内蒙紫草中分离提取异戊酰紫草素
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摘要
建立一种从内蒙紫草中分离提取异戊酰紫草素的制备方法.通过对有机溶剂的合理选择,将异戊酰紫草素与内蒙紫草中其他化学物质进行有效分离,提取分离出高纯度异戊酰紫草素单体.本文提取方法简单、污染少,制备的异戊酰紫草素纯度高,可用于药物的继续研发,具有较高的社会经济效益.
To establish a method for Isolation and extraction of isovalerylshikonin in Arnebia guttata Bunge.Isovalerylshikonin was separated from other chemicals in Arnebia guttata Bunge by the rational selection of organic solvents. Extraction and separation of high-purity Isovalerylshikonin were successful. The extraction method is simple,less pollution,and the purity of isovalerylshikonin is good. It can be used for further research and development of drugs,and it has high social and economic benefits.
To establish a method for Isolation and extraction of isovalerylshikonin in Arnebia guttata Bunge.Isovalerylshikonin was separated from other chemicals in Arnebia guttata Bunge by the rational selection of organic solvents. Extraction and separation of high-purity Isovalerylshikonin were successful. The extraction method is simple,less pollution,and the purity of isovalerylshikonin is good. It can be used for further research and development of drugs,and it has high social and economic benefits.
引文
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[17]刘欣,赵京霞,王燕,等.紫草素对银屑病T淋巴细胞增殖、活化的影响[J].世界中医药,2018,13(11):2862-2867,2871.
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[2]昝珂,苏蕊,滕爱君,等.新疆紫草HPLC特征图谱和紫草类药材6种萘醌类成分含量测定[J].药物分析杂志,2016,36(9):1526-1535.
[3]廖梅,姜宏梁. HPLC-MS同时测定药用紫草中13种紫草素和紫草呋喃类化合物的含量[J].中国药学杂志,2016,51(14):1212-1218.
[4]廖梅.基于UHPLC-QTRAP-MS/MS(MRM)技术的紫草中紫草素和紫草呋喃类成分特征轮廓谱的构建及其应用于紫草资源品质评价研究[D].武汉:华中科技大学,2016.
[5]林海桢,施胜英,李舒婕,等.内蒙紫草总黄酮提取工艺及其抗氧化活性研究[J].食品研究与开发,2016,37(5):36-41.
[6]魏梦涛,徐佳,舒青龙,等.紫草素清除自由基和抑制脂质过氧化活性研究[J].食品工业,2018,39(3):140-143.
[7]杨阳,陶仕英,牛建昭,等.紫草素对宫颈癌SiHa细胞增殖周期的影响[J].环球中医药,2018,11(1):6-10.
[8]滕菲.紫草素对卵母细胞成熟及早期胚胎发育的影响及机制研究[D].北京中医药大学,2017.
[9]谢羽,侯小龙,伍春莲.紫草素诱导细胞凋亡及凋亡信号途径研究进展[J].中国中医药信息杂志,2017,24(3):125-129.
[10]朱梦媛,王汝冰,周文,等.紫草素及其衍生物抗肿瘤作用研究进展[J].药学学报,2012,47(5):588-593.
[11]KRIVOSHCHEKOVA O E,FEDOREEV S A,DENISENKO V A. Naphthoquinones of Lithospermum erythrorhizon[J]. Chemistry of Natural Compounds,1976,12(6):652-655.
[12]魏玉,康冰亚,张明昊,等.紫草素纳米乳的制备及其稳定性考察[J].时珍国医国药,2018,29(12):2932-2935.
[13]杨武斌,罗晓玲,胡娟,等.紫草抗肿瘤活性成分及作用机制研究现状[J].重庆中草药研究,2018(02):56.
[14]周娟,钟询龙,黄素超,等.紫草素逆转人肺腺癌顺铂耐药的实验研究[J].重庆医学,2018,47(34):4327-4330.
[15]贾永刚.紫草膏治疗小儿尿布疹及湿疹的临床疗效观察[J].数理医药学杂志,2018,31(12):1845-1846.
[16]鲍敏,杨文龙,潘枢,等.β-羟基异戊酰紫草素对人肺癌A549裸鼠移植瘤生长的影响及其机制研究[J].中草药,2018,49(22):5339-5344.
[17]刘欣,赵京霞,王燕,等.紫草素对银屑病T淋巴细胞增殖、活化的影响[J].世界中医药,2018,13(11):2862-2867,2871.
[18]曾祖平,石佳,王子君,等.紫草乳膏提取工艺研究[J].世界中医药,2018,13(11):2872-2875.