盐酸米诺环素软膏联合牛黄解毒片治疗轻症急性冠周炎的临床疗效观察
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摘要
目的观察盐酸米诺环素软膏联合牛黄解毒片治疗急性冠周炎的临床疗效。方法选取临床就诊的240例轻症急性冠周炎患者,随机分成4组,观察组给予盐酸米诺环素软膏袋内上药和口服牛黄解毒片,对照组1给予盐酸米诺环素软膏袋内上药,对照组2给予碘甘油袋内上药和口服牛黄解毒片,对照组3给予碘甘油袋内上药和口服阿莫西林胶囊+甲硝唑片。比较4组临床疗效。结果观察组经治疗后无不良反应,疗效优于对照组1和对照组2(P<0.01);与对照组3相比差异无统计学意义(P>0.05)。结论盐酸米诺环素软膏联合牛黄解毒片治疗轻症急性冠周炎疗效显著,值得临床推广应用。
Objective To observe the effect of minocycline hydrochloride ointment combined with niuhuang jiedu pian on mild acute pericoronitis. Methods 240 patients with mild acute pericoronitis were randomly assigned into treatment group, control 1 group, control 2 group and control 3 group. The treatment group was treated by external use of minocycline hydrochloride ointment and oral administration of niuhuang jiedu pian, the control 1 group was treated by external use of minocycline hydrochloride ointment, the control 2 group was treated by external use of iodine glycerin and oral administration of niuhuang jiedu pian, and the control 3 was treated by external use of iodine glycerin and oral administration of amoxicillin capsules and metronidazole tablets. The clinical curative effects were compared among these four groups. Results No adverse reaction was observed in the treatment group. The clinical curative effect observed in the control 1 group was better than that in the control 2 group(P<0.01), but not signifi cantly different from the control 3 group(P>0.05). ConclusionThe minocycline hydrochloride ointment combined with niuhuang jiedu pian is safe and effective for treating mild acute pericoronitis. It is worthy of further promotion and application in clinic.
Objective To observe the effect of minocycline hydrochloride ointment combined with niuhuang jiedu pian on mild acute pericoronitis. Methods 240 patients with mild acute pericoronitis were randomly assigned into treatment group, control 1 group, control 2 group and control 3 group. The treatment group was treated by external use of minocycline hydrochloride ointment and oral administration of niuhuang jiedu pian, the control 1 group was treated by external use of minocycline hydrochloride ointment, the control 2 group was treated by external use of iodine glycerin and oral administration of niuhuang jiedu pian, and the control 3 was treated by external use of iodine glycerin and oral administration of amoxicillin capsules and metronidazole tablets. The clinical curative effects were compared among these four groups. Results No adverse reaction was observed in the treatment group. The clinical curative effect observed in the control 1 group was better than that in the control 2 group(P<0.01), but not signifi cantly different from the control 3 group(P>0.05). ConclusionThe minocycline hydrochloride ointment combined with niuhuang jiedu pian is safe and effective for treating mild acute pericoronitis. It is worthy of further promotion and application in clinic.
引文
1卢海波,廖建兴,康非吾,等.米诺环素对急性智齿冠周炎治疗效果的观察.口腔颌面外科杂志,2012,03(1):148-151.
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4 申晋斌,张许杰.盐酸米诺环素软膏治疗急性局限型智齿冠周炎临床疗效Meta分析.中国实用口腔科杂志,2014,06(2):122-126.
5 张贤华,杜岩,沈辉,等.盐酸米诺环素软膏治疗急性智齿冠周炎的临床效果和微生物学评价.实用口腔医学杂志,2014,09(2):12-15.
6 封玉玲,苗加伟,李晶,等.牛黄解毒片的安全性评价.中国中药杂志,2014,17(2):88-91.
7 韩亚琨,于程程,贾涵.牛黄解毒片联合洁治术治疗菌斑型牙周病的动物实验观察.吉林医学院学报,2016,12(1):12-16.
8 贾文明,曹藏柱,张雯丽.牛黄解毒方治疗复发性口腔溃疡172 例疗效观察.河北北方学院学报,2015,06(1):122-126.
9 罗建红.人工牛黄甲硝唑胶囊结合云南白药治疗复发性口腔溃疡的临床观察.口腔材料器械杂志,2016,25(1):51-53.
2 陆兆威,王少英,陈燕,等.派丽奥治疗急性牙周炎及急性冠周炎的临床疗效评价.广西医学,2006,07(2):232-235.
3 姚波,杨丽,赵俊,等.三种局部用药治疗急性冠周炎的临床疗效比较.中国现代药物应用,2012,03(1):43-47.
4 申晋斌,张许杰.盐酸米诺环素软膏治疗急性局限型智齿冠周炎临床疗效Meta分析.中国实用口腔科杂志,2014,06(2):122-126.
5 张贤华,杜岩,沈辉,等.盐酸米诺环素软膏治疗急性智齿冠周炎的临床效果和微生物学评价.实用口腔医学杂志,2014,09(2):12-15.
6 封玉玲,苗加伟,李晶,等.牛黄解毒片的安全性评价.中国中药杂志,2014,17(2):88-91.
7 韩亚琨,于程程,贾涵.牛黄解毒片联合洁治术治疗菌斑型牙周病的动物实验观察.吉林医学院学报,2016,12(1):12-16.
8 贾文明,曹藏柱,张雯丽.牛黄解毒方治疗复发性口腔溃疡172 例疗效观察.河北北方学院学报,2015,06(1):122-126.
9 罗建红.人工牛黄甲硝唑胶囊结合云南白药治疗复发性口腔溃疡的临床观察.口腔材料器械杂志,2016,25(1):51-53.