高血压病与勃起功能障碍研究进展
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摘要
近年来研究表明高血压病与勃起功能障碍存在明显相关性,二者有着共同的病理生理机制。一氧化氮和内皮功能障碍在高血压病合并勃起功能障碍的发生发展中发挥着重要作用,现就高血压病与勃起功能障碍的关系机制做一综述,并对高血压合并勃起功能障碍的综合管理做一简单介绍。
In recent years,studies have shown that there is a significant correlation between hypertension and erectile dysfunction,and they have a common pathophysiological mechanism. Nitric oxide and endothelial dysfunction play an important role in the development of hypertension complicated with erectile dysfunction. This article reviews the relationship and common mechanisms of hypertension and erectile dysfunction and presents a strategy for the comprehensive management of erectile dysfunction in hypertension.
In recent years,studies have shown that there is a significant correlation between hypertension and erectile dysfunction,and they have a common pathophysiological mechanism. Nitric oxide and endothelial dysfunction play an important role in the development of hypertension complicated with erectile dysfunction. This article reviews the relationship and common mechanisms of hypertension and erectile dysfunction and presents a strategy for the comprehensive management of erectile dysfunction in hypertension.
引文
[1] Katsiki N,Wierzbicki AS,Mikhailidis DP. Erectile dysfunction and coronary heart disease[J].Curr Opin Cardiol,2015,30(4):416-421.
[2] Gurtner K,Saltzman A,Hebert K,et al.Erectile dysfunction:a review of historical treatments with a focus on the development of the inflatable penile prosthesis[J].Am J Mens Health,2017,11(3):479-486.
[3] Elkhoury FF,Rambhatla A,Mills JN,et al.Cardiovascular health,erectile dysfunction,and testosterone replacement:controversies and correlations[J].Urology,2017,110:1-8.
[4] Pessinaba S,Baragou S,Pio M,et al.Erectile dysfunction in hypertensive patient in Togo:cross-sectional study in 100 patients in the Cardiology Department of the University Hospital Campus of Lome[J].Pan Afr Med J,2015,21:47.
[5] Fafiolu AS,Adebayo AM,Akande TO,et al.Erectile dysfunction among male hypertensives in a tertiary health facility in South-West Nigeria[J]. Glob J Health Sci,2014,7(1):154-160.
[6] Ning L,Yang L.Hypertension might be a risk factor for erectile dysfunction:a meta-analysis[J]. Andrologia,2017,49(4). DOI:10. 1111/and. 12644. Epub2016 Aug 5.
[7] Kakkavas A,Tsioufis C,Tsiachris D,et al.Erectile dysfunction and target organ damage in the early stages of hypertension[J]. J Clin Hypertens(Greenwich),2013,15(9):644-649.
[8] Liu YF,Hu LQ,Zheng XM,et al.Changes of morphology and erectile function of the cavernous tissues in spontaneously hypertensive rats[J]. Zhonghua Nan Ke Xue,2005,11(11):832-834,837.
[9] Ma ZP,Jiang R,Cheng Y,et al.Fasudil improves erectile function of hypertensive rats[J].Zhonghua Nan Ke Xue,2012,18(1):11-15.
[10] Zhou ZY,Cheng SP,Huang H,et al.Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction[J].Andrologia,2016,48(7):824-828.
[11] Chrysant SG.Antihypertensive therapy causes erectile dysfunction[J].Curr Opin Cardiol,2015,30(4):383-390.
[12] Silva FH,Monica FZ,Bau FR,et al.Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats:prevention by antioxidant therapy[J].J Sex Med,2013,10(4):960-971.
[13] Sopko NA,Hannan JL,Bivalacqua TJ.Understanding and targeting the Rho kinase pathway in erectile dysfunction[J].Nat Rev Urol,2014,11(11):622-628.
[14] Lee YC,Huang SP,Tsai CC,et al.Associations of VEGF gene polymorphisms with erectile dysfunction and related risk factors[J]. J Sex Med,2017,14(4):510-517.
[15] Basat S,Sivritepe R,Ortaboz D,et al.The relationship between vitamin D level and erectile dysfunction in patients with type 2 diabetes mellitus[J]. Aging Male,2018,21(2):111-115.
[16] Choi YJ,Yoon Y,Lee KY,et al.Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis[J].FASEB J,2014,28(7):3197-3204.
[17] Komori H,Yamada K,Tamai I.Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells[J].Biochim Biophys Acta,2018,1860(5):973-980.
[18] Zhang JX,Zhang YP,Wu QN,et al.Uric acid induces oxidative stress via an activation of the renin-angiotensin system in 3T3-L1 adipocytes[J]. Endocrine,2015,48(1):135-142.
[19] Salem S,Mehrsai A,Heydari R,et al.Serum uric acid as a risk predictor for erectile dysfunction[J].J Sex Med,2014,11(5):1118-124.
[20] Aribas A,Kayrak M,Ulucan S,et al.The relationship between uric acid and erectile dysfunction in hypertensive subjects[J].Blood Press,2014,23(6):370-376.
[21] Giovannone R,Busetto GM,Antonini G,et al. Hyperhomocysteinemia as an Early Predictor of Erectile Dysfunction:International Index of Erectile Function(IIEF)and Penile Doppler Ultrasound Correlation With Plasma Levels of Homocysteine[J].Medicine. 2015,94(39):e1556.
[22]李明,丁连芹,唐文豪,等.中青年男性高血压患者中同型半胱氨酸含量与勃起功能障碍发生的关系[J].中国性科学,2015,24(10):19-21.
[23] Karabakan M,Erkmen AE,Guzel O,et al. Association between serum folic acid level and erectile dysfunction[J].Andrologia,2016,48,24(5):532-535.
[24] Sansone M,Sansone A,Romano M,et al. Folate:a possible role in erectile dysfunction?[J].Aging Male,2018,21(2):116-120.
[25] Fongemie J,Felix-Getzik E.A review of nebivolol pharmacology and clinical evidence[J].Drugs. 2015,75(12):1349-1371.
[26] Parthasarathy HK,Ménard J,White WB,et al. A double-blind,randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism[J]. J Hypertens,2011,29:980-990.
[27]刘仁胜,谢新军.用吲达帕胺治疗高血压对男性患者性功能的影响分析[J].当代医药论丛,2016,14(8):85-86.
[28] Li H,Gao T,Wang R.The role of the sexual partner in managing erectile dysfunction[J].Nat Rev Urol,2016,13(3):168-177.
[29] Seo DY,Lee SR,Kwak HB,et al.Exercise training causes a partial improvement through increasing testosterone and e NOS for erectile function in middleaged rats[J].Exp Gerontol,2018,108:131-138.
[30] Patel JP,Lee EH,Mena-Hurtado CI,et al.Evaluation and management of erectile dysfunction in the hypertensive patient[J].Curr Cardiol Rep,2017,19(9):89.
[31] Bohm M,Baumhakel M,Koon T,et al.Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan,ramipril,or both:The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessme Nt Study in ACE i Ntolerant subjects with cardiovascular Disease(ONTARGET/TRANSCEND)Trials[J]. Circulation,2010,121(12):1439-1446.
[32] Baumhkel M,Schlimmer N,Kratz M,et al. Cardiovascular risk,drugs and erectile function—a systematic analysis[J]. Int J Clin Pract,2011,65(3):289-298.
[33] Shimizu S,Tsounapi P,Honda M,et al.Effect of an angiotensinⅡreceptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model[J].Biomed Res,2014,35(3):215-221.
[34] Lin LL,Wang D,Wang W,et al.Long-term treatment of clonidine,atenolol,amlodipine and dihydrochlorothiazide,but not enalapril,impairs the sexual function in male spontaneously hypertensive rats[J]. PLoS One,2015,10(1):e0116155.
[35] Martinez DR,Terlecki R,Brant WO.The evolution and utility of the small-carrion prosthesis,its impact,and progression to the modern-day malleable penile prosthesis[J].J Sex Med,2015,12(Suppl 7):423-430.
[2] Gurtner K,Saltzman A,Hebert K,et al.Erectile dysfunction:a review of historical treatments with a focus on the development of the inflatable penile prosthesis[J].Am J Mens Health,2017,11(3):479-486.
[3] Elkhoury FF,Rambhatla A,Mills JN,et al.Cardiovascular health,erectile dysfunction,and testosterone replacement:controversies and correlations[J].Urology,2017,110:1-8.
[4] Pessinaba S,Baragou S,Pio M,et al.Erectile dysfunction in hypertensive patient in Togo:cross-sectional study in 100 patients in the Cardiology Department of the University Hospital Campus of Lome[J].Pan Afr Med J,2015,21:47.
[5] Fafiolu AS,Adebayo AM,Akande TO,et al.Erectile dysfunction among male hypertensives in a tertiary health facility in South-West Nigeria[J]. Glob J Health Sci,2014,7(1):154-160.
[6] Ning L,Yang L.Hypertension might be a risk factor for erectile dysfunction:a meta-analysis[J]. Andrologia,2017,49(4). DOI:10. 1111/and. 12644. Epub2016 Aug 5.
[7] Kakkavas A,Tsioufis C,Tsiachris D,et al.Erectile dysfunction and target organ damage in the early stages of hypertension[J]. J Clin Hypertens(Greenwich),2013,15(9):644-649.
[8] Liu YF,Hu LQ,Zheng XM,et al.Changes of morphology and erectile function of the cavernous tissues in spontaneously hypertensive rats[J]. Zhonghua Nan Ke Xue,2005,11(11):832-834,837.
[9] Ma ZP,Jiang R,Cheng Y,et al.Fasudil improves erectile function of hypertensive rats[J].Zhonghua Nan Ke Xue,2012,18(1):11-15.
[10] Zhou ZY,Cheng SP,Huang H,et al.Decrease of the insulin-like growth factor-1 bioavailability in spontaneously hypertensive rats with erectile dysfunction[J].Andrologia,2016,48(7):824-828.
[11] Chrysant SG.Antihypertensive therapy causes erectile dysfunction[J].Curr Opin Cardiol,2015,30(4):383-390.
[12] Silva FH,Monica FZ,Bau FR,et al.Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats:prevention by antioxidant therapy[J].J Sex Med,2013,10(4):960-971.
[13] Sopko NA,Hannan JL,Bivalacqua TJ.Understanding and targeting the Rho kinase pathway in erectile dysfunction[J].Nat Rev Urol,2014,11(11):622-628.
[14] Lee YC,Huang SP,Tsai CC,et al.Associations of VEGF gene polymorphisms with erectile dysfunction and related risk factors[J]. J Sex Med,2017,14(4):510-517.
[15] Basat S,Sivritepe R,Ortaboz D,et al.The relationship between vitamin D level and erectile dysfunction in patients with type 2 diabetes mellitus[J]. Aging Male,2018,21(2):111-115.
[16] Choi YJ,Yoon Y,Lee KY,et al.Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis[J].FASEB J,2014,28(7):3197-3204.
[17] Komori H,Yamada K,Tamai I.Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells[J].Biochim Biophys Acta,2018,1860(5):973-980.
[18] Zhang JX,Zhang YP,Wu QN,et al.Uric acid induces oxidative stress via an activation of the renin-angiotensin system in 3T3-L1 adipocytes[J]. Endocrine,2015,48(1):135-142.
[19] Salem S,Mehrsai A,Heydari R,et al.Serum uric acid as a risk predictor for erectile dysfunction[J].J Sex Med,2014,11(5):1118-124.
[20] Aribas A,Kayrak M,Ulucan S,et al.The relationship between uric acid and erectile dysfunction in hypertensive subjects[J].Blood Press,2014,23(6):370-376.
[21] Giovannone R,Busetto GM,Antonini G,et al. Hyperhomocysteinemia as an Early Predictor of Erectile Dysfunction:International Index of Erectile Function(IIEF)and Penile Doppler Ultrasound Correlation With Plasma Levels of Homocysteine[J].Medicine. 2015,94(39):e1556.
[22]李明,丁连芹,唐文豪,等.中青年男性高血压患者中同型半胱氨酸含量与勃起功能障碍发生的关系[J].中国性科学,2015,24(10):19-21.
[23] Karabakan M,Erkmen AE,Guzel O,et al. Association between serum folic acid level and erectile dysfunction[J].Andrologia,2016,48,24(5):532-535.
[24] Sansone M,Sansone A,Romano M,et al. Folate:a possible role in erectile dysfunction?[J].Aging Male,2018,21(2):116-120.
[25] Fongemie J,Felix-Getzik E.A review of nebivolol pharmacology and clinical evidence[J].Drugs. 2015,75(12):1349-1371.
[26] Parthasarathy HK,Ménard J,White WB,et al. A double-blind,randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism[J]. J Hypertens,2011,29:980-990.
[27]刘仁胜,谢新军.用吲达帕胺治疗高血压对男性患者性功能的影响分析[J].当代医药论丛,2016,14(8):85-86.
[28] Li H,Gao T,Wang R.The role of the sexual partner in managing erectile dysfunction[J].Nat Rev Urol,2016,13(3):168-177.
[29] Seo DY,Lee SR,Kwak HB,et al.Exercise training causes a partial improvement through increasing testosterone and e NOS for erectile function in middleaged rats[J].Exp Gerontol,2018,108:131-138.
[30] Patel JP,Lee EH,Mena-Hurtado CI,et al.Evaluation and management of erectile dysfunction in the hypertensive patient[J].Curr Cardiol Rep,2017,19(9):89.
[31] Bohm M,Baumhakel M,Koon T,et al.Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan,ramipril,or both:The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessme Nt Study in ACE i Ntolerant subjects with cardiovascular Disease(ONTARGET/TRANSCEND)Trials[J]. Circulation,2010,121(12):1439-1446.
[32] Baumhkel M,Schlimmer N,Kratz M,et al. Cardiovascular risk,drugs and erectile function—a systematic analysis[J]. Int J Clin Pract,2011,65(3):289-298.
[33] Shimizu S,Tsounapi P,Honda M,et al.Effect of an angiotensinⅡreceptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model[J].Biomed Res,2014,35(3):215-221.
[34] Lin LL,Wang D,Wang W,et al.Long-term treatment of clonidine,atenolol,amlodipine and dihydrochlorothiazide,but not enalapril,impairs the sexual function in male spontaneously hypertensive rats[J]. PLoS One,2015,10(1):e0116155.
[35] Martinez DR,Terlecki R,Brant WO.The evolution and utility of the small-carrion prosthesis,its impact,and progression to the modern-day malleable penile prosthesis[J].J Sex Med,2015,12(Suppl 7):423-430.