海洋生物活性物质主要功能特性的研究进展
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摘要
海洋中蕴藏着丰富的生物资源,海洋生物作为独特生物活性物质的重要来源,其主要功能特性逐渐受到研究学者的关注。本文主要介绍了海洋生物活性物质在抗菌、抗氧化、抗心血管疾病、抗癌、神经保护、抗炎、抑制肥胖与益生元活性等方面的功能特性,并对其未来的开发前景进行展望。
There are abundant of biological resources in the sea. As one of the bioactive substances resource,the functional characteristics of marine creatures were gradually emphasized by researchers.In this paper,the main functional characteristics of marine bioactive substances,such as antibacterial,antioxidant,anticardiovascular disease,cancer-prevention,neuroprotection,anti-inflammatory,obesity-prevention and prebiotic activity,etc,were introduced respectively. Moreover,the future development of marine bioactive substances was also prospected.
There are abundant of biological resources in the sea. As one of the bioactive substances resource,the functional characteristics of marine creatures were gradually emphasized by researchers.In this paper,the main functional characteristics of marine bioactive substances,such as antibacterial,antioxidant,anticardiovascular disease,cancer-prevention,neuroprotection,anti-inflammatory,obesity-prevention and prebiotic activity,etc,were introduced respectively. Moreover,the future development of marine bioactive substances was also prospected.
引文
[1]Kim S K,Wijesekara I.Development and biological activities of marine-derived bioactive peptides:a review[J].Journal of Functional Foods,2010,2(1):1-9.
[2]Mayer A M S,Rodríguez A D,Berlinck R G S,et al.Marine pharmacology in 2007-8:marine compounds with antibacterial,anticoagulant,antifungal,anti-inflammatory,antimalarial,antiprotozoal,antituberculosis,and antiviral activities;affecting the immune and nervous system,and other miscellaneous mechanisms of action[J].Comparative Biochemistry&Physiology Toxicology&Pharmacology,2011,153(2):191-222.
[3]张明辉.海洋生物活性物质的研究进展[J].水产科技情报,2007,34(5):201-205.
[4]陈曦,陈秀霞,陈强,等.海洋生物活性物质研究简述[J].福建农业科技,2012(2):83-85.
[5]Li D,Xu Y,Shao C L,et al.Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus aspergillus sp[J].Marine Drugs,2012,10(1):234-241.
[6]Habbu P,Warad V,Shastri R,et al.Antimicrobial metabolites from marine microorganisms[J].Chinese Journal of Natural Medicines,2016,14(2):101-116.
[7]单红,周国勤,朱银安,等.鱼类抗菌肽的研究进展[J].水产养殖,2012,33(1):20-25.
[8]吴晓洒,蔡路昀,曹爱玲,等.水产品加工废弃物中的蛋白及生物活性肽的研究进展[J].食品工业科技,2014,35(23):372-376.
[9]Arancibia M Y,Alemán A,Calvo M M,et al.Antimicrobial and antioxidant chitosan solutions enriched with active shrimp(Litopenaeusvannamei)waste materials[J].Food Hydrocolloids,2014,35(1):710-717.
[10]蓝蔚青,谢晶,侯伟峰,等.复合生物保鲜剂对腐败希瓦氏菌的抑菌机理[J].江苏农业学报,2012,28(1):186-192.
[11]Sudhakar S,Nazeer R A.Structural characterization of an Indian squid antioxidant peptide and its protective effect against cellular reactive oxygen species[J].Journal of Functional Foods,2015,14:502-512.
[12]冯建慧,曹爱玲,蔡路昀,等.鱼类副产物中抗氧化肽及活性机理研究进展[J].食品工业科技,2016,37(15):365-369,374.
[13]吴晓洒,蔡路昀,黄作庆,等.响应面法优化草鱼皮中有效抗氧化物质提取工艺[J].食品工业科技,2015(19):202-206.
[14]Cornish M L,Garbary D J.Antioxidants from macroalgae:potential applications in human health and nutrition[J].American Journal of Physiology,2010,255(3):280-286.
[15]Hamed I,zogul F,zogul Y,et al.Marine bioactive compounds and their health benefits:a review[J].Comprehensive Reviews in Food Science&Food Safety,2015,14(4):446-465.
[16]Rao A R,Sarada R,Shylaja M D,et al.Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga haematococcuspluvialis[J].Journal of Food Science&Technology,2015,52(10):6703-6710.
[17]Gupta A,Lampropulos J F,Bikdeli B,et al.Most important outcomes research papers on cardiovascular disease in women[J].Circulation Cardiovascular Quality&Outcomes,2013,6(1):e1-e7.
[18]Chiesa G,Busnelli M,Manzini S,et al.Nutraceuticals and bioactive components from fish for dyslipidemia and cardiovascular risk reduction[J].Marine Drugs,2016,14(6):1-15.
[19]Lee S H,Qian Z J,Kim S K.A novel angiotensin iconverting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats[J].Food Chemistry,2010,18(1):96-102.
[20]Rodrigues J A G,Vanderlei E S O,Silva L M C M,et al.Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed caulerpacupressoides[J].Pharmacological Reports,2012,64(2):282-292.
[21]Calder P C.n-3 Fatty acids and cardiovascular disease:evidence explained and mechanisms explored[J].Clinical Science,2004,107(1):1-11.
[22]Naveed N.Medicinal uses of red algae and blue-green algae[J].Research Journal of Pharmacy&Technology,2014,7(12):1472-1475.
[23]Imumorin I G,Eun-Hee K,Lee Y M,et al.Genome scan for parent-of-origin QTL effects on bovine growth and carcass traits[J].Frontiers in Genetics,2011(2):1-13.
[24]刘媛,王健,孙剑峰,等.我国海洋贝类资源的利用现状和发展趋势[J].现代食品科技,2013(3):673-677.
[25]杨永芳,闫海强,丁国芳,等.贻贝水解物抗肿瘤活性肽的分离纯化[J].中国药科大学学报,2011,42(3):272-275.
[26]冯刚,王斌,罗红宇,等.海洋软骨鱼软骨抗肿瘤物质的研究进展[J].浙江海洋学院学报(自然科学版),2011,30(2):168-172.
[27]Meij V D,Langius J A,Brouwer I A,et al.n-3 PUFAs in cancer,surgery,and critical care:a systematic review on clinical effects,incorporation,and washout of oral or enteral compared with parenteral supplementation[J].American Journal of Clinical Nutrition,2011,94(5):1248-1265.
[28]Carvalho J F S,Silva M M C,Moreira J N,et al.Sterols as anticancer agents:synthesis of ring-b oxygenated steroids,cytotoxic profile,and comprehensive SAR analysis[J].Journal of Medicinal Chemistry,2010,53(21):7632-7638.
[29]Murphy C,Hotchkiss S,Worthington J,et al.The potential of seaweed as a source of drugs for use in cancer chemotherapy[J].Journal of Applied Phycology,2014,26(5):2211-2264.
[30]Jiao G,Yu G,Zhang J,et al.Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae[J].Marine Drugs,2011,9(2):196-223.
[31]Freeman L C,Ting P Y.The pathogenic role of the inflammasome in neurodegenerative diseases[J].Journal of Neurochemistry,2016,136:29-38.
[32]王艳平.海洋生物活性物质SBH-Ⅰ的神经保护和神经发生增强作用[D].湛江:广东海洋大学,2009.
[33]Cheung R C F,Ng T B,Wong J H.Marine peptides:bioactivities and applications[J].Marine Drugs,2015,13(7):4006-4043.
[34]Armishaw C J,Dutton J L,Craik D J,et al.Establishing regiocontrol of disulfide bond isomers ofα-conotoxinimi via the synthesis of N-to-C cyclic analogs[J].Peptide Science,2010,94(3):307-313.
[35]Bingham J P,Mitsunaga E,Bergeron Z L.Drugs from slugspast,present and future perspectives ofω-conotoxin research[J].Chemico-Biological Interactions,2010,183(1):1-18.
[36]Chen R,Chung S H.Binding modes ofμ-conotoxin to the bacterial sodium channel(Na V Ab)[J].Biophysical Journal,2012,102(3):483-488.
[37]Franzin A,Vimercati A,Picozzi P,et al.Stereotactic drainage and gamma knife radiosurgery of cystic brain metastasis[J].Journal of Neurosurgery,2008,109(2):259-267.
[38]Choi D Y,Choi H.Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer’s disease,Parkinson’s disease and ischemic brain stroke:their molecular targets and action mechanisms[J].Archives of Pharmacal Research,2015,38(2):139-170.
[39]D’Archivio M,Scazzocchio B,Giammarioli S,et al.ω-3PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients[J].Plos One,2013,8(10):77432-77442.
[40]Muriuki M,Purdie N,Dumancas G.Quantification of the majorω-3,ω-6 PUFAs using the purdie assay and their ratios in different cholesterol types and the effects of gender and cholesterol on PUFA levels[J].Trac-Trends in Analytical Chemistry,2012,31:157-164.
[41]Saw C L,Huang Y,Kong A N.Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids:docosahexaenoic acid or eicosapentaenoic acid[J].Biochemical Pharmacology,2010,79(3):421-430.
[42]杨帆.海洋动物中甾醇类化合物的研究近况[J].粮食与食品工业,2014,21(1):47-51.
[43]Heo S J,Yoon W J,Kim K N,et al.Evaluation of antiinflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages[J].Food&Chemical Toxicology,2010,48(8-9):2045-2051.
[44]Soheili M,Khosravidarani K.The potential health benefits of algae and microalgae in medicine:a review on spirulina platensis[J].Current Nutrition&Food Science,2011,7(4):279-285.
[45]Locke A E,Kahali B,Berndt S I,et al.Genetic studies of body mass index yield new insights for obesity biology[J].Nature,2015,518:197-206.
[46]Cudennec B,Ravallec-Ple'R,Courois E,et al.Peptides from fish and crustacean by-products hydrolysates stimulate cholecystokinin release in STC-1 cells[J].Food Chemistry,2008,111(4):970-975.
[47]张文源,高保燕,雷学青,等.岩藻黄素的理化与生物学特性、制备技术及其生理活性研究进展[J].中国海洋药物,2015(3):81-95.
[48]Golub N,Geba D,Mousa S A,et al.Greasing the wheels of managing overweight and obesity with omega-3 fatty acids[J].Medical Hypotheses,2011,77(6):1114-1120.
[49]蒋立勤,余陈欢,余勤,等.两种海洋副产品的脂肪酸组成及其对高脂小鼠的影响[J].食品与机械,2009,25(2):58-61.
[50]Jakobsdottir G,Nyman M,Fak F.Designing future prebiotic fiber to target metabolic syndrome[J].Nutrition,2014,30(5):497-502.
[51]O’Sullivan L,Murphy B,Mc Loughlin P,et al.Prebiotics from marine macroalgae for human and animal health applications[J].Marine Drugs,2010,8(7):2038-2064.
[52]Raposo M F D J,Rui M S C D M.Emergent sources of prebiotics:seaweeds and microalgae[J].Marine Drugs,2016,14(2):1-27.
[53]Al-Sheraji S H,Ismail A,Manap M Y,et al.Prebiotics as functional foods:a review[J].Journal of Functional Foods,2013,5(4):1542-1553.
[2]Mayer A M S,Rodríguez A D,Berlinck R G S,et al.Marine pharmacology in 2007-8:marine compounds with antibacterial,anticoagulant,antifungal,anti-inflammatory,antimalarial,antiprotozoal,antituberculosis,and antiviral activities;affecting the immune and nervous system,and other miscellaneous mechanisms of action[J].Comparative Biochemistry&Physiology Toxicology&Pharmacology,2011,153(2):191-222.
[3]张明辉.海洋生物活性物质的研究进展[J].水产科技情报,2007,34(5):201-205.
[4]陈曦,陈秀霞,陈强,等.海洋生物活性物质研究简述[J].福建农业科技,2012(2):83-85.
[5]Li D,Xu Y,Shao C L,et al.Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus aspergillus sp[J].Marine Drugs,2012,10(1):234-241.
[6]Habbu P,Warad V,Shastri R,et al.Antimicrobial metabolites from marine microorganisms[J].Chinese Journal of Natural Medicines,2016,14(2):101-116.
[7]单红,周国勤,朱银安,等.鱼类抗菌肽的研究进展[J].水产养殖,2012,33(1):20-25.
[8]吴晓洒,蔡路昀,曹爱玲,等.水产品加工废弃物中的蛋白及生物活性肽的研究进展[J].食品工业科技,2014,35(23):372-376.
[9]Arancibia M Y,Alemán A,Calvo M M,et al.Antimicrobial and antioxidant chitosan solutions enriched with active shrimp(Litopenaeusvannamei)waste materials[J].Food Hydrocolloids,2014,35(1):710-717.
[10]蓝蔚青,谢晶,侯伟峰,等.复合生物保鲜剂对腐败希瓦氏菌的抑菌机理[J].江苏农业学报,2012,28(1):186-192.
[11]Sudhakar S,Nazeer R A.Structural characterization of an Indian squid antioxidant peptide and its protective effect against cellular reactive oxygen species[J].Journal of Functional Foods,2015,14:502-512.
[12]冯建慧,曹爱玲,蔡路昀,等.鱼类副产物中抗氧化肽及活性机理研究进展[J].食品工业科技,2016,37(15):365-369,374.
[13]吴晓洒,蔡路昀,黄作庆,等.响应面法优化草鱼皮中有效抗氧化物质提取工艺[J].食品工业科技,2015(19):202-206.
[14]Cornish M L,Garbary D J.Antioxidants from macroalgae:potential applications in human health and nutrition[J].American Journal of Physiology,2010,255(3):280-286.
[15]Hamed I,zogul F,zogul Y,et al.Marine bioactive compounds and their health benefits:a review[J].Comprehensive Reviews in Food Science&Food Safety,2015,14(4):446-465.
[16]Rao A R,Sarada R,Shylaja M D,et al.Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga haematococcuspluvialis[J].Journal of Food Science&Technology,2015,52(10):6703-6710.
[17]Gupta A,Lampropulos J F,Bikdeli B,et al.Most important outcomes research papers on cardiovascular disease in women[J].Circulation Cardiovascular Quality&Outcomes,2013,6(1):e1-e7.
[18]Chiesa G,Busnelli M,Manzini S,et al.Nutraceuticals and bioactive components from fish for dyslipidemia and cardiovascular risk reduction[J].Marine Drugs,2016,14(6):1-15.
[19]Lee S H,Qian Z J,Kim S K.A novel angiotensin iconverting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats[J].Food Chemistry,2010,18(1):96-102.
[20]Rodrigues J A G,Vanderlei E S O,Silva L M C M,et al.Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed caulerpacupressoides[J].Pharmacological Reports,2012,64(2):282-292.
[21]Calder P C.n-3 Fatty acids and cardiovascular disease:evidence explained and mechanisms explored[J].Clinical Science,2004,107(1):1-11.
[22]Naveed N.Medicinal uses of red algae and blue-green algae[J].Research Journal of Pharmacy&Technology,2014,7(12):1472-1475.
[23]Imumorin I G,Eun-Hee K,Lee Y M,et al.Genome scan for parent-of-origin QTL effects on bovine growth and carcass traits[J].Frontiers in Genetics,2011(2):1-13.
[24]刘媛,王健,孙剑峰,等.我国海洋贝类资源的利用现状和发展趋势[J].现代食品科技,2013(3):673-677.
[25]杨永芳,闫海强,丁国芳,等.贻贝水解物抗肿瘤活性肽的分离纯化[J].中国药科大学学报,2011,42(3):272-275.
[26]冯刚,王斌,罗红宇,等.海洋软骨鱼软骨抗肿瘤物质的研究进展[J].浙江海洋学院学报(自然科学版),2011,30(2):168-172.
[27]Meij V D,Langius J A,Brouwer I A,et al.n-3 PUFAs in cancer,surgery,and critical care:a systematic review on clinical effects,incorporation,and washout of oral or enteral compared with parenteral supplementation[J].American Journal of Clinical Nutrition,2011,94(5):1248-1265.
[28]Carvalho J F S,Silva M M C,Moreira J N,et al.Sterols as anticancer agents:synthesis of ring-b oxygenated steroids,cytotoxic profile,and comprehensive SAR analysis[J].Journal of Medicinal Chemistry,2010,53(21):7632-7638.
[29]Murphy C,Hotchkiss S,Worthington J,et al.The potential of seaweed as a source of drugs for use in cancer chemotherapy[J].Journal of Applied Phycology,2014,26(5):2211-2264.
[30]Jiao G,Yu G,Zhang J,et al.Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae[J].Marine Drugs,2011,9(2):196-223.
[31]Freeman L C,Ting P Y.The pathogenic role of the inflammasome in neurodegenerative diseases[J].Journal of Neurochemistry,2016,136:29-38.
[32]王艳平.海洋生物活性物质SBH-Ⅰ的神经保护和神经发生增强作用[D].湛江:广东海洋大学,2009.
[33]Cheung R C F,Ng T B,Wong J H.Marine peptides:bioactivities and applications[J].Marine Drugs,2015,13(7):4006-4043.
[34]Armishaw C J,Dutton J L,Craik D J,et al.Establishing regiocontrol of disulfide bond isomers ofα-conotoxinimi via the synthesis of N-to-C cyclic analogs[J].Peptide Science,2010,94(3):307-313.
[35]Bingham J P,Mitsunaga E,Bergeron Z L.Drugs from slugspast,present and future perspectives ofω-conotoxin research[J].Chemico-Biological Interactions,2010,183(1):1-18.
[36]Chen R,Chung S H.Binding modes ofμ-conotoxin to the bacterial sodium channel(Na V Ab)[J].Biophysical Journal,2012,102(3):483-488.
[37]Franzin A,Vimercati A,Picozzi P,et al.Stereotactic drainage and gamma knife radiosurgery of cystic brain metastasis[J].Journal of Neurosurgery,2008,109(2):259-267.
[38]Choi D Y,Choi H.Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer’s disease,Parkinson’s disease and ischemic brain stroke:their molecular targets and action mechanisms[J].Archives of Pharmacal Research,2015,38(2):139-170.
[39]D’Archivio M,Scazzocchio B,Giammarioli S,et al.ω-3PUFAs exert anti-inflammatory activity in visceral adipocytes from colorectal cancer patients[J].Plos One,2013,8(10):77432-77442.
[40]Muriuki M,Purdie N,Dumancas G.Quantification of the majorω-3,ω-6 PUFAs using the purdie assay and their ratios in different cholesterol types and the effects of gender and cholesterol on PUFA levels[J].Trac-Trends in Analytical Chemistry,2012,31:157-164.
[41]Saw C L,Huang Y,Kong A N.Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids:docosahexaenoic acid or eicosapentaenoic acid[J].Biochemical Pharmacology,2010,79(3):421-430.
[42]杨帆.海洋动物中甾醇类化合物的研究近况[J].粮食与食品工业,2014,21(1):47-51.
[43]Heo S J,Yoon W J,Kim K N,et al.Evaluation of antiinflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages[J].Food&Chemical Toxicology,2010,48(8-9):2045-2051.
[44]Soheili M,Khosravidarani K.The potential health benefits of algae and microalgae in medicine:a review on spirulina platensis[J].Current Nutrition&Food Science,2011,7(4):279-285.
[45]Locke A E,Kahali B,Berndt S I,et al.Genetic studies of body mass index yield new insights for obesity biology[J].Nature,2015,518:197-206.
[46]Cudennec B,Ravallec-Ple'R,Courois E,et al.Peptides from fish and crustacean by-products hydrolysates stimulate cholecystokinin release in STC-1 cells[J].Food Chemistry,2008,111(4):970-975.
[47]张文源,高保燕,雷学青,等.岩藻黄素的理化与生物学特性、制备技术及其生理活性研究进展[J].中国海洋药物,2015(3):81-95.
[48]Golub N,Geba D,Mousa S A,et al.Greasing the wheels of managing overweight and obesity with omega-3 fatty acids[J].Medical Hypotheses,2011,77(6):1114-1120.
[49]蒋立勤,余陈欢,余勤,等.两种海洋副产品的脂肪酸组成及其对高脂小鼠的影响[J].食品与机械,2009,25(2):58-61.
[50]Jakobsdottir G,Nyman M,Fak F.Designing future prebiotic fiber to target metabolic syndrome[J].Nutrition,2014,30(5):497-502.
[51]O’Sullivan L,Murphy B,Mc Loughlin P,et al.Prebiotics from marine macroalgae for human and animal health applications[J].Marine Drugs,2010,8(7):2038-2064.
[52]Raposo M F D J,Rui M S C D M.Emergent sources of prebiotics:seaweeds and microalgae[J].Marine Drugs,2016,14(2):1-27.
[53]Al-Sheraji S H,Ismail A,Manap M Y,et al.Prebiotics as functional foods:a review[J].Journal of Functional Foods,2013,5(4):1542-1553.