基于中医传承辅助平台分析姜良铎教授治疗积聚的用药规律
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摘要
基于中医传承辅助平台软件(v2.5),探讨姜良铎教授治疗积聚组方用药规律,挖掘治疗积聚的新组方,为进一步挖掘中医药治疗积聚提供参考。通过回顾性研究方法,收集姜良铎教授治疗积聚门诊处方132首,应用中医传承辅助传承平台软件构建姜良铎教授治疗积聚的数据库,对方剂数据库进行四气、五味、归经分布、频次统计、组方规律、新方分析,筛选治疗积聚的方剂132首,使用频次≥15的药物有57味,进而演化出2~5味药的核心组合91个,形成新处方9个。用药以柔肝疏肝,柔润通补,扶正驱邪之法为主,据正邪消长佐以平肝、软坚散结之法,攻补兼施,因人而异,体现中医辨证论治思想,为临床治疗和科研提供新的参考。
To investigate the herbal prescription rules of Professor Jiang Liangduo in the treatment of abdominal mass based on the traditional Chinese medicine inheritance support system software(TCMISS) of version 2.5,find out new herbal formulas for the treatment of abdominal mass,and then provide new reference to its traditional Chinese medicine therapy.By the method of retrospective study,one hundred and thirty-two outpatient prescriptions of Professor Jiang for the treatment of abdominal mass were collected to establish a typical database with TCMISS.Four properties,five tastes,channel tropism,frequency count,Chinese herbal prescriptions rules and the new prescriptions were analyzed so as to dig out the prescription rules.There were 57 herbs with a frequency ≥15,and then 91 core combinations of 2-5 herbs were evolved and 9 new prescriptions were created.It was found out that these drugs mainly had the effects of liver nourishing and soothing,soft-moist and dredging-tonifying,supporting right and dispeling evil,cooperating with the method of calming the liver and resolving hard lump according to the actual situation.It reflected the thought of treatment based on syndrome differentiation in TCM,and provided a new reference for its clinical treatment and research.
To investigate the herbal prescription rules of Professor Jiang Liangduo in the treatment of abdominal mass based on the traditional Chinese medicine inheritance support system software(TCMISS) of version 2.5,find out new herbal formulas for the treatment of abdominal mass,and then provide new reference to its traditional Chinese medicine therapy.By the method of retrospective study,one hundred and thirty-two outpatient prescriptions of Professor Jiang for the treatment of abdominal mass were collected to establish a typical database with TCMISS.Four properties,five tastes,channel tropism,frequency count,Chinese herbal prescriptions rules and the new prescriptions were analyzed so as to dig out the prescription rules.There were 57 herbs with a frequency ≥15,and then 91 core combinations of 2-5 herbs were evolved and 9 new prescriptions were created.It was found out that these drugs mainly had the effects of liver nourishing and soothing,soft-moist and dredging-tonifying,supporting right and dispeling evil,cooperating with the method of calming the liver and resolving hard lump according to the actual situation.It reflected the thought of treatment based on syndrome differentiation in TCM,and provided a new reference for its clinical treatment and research.
引文
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[2]唐仕欢,申丹,卢明,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015,30(2):329.
[3]唐仕欢,陈建新,杨洪军,等.基于复杂系统熵聚类方法的中药新药处方发现研究思路[J].世界科学技术——中医药现代化,2009,11(2):225.
[4]刘成海,危北海,姚树坤.肝硬化中西医结合诊疗共识[J].中国中西医结合消化杂志,2011,19(4):277.
[5]中国抗癌协会肝癌专业委员会(CSLC),中国抗癌协会临床肿瘤学协作专业委员会(CSCO),中华医学会肝病学分会肝癌学组.原发性肝癌规范化诊治的专家共识[J].肝脏,2009,14(3):237.
[6]Kage M,Shimamatu K,Naskashima E,et al.Long-term evolution offibrosis from chronic hepatitis to cirrhosis in patients with hepatitis C:morphometric analysis of repeated biopsies[J].Hepatology,1997,25(4):1028.
[7]应楹,张常晶,姚定康.肝硬化病因流行病学研究进展[J].人民军医,2001,44(10):594.
[8]徐俪颖,蔡宛如,王会仍.王会仍从积聚论治结节病[J].中华中医药杂志,2015,30(11):3973.
[9]李佃贵,李刚,刘金里.李佃贵以“浊毒”立论治疗肝硬化经验[J].陕西中医,2006,27(11):1394.
[10]于鲲,郭淑云.国医大师李振华教授辨治积聚经验[J].中医研究,2016,29(7):25.
[11]谢兆丰.漫谈肝硬化的中医治疗八法[J].辽宁中医杂志,1980,12(30):28.
[12]黄淑芳,梁纪文.姜良铎教授辨治肝炎肝硬化思路探析[J].中国临床医生,2006,34(2):59.
[13]孙元培,郭晓霞.基于中医传承辅助平台挖掘姜良铎教授治疗慢性乙型肝炎方药规律[J].中国实验方剂学杂志,2017,23(6):210.
[14]魏文浩,魏槃.论姜良铎教授临床遣方用药经验[J].环球中医药,2013,6(7):521.
[15]姜良铎,焦扬,王蕾.从毒论理,从通论治,以调求平[J].中医杂志,2006,47(3):169.