从《中华医典》探析中风后口眼歪斜的用药特点
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摘要
[目的]通过文献总结归纳中风后口眼歪斜的常用药物及配伍规律。[方法]收集《中华医典5.0》中治疗中风后口眼歪斜的古代及近代中药处方,通过Microsoft Office Excel 2013软件建立规范化数据库,并利用SPSS Statistics24和SPSS Modeler18.0软件对数据库中的处方进行频数分析和关联分析。[结果]研究最终纳入方剂621首,中药331味,药物总频次7880次。其中最常用单味药物为防风,频率达47.5%。最常见药类为解表药、补虚药、平肝熄风药、祛风湿药、活血化瘀药、温里药。常用药组蝎梢-天麻-僵蚕在设定支持度15%、置信度70%条件下出现频次最高。[结论]数据挖掘结果体现了先贤治疗中风后口眼歪斜重视单味药物防风的应用及虫类药与平肝熄风药的配伍使用,对现代遣方用药具有一定借鉴意义。
[Objective] To summarize the commonly used drugs and compatibility rules of deviation of mouth and eye after apoplexy through literature review. [Method] The ancient and modern Chinese medicine prescriptions for the treatment of mouth and eye deviation after apoplexy in Chinese Medical Code 5.0 were collected. A standardized database was established by Microsoft Office Excel 2013 software. The prescriptions in the database were analyzed by SPSS Statistics 24 and SPSS Modeler 18.0 software. [Result] 621 prescriptions, 331 traditional Chinese medicines and 7880 total drug frequencies were included in the study.The most commonly used single drug is Fangfeng, with a frequency of 47.5%. The most common medicines are antiphlogistic drugs, tonifying deficiency drugs, liver-calming and wind-quenching drugs, rheumatism-dispelling drugs, blood-activating and stasis-removing drugs and warming-interior drugs. Scorpion shoot-Gastrodia elata-Bombyx Batryticatus has the highest frequency under the condition of 15%set support and 70% confidence. [Conclusion] Data mining method can explain the experience of ancient prescription medication comprehensively, which has certain reference significance for modern prescription medication.
[Objective] To summarize the commonly used drugs and compatibility rules of deviation of mouth and eye after apoplexy through literature review. [Method] The ancient and modern Chinese medicine prescriptions for the treatment of mouth and eye deviation after apoplexy in Chinese Medical Code 5.0 were collected. A standardized database was established by Microsoft Office Excel 2013 software. The prescriptions in the database were analyzed by SPSS Statistics 24 and SPSS Modeler 18.0 software. [Result] 621 prescriptions, 331 traditional Chinese medicines and 7880 total drug frequencies were included in the study.The most commonly used single drug is Fangfeng, with a frequency of 47.5%. The most common medicines are antiphlogistic drugs, tonifying deficiency drugs, liver-calming and wind-quenching drugs, rheumatism-dispelling drugs, blood-activating and stasis-removing drugs and warming-interior drugs. Scorpion shoot-Gastrodia elata-Bombyx Batryticatus has the highest frequency under the condition of 15%set support and 70% confidence. [Conclusion] Data mining method can explain the experience of ancient prescription medication comprehensively, which has certain reference significance for modern prescription medication.
引文
[1]高长玉,吴成翰,赵建国,等.中国脑梗死中西医结合诊治指南(2017)[J].中国中西医结合杂志,2018,38(2):136-144.
[2]何光明,李晓鹤.浅谈辨证、辨病、辨症论治三结合诊疗体系[J].江苏中医药,2015,47(5):13-14.
[3]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[4]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国脑出血诊治指南[J].中华神经科杂志,2015,48(6):435-444.
[5]钟赣生.中药学[M].北京:中国中医药出版社,2012:251.
[6]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:301-303.
[7]《中华本草》编委会.中华本草[M].上海:上海科技出版社,1999:245-250.
[8]戴元礼.秘传证治要诀及类方[M].北京:商务印书馆,1955:1.
[9]叶天士.本草经解[M].上海:上海科学技术出版社,1963:40.
[10]李杲.医学发明[M].北京:人民卫生出版社,1959:42.
[11]日华子.日华子本草[M].芜湖:皖南医学院科研处,1983:31.
[12] Iadecola C, Anrather,Stroke research at a crossroad:asking the brain for directions[J]. Nat Neurosci, 2011,14(11):1363-1368.
[13]吴舟娜,杜文杰,包苏凤,等.脑梗死患者医院感染的危险因素分析[J].中华医院感染学杂志,2014,24(6):1421-1422, 1425.
[14]刘双利,姜程曦,赵岩,等.防风化学成分及其药理作用研究进展[J].中草药,2017,48(10):2146-2152.
[15]张桥,沈娟,赵祎武,等.小续命汤有效成分组化学成分研究[J].世界科学技术-中医药现代化,2015,17(3):583-586.
[16]路畅,杜肖,贺晓丽,等.小续命汤有效成分组对局灶性脑缺血/再灌注大鼠恢复早期的神经保护作用研究[J].中国药理学通报,2016,32(7):938-944.
[17]王维峰,赵铎,王丹.郑绍周教授运用全蝎、僵蚕药对经验[J].中医研究,2016,29(4):29-31.
[18]唐容川.本草问答[M].北京:中国中医药出版社,2013:44.
[19]卢多逊.开宝本草辑复本[M].尚志钧,辑校.合肥:安徽科学技术出版社,1998:367.
[20]姜飞鹏.涤痰汤合牵正散加减治疗急性缺血性脑卒中恢复期90例疗效观察[J].浙江中医药大学学报,2014,38(6):724-726.
[21]李时珍.本草纲目[M].北京:人民卫生出版社,1982:2282.
[22]张声俊,许长华,陈建波,等.全蝎不同部位的红外光谱分析与评价[J].光谱学与光谱分析,2011,31(10):2711-2714.
[23]梁兰,王庆华,胡宗风,等.蝎毒活性肽BmK AngM1的定点突变及其抗炎活性研究[J].药学学报,2017,52(6):1007-1011.
[2]何光明,李晓鹤.浅谈辨证、辨病、辨症论治三结合诊疗体系[J].江苏中医药,2015,47(5):13-14.
[3]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[4]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国脑出血诊治指南[J].中华神经科杂志,2015,48(6):435-444.
[5]钟赣生.中药学[M].北京:中国中医药出版社,2012:251.
[6]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:301-303.
[7]《中华本草》编委会.中华本草[M].上海:上海科技出版社,1999:245-250.
[8]戴元礼.秘传证治要诀及类方[M].北京:商务印书馆,1955:1.
[9]叶天士.本草经解[M].上海:上海科学技术出版社,1963:40.
[10]李杲.医学发明[M].北京:人民卫生出版社,1959:42.
[11]日华子.日华子本草[M].芜湖:皖南医学院科研处,1983:31.
[12] Iadecola C, Anrather,Stroke research at a crossroad:asking the brain for directions[J]. Nat Neurosci, 2011,14(11):1363-1368.
[13]吴舟娜,杜文杰,包苏凤,等.脑梗死患者医院感染的危险因素分析[J].中华医院感染学杂志,2014,24(6):1421-1422, 1425.
[14]刘双利,姜程曦,赵岩,等.防风化学成分及其药理作用研究进展[J].中草药,2017,48(10):2146-2152.
[15]张桥,沈娟,赵祎武,等.小续命汤有效成分组化学成分研究[J].世界科学技术-中医药现代化,2015,17(3):583-586.
[16]路畅,杜肖,贺晓丽,等.小续命汤有效成分组对局灶性脑缺血/再灌注大鼠恢复早期的神经保护作用研究[J].中国药理学通报,2016,32(7):938-944.
[17]王维峰,赵铎,王丹.郑绍周教授运用全蝎、僵蚕药对经验[J].中医研究,2016,29(4):29-31.
[18]唐容川.本草问答[M].北京:中国中医药出版社,2013:44.
[19]卢多逊.开宝本草辑复本[M].尚志钧,辑校.合肥:安徽科学技术出版社,1998:367.
[20]姜飞鹏.涤痰汤合牵正散加减治疗急性缺血性脑卒中恢复期90例疗效观察[J].浙江中医药大学学报,2014,38(6):724-726.
[21]李时珍.本草纲目[M].北京:人民卫生出版社,1982:2282.
[22]张声俊,许长华,陈建波,等.全蝎不同部位的红外光谱分析与评价[J].光谱学与光谱分析,2011,31(10):2711-2714.
[23]梁兰,王庆华,胡宗风,等.蝎毒活性肽BmK AngM1的定点突变及其抗炎活性研究[J].药学学报,2017,52(6):1007-1011.