独蒜兰化学成分及生物活性研究进展
|
摘要
独蒜兰为兰科植物,是中药山慈菇的主要来源之一,包含菲类、联苄、苷类、木脂素、蒽醌、黄酮等多种化学成分,这些化学成分具有抗肿瘤、抗氧化、抗炎、神经毒活性等多种药理活性。本文系统总结独蒜兰化学成分及药理作用的研究现状,为其临床应用和新药开发奠定理论基础。
Pleione bulbocodioides(Franch.) Rolfe is a plant of Orchidaceae and is one of the major sources of Pseudobulbus Cremastrae seu Pleiones.It contains many constituents,such as phenanthrene,bibenzyl,glycoside,lignan,anthraquinone,flavonoid and so on,which have plenty of bioactivities,including anti-tumor,anti-oxidation,anti-inflammatory,neurotoxic activity and other pharmacological activities.In the article constituents and pharmacological effects were systematically summarized,which will provide a theoretical foundation for the clinical application and new drug development.
Pleione bulbocodioides(Franch.) Rolfe is a plant of Orchidaceae and is one of the major sources of Pseudobulbus Cremastrae seu Pleiones.It contains many constituents,such as phenanthrene,bibenzyl,glycoside,lignan,anthraquinone,flavonoid and so on,which have plenty of bioactivities,including anti-tumor,anti-oxidation,anti-inflammatory,neurotoxic activity and other pharmacological activities.In the article constituents and pharmacological effects were systematically summarized,which will provide a theoretical foundation for the clinical application and new drug development.
引文
[1]国家药典委员会.中华人民共和国药典·一部[S].北京:中国医药科技出版社,2015:32-33.
[2]张燕,李思锋,黎斌.独蒜兰属植物研究现状[J].北方园艺,2010(10):232-234.
[3]范海洲.山慈菇药理研究[J].湖北中医杂志,2015,37(2):74-75.
[4]王超,韩少伟,崔保松,等.独蒜兰的化学成分研究[J].中国中药杂志,2014,39(3):442-447.
[5]Li B,Yamaki M,Takagi S.Stilbenoids from Pleione bulbocodioides[J].Phytochemistry,1996,42(3):853-856.
[6]Dong Hai ling,Wang Chun lan,Li Yan,et al.Complete assignments of1H and13C-NMR data of three new dihydrophenanthrofuran from Pleione yunnanensis[J].Magn Reson Chem,2010,48(3):256-260.
[7]Xin Qiao Liu,Qiao Yu Yuan,Yuan Qiang Guo.Two new stilbenoids from Pleione bulbocodioides[J].Asian Nat.Prod.Res,2009,11(2):116-121.
[8]Xin Qiao Liu,Yuan Qiang Guo,Wen Yuan Gao,etal.Two new phenanthrofumns from Pleiorebulbocodioide[J].Asian Nat.Prod.Res,2008,10(5):453-457.
[9]Li B,Yamaki M,Yamagata Y,et al.Shanciol,a dihydrophenanth mpymns from Pleione bulbocodioides[J].phytochemistry,1996,41(2):625-628.
[10]Bai L,Maxukawa N,Yamaki M,et al.Four stilbenoids from Pleione bulbocodioides[J].Phytochemistry,1998,48(2):327-331.
[11]Li Bai,Masae Yamaki,Shuzo takagi.Flavan-3-ols And dihydmphenanthmpymns From pleionebulbocodioides[J].Phytochemistry,1998,47(6):1 125-1 129.
[12]Hailing Dong,Han Qiaoliang,Chunlan Wang,et al.Shancigusins E-I,five new glu-cosides from the tubersofpleione yunnanensis[J].Magn ResonChem,2013,51(6):371-377.
[13]刘新桥,万定荣,袁桥玉.中药独蒜兰的化学成分[J].中国医院药学杂志,2011,31(19):1 649-1 650.
[14]张凡,赵明波,李军,等.独蒜兰的化学成分研究[J].中草药,2013,44(12):1 529-1 533.
[15]Li B,Masukawa N,Yamaki M,et al.A polyphenol and two bibenzyls from Pleione bulbocodioides[J].Phytochemistry,1998,47(8):1637-1 640.
[16]袁桥玉,刘新桥.独蒜兰化学成分研究[J].中药材,2012,35(10):1 602-1 604.
[17]Hai Ling Dong,Chun Lan Wang,Shun Xing Guo,et al.New bibenzyl derivatives from the tubers of Pleione yunnanensis[J].Chem Pharm Bull,2009,57(5):513-515.
[18]Xin Qiao Liu,Qiao Yu Yuan,Yuan Qiang Guo.A new bibenzyl derivative from Pleione bulbocodioides[J].Chinese Chemical Letters,2008,19(5):559-561.
[19]Li Bai,Masae Yamaki,keiko Inoue,et al.BlestrinAandB,bis(dihydrophenanthrene)ethers from Bletilla Striata[J].Phytochemistry,1990,29(4):1 259-1 260.
[20]韩少伟,王超,崔保松,等.独蒜兰中丁二酸苄酯苷类化学成分的研究[J].中国中药杂志,2015,40(5):908-914.
[21]刘新桥,袁桥玉,邵群梅.土家族药独蒜兰的化学成分研究[J].中南民族大学学报(自然科学版),2011,30(3):54-56.
[22]Xin Qiao Liu,Wen Yuan Gao,Yuan Qiang Guo,et al.Twoα,β-unsaturated butyrolactone derivatives from Pleione bulbocodioides[J].Chinese Chemical Letters,2007,18(9):1 075-1 077.
[23]王超.独蒜兰乙酸乙酯部位的化学成分研究[J].北京:北京协和医学院,2014.
[24]Chen Yegao,Xu Junju,Yu Hong,et al.Cytotoxic phenolics from Bulbophyllum odoratissimum[J].Food Chem,2008,107(1):169-173.
[25]Russell B Williams,Steven M Martin,HuJinfeng,et al.Isolation of apoptosis-inducing stilbenoids from four members of the orchidaceae family[J].Planta Med,2012,78(2):160-165.
[26]Boonchoo Sritularak,Mutita Anuwat,Kittisak Likhitwitayawuid.Anew phenanthrenequinone from Dendrobium draconis[J].Asian Nat Prod Res,2011,13(3):251.
[27]Jue Wang,Li yan Wang,Susumu Kitanaka.Stilbene and dihydrophenanthrene derivatives from Pholidota chinensis and their nitric oxide inhibitory and radical-scavenging activities[J].Nat Med,2007,61(4):381-386.
[28]Ji Sang Hwang,Seon A Lee,Seong Su Hong,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitrie oxide in macrophage RAW 264.7 cells[J].Bioorg Med Chem Lett,2010,20:3 785-3 787.
[29]Adelfo Reyes-Ramirez,Martha Leyte-Lugo,Mario Figueroa,et al.Synthesis,biological evaluation,and docking studies of gigantol analogs as calmodulin inhibitors[J].Eur J Med Chem,2011,46(7):2 699-2 708.
[30]David T Coxon,Sam K Ogundana,Colin Dennis.Antifungal phenanthrenes in Yam tubers[J].Phytochemistry,1982,21(6):1 389-1392.
[2]张燕,李思锋,黎斌.独蒜兰属植物研究现状[J].北方园艺,2010(10):232-234.
[3]范海洲.山慈菇药理研究[J].湖北中医杂志,2015,37(2):74-75.
[4]王超,韩少伟,崔保松,等.独蒜兰的化学成分研究[J].中国中药杂志,2014,39(3):442-447.
[5]Li B,Yamaki M,Takagi S.Stilbenoids from Pleione bulbocodioides[J].Phytochemistry,1996,42(3):853-856.
[6]Dong Hai ling,Wang Chun lan,Li Yan,et al.Complete assignments of1H and13C-NMR data of three new dihydrophenanthrofuran from Pleione yunnanensis[J].Magn Reson Chem,2010,48(3):256-260.
[7]Xin Qiao Liu,Qiao Yu Yuan,Yuan Qiang Guo.Two new stilbenoids from Pleione bulbocodioides[J].Asian Nat.Prod.Res,2009,11(2):116-121.
[8]Xin Qiao Liu,Yuan Qiang Guo,Wen Yuan Gao,etal.Two new phenanthrofumns from Pleiorebulbocodioide[J].Asian Nat.Prod.Res,2008,10(5):453-457.
[9]Li B,Yamaki M,Yamagata Y,et al.Shanciol,a dihydrophenanth mpymns from Pleione bulbocodioides[J].phytochemistry,1996,41(2):625-628.
[10]Bai L,Maxukawa N,Yamaki M,et al.Four stilbenoids from Pleione bulbocodioides[J].Phytochemistry,1998,48(2):327-331.
[11]Li Bai,Masae Yamaki,Shuzo takagi.Flavan-3-ols And dihydmphenanthmpymns From pleionebulbocodioides[J].Phytochemistry,1998,47(6):1 125-1 129.
[12]Hailing Dong,Han Qiaoliang,Chunlan Wang,et al.Shancigusins E-I,five new glu-cosides from the tubersofpleione yunnanensis[J].Magn ResonChem,2013,51(6):371-377.
[13]刘新桥,万定荣,袁桥玉.中药独蒜兰的化学成分[J].中国医院药学杂志,2011,31(19):1 649-1 650.
[14]张凡,赵明波,李军,等.独蒜兰的化学成分研究[J].中草药,2013,44(12):1 529-1 533.
[15]Li B,Masukawa N,Yamaki M,et al.A polyphenol and two bibenzyls from Pleione bulbocodioides[J].Phytochemistry,1998,47(8):1637-1 640.
[16]袁桥玉,刘新桥.独蒜兰化学成分研究[J].中药材,2012,35(10):1 602-1 604.
[17]Hai Ling Dong,Chun Lan Wang,Shun Xing Guo,et al.New bibenzyl derivatives from the tubers of Pleione yunnanensis[J].Chem Pharm Bull,2009,57(5):513-515.
[18]Xin Qiao Liu,Qiao Yu Yuan,Yuan Qiang Guo.A new bibenzyl derivative from Pleione bulbocodioides[J].Chinese Chemical Letters,2008,19(5):559-561.
[19]Li Bai,Masae Yamaki,keiko Inoue,et al.BlestrinAandB,bis(dihydrophenanthrene)ethers from Bletilla Striata[J].Phytochemistry,1990,29(4):1 259-1 260.
[20]韩少伟,王超,崔保松,等.独蒜兰中丁二酸苄酯苷类化学成分的研究[J].中国中药杂志,2015,40(5):908-914.
[21]刘新桥,袁桥玉,邵群梅.土家族药独蒜兰的化学成分研究[J].中南民族大学学报(自然科学版),2011,30(3):54-56.
[22]Xin Qiao Liu,Wen Yuan Gao,Yuan Qiang Guo,et al.Twoα,β-unsaturated butyrolactone derivatives from Pleione bulbocodioides[J].Chinese Chemical Letters,2007,18(9):1 075-1 077.
[23]王超.独蒜兰乙酸乙酯部位的化学成分研究[J].北京:北京协和医学院,2014.
[24]Chen Yegao,Xu Junju,Yu Hong,et al.Cytotoxic phenolics from Bulbophyllum odoratissimum[J].Food Chem,2008,107(1):169-173.
[25]Russell B Williams,Steven M Martin,HuJinfeng,et al.Isolation of apoptosis-inducing stilbenoids from four members of the orchidaceae family[J].Planta Med,2012,78(2):160-165.
[26]Boonchoo Sritularak,Mutita Anuwat,Kittisak Likhitwitayawuid.Anew phenanthrenequinone from Dendrobium draconis[J].Asian Nat Prod Res,2011,13(3):251.
[27]Jue Wang,Li yan Wang,Susumu Kitanaka.Stilbene and dihydrophenanthrene derivatives from Pholidota chinensis and their nitric oxide inhibitory and radical-scavenging activities[J].Nat Med,2007,61(4):381-386.
[28]Ji Sang Hwang,Seon A Lee,Seong Su Hong,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitrie oxide in macrophage RAW 264.7 cells[J].Bioorg Med Chem Lett,2010,20:3 785-3 787.
[29]Adelfo Reyes-Ramirez,Martha Leyte-Lugo,Mario Figueroa,et al.Synthesis,biological evaluation,and docking studies of gigantol analogs as calmodulin inhibitors[J].Eur J Med Chem,2011,46(7):2 699-2 708.
[30]David T Coxon,Sam K Ogundana,Colin Dennis.Antifungal phenanthrenes in Yam tubers[J].Phytochemistry,1982,21(6):1 389-1392.