脱氧核苷酸钠注射治疗急性白血病化疗后粒细胞缺乏的效果分析
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摘要
目的探讨分析脱氧核苷酸钠注射治疗急性白血病化疗后粒细胞缺乏的效果。方法选取2015年2月至2017年12月本院血液内科接收的88例急性白血病患者为研究对象(该研究所选病例已经过伦理委员会批准),按入院先后顺序分为对照组和观察组,每组44例,给予对照组重组人粒细胞集落刺激因子治疗,观察组在对照组的基础上加用脱氧核苷酸钠注射治疗,对比两组患者治疗前后焦虑抑郁评分和意外事件发生率。结果在对观察组患者实施脱氧核苷酸钠注射治疗之后,患者焦虑抑郁评分、意外事件发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论对急性白血病患者的治疗中实施脱氧核苷酸钠注射治疗,能够有效的降低并发症的发生率,使其早日康复,能够很好的提升患者的生活质量,值得医护人员在临床中推广并使用。
Objective To investigate the effect of deoxynucleotide sodium injection in the treatment of leukemia after chemotherapy in acute leukemia. Methods During February 2015 to December 2017, 88 patients with acute leukemia received by the Department of Hematology of our hospital as subjects(selected cases of this study have been approved by the Ethics Committee), divided into control groups according to the order of admission In the observation group, 44 patients in each group were treated with recombinant human granulocyte colony-stimulating factor in the control group and the observation group was treated with deoxynucleotide sodium injection in the control group. The anxiety and depression scores and accidents before and after treatment were compared between the two groups of patients and incident rate. Results After the deoxynucleotide injection in the observation group, the anxiety and depression scores and the incidence of accidents were significantly lower than those in the control group. The difference was statistically significant(P<0.05). Conclusion The application of deoxynucleotide sodium injection in the treatment of patients with acute leukemia can effectively reduce the incidence of complications, make it recover soon, and can well improve the quality of life of patients. It is worth promoting.
Objective To investigate the effect of deoxynucleotide sodium injection in the treatment of leukemia after chemotherapy in acute leukemia. Methods During February 2015 to December 2017, 88 patients with acute leukemia received by the Department of Hematology of our hospital as subjects(selected cases of this study have been approved by the Ethics Committee), divided into control groups according to the order of admission In the observation group, 44 patients in each group were treated with recombinant human granulocyte colony-stimulating factor in the control group and the observation group was treated with deoxynucleotide sodium injection in the control group. The anxiety and depression scores and accidents before and after treatment were compared between the two groups of patients and incident rate. Results After the deoxynucleotide injection in the observation group, the anxiety and depression scores and the incidence of accidents were significantly lower than those in the control group. The difference was statistically significant(P<0.05). Conclusion The application of deoxynucleotide sodium injection in the treatment of patients with acute leukemia can effectively reduce the incidence of complications, make it recover soon, and can well improve the quality of life of patients. It is worth promoting.
引文
[1]吴希锋,王丽娟,孙玲.脱氧核苷酸钠注射治疗急性白血病化疗后粒细胞缺乏的临床探讨[J].解放军预防医学杂志,2016,34(S1):125-126.
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[4]朱红,任秋霞,李建,等.脱氧核苷酸钠的不良反应分析[J].中国医院药学杂志,2016,36(14):1196-1199.
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[6]熊玮.脱氧核苷酸钠治疗乙肝后肝硬化的疗效研究[J].黑龙江医药科学,2016,39(4):46-47.
[7]秦建华,李莹.脱氧核苷酸钠注射液治疗急性肾损伤的疗效观察[J].西部医学,2010,22(8):1482-1483.
[8]盂飞云.108例感染性粒细胞减少症患儿病例分析及脱氧核苷酸注射液疗效评价[J].内蒙古中医药,2011,30(21):17-18.
[9]张呈,陈昌南,苏铭俊,等.脱氧核苷酸钠治疗白细胞减少化疗肿瘤患者效果分析[J].中国热带医学,2013,13(2):220-221.
[10]张子韬,熊进,王守丰,等.成骨肉瘤新辅助化疗后白细胞减少患者的脱氧核苷酸钠治疗[J].中国骨与关节杂志,2015,13(9):697-700.
[2]梁月娜.脱氧核苷酸钠注射治疗急性白血病化疗后粒细胞缺乏效果观察[J].当代医学,2014,20(3):98.
[3]李素梅,储建坤,霍晓辉.脱氧核苷酸钠联合重组人粒细胞集落刺激因子预防治疗胃癌化疗后白细胞减少的临床观察[J].中国实用医药,2015,10(31):6-8.
[4]朱红,任秋霞,李建,等.脱氧核苷酸钠的不良反应分析[J].中国医院药学杂志,2016,36(14):1196-1199.
[5]黄小兴,黄丽明.脱氧核苷酸钠注射液致过敏反应1例[J].临床合理用药杂志,2015,22(32):97-98.
[6]熊玮.脱氧核苷酸钠治疗乙肝后肝硬化的疗效研究[J].黑龙江医药科学,2016,39(4):46-47.
[7]秦建华,李莹.脱氧核苷酸钠注射液治疗急性肾损伤的疗效观察[J].西部医学,2010,22(8):1482-1483.
[8]盂飞云.108例感染性粒细胞减少症患儿病例分析及脱氧核苷酸注射液疗效评价[J].内蒙古中医药,2011,30(21):17-18.
[9]张呈,陈昌南,苏铭俊,等.脱氧核苷酸钠治疗白细胞减少化疗肿瘤患者效果分析[J].中国热带医学,2013,13(2):220-221.
[10]张子韬,熊进,王守丰,等.成骨肉瘤新辅助化疗后白细胞减少患者的脱氧核苷酸钠治疗[J].中国骨与关节杂志,2015,13(9):697-700.