ABZ/PPENK微球的制备及其表征
|
摘要
研究了乳化溶剂挥发法制备ABZ-PPENK微球的方法。利用扫描电镜、透射电镜、红外光谱表征了ABZ-PPENK微球的形态及结构,利用光学显微镜计算了微球的粒径分布,并筛分出不同粒径段的ABZ-PPENK微球,计算了微球的载药量与包封率。制备的ABZ-PPENK微球,表面光滑、球形圆整,制得的微球平均粒径为9.9μm,微球粒径接近正态分布,ABZ药物完全被包裹在PPENK微球之中,且载药量与包封率均较高。
The preparation of ABZ-PPENK microspheres by emulsifying solvent evaporation method was studied. The morphology and structure of ABZ-PPENK microspheres were characterized by SEM, TEM and FT-IR. The particle size distribution of ABZ-PPENK microspheres was calculated by optical microscopy, and ABZ-PPENK microspheres with different particle size were screened out. The drug loading and encapsulation efficiency of the microspheres were calculated. The ABZ-PPENK microspheres prepared by this method had smooth surface and spherical shape. The average diameter of the microspheres was 9.9 μm. The diameter of the microspheres was close to normal distribution. ABZ drugs were completely encapsulated in the PPENK microspheres, and the drug loading and encapsulation efficiency were high.
The preparation of ABZ-PPENK microspheres by emulsifying solvent evaporation method was studied. The morphology and structure of ABZ-PPENK microspheres were characterized by SEM, TEM and FT-IR. The particle size distribution of ABZ-PPENK microspheres was calculated by optical microscopy, and ABZ-PPENK microspheres with different particle size were screened out. The drug loading and encapsulation efficiency of the microspheres were calculated. The ABZ-PPENK microspheres prepared by this method had smooth surface and spherical shape. The average diameter of the microspheres was 9.9 μm. The diameter of the microspheres was close to normal distribution. ABZ drugs were completely encapsulated in the PPENK microspheres, and the drug loading and encapsulation efficiency were high.
引文
[1] Wang Jianhua,Wen Hao,Sun Dianjia.Advanced on studies of process in vivo and dosage form of albendazole[J].Chinese Journal of Parasitic Disease Control,2002,15(3):187-189(in Chinese).王建华,温浩,孙殿甲.阿苯达唑的体内过程和剂型研究进展[J].中国寄生虫病防治杂志,2002,15(3):187-189.
[2] Schwendeman S P,Shah R B,Bailey B A,et al.Injectable controlled release depots for large molecules [J].J Control Release,2014,190(9):240-253.
[3] Xia Ying,Zhang Lan,Zhao Ercheng,et al.Preparation of nicosulfuron molecularly imprinted microspheres and research of adsorption characteristics [J].Chinese Journal of Chromatography,2014,32(2):117-125(in Chinese).夏英,张澜,赵尔成,等.烟嘧磺隆分子印迹微球的制备及其吸附性能的考察 [J].色谱,2014,32(2):117-125.
[4] Zhu Qiurong,Hou Wensheng,Shi Sheng,et al.Research progress in carbon microspheres [J].Chemical Industry and Engineering Progress,2014,33(7):1780-1785(in Chinese).朱秋荣,侯文生,史晟,等.碳微球的研究进展 [J].化工进展,2014,33(7):1780-1785.
[5] Wang H,Leeuwenburgh S C,Li Y,et al.The use of micro- and nano-spheres as functional components for bone tissue regeneration [J].Tissue Engineering Part B Reviews,2012,18(1):24-39.
[6] Liu X,Jin X,Ma P X.Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair [J].Nature Materials,2011,10(5):398-406.
[7] Fisher M B,Mauck R L.Tissue engineering and regenerative medicine:recent innovations and the transition to translation [J].Tissue Engineering Part B Reviews,2013,19(1):1-13.
[8] Hu L J,Zhang S H,Han R L,et al.Preparation and performance of novel thermally stable polyamide/PPENK composite nanofiltration membranes[J].Applied Surface Science,2012,258(22):9047-9053.
[9] Wang G,Zhang H,Qian B Q,et al.Preparation and characterization of electrospun poly(phthalazinoneether nitrile ketone) membrane with novel thermally stableproperties[J].Applied Surface Science,2015,351(5):169-174.
[10] Liu R,Wang J Y,He Q Z,et al.Ineraction and properties of epoxy-amine system modified with poly(phthalazinone ether nitrile ketone)[J].Journal of Applied Polymer Science,2016,133(10):2301-2309.
[11] Liu R,Wang J Y,Li J L,et al.An investigation of expoxy/thermoplastic blends based on addition of a novel copoly(aryl ether nitrile) containing phthalazinone and biphenyl moieties[J].Polymer Inernational,2015,64(12):1786-1793.
[12] Liu R,Wang J Y,Li J L,et al.Characterization and thermal decomposition of novel soluble copoly(aryl ether nitrile) containing phthalazinone and biphenyl moieties[J].Polymer Bulletin,2015,73(7):1811-1826.
[13] He Q Z,Wang J Y,Zong L S,et al.Soluble and croess-linkable poly(phthalazinone ether ketone)s with pendent terminal ethynyl group:synthesis,characterization,and click modification [J].Polymer International,2015,64(7):875-883.
[14] Dong Liming,Jian Xigao.Synthesis and characterization of cross-linkable poly ( aryl ether nitrile)s containing phthalazinone moiety[J].Polymer Materials Science and Engineering,2014,30(6):1-4(in Chinese).董黎明,蹇锡高.杂萘联苯结构可交联聚芳醚腈的合成与表征[J].高分子材料科学与工程,2014,30(6):1-4.
[15] Jian Xigao,Wang Jinyan.Progresson high performance engineering plastice containing phthalazinone moieties and their applications[J].Mater China,2012,31(2):16-23(in Chinese).蹇锡高,王锦艳.含二氮杂萘酮联苯结构高性能工程塑料研究进展[J].中国材料进展,2012,31(2):16-23.
[16] Jin Qifeng,Jiang Dongyue,Tong Lina,et al.Preparation and properties of triethoxysilane functionalized poly(phthalazinone ether nitrile) self-assembled thin films[J].Chinese Journal of Applied Chemistry,2016,33(2):169-174(in Chinese).靳奇峰,姜冬月,佟丽娜,等.硅氧烷官能化聚芳醚腈自组装膜的制备及其性能[J].应用化学,2016,33(2):169-174.
[2] Schwendeman S P,Shah R B,Bailey B A,et al.Injectable controlled release depots for large molecules [J].J Control Release,2014,190(9):240-253.
[3] Xia Ying,Zhang Lan,Zhao Ercheng,et al.Preparation of nicosulfuron molecularly imprinted microspheres and research of adsorption characteristics [J].Chinese Journal of Chromatography,2014,32(2):117-125(in Chinese).夏英,张澜,赵尔成,等.烟嘧磺隆分子印迹微球的制备及其吸附性能的考察 [J].色谱,2014,32(2):117-125.
[4] Zhu Qiurong,Hou Wensheng,Shi Sheng,et al.Research progress in carbon microspheres [J].Chemical Industry and Engineering Progress,2014,33(7):1780-1785(in Chinese).朱秋荣,侯文生,史晟,等.碳微球的研究进展 [J].化工进展,2014,33(7):1780-1785.
[5] Wang H,Leeuwenburgh S C,Li Y,et al.The use of micro- and nano-spheres as functional components for bone tissue regeneration [J].Tissue Engineering Part B Reviews,2012,18(1):24-39.
[6] Liu X,Jin X,Ma P X.Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair [J].Nature Materials,2011,10(5):398-406.
[7] Fisher M B,Mauck R L.Tissue engineering and regenerative medicine:recent innovations and the transition to translation [J].Tissue Engineering Part B Reviews,2013,19(1):1-13.
[8] Hu L J,Zhang S H,Han R L,et al.Preparation and performance of novel thermally stable polyamide/PPENK composite nanofiltration membranes[J].Applied Surface Science,2012,258(22):9047-9053.
[9] Wang G,Zhang H,Qian B Q,et al.Preparation and characterization of electrospun poly(phthalazinoneether nitrile ketone) membrane with novel thermally stableproperties[J].Applied Surface Science,2015,351(5):169-174.
[10] Liu R,Wang J Y,He Q Z,et al.Ineraction and properties of epoxy-amine system modified with poly(phthalazinone ether nitrile ketone)[J].Journal of Applied Polymer Science,2016,133(10):2301-2309.
[11] Liu R,Wang J Y,Li J L,et al.An investigation of expoxy/thermoplastic blends based on addition of a novel copoly(aryl ether nitrile) containing phthalazinone and biphenyl moieties[J].Polymer Inernational,2015,64(12):1786-1793.
[12] Liu R,Wang J Y,Li J L,et al.Characterization and thermal decomposition of novel soluble copoly(aryl ether nitrile) containing phthalazinone and biphenyl moieties[J].Polymer Bulletin,2015,73(7):1811-1826.
[13] He Q Z,Wang J Y,Zong L S,et al.Soluble and croess-linkable poly(phthalazinone ether ketone)s with pendent terminal ethynyl group:synthesis,characterization,and click modification [J].Polymer International,2015,64(7):875-883.
[14] Dong Liming,Jian Xigao.Synthesis and characterization of cross-linkable poly ( aryl ether nitrile)s containing phthalazinone moiety[J].Polymer Materials Science and Engineering,2014,30(6):1-4(in Chinese).董黎明,蹇锡高.杂萘联苯结构可交联聚芳醚腈的合成与表征[J].高分子材料科学与工程,2014,30(6):1-4.
[15] Jian Xigao,Wang Jinyan.Progresson high performance engineering plastice containing phthalazinone moieties and their applications[J].Mater China,2012,31(2):16-23(in Chinese).蹇锡高,王锦艳.含二氮杂萘酮联苯结构高性能工程塑料研究进展[J].中国材料进展,2012,31(2):16-23.
[16] Jin Qifeng,Jiang Dongyue,Tong Lina,et al.Preparation and properties of triethoxysilane functionalized poly(phthalazinone ether nitrile) self-assembled thin films[J].Chinese Journal of Applied Chemistry,2016,33(2):169-174(in Chinese).靳奇峰,姜冬月,佟丽娜,等.硅氧烷官能化聚芳醚腈自组装膜的制备及其性能[J].应用化学,2016,33(2):169-174.