聚乳酸经编盆底修补网片的制备与热定型工艺
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摘要
聚乳酸(PLA)生物相容性较好,在人体内可降解且产物的安全性较高。采用直径为0.138mm的国产PLA单丝,选用编链衬纬的经编网孔组织结构,在机号为E20的经编小样机上进行编织,制备得到可降解的PLA盆底修补网片。探讨了热定型工艺中的时间、温度对PLA网片的结构参数和力学性能的影响。结果表明,随着热定型温度的升高,网片的断裂强力增加,顶破强力降低,抗弯刚度增加,缝线拉脱力降低。网片在过高温度定型后性能改变明显,即网片变得更加脆硬并且易受冲击影响而发生断裂。网片在120和130℃下热定型后力学性能相近,但是高温更有利于稳定网片的尺寸和形状。热定型时间对网片的性能的影响基本无固定规律可寻,但是时间过长易导致网片的纵向弯曲刚度增加。因此基于稳定的强力和较低的弯曲刚度,PLA网片的热定型工艺选择温度为130℃,热定型时间为10min。以此工艺定型后的网片生物相容性显示:PLA网片厚重的结构和刚硬的性能特点导致网片暴露(发生率为13.33%),但是也使网片具有较低的收缩率(2.15±0.26)%。
Polylactic acid(PLA)material has good biocompatibility and degradability,its degradation product has high security.The PLA mesh was made of PLA monofilaments with diameter of 0.138 mm and knit structure of pillar/inlay stitch.The mesh was fabricated in the E20 raschel knitting machine.The effect of temperature and time in the heat-setting process on PLA mesh's structural parameters and mechanical property was discussed.The results reveal that with the increase of setting temperature,the mesh's breaking strength and bending stiffness are increased,the bursting strength and suture pulling-out force are decreased.The PLA mesh is largely changed after heat-setting under high temperature,with more brittle and stiffness which may be easily broken under large impact force.The PLA mesh has similar property under heat setting temperature of 120 and 130℃,but mesh would have more stable size and shape with higher heat setting temperature.The heat setting time has no clear regularity on the meshproperty.However,the longitudinal bending stiffness would be increased with longer setting time.Therefore,the optimal heat setting process for PLA mesh is selected based on a stable strength and a suitable bending stiffness,that the temperature is 130 ℃ and time is 10 min.The biocompatibility of PLA mesh being heat set under the optimal parameters show that the thick and heavy structure and stiff property of PLA mesh lead to mesh exposure(13.33%)but also lead to a significantly low shrinkage of(2.15±0.26)%.
Polylactic acid(PLA)material has good biocompatibility and degradability,its degradation product has high security.The PLA mesh was made of PLA monofilaments with diameter of 0.138 mm and knit structure of pillar/inlay stitch.The mesh was fabricated in the E20 raschel knitting machine.The effect of temperature and time in the heat-setting process on PLA mesh's structural parameters and mechanical property was discussed.The results reveal that with the increase of setting temperature,the mesh's breaking strength and bending stiffness are increased,the bursting strength and suture pulling-out force are decreased.The PLA mesh is largely changed after heat-setting under high temperature,with more brittle and stiffness which may be easily broken under large impact force.The PLA mesh has similar property under heat setting temperature of 120 and 130℃,but mesh would have more stable size and shape with higher heat setting temperature.The heat setting time has no clear regularity on the meshproperty.However,the longitudinal bending stiffness would be increased with longer setting time.Therefore,the optimal heat setting process for PLA mesh is selected based on a stable strength and a suitable bending stiffness,that the temperature is 130 ℃ and time is 10 min.The biocompatibility of PLA mesh being heat set under the optimal parameters show that the thick and heavy structure and stiff property of PLA mesh lead to mesh exposure(13.33%)but also lead to a significantly low shrinkage of(2.15±0.26)%.
引文
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[2]曲丽霞,权丽丽,韦贞汁,等.聚丙烯网片在腹腔镜下改良阴道骶前固定术中的应用效果[J].中华实用诊断与治疗杂志,2016,30(8):802-804.
[3]LU D,YANG L Q,ZHOU T H,et al.Synthesis,characterization and properties of biodegradable polylactic acid-β-cyclodextrin cross-linked copolymer microgels[J].European Polymer Journal,2008,44(7):2140-2145.
[4]FEOLA A,BARONE W,MOALLI P,et al.Characterizing the ex vivo textile and structural properties of synthetic prolapsed mesh products[J].International Urogynecology Journal,2013,24(4):559-564.
[5]BOT-ROBIN V,LUCOT J P,GIRAUDET G,et al.Use of vaginal mesh for pelvic organ prolapse repair:A literature review[J].Gynecological Surgery,2012,9(1):3-15.
[6]COSSON M,DEBODINANCE P,BOUKERROU M.Mechanical properties of synthetic implants used in the repair of prolapse and urinary incontinence in women:Which is the ideal material?[J].International Urogynecology Journal,2003,14(3):169-178.
[7]LI D,XIA Y.Electrospinning of nanofibers:Reinventing the wheel?[J].Advanced Materials,2004,16(14):1151-1170.
[8]RODENAS-ROCHINA J,VIDAURRE A,CORTZAR I C,et al.Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL porous scaffolds[J].Polymer Degradation&Stability,2015,119:121-131.
[9]GRUBER-BLUM S,RIEPL N,BRAND J,et al.A comparison of Progrip()and Adhesix()self-adhering hernia meshes in an onlay model in the rat[J].Hernia:The Journal of Hernias and Abdominal Wall Surgery,2014,18(5):761-769.
[10]FUJINO K,KINOSHITA M,SAITOH A,et al.Novel technique of overlaying apoly-L:-lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model[J].Surgical Endoscopy,2011,25(10):3428-3436.
[11]MAMY L,LETOUZEY V,MARES P,et al.Correlation between shrinkage and infection of implanted synthetic meshes using an animal model of mesh infection[J].International Urogynecology Journal and Pelvic Floor Dysfunction,2011,22(1):47-52.
[12]龙海如.针织学[M].北京:中国纺织出版社,2008:254-255.
[13]李又元.电脑整经机的工作原理与故障维修[J].针织工业,2008(8):14-16.
[14]曾林泉.纺织品热定型原理及实践[J].染整技术,2011,33(12):1-6.