麻杏石甘汤联合阿奇霉素对小儿呼吸道感染患儿肺功能及呼吸动力学的影响
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摘要
目的观察麻杏石甘汤联合阿奇霉素对小儿呼吸道感染患儿肺功能及呼吸动力学的影响。方法将80例呼吸道感染患儿随机分为两组,对照组患儿采用阿奇霉素进行治疗,观察组患儿采用麻杏石甘汤联合阿奇霉素进行治疗。比较两组患儿临床疗效以及对肺功能、呼吸动力学的影响。结果观察组患儿临床疗效高于对照组(P<0.05);观察组患儿在咳嗽消失时间、X线炎症吸收时间、气急消失时间、体温稳定时间及啰音消失时间均低于对照组(P<0.05);观察组患儿的呼吸频率(RR)低于对照组(P<0.05),但达峰时间比(t PTEF/tE)、达峰容积比(VPTEF/tE)及每公斤体重潮气量(Vt/kg)均高于对照组(P<0.05);两组患儿动态顺应性(Cdyn)水平均有所升高(P<0.05),呼吸做功(WOB)、气道阻力(Raw)、气道峰压(PIP)水平均有所降低(P<0.05),且观察组患儿Cdyn水平上升程度与WOB、Raw、PIP水平下降程度均优于对照组(P<0.05)。结论麻杏石甘汤联合阿奇霉素共同治疗小儿呼吸道感染临床效果更好,能有效缓解患儿各项临床症状指标,患儿肺功能及呼吸动力学也得到显著改善,值得临床积极推广。
引文
[1]王培香,印亚双,陈月,等.阿奇霉素对比阿莫西林-克拉维酸治疗儿童部分急性呼吸道感染临床疗效与安全性的系统评价[J].国际药学研究杂志,2016,43(4):646-651.
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[7]张喆,杜青,施红波,等.阿奇霉素联合甘草锌治疗支原体肺炎患儿疗效的研究[J].中华医院感染学杂志,2016,26(12):2848-2850.
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[9] Kim HS,Won S,Lee EK,et al. Pentraxin 3as a clinical marker in children with lower respiratory tract infection:PTX3 in Children With LRTI[J]. Pediatric Pulmonology,2016,51(1):42-48.
[10]亢杨,邓李玲,张雪医.医院就诊儿童肺炎支原体感染流行病学特征及耐药情况分析[J].中国病原生物学杂志,2017,46(7):666-670.
[11]向茜,熊昕.苇茎汤合麻杏石甘汤加减治疗卒中相关性肺炎痰热蕴肺证疗效及对患者外周血T淋巴细胞亚群、血清炎症因子的影响[J].中国实验方剂学杂志,2018,38(4):180-184.
[12] Giamberardin HIG,Homsani S,Bricks LF,et al. Clinical and epidemiological features of respiratory virus infections in preschool children over two consecutive influenza seasons in southern Brazil[J]. Journal of Medical Virology,2016,88(8):1325-1333.
[13]孟玉凤,杜建超,冯淬灵,等.加味麻杏石甘汤治疗慢性阻塞性肺疾病急性加重的机制研究[J].北京中医药大学学报,2018,21(1):45-52.
[14]温柠如,黄赫,张雅凤.不同配伍比例的麻杏石甘汤治疗支气管哮喘急性发作期疗效观察[J].中华中医药学刊,2016,42(2):444-447.
[15] Qi YY,Jiang GL,Wang LB,et al. Lung Function in Wheezing Infants after Acute Lower Respiratory Tract Infection and Its Association with Respiratory Outcome[J]. Chinese Medical Journal,2017,130(1):4-10.
[2] Wright H,Skinner AC,Jhaveri R. Evaluating Guideline-Recommended Antibiotic Practices for Childhood Respiratory Infections:Is It Time to Consider Case-Based Formats[J].Clinical Pediatrics,2016,55(2):118-121.
[3]黄汉琮,杨晓蕊,曾林祥,等.阿奇霉素与左氧氟沙星治疗社区获得性下呼吸道感染疗效对比观察[J].中华医院感染学杂志,2016,26(16):3685-3687.
[4]崔学军,宋洪波,王天才.对贵刊《阿奇霉素序贯疗法治疗下呼吸道感染61例》一文的验证[J].中国新药与临床杂志,2016,29(2):151-152.
[5] Na?m O,Xavier B,Milcent K,et al. Impact of Implementing National Guidelines on Antibiotic Prescriptions for Acute Respiratory Tract Infections in Pediatric Emergency Departments:An Interrupted Time Series Analysis[J]. Clinical Infectious Diseases,2017,65(9):1469-1476.
[6]余晓芬,陈进,陈新伟.经肺俞穴超声导入阿奇霉素治疗小儿支原体感染的安全性及临床疗效[J].中国地方病防治杂志,2017,24(1):83-83.
[7]张喆,杜青,施红波,等.阿奇霉素联合甘草锌治疗支原体肺炎患儿疗效的研究[J].中华医院感染学杂志,2016,26(12):2848-2850.
[8]迟岩,怀丽梅,赵鑫亮.老年慢性支气管炎呼吸道感染病原菌分布特点[J].中国病原生物学杂志,2016,37(12):1137-1139.
[9] Kim HS,Won S,Lee EK,et al. Pentraxin 3as a clinical marker in children with lower respiratory tract infection:PTX3 in Children With LRTI[J]. Pediatric Pulmonology,2016,51(1):42-48.
[10]亢杨,邓李玲,张雪医.医院就诊儿童肺炎支原体感染流行病学特征及耐药情况分析[J].中国病原生物学杂志,2017,46(7):666-670.
[11]向茜,熊昕.苇茎汤合麻杏石甘汤加减治疗卒中相关性肺炎痰热蕴肺证疗效及对患者外周血T淋巴细胞亚群、血清炎症因子的影响[J].中国实验方剂学杂志,2018,38(4):180-184.
[12] Giamberardin HIG,Homsani S,Bricks LF,et al. Clinical and epidemiological features of respiratory virus infections in preschool children over two consecutive influenza seasons in southern Brazil[J]. Journal of Medical Virology,2016,88(8):1325-1333.
[13]孟玉凤,杜建超,冯淬灵,等.加味麻杏石甘汤治疗慢性阻塞性肺疾病急性加重的机制研究[J].北京中医药大学学报,2018,21(1):45-52.
[14]温柠如,黄赫,张雅凤.不同配伍比例的麻杏石甘汤治疗支气管哮喘急性发作期疗效观察[J].中华中医药学刊,2016,42(2):444-447.
[15] Qi YY,Jiang GL,Wang LB,et al. Lung Function in Wheezing Infants after Acute Lower Respiratory Tract Infection and Its Association with Respiratory Outcome[J]. Chinese Medical Journal,2017,130(1):4-10.