical and photoelectrochemical biosensor[J]. Sci. Rep.,2015,5:10838-1-12.
[4]XU R,JIANG Y D,XIA L,et al.. A sensitive photoelectrochemical biosensor for AFP detection based on Zn O inverse opal electrodes with signal amplification of Cd S-QDs[J]. Biosens. Bioelectron.,2015,74:411-417.
[5]DEVADOSS A,SUDHAGAR P,TERASHIMA C,et al.. Photoelectrochemical biosensors:new insights into promising photoelectrodes and signal amplification strategies[J]. J. Photochem. Photobiol. C:Photochem. Rev.,2015,24:43-63.
[6]ZHAO W W,XU J J,CHEN H Y. Photoelectrochemical DNA biosensors[J]. Chem. Rev.,2014,114(15):7421-7241.
[7]ZHAO W W,XU J J,CHEN H Y. Photoelectrochemical bioanalysis:the state of the art[J]. Chem. Soc. Rev.,2015,44(3):729-741.
[8]覃柳,刘仲明,邹小勇.电化学生物传感器研究进展[J].中国医学物理杂志,2017,24(1):60-62.QIN L,LIU Z M,ZOU X Y. Research evolvement of electrochemical biosensor[J]. Chin. J. Med. Phys.,2007,24(1):60-62.(in Chinese)
[9]CLARK JR L C,LYONS C. Electrode systems for continuous monitoring in cardiovascular surgery[J]. Ann. N. Y. Acad.Sci.,1962,102(1):29-45.
[10]钟立,魏小平,冯莎莎,等.光电化学传感器的研究进展[J].分析测试学报,2018,37(4):496-506.ZHONG L,WEI X P,FENG S S,et al.. Research progress of photoelectrochemical sensor[J]. J. Instrum. Anal.,2018,37(4):496-506.(in Chinese)
[11]党蓝图,宋梦梦,胡成国.光电化学传感材料的制备及应用进展[J].分析科学学报,2018,34(4):553-559.DANG L T,SONG M M,HU C G. Photoelectrochemical sensing materials:synthesis and application[J]. J. Anal. Sci.,2018,34(4):553-559.(in Chinese)
[12]陈洪渊.光电化学生物传感器的研究与应用[C].中国化学会第28届学术年会,成都,2012.CHEN H Y. Research and application of photoelectrochemical biosensor[C]. The 28th Annual Conference of The Chinese Chemical Society,Chengdu,2012.(in Chinese)
[13]CHEN H Y. Recent advances in photoelectrochemical biosensors[C]. The Fourteenth International Symposium on Electroanalytical Chemistry,Changchun,2013.
[14]WANG R Y,MA H M,ZHANG Y,et al.. Photoelectrochemical sensitive detection of insulin based on Cd S/polydopamine co-sensitized WO3nanorod and signal amplification of carbon nanotubes@polydopamine[J]. Biosens. Bioelectron.,2017,96:345-350.
[15]YANG R Y,YAN X X,LI Y M,et al.. Nitrogen-doped porous carbon-ZnO nanopolyhedra derived from ZIF-8:new materials for photoelectrochemical biosensors[J]. ACS Appl. Mater. Interfaces,2017,9(49):42482-42491.
[16]CHEN X,XU W,JIANG Y D,et al.. A novel upconversion luminescence derived photoelectrochemical immunoassay:ultrasensitive detection to alpha-fetoprotein[J]. Nanoscale,2017,9(42):16357-16364.
[17]徐文,陈旭,宋宏伟.稀土离子上转换发光中的局域电磁场调控[J].发光学报,2018,39(1):1-26.XU W,CHEN X,SONG H W. Manipulation of local electromagnetic field in upconversion luminescence of rare earth ions[J]. Chin. J. Lumin.,2018,39(1):1-26.(in Chinese)
[18]HAN Q Z,WANG R Y,XING B,et al.. Label-free photoelectrochemical aptasensor for tetracycline detection based on cerium doped Cd S sensitized Bi YWO6[J]. Biosens. Bioelectron.,2018,106:7-13.
[19]CHEN J X,ZHAO G C. A novel signal-on photoelectrochemical immunosensor for detection of alpha-fetoprotein by in situ releasing electron donor[J]. Biosens. Bioelectron.,2017,98:155-160.
[20]WANG X P,XU R,SUN X,et al.. Using reduced graphene oxide-Ca∶Cd Se nanocomposite to enhance photoelectrochemical activity of gold nanoparticles functionalized tungsten oxide for highly sensitive prostate specific antigen detection[J]. Biosens. Bioelectron.,2017,96:239-245.
[21]HAN Q Z,WANG R Y,XING B,et al.. Label-free photoelectrochemical immunoassay for CEA detection based on Cd S sensitized WO3@Bi OI heterostructure nanocomposite[J]. Biosens. Bioelectron.,2018,99:493-499.
[22]HOU Y B,SHENG K,LU Y,et al.. Three-dimensional graphene oxide foams loaded with Au Pd alloy:a sensitive electrochemical sensor for dopamine[J]. Microchim. Acta,2018,185(8):397-1-9.
[23]PANG X H,PAN J H,WANG L,et al.. Cd Se quantum dot-functionalized Ti O2nanohybrids as a visible light induced photoelectrochemical platform for the detection of proprotein convertase subtilisin/kexin type 6[J]. Biosens. Bioelectron.,2015,71:88-97.
[24]SHENG K,LIU W,XU L,et al.. An ultra-sensitive label-free immunosensor toward alpha-fetoprotein detection based on three-dimensional ordered Ir Oxinverse opals[J]. Sens. Actuators B:Chem.,2018,254:660-668.
[25]WANG J,LONG J,LIU Z H,et al.. Label-free and high-throughput biosensing of multiple tumor markers on a single lightaddressable photoelectrochemical sensor[J]. Biosens. Bioelectron.,2017,91:53-59.
[26]WANG Y G,WANG Y L,WU D,et al.. Label-free electrochemical immunosensor based on flower-like Ag/MoS2/r GO nanocomposites for ultrasensitive detection of carcinoembryonic antigen[J]. Sen. Actuators B:Chem.,2018,255:125-132.
[2]XIA L,SONG J,XU R,et al.. Zinc oxide inverse opal electrodes modified by glucose oxidase for electrochemical and photoelectrochemical biosensor[J]. Biosens. Bioelectron.,2014,59:350-357.
[3]XIA L,XU L,SONG J,et al.. Cd S quantum dots modified Cu O inverse opal electrodes for ultrasensitive electrochemical and photoelectrochemical biosensor[J]. Sci. Rep.,2015,5:10838-1-12.
[4]XU R,JIANG Y D,XIA L,et al.. A sensitive photoelectrochemical biosensor for AFP detection based on Zn O inverse opal electrodes with signal amplification of Cd S-QDs[J]. Biosens. Bioelectron.,2015,74:411-417.
[5]DEVADOSS A,SUDHAGAR P,TERASHIMA C,et al.. Photoelectrochemical biosensors:new insights into promising photoelectrodes and signal amplification strategies[J]. J. Photochem. Photobiol. C:Photochem. Rev.,2015,24:43-63.
[6]ZHAO W W,XU J J,CHEN H Y. Photoelectrochemical DNA biosensors[J]. Chem. Rev.,2014,114(15):7421-7241.
[7]ZHAO W W,XU J J,CHEN H Y. Photoelectrochemical bioanalysis:the state of the art[J]. Chem. Soc. Rev.,2015,44(3):729-741.
[8]覃柳,刘仲明,邹小勇.电化学生物传感器研究进展[J].中国医学物理杂志,2017,24(1):60-62.QIN L,LIU Z M,ZOU X Y. Research evolvement of electrochemical biosensor[J]. Chin. J. Med. Phys.,2007,24(1):60-62.(in Chinese)
[9]CLARK JR L C,LYONS C. Electrode systems for continuous monitoring in cardiovascular surgery[J]. Ann. N. Y. Acad.Sci.,1962,102(1):29-45.
[10]钟立,魏小平,冯莎莎,等.光电化学传感器的研究进展[J].分析测试学报,2018,37(4):496-506.ZHONG L,WEI X P,FENG S S,et al.. Research progress of photoelectrochemical sensor[J]. J. Instrum. Anal.,2018,37(4):496-506.(in Chinese)
[11]党蓝图,宋梦梦,胡成国.光电化学传感材料的制备及应用进展[J].分析科学学报,2018,34(4):553-559.DANG L T,SONG M M,HU C G. Photoelectrochemical sensing materials:synthesis and application[J]. J. Anal. Sci.,2018,34(4):553-559.(in Chinese)
[12]陈洪渊.光电化学生物传感器的研究与应用[C].中国化学会第28届学术年会,成都,2012.CHEN H Y. Research and application of photoelectrochemical biosensor[C]. The 28th Annual Conference of The Chinese Chemical Society,Chengdu,2012.(in Chinese)
[13]CHEN H Y. Recent advances in photoelectrochemical biosensors[C]. The Fourteenth International Symposium on Electroanalytical Chemistry,Changchun,2013.
[14]WANG R Y,MA H M,ZHANG Y,et al.. Photoelectrochemical sensitive detection of insulin based on Cd S/polydopamine co-sensitized WO3nanorod and signal amplification of carbon nanotubes@polydopamine[J]. Biosens. Bioelectron.,2017,96:345-350.
[15]YANG R Y,YAN X X,LI Y M,et al.. Nitrogen-doped porous carbon-ZnO nanopolyhedra derived from ZIF-8:new materials for photoelectrochemical biosensors[J]. ACS Appl. Mater. Interfaces,2017,9(49):42482-42491.
[16]CHEN X,XU W,JIANG Y D,et al.. A novel upconversion luminescence derived photoelectrochemical immunoassay:ultrasensitive detection to alpha-fetoprotein[J]. Nanoscale,2017,9(42):16357-16364.
[17]徐文,陈旭,宋宏伟.稀土离子上转换发光中的局域电磁场调控[J].发光学报,2018,39(1):1-26.XU W,CHEN X,SONG H W. Manipulation of local electromagnetic field in upconversion luminescence of rare earth ions[J]. Chin. J. Lumin.,2018,39(1):1-26.(in Chinese)
[18]HAN Q Z,WANG R Y,XING B,et al.. Label-free photoelectrochemical aptasensor for tetracycline detection based on cerium doped Cd S sensitized Bi YWO6[J]. Biosens. Bioelectron.,2018,106:7-13.
[19]CHEN J X,ZHAO G C. A novel signal-on photoelectrochemical immunosensor for detection of alpha-fetoprotein by in situ releasing electron donor[J]. Biosens. Bioelectron.,2017,98:155-160.
[20]WANG X P,XU R,SUN X,et al.. Using reduced graphene oxide-Ca∶Cd Se nanocomposite to enhance photoelectrochemical activity of gold nanoparticles functionalized tungsten oxide for highly sensitive prostate specific antigen detection[J]. Biosens. Bioelectron.,2017,96:239-245.
[21]HAN Q Z,WANG R Y,XING B,et al.. Label-free photoelectrochemical immunoassay for CEA detection based on Cd S sensitized WO3@Bi OI heterostructure nanocomposite[J]. Biosens. Bioelectron.,2018,99:493-499.
[22]HOU Y B,SHENG K,LU Y,et al.. Three-dimensional graphene oxide foams loaded with Au Pd alloy:a sensitive electrochemical sensor for dopamine[J]. Microchim. Acta,2018,185(8):397-1-9.
[23]PANG X H,PAN J H,WANG L,et al.. Cd Se quantum dot-functionalized Ti O2nanohybrids as a visible light induced photoelectrochemical platform for the detection of proprotein convertase subtilisin/kexin type 6[J]. Biosens. Bioelectron.,2015,71:88-97.
[24]SHENG K,LIU W,XU L,et al.. An ultra-sensitive label-free immunosensor toward alpha-fetoprotein detection based on three-dimensional ordered Ir Oxinverse opals[J]. Sens. Actuators B:Chem.,2018,254:660-668.
[25]WANG J,LONG J,LIU Z H,et al.. Label-free and high-throughput biosensing of multiple tumor markers on a single lightaddressable photoelectrochemical sensor[J]. Biosens. Bioelectron.,2017,91:53-59.
[26]WANG Y G,WANG Y L,WU D,et al.. Label-free electrochemical immunosensor based on flower-like Ag/MoS2/r GO nanocomposites for ultrasensitive detection of carcinoembryonic antigen[J]. Sen. Actuators B:Chem.,2018,255:125-132.