抑郁症中医证候动物模型研究进展
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摘要
抑郁障碍是一种常见的、复杂的、可能威胁生命的精神障碍,在全世界造成严重的社会和经济负担。多年来,现代医学建立了多种动物模型来阐明抑郁症的致病机制、生理病理学基础和研究新的抗抑郁治疗策略。随着中医学实验研究的发展,证候模型也广泛应用于此领域,为抑郁症的认识带来了新的视角。文章总结了抑郁症中医证候动物模型研究进展,并对其局限性进行了讨论。
Depression disorder is a common, complex and potentially life-threatening mental disorder, which causes serious social and economic burdens in the whole world. Over the years, many kinds of animal models have been established in modern medicine to elucidate the pathogenic mechanisms, physiological and pathological basis of depression and to study new antidepressant treatment strategies. With the development of TCM experimental research, TCM syndrome animal models are also widely used in this field, which brings a new perspective for the understanding of depression. In this article, the research progress of animal models of TCM syndrome of depression was summarized and the limitations of them were discussed.
Depression disorder is a common, complex and potentially life-threatening mental disorder, which causes serious social and economic burdens in the whole world. Over the years, many kinds of animal models have been established in modern medicine to elucidate the pathogenic mechanisms, physiological and pathological basis of depression and to study new antidepressant treatment strategies. With the development of TCM experimental research, TCM syndrome animal models are also widely used in this field, which brings a new perspective for the understanding of depression. In this article, the research progress of animal models of TCM syndrome of depression was summarized and the limitations of them were discussed.
引文
[1]王瑞杰.抑郁症动物模型的研究进展.陕西医学杂志,2013,42(2):235-236
[2]Whiteford H A,Degenhardt L,Rehm,et al.Global burden of disease attributable to mental and substance use disorders:findings from the Global Burden of Disease Study 2010.Lancet,2013,382(9904):1575-1586
[3]薛涛,邬丽莎,刘新民,等.抑郁症动物模型及评价方法研究进展.中国实验动物学报,2015,23(3):321-326
[4]修宗昌,金红姝,易杰,等.建立中医证候动物模型值得注意的几个问题.辽宁中医学院学报,2001,3(3):185-186
[5]邢建华,翟红莉.中医证候动物模型研究近况.中国疗养医学,2007,16(2):68-69
[6]徐春燕,田金洲,时晶,等.抑郁症的中医证候特征研究.中华中医药学刊,2013,31(4):810-812
[7]张国萍,郭蕾.浅述肝郁脾虚证的实验研究进展.光明中医,2011,26(9):1943-1945
[8]岳利峰,丁杰,陈家旭,等.肝郁脾虚证大鼠模型的建立与评价.北京中医药大学学报,2008,31(6):396-400
[9]周国儿,吴静,黄云娟,等.“肝郁气滞”及“肝郁脾虚”型抑郁症动物模型建立初探.中华中医药学刊,2014,32(5):1035-1038
[10]赵荣华,谢鸣,刘进娜,等.肝郁脾虚和肝郁脾虚证模型大鼠行为学变化及柴疏四君子汤对其作用的比较.北京中医药大学学报,2015,38(8):515-518
[11]李艳彦,谢鸣,陈禹,等.一种运用复合病因造模法复制大鼠肝郁脾虚证模型的研究.中国中医基础医学杂志,2006,12(6):439-442
[12]张军会,李铭,李智辉.肝郁证动物模型造模方法与判定标准纵览.山西中医,2012,28(8):51-53
[13]于琦,金光亮.三种复方对慢性应激肝郁模型大鼠海马5-HT1A受体基因表达的影响.北京中医药,2008,27(1):57-59
[14]包祖晓,赵国平,何贵平,等.肝肾阳虚型抑郁症大鼠模型的建立与评价.中华中医药学刊,2015,33(1):42-45
[15]王丹.利血平抑郁模型的剂量探讨.医学美学美容:中旬刊,2013,22(10):71-72
[16]刘欣,张冰,刘小青,等.氢化可的松诱导大鼠类阳虚状态的动态观察.中华中医药杂志,2011,26(1):126-128
[17]陈晓阳,陈容,李晟,等.肾阴虚抑郁症大鼠模型的建立及评价.湖南中医药大学学报,2007,27(5):28-31
[18]何书芬,居文政,胡浩彬,等.肾阳虚抑郁症模型大鼠的肝脏药物代谢酶活性变化研究.药学学报,2017,52(2):258-263
[19]林志健,张冰,刘小青,等.中医证候动物模型评价研究.中华中医药杂志,2013,28(8):2217-2221
[20]王少贤,白明华,陈家旭,等.关于建立中医证候模型评价量表的思考.中华中医药杂志,2011,26(3):531-534
[2]Whiteford H A,Degenhardt L,Rehm,et al.Global burden of disease attributable to mental and substance use disorders:findings from the Global Burden of Disease Study 2010.Lancet,2013,382(9904):1575-1586
[3]薛涛,邬丽莎,刘新民,等.抑郁症动物模型及评价方法研究进展.中国实验动物学报,2015,23(3):321-326
[4]修宗昌,金红姝,易杰,等.建立中医证候动物模型值得注意的几个问题.辽宁中医学院学报,2001,3(3):185-186
[5]邢建华,翟红莉.中医证候动物模型研究近况.中国疗养医学,2007,16(2):68-69
[6]徐春燕,田金洲,时晶,等.抑郁症的中医证候特征研究.中华中医药学刊,2013,31(4):810-812
[7]张国萍,郭蕾.浅述肝郁脾虚证的实验研究进展.光明中医,2011,26(9):1943-1945
[8]岳利峰,丁杰,陈家旭,等.肝郁脾虚证大鼠模型的建立与评价.北京中医药大学学报,2008,31(6):396-400
[9]周国儿,吴静,黄云娟,等.“肝郁气滞”及“肝郁脾虚”型抑郁症动物模型建立初探.中华中医药学刊,2014,32(5):1035-1038
[10]赵荣华,谢鸣,刘进娜,等.肝郁脾虚和肝郁脾虚证模型大鼠行为学变化及柴疏四君子汤对其作用的比较.北京中医药大学学报,2015,38(8):515-518
[11]李艳彦,谢鸣,陈禹,等.一种运用复合病因造模法复制大鼠肝郁脾虚证模型的研究.中国中医基础医学杂志,2006,12(6):439-442
[12]张军会,李铭,李智辉.肝郁证动物模型造模方法与判定标准纵览.山西中医,2012,28(8):51-53
[13]于琦,金光亮.三种复方对慢性应激肝郁模型大鼠海马5-HT1A受体基因表达的影响.北京中医药,2008,27(1):57-59
[14]包祖晓,赵国平,何贵平,等.肝肾阳虚型抑郁症大鼠模型的建立与评价.中华中医药学刊,2015,33(1):42-45
[15]王丹.利血平抑郁模型的剂量探讨.医学美学美容:中旬刊,2013,22(10):71-72
[16]刘欣,张冰,刘小青,等.氢化可的松诱导大鼠类阳虚状态的动态观察.中华中医药杂志,2011,26(1):126-128
[17]陈晓阳,陈容,李晟,等.肾阴虚抑郁症大鼠模型的建立及评价.湖南中医药大学学报,2007,27(5):28-31
[18]何书芬,居文政,胡浩彬,等.肾阳虚抑郁症模型大鼠的肝脏药物代谢酶活性变化研究.药学学报,2017,52(2):258-263
[19]林志健,张冰,刘小青,等.中医证候动物模型评价研究.中华中医药杂志,2013,28(8):2217-2221
[20]王少贤,白明华,陈家旭,等.关于建立中医证候模型评价量表的思考.中华中医药杂志,2011,26(3):531-534