卵巢粒层细胞瘤的超声图像特征和术前分期价值
|
摘要
目的探讨超声对卵巢粒层细胞瘤的诊断和术前分期价值。方法回顾性分析我院病理科诊断的卵巢粒层细胞瘤患者56例,将超声图像特征与临床分期数据对照分析。结果 56例粒层细胞瘤患者的超声表现可分为囊性、囊实性和实性占位三类,瘤体体积大小和囊性化程度呈线性关系,使用ROC曲线分析取得各个分期的瘤体体积的最佳截断值,Ⅱ期患者最佳诊断截断值为瘤体体积129cm3,Ⅲ期为1 227cm3。结论超声对卵巢粒层细胞瘤术前分期有一定指导意义,瘤体体积越大越容易囊性变,瘤体体积越大临床分期越晚。
Objective To evaluate the value of ultrasonography in diagnosis and preoperative staging of granulosa cell tumor of ovary(OGCT).Methods A retrospective analysis of 56 patients with OGCT who diagnosed by pathology department in our hospital was carried out,The ultrasonographic features and clinical stage data were both collected and compared.Results The Ultrasonic manifestation of OGCT could be divided into three categories,cystic,cysticsolid,and solid.There was a linear relationship between the size of the tumor and the degree of cystization.ROC curve was used to determinate the cut-off value of tumor volume at various stages.StageⅡ was 129 cm3,and StageⅢ was 1227 cm3.Conclusions Ultrasound has some advantages in preoperative staging of OGCT.Cystic changes are likely to occur in larger tumors,and larger tumor volume suggests higher clinical stage.
Objective To evaluate the value of ultrasonography in diagnosis and preoperative staging of granulosa cell tumor of ovary(OGCT).Methods A retrospective analysis of 56 patients with OGCT who diagnosed by pathology department in our hospital was carried out,The ultrasonographic features and clinical stage data were both collected and compared.Results The Ultrasonic manifestation of OGCT could be divided into three categories,cystic,cysticsolid,and solid.There was a linear relationship between the size of the tumor and the degree of cystization.ROC curve was used to determinate the cut-off value of tumor volume at various stages.StageⅡ was 129 cm3,and StageⅢ was 1227 cm3.Conclusions Ultrasound has some advantages in preoperative staging of OGCT.Cystic changes are likely to occur in larger tumors,and larger tumor volume suggests higher clinical stage.
引文
[1]Rokitansky CV(1859)Uber Abnormalit~iten des Corpus luteum[J].Allg Wien Med Z 4:253.
[2]SCHUMER S T,CANNISTRA S A.Granulosa cell tumor of the ovary[J].J Clin Oncol,2003,21(6):1180-1189.
[3]KOTTARATHIL V D,ANTONY M A,NAIR I R,et al.Recent advances in granulosa cell tumor ovary:a review[J].Indian J Surg Oncol,2013,4(1):37-47.
[4]KIM J A,CHUN Y K,MOON M H,et al.High-resolution sonographic findings of ovarian granulosa cell tumors:correlation with pathologic findings[J].J Ultrasound Med,2010,29(2):187-193.
[5]PARK J Y,JIN K L,KIM D Y,et al.(2012)Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary[J].Gynecol Oncol,125:80-86.
[6]MANGILI G,OTTOLINA J,GADDUCCI A.Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary[J].Br J Cancer,2013,109(1):29-34.
[7]SCHARL A,VIERBUCHEN M,KUSCHE M.Clinical aspects and prognosis of granulosa cell tumors of the ovary[J].Geburtshilfe Frauenheilkd,1988,48(8):567-573.
[8]FOTOPOLOU C,SAWATIS K,BRAICU E I,et al.(2010)Adult granulosa cell tumors of the ovary:tumor dissemination patern at primary and recurrent situation,surgical outcome[J].Gynecol Oncol,2010,119(2):285-290.
[9]STENWIG J T,HAZEKAMP J T,BEECHAM J B.Granulosa cell tumors of the ovary:a clinicopathological study of 118cases with long-term follow-up[J].Gynecol Oncol,1979,7:136-152.
[10]SCULLY R E.Tumors of the ovary and maldeveloped gonads.Atlas of tumor pathology,series 2,fascicles 16[J].Washington,DC:Armed Forces Institute of Pathology,1979:152-173.
[11]MENDELSON E B,BOHM-VELEZ M.Transvaginal ultrasonography of pelvic neoplasms[J].RadiolClin North Am,1992,30:703-734.
[12]付志勇,万淑华,孙智芳,等.卵巢颗粒细胞瘤34例临床分析[J].中国超声医学杂志,2012,28(4):376-377.
[13]丁青薇,孙宁,王绍文,等.灰阶超声诊断卵巢囊腺瘤的价值[J].中国医学影像学杂志,2008,(6):450-452.
[14]刘洪涛,卢漫.皮样囊肿与表皮样囊肿的超声诊断[J].中国现代医师,2009,47(33):82-83.
[15]乐桂蓉,陈秀卿,张青萍.超声检查对Krukenberg肿瘤诊断的临床价值[J].同济医科大学学报,1994,(4):319-321,350.
[16]王正军.卵巢无性细胞瘤12例的超声诊断[J].中国卫生产业,2014,11(22):12-13.
[17]SHARONY R,AVIRAM R,FISHMAN A.Granulosa cell tumors of the ovary:do they have any unique ultrasonographic and color Doppler flow features[J]?nt J Gynecol Cancer,2001,11(3):229-233.
[18]YESILYURT H,TOKMAK A,GUZEL A I.Parameters for predicting granulosa cell tumor of the ovary:a single center retrospective comparative study[J].Asian Pac J Cancer Prev,2014,15(19):8447-8450.
[19]LEE W L,YUAN C C,LAI C R,et al.Hemoperitoneum is an initial presentation of recurrent granulosa cell tumors of the ovary[J].Jpn J Clin Oncol,1999,29(10):509-512.
[20]CHAN J K,ZHANG M,KALEB V,et al.Prognostic factors responsible for survival in sex cord stromal tumors of the ovarya multivariate analysis[J].Gynecol Oncol,2007,104(2):396-400.
[21]RANGANATH R,SRIDEVI V,SHIRLEY SS,et al.(2008)Clinical and pathologic prognostic factors in adult granulose cell tumors of the ovary[J].Int J Gynecol Cancer,18:929-933.
[22]SCHUMER S T,CANNISTRA S A.(2003)Granulosa cell tumor of the ovary[J].J Clin Oncol,2003,21(6):1180-1189.
[2]SCHUMER S T,CANNISTRA S A.Granulosa cell tumor of the ovary[J].J Clin Oncol,2003,21(6):1180-1189.
[3]KOTTARATHIL V D,ANTONY M A,NAIR I R,et al.Recent advances in granulosa cell tumor ovary:a review[J].Indian J Surg Oncol,2013,4(1):37-47.
[4]KIM J A,CHUN Y K,MOON M H,et al.High-resolution sonographic findings of ovarian granulosa cell tumors:correlation with pathologic findings[J].J Ultrasound Med,2010,29(2):187-193.
[5]PARK J Y,JIN K L,KIM D Y,et al.(2012)Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary[J].Gynecol Oncol,125:80-86.
[6]MANGILI G,OTTOLINA J,GADDUCCI A.Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary[J].Br J Cancer,2013,109(1):29-34.
[7]SCHARL A,VIERBUCHEN M,KUSCHE M.Clinical aspects and prognosis of granulosa cell tumors of the ovary[J].Geburtshilfe Frauenheilkd,1988,48(8):567-573.
[8]FOTOPOLOU C,SAWATIS K,BRAICU E I,et al.(2010)Adult granulosa cell tumors of the ovary:tumor dissemination patern at primary and recurrent situation,surgical outcome[J].Gynecol Oncol,2010,119(2):285-290.
[9]STENWIG J T,HAZEKAMP J T,BEECHAM J B.Granulosa cell tumors of the ovary:a clinicopathological study of 118cases with long-term follow-up[J].Gynecol Oncol,1979,7:136-152.
[10]SCULLY R E.Tumors of the ovary and maldeveloped gonads.Atlas of tumor pathology,series 2,fascicles 16[J].Washington,DC:Armed Forces Institute of Pathology,1979:152-173.
[11]MENDELSON E B,BOHM-VELEZ M.Transvaginal ultrasonography of pelvic neoplasms[J].RadiolClin North Am,1992,30:703-734.
[12]付志勇,万淑华,孙智芳,等.卵巢颗粒细胞瘤34例临床分析[J].中国超声医学杂志,2012,28(4):376-377.
[13]丁青薇,孙宁,王绍文,等.灰阶超声诊断卵巢囊腺瘤的价值[J].中国医学影像学杂志,2008,(6):450-452.
[14]刘洪涛,卢漫.皮样囊肿与表皮样囊肿的超声诊断[J].中国现代医师,2009,47(33):82-83.
[15]乐桂蓉,陈秀卿,张青萍.超声检查对Krukenberg肿瘤诊断的临床价值[J].同济医科大学学报,1994,(4):319-321,350.
[16]王正军.卵巢无性细胞瘤12例的超声诊断[J].中国卫生产业,2014,11(22):12-13.
[17]SHARONY R,AVIRAM R,FISHMAN A.Granulosa cell tumors of the ovary:do they have any unique ultrasonographic and color Doppler flow features[J]?nt J Gynecol Cancer,2001,11(3):229-233.
[18]YESILYURT H,TOKMAK A,GUZEL A I.Parameters for predicting granulosa cell tumor of the ovary:a single center retrospective comparative study[J].Asian Pac J Cancer Prev,2014,15(19):8447-8450.
[19]LEE W L,YUAN C C,LAI C R,et al.Hemoperitoneum is an initial presentation of recurrent granulosa cell tumors of the ovary[J].Jpn J Clin Oncol,1999,29(10):509-512.
[20]CHAN J K,ZHANG M,KALEB V,et al.Prognostic factors responsible for survival in sex cord stromal tumors of the ovarya multivariate analysis[J].Gynecol Oncol,2007,104(2):396-400.
[21]RANGANATH R,SRIDEVI V,SHIRLEY SS,et al.(2008)Clinical and pathologic prognostic factors in adult granulose cell tumors of the ovary[J].Int J Gynecol Cancer,18:929-933.
[22]SCHUMER S T,CANNISTRA S A.(2003)Granulosa cell tumor of the ovary[J].J Clin Oncol,2003,21(6):1180-1189.